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Geomorphological evidence inconvenient for the antecedent rivers of the Arun and Tista across the Himalayan range

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Journal of Mountain Science 2024年第9期21卷 3001-3017页

作者： NAKATA Takashi KUMAHARA yasuhiro NAIK Sambit Prasanajit sakai Harutaka Graduate School of Humanities and Social Sciences Hiroshima UniversityHigashi-Hiroshima 739-8522Japan Active Fault and Earthquake Hazard Mitigation Research Center Pukyong National UniversityBusan 48513South Korea Department of Petroleum Engineering and Earth Sciences University of Petroleum and Energy StudiesDehradun 248007India Graduate School of Science Kyoto UniversityKyoto 606-8502Japan

The Arun and Tista Rivers,which flow across the Himalayas,are commonly known as antecedent valleys that overcame the rapid uplift of the Higher Himalayan *** clarify whether the idea of antecedent rivers is acceptable,we investigated the geomorphology of the Himalayas between eastern Nepal and Bhutan *** southern part of Tibetan Plateau,extending across the Himalayas as tectonically un-deformed glaciated terrain named as'Tibetan Corridor,'does not suggest the regional uplift of the Higher *** 8,000-m class mountains of Everest,Makalu,and Kanchenjunga are isolated residual peaks on the glaciated terrain composed of mountain peaks of 4,000–6,000 m *** Tibetan glaciers commonly beheaded by Himalayan glaciers along the great watershed of the Himalayas suggest the expansion of Himalayan river drainage by *** the narrow upstream regions of the Arun and Tista Rivers with less precipitation behind the range,it is hard to collect enough water for the power of down-cutting their channels against the uplifting *** fission track ages of the Higher Himalayan Crystalline Nappe suggest that the Himalayas attained their present altitude by 11–10 Ma,and the Arun and Tista Rivers formed deep gorges across the Himalayas by headward erosion.

关键词： Himalaya Antecedent river Geomorphology AW3D30 DSM Glacier piracy

枯草芽孢杆菌对石门土鸡生长性能、屠宰性能、血清抗氧化指标和肠道形态的影响

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动物营养学报 2019年第5期31卷 2119-2126页

作者：彭豫东康克浪曲湘勇贺长青陈继发彭灿阳 yasuhiro sakai 周学彬湖南农业大学动物科学技术学院长沙410128 湖南省畜禽安全生产协同创新中心长沙410128 湖南家禽安全生产工程技术研究中心长沙410128 朝日可尔必思健康管理有限公司东京1500022 上海牧冠企业发展有限公司上海201199

本试验旨在研究饲粮中添加枯草芽孢杆菌(Bacillus subtilis,BS)对石门土鸡生长性能、屠宰性能、血清抗氧化指标和肠道形态的影响。选取540只55日龄、体重[(0.75±0.02) kg]相近的健康石门土鸡母鸡,随机分成3组,每组6个重复,每个重复30... 详细信息

本试验旨在研究饲粮中添加枯草芽孢杆菌(Bacillus subtilis,BS)对石门土鸡生长性能、屠宰性能、血清抗氧化指标和肠道形态的影响。选取540只55日龄、体重[(0.75±0.02) kg]相近的健康石门土鸡母鸡,随机分成3组,每组6个重复,每个重复30只鸡。对照组饲喂基础饲粮,试验组分别饲喂在基础饲粮的基础上添加300和600 mg/kg BS的试验饲粮。预试期7 d,正试期28 d。结果表明:1) 1～14 d时,与对照组相比,300、600 mg/kg BS组石门土鸡的平均日采食量(ADFI)和平均日增重(ADG)有提高趋势(P>0.05); 15～28 d和1～28 d时,各组间的ADFI、ADG和料重比(F/G)均无显著差异(P> 0.05)。2)与对照组相比,600 mg/kg BS组石门土鸡的屠宰率显著提高(P0.05);各组间的半净膛率、全净膛率、胸肌率、腿肌率均无显著差异(P>0.05)。3)与对照组相比,14 d时,300 mg/kg BS组石门土鸡的血清总超氧化物歧化酶(T-SOD)活性显著提高(P 0.05),300 mg/kg BS组的空肠绒毛宽度显著提高(P0.05)。综上,饲粮中添加BS提高了石门土鸡的屠宰性能,增强了机体抗氧化能力,改善了肠道形态。

