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Dendritic cell therapy with improved outcome in glioma multiforme―a case report

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第2期7卷 114-117页

作者： KHAN Jamal A. yaqin sharmin Microbiology Research Lab C-38/Sector 20 Noida (U.P.) 201301 India

Malignant gliomas are the most devastating tumors in clinical practice and nave poorest survival, Immunological treatment of such patients may likely increase the survival and quality of life. Dendritic cells （DCs）, most potent antigen presenting cells in combination with oral chemotherapeutic agents may be tried for patients giving consent to such treatment. We have successfully combined the two therapies in an adult male patient who was on downhill course after being operated on once with post operation chemotherapy and radiotherapy for glioma in the left parietal area. He received five dendritic cell therapy vaccines in combination with oral chemotherapy and responded dramatically having near normal quality of life for an additional five months with this regime, increasing the survival after operation to 11 months. This therapy is continuing with radiological betterment of the lesion. The DCs are matured with antigen extracted from wax embedded tissue at 6th day of culture. We feel that the treatment can be given to more number of patients to establish its efficacy for the dreaded cancer glioblastoma multiforme.

关键词： Dendritic cells Glioma Immunetherapy

Directly predicting N2 electroreduction reaction free energy using interpretable machine learning with non-DFT calculated features

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Journal of Energy Chemistry 2024年第10期97卷 139-148页

作者： yaqin Zhang Yuhang Wang Ninggui Ma Jun Fan Department of Materials Science and Engineering City University of Hong Kong Center for Advanced Nuclear Safety and Sustainable Development City University of Hong Kong Department of Mechanical Engineering City University of Hong Kong

Electrocatalytic nitrogen reduction to ammonia has garnered significant attention with the blooming of single-atom catalysts（SACs）,showcasing their potential for sustainable and energy-efficient ammonia ***,cost-effectively designing and screening efficient electrocatalysts remains a *** this study,we have successfully established interpretable machine learning（ML） models to evaluate the catalytic activity of SACs by directly and accurately predicting reaction Gibbs free *** models were trained using non-density functional theory（DFT） calculated features from a dataset comprising 90 graphene-supported *** results underscore the superior prediction accuracy of the gradient boosting regression（GBR） model for both Δg（N2→NNH） and ΔG（NH2→NH3）,boasting coefficient of determination（R2） score of 0.972 and 0.984,along with root mean square error（RMSE） of 0.051 and 0.085 eV,***,feature importance analysis elucidates that the high accuracy of GBR model stems from its adept capture of characteristics pertinent to the active center and coordination environment,unveilling the significance of elementary descriptors,with the colvalent radius playing a dominant ***,Shapley additive explanations（SHAP） analysis provides global and local interpretation of the working mechanism of the GBR *** analysis identifies that a pyrrole-type coordination（flag=0）,d-orbitals with a moderate occupation（Nd=5）,and a moderate difference in covalent radius(rTM-avenear 140 pm) are conducive to achieving high ***,we extend the prediction of activity to more catalysts without additional DFT calculations,validating the reliability of our feature engineering,model training,and design *** findings not only highlight new opportunity for accelerating catalyst design using non-DFT calculated features,but also shed light on the working mechanism of "black box" ML ***,the model provides valuable guidanc

关键词： Graphene Interpretable machine learning Nitrogen reduction Non-DFT features Single-atom catalyst

Comparison of the Minimum Bounding Rectangle and Minimum Circumscribed Ellipse of Rain Cells from TRMM

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Advances in Atmospheric Sciences 2024年第3期41卷 391-406页

作者： Hongke CAI yaqin MAO Xuanhao ZHU Yunfei FU Renjun ZHOU Plateau Atmospheric and Environment Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Center for Atmospheric Optics Anhui Institute of Optics and Fine MechanicsChinese Academy of SciencesHefei 230031China

