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MSCs derived extracellular vesicles as a therapeutic paragon for neurodegenerative disorders:A viewpoint

BIOCELL 2022年第6期46卷 1435-1438页

作者： yashvi sharma SHARDA RAY SUJATA MOHANTY Stem Cell Facility(DBT-Centre of Excellence for Stem Cell Research) All India Institute of Medical SciencesNew DelhiIndia Jawaharlal Nehru Medical College KarnatakaIndia

Neurodegenerative disorders are a vicious woe to the public health and *** in their underlying causes,lack of effective biomarkers for their early detection,existence of only supportive therapy,and their ever rising incidence creates an unmatched need for targeted *** Stem Cells(MSCs)have found to be promising candidates for regenerative and remedial therapy in neurodegenerative disorders,however several biological risks and practical issues impede in their translational *** from MSCs are certain Extracellular Vesicles(EVs),which aid in the paracrine action of MSCs and have lately gained the scientific interest for their implacability in diverse set *** cargo is of utmost importance and is being explored in various different diseases like heart diseases,neuronal diseases,respiratory diseases and hepatic *** thereby hold the position of a likely prospective remedial candidate for therapy against neurodegenerative disorders.

关键词： Mesenchymal stem cells Extracellular vesicles Neurodegenerative disorders Cell-free therapy Regeneration

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Mesenchymal stem cell-derived exosome as a nano weapon to target the COVID-19 pandemic

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BIOCELL 2021年第3期45卷 517-520页

作者： yashvi sharma SUCHI GUPTA SUJATA MOHANTY Stem Cell Facility(DBT-Centre of Excellence for Stem Cell Research) All India Institute of Medical SciencesNew Delhi110029India

In these times of despair when a nano-sized organism,the SARS-CoV-2,has rendered the human race helpless,made the global health status decline,and drowned the world economy,a ray of hope comes from another nano-sized particle,the *** potential of mesenchymal stem cells has already been established in COVID-19;however,cell-based therapy has its *** thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19,as they can be a game-changer owing to their immunomodulatory nature,which combats the cytokine storm characterizing this disease,and their practical efficiency,which will realistically aid large access to therapy worldwide.

关键词： SARS-CoV-2 Wharton’s Jelly COVID-19 Cell-free therapy Exosomes Immunomodulation

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