关键词：枯草芽孢杆菌石门土鸡生长性能屠宰性能抗氧化肠道形态

Effects of elevated [CO_2] on stem and root lodging among rice cultivars

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Chinese Science Bulletin 2013年第15期58卷 1787-1794页

作者： ZHU ChunWu CHENG WeiGuo sakai Hidemitsu OIKAWA Shimpei LAZA Rebecca C USUI yasuhiro HASEGAWA Toshihiro National Institute for Agro-Environmental Sciences Ibaraki 305-8604Japan Faculty of Agriculture Yamagata UniversityYamagata 997-8555Japan Faculty of International Agriculture and Food Studies Tokyo University of AgricultureTokyo 156-8502Japan Crop and Environmental Sciences Division International Rice Research InstituteDAPO Box 7777Metro ManilaPhilippines

Studies showed that elevated [CO2] would improve photosynthetic rates and enhance yields of rice;however,few studies have focused on the response of rice lodging,which is a major cause of cereal yield loss and quality reduction,under elevated [CO2].In this study,we examined the effects of elevated [CO2] on stem and root lodging using 4 rice cultivars(86Y8,japonica hybrid;LYP9,2-line indica hybrid;variety 9311,type of indica inbred rice,and SY63,3-line indica hybrid) grown under two [CO2] levels:400 and 680 μmol *** results indicated that under elevated [CO2],the stem-lodging risk(SLR) of 9311 decreased,while in SY63 the SLR increased,86Y8 and LYP9 were not significantly affected;the risk of root lodging was reduced for all cultivars,because root biomass(instead of root number) and bending strength were increased significantly,and then the increase of anti-lodging ability is far higher than that of self-weight mass moment for all *** findings suggested that higher [CO2] can enhance the risk of stem-lodging for cultivars with strong-[CO2]-responses,but may not aggravate the root lodging for all rice cultivars.

关键词： CO2浓度升高倒伏水稻品种间种茎二氧化碳浓度升高水稻品种杂交粳稻两优培九

Control strategy and methods for continuous direct compression processes

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Asian Journal of Pharmaceutical Sciences 2021年第2期16卷 253-262页

作者： yasuhiro Suzuki Hirokazu Sugiyama Manabu Kano Ryutaro Shimono Gosuke Shimada Ryoichi Furukawa Eichi Mano Keiichi Motoyama Tatsuo Koide yasuhiro Matsui Kazuki Kurasaki Issei Takayama Shunin Hikage Noriko Katori Masahiko Kikuchi Hiroshi sakai Yoshihiro Matsuda Formulation Technology Research Laboratories Daiichi Sankyo Co.Ltd.Kanagawa 254-0014Japan Department of Chemical System Engineering The University of TokyoTokyo 113-8656Japan Department of Systems Science Kyoto UniversityKyoto 606-8501Japan CMC Sciences Department Regulatory Affairs DivisionR&D DivisionJanssen Pharmaceutical K.K.Tokyo 101-0065Japan EuroTechno Ltd. Kanagawa 223-0057Japan Pharmaceutical Research Department Mitsubishi Tanabe Pharma CorporationOsaka 532-8505Japan Chemical Products CMC Regulatory Affairs Area Japan DevelopmentMSD K.K.Tokyo 102-8667Japan Graduate School of Pharmaceutical Sciences Kumamoto UniversityKumamoto 862-0973Japan Division of Drugs National Institute of Health SciencesKawasaki 210-9501Japan Technology Research&Development Sumitomo Dainippon Pharma Co.Ltd.Osaka 564-0053Japan Formulation Development Department Chugai pharmaceutical Co.Ltd.Tokyo 115-8543Japan Office of New Drug IV Pharmaceuticals and Medical Devices AgencyShin-Kasumigaseki Bldg.Tokyo 100-0013Japan Office of Generic Drugs Pharmaceuticals and Medical Devices AgencyShin-Kasumigaseki Bldg.Tokyo 100-0013Japan KOKANDO Co. Ltd.Toyama 930-8580Japan Pharmaceuticals and Medical Devices Agency Shin-Kasumigaseki Bldg.Tokyo 100-0013Japan