Based on the TRMM dataset, this paper compares the applicability of the improved MCE(minimum circumscribed ellipse), MBR(minimum bounding rectangle), and DIA(direct indexing area) methods for rain cell fitting. These three methods can reflect the geometric characteristics of clouds and apply geometric parameters to estimate the real dimensions of rain cells. The MCE method shows a major advantage in identifying the circumference of rain cells. The circumference of rain cells identified by MCE in most samples is smaller than that identified by DIA and MBR, and more similar to the observed rain cells. The area of rain cells identified by MBR is relatively robust. For rain cells composed of many pixels(N> 20), the overall performance is better than that of MCE, but the contribution of MBR to the best identification results,which have the shortest circumference and the smallest area, is less than that of MCE. The DIA method is best suited to small rain cells with a circumference of less than 100 km and an area of less than 120 km^(2), but the overall performance is mediocre. The MCE method tends to achieve the highest success at any angle, whereas there are fewer “best identification”results from DIA or MBR and more of the worst ones in the along-track direction and cross-track direction. Through this comprehensive comparison, we conclude that MCE can obtain the best fitting results with the shortest circumference and the smallest area on behalf of the high filling effect for all sizes of rain cells.

关键词： TRMM minimum bounding rectangle minimum circumscribed ellipse

Multiplexed manipulation of orbital angular momentum and wavelength in metasurfaces based on arbitrary complex-amplitude control

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Light(Science & Applications) 2024年第5期13卷 930-940页

作者： Guoli He yaqin Zheng Changda Zhou Siyang Li Zhonghong Shi Yanhui Deng Zhang-Kai Zhou State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China

Due to its unbounded and orthogonal modes,the orbital angular momentum(OAM)is regarded as a key optical degree of freedom(DoF)for future information processing with ultra-high capacity and *** the manipulation of OAM based on metasurfaces has brought about great achievements in various fields,such manipulation currently remains at single-DoF level,which means the multiplexed manipulation of OAM with other optical DoFs is still lacking,greatly hampering the application of OAM beams and advancement of *** order to overcome this challenge,we propose the idea of multiplexed coherent pixel(MCP)for *** approach enables the manipulation of arbitrary complex-amplitude under incident lights of both plane and OAM waves,on the basis of which we have realized the multiplexed DoF control of OAM and *** a result,the MCP method expands the types of incident lights which can be simultaneously responded by metasurfaces,enriches the information processing capability of metasurfaces,and creates applications of information encryption and OAM *** findings not only provide means for the design of high-security and high-capacity metasurfaces,but also raise the control and application level of OAM,offering great potential for multifunctional nanophotonic devices in the future.

关键词： momentum offering overcome

Improving hydrogen storage thermodynamics and kinetics of Ce-Mg-Ni-based alloy by mechanical milling with TiF_(3)

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Journal of Magnesium and Alloys 2024年第4期12卷 1593-1607页

作者： Hongwei Shang Wei Zhang Xin Wei yaqin Li Zeming Yuan Jun Li Yanghuan Zhang School of Mechanical and Electrical Engineering Chuzhou UniversityChuzhou 239000China Department of Functional Material Research Central Iron and Steel Research InstituteNo.76 Xueyuannan RoadHaidian DistrictBeijing 100081China Key Laboratory of Integrated Exploitation of Bayan-Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010China China Rare Earth New Material(Weishan)Co. Ltd.Jining 277600China

Mg-based hydrides are too stable and the kinetics of hydrogen absorption and desorption is not *** efficient way to improve these shortcomings is to employ reactive ball milling to synthesize the nanocomposite materials of Mg and *** this experiment,TiF_(3)was selected as an additive,and the mechanical milling method was employed to prepare the experimental *** alloys used in this experiment were the as-cast Ce_(5)Mg_(85)Ni_(10),as-milled Ce_(5)Mg_(85)Ni_(10)and Ce_(5)Mg_(85)Ni_(10)+3 wt.%*** phase transformation,structural evolution,isothermal and non-isothermal hydrogenation and dehydrogenation performances of the alloys were inspected by XRD,SEM,TEM,Sievert apparatus,DSC and *** revealed that nanocrystalline appeared in the as-milled *** with the as-cast alloy,ball milling made the particle dimension and grain size decrease dramatically and the defect density increase *** addition of TiF_(3)made the surface of ball milling alloy particles markedly coarser and more *** milling and adding TiF_(3)distinctly improved the activation and kinetics of the ***,ball milling along with TiF_(3)can decrease the onset dehydrogenation temperature of Mg-based hydrides and slightly ameliorate their thermodynamics.