We presented a control strategy for tablet manufacturing processes based on continuous direct *** work was conducted by the experts of pharmaceutical companies,machine suppliers,academia,and regulatory authority in *** different items in the process,the component ratio and blended powder content were selected as the items requiring the control method specific to continuous manufacturing different from the conventional batch *** control and management of the Loss in Weight(LIW)feeder were deemed the most important,and the Residence Time Distribution(RTD)model were regarded effective for setting the control range and for controlling of the LIW *** on these ideas,the concept of process control using RTD was summarized.

关键词： Continuous manufacturing Solid drug products Process control Residence time distribution Loss in weight feeder Regulatory science

A Small One-Fiber WDM Optical Ethernet PC Card for FTTD

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光学学报 2003年第S1期23卷 605-606页

作者： Naoto Sugimoto Seiji Fukushima yasuhiro Suzuki Yoshihisa sakai Hiromasa Tanobe Takeshi Kurosaki Kazuto Noguchi Kimio Oguchi Hiromu Toba Photonics Laboratories Nippon Telegraph and Telephone Corporation Morinosatowakamiya 3-1 Atsugi-shi Kanagawa 248-0198 Japan Network Innovation Laboratories Nippon Telegraph and Telephone Corporation

A new generation of network interface card for fiber-to-the-desktop has been fabricated. The fabricated card is PC-card size and suitable for notebook PCs. It could become the key element in the coming optical Etherne... 详细信息

关键词： key element

Selective Monoprotection of Symmetrical Diols in a Flow Reactor

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International Journal of Organic Chemistry 2018年第2期8卷 264-271页

作者： Hisashi Masui Masaru Takizawa Yuki sakai yasuhiro Kajiwara Kiyofumi Wanibuchi Mitsuru Shoji Takashi Takahashi Department of Pharmaceutical Sciences Yokohama University of Pharmacy Yokohama Japan

Desymmetrization reactions provide a powerful approach for the construction of complex molecules. Various methods have been developed for the selective monoprotection of symmetrical diols;however, their application to large-scale operations is limited. In this study, the monotetrahydropyranylation of symmetrical diols in a flow reactor has been developed, whereby the length of the flow reactor tube and the amount of acid were optimized. A higher selectivity for the monoprotected derivative was observed when the reaction was performed in a flow reactor compared with that observed in a conventional batch experiment. The efficient flow method developed herein can be applied to large-scale synthesis by numbering up the flow reactor without affecting the selectivity and yield. Since monoprotection can be achieved without using a large excess of diol, our developed flow method is effective when expensive diol must be used.

关键词： Desymmetrization Selective Monoprotection Flow Synthesis Diols Tetrahydropyranylation

Feasibility of the Routine Clinical Use of a Multiplex Virus Polymerase Chain Reaction Assay Based on Blood Virus Detection in Hematopoietic Stem Cell-Transplanted Patients

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International Journal of Clinical Medicine 2022年第2期13卷 67-81页

作者： Hiroko Tsunemine Miho Sasaki Yuriko Zushi Toshiharu Saitoh Norio Shimizu yasuhiro Tomaru Yumi Aoyama Ryusuke Yamamoto Tomomi sakai Nobuyoshi Arima Taiichi Kodaka Takayuki Takahashi Departments of Hematology Shinko Hospital Kobe Japan Cell Therapy Shinko Hospital Kobe Japan Center for Stem Cell and Regenerative Medicine Tokyo Medical and Dental University Tokyo Japan Akasaka Hematology & Oncology Clinic Kobe Japan

Background: Multiplex virus assays are useful in immunocompromised hosts but still challenging in routine clinical settings in terms of their sensitivity, specificity, reproducibility, and time and cost performances. In recent years, we developed a qualitative multiplex virus PCR assay capable of the simultaneous detection of 13 virus species within 3 h. However, because of the multiple and concomitant nature of this virus assay, it should be validated for qualitative reliability. Materials and Methods: As a preclinical examination, this multiplex PCR was able to detect 1.25 × 103 copies/mL of 13 synthesized virus genomes and preserved same virus DNAs by the serial dilution method. Blood samples from 40 patients who underwent hematopoietic stem cell transplantation were then examined by multiplex PCR for 13 virus species, followed by quantitative real-time PCR for all 13 virus species as reference PCR when these patients developed symptoms suggestive of viral infection. Results: In 421 cumulative qualitative-quantitative tests, the multiplex PCR certainly detected 1.0 × 103 copies/mL of 5 viruses (CMV, JCV, BKV, HHV-6, ADV) that were frequently detected and thus reasonably analyzed. The positive and negative predictive values of multiplex PCR were 84.2% - 93.3% and 90.7% - 99.0%, respectively, and sensitivity and specificity were 59.0% - 83.3% and 97.2% - 99.2%, respectively, for these 5 viruses. Conclusion: From these performances, the multiplex PCR assay may be acceptable in a routine clinical laboratory setting.

关键词： Multiplex Virus PCR Assay Routine Laboratory Use Positive Predictive Value Negative Predictive Value Sensitivity Specificity

静脉注射尼可地尔对短期和长期患有心绞痛的急性ST段抬高型心肌梗塞患者的影响

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首都食品与医药 2015年第18期22卷 87-88页

作者： Hideki Ishii Satoshi Ichimiya Masaaki Kanashiro Tetsuya Amano yasuhiro Ogawa Hirotsugu Mitsuhashi Shinichi sakai Tadayuki Uetani Ryuichiro Murakami Keiko Naruse Toyoaki Murohara Tatsuaki Matsubara 王青不详北京四环科宝制药有限公司 100079

（接8月下）在这篇文章的研究中,每组又被分为2个子组：给予52名前驱心绞痛患者安慰剂,给予129名非前驱心绞痛患者尼克地尔治疗,给予56名前驱心绞痛患者尼克地尔治疗,给予131名非前驱心绞痛患者安慰剂。前驱心绞痛被定义为急性心肌梗死... 详细信息

（接8月下）在这篇文章的研究中,每组又被分为2个子组：给予52名前驱心绞痛患者安慰剂,给予129名非前驱心绞痛患者尼克地尔治疗,给予56名前驱心绞痛患者尼克地尔治疗,给予131名非前驱心绞痛患者安慰剂。前驱心绞痛被定义为急性心肌梗死前的休息时持续时间少于30分钟的短暂性胸痛。

关键词：尼可地尔 ST段抬高前驱心绞痛急性心肌梗死心肌梗塞患者胸痛再灌注损伤心电图描记疼痛持续时间再灌注心律失常

静脉注射尼可地尔对短期和长期患有心绞痛的急性ST段抬高型心肌梗塞患者的影响

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首都食品与医药 2015年第16期22卷 128-128页

研究表明,急性心肌梗死（AMI）的前驱心绞痛有助于达到较好的治疗效果,尼可地尔对缺血性心脏具有保护作用。我们比较了静脉注射尼可地尔对前驱心绞痛预处理的急性心肌梗死患者和接受经皮冠状动脉介入治疗（PCI）的急性心肌梗死患者的心... 详细信息

研究表明,急性心肌梗死（AMI）的前驱心绞痛有助于达到较好的治疗效果,尼可地尔对缺血性心脏具有保护作用。我们比较了静脉注射尼可地尔对前驱心绞痛预处理的急性心肌梗死患者和接受经皮冠状动脉介入治疗（PCI）的急性心肌梗死患者的心脏保护作用。总体而言,将368名接受经皮冠状动脉介入治疗（PCI）的患有急性ST段抬高型心肌梗死的患者随机分组,于PCI治疗前,分别给予静脉注射12mg尼可地尔和安慰刷治疗。

关键词：急性ST段抬高型心肌梗死急性心肌梗死心肌梗死患者前驱心绞痛尼可地尔静脉注射经皮冠状动脉介入治疗心肌梗塞