关键词： Mg-based hydrides TiF_(3) Ball milling Thermodynamics Kinetics

Revealing the Multifunctional Electrocatalysis of Indium-Modulated Phthalocyanine for High-Performance Lithium-Sulfur Batteries

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Energy & Environmental Materials 2024年第1期7卷 1-8页

作者： Yang Guo Zhaoqing Jin Jianhao Lu Zilong Wang Zihao Song Anbang Wang Weikun Wang yaqin Huang Beijing Key Laboratory of Electrochemical Process and Technology for Materials Key Laboratory of Biomedical Materials of Natural MacromoleculesMinistry of EducationBeijing University of Chemical TechnologyBeijing 100029China Research Institute of Chemical Defense Beijing Key Laboratory of Advanced Chemical Energy Storage Technology and MaterialsBeijing 100191China

The sluggish kinetics of complicated multiphase conversions and the severe shuttling effect of lithium polysulfides(LiPSs)significantly hinder the applications of Li-S battery,which is one of the most promising candidates for the next-generation energy storage ***,a bifunctional electrocatalyst,indium phthalocyanine self-assembled with carbon nanotubes(InPc@CNT)composite material,is proposed to promote the conversion kinetics of both reduction and oxidation processes,demonstrating a bidirectional catalytic effect on both nucleation and dissolution of Li_(2)S *** theoretical calculation shows that the unique electronic configuration of InPc@CNT is conducive to trapping soluble polysulfides in the reduction process,as well as the modulation of electron transfer dynamics also endows the dissolution of Li_(2)S in the oxidation reaction,which will accelerate the effectiveness of catalytic conversion and facilitate sulfur ***,the InPc@CNT modified separator displays lower overpotential for polysulfide transformation,alleviating polarization of electrode during *** integrated spectroscopy analysis,HRTEM,and electrochemical study reveal that the InPc@CNT acts as an efficient multifunctional catalytic center to satisfy the requirements of accelerating charging and discharging ***,the Li-S battery with InPc@CNT-modified separator obtains a discharge-specific capacity of 1415 mAh g^(-1)at a high rate of 0.5 ***,the 2 Ah Li-S pouch cells deliver 315 Wh kg^(-1)and achieved 80%capacity retention after 50 cycles at 0.1 C with a high sulfur loading of 10 mg cm^(-2).Our study provides a practical method to introduce bifunctional electrocatalysts for boosting the electrochemical properties of Li-S batteries.

关键词： bidirectional catalyst indium phthalocyanine lithium-sulfur batteries pouch cells

Three-dimensionally ordered macroporous(3DOM) structure promoted the activity and H_(2)O poisoning resistance of Ce Mn/3DOM-TiO_(2) catalyst in NH_(3)-SCR

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Journal of Rare Earths 2024年第3期42卷 523-533,I0004页

作者： yaqin Hu Shipeng Ding Chenchen Tan Peng Wu Guobo Li Sheng Wang Hongqiang Yang Yaping Zhang Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing210096China State Power Environmental Protection Research Institute Nanjing210031China

NH_(3)-SCR is an effective mean of NOxremoval in the non-electric industry, however, the high activation temperature and poor H_(2)O resistance of SCR catalysts posed a barrier to its application. In this work, a series of three-dimensionally ordered macroporous(3DOM) catalysts were synthesized via a colloidal crystal template(CCT) method, and various characterizations were carried out to explore the physicochemical property of catalysts. The experiment results reveal that Ce_(0.2)Mn_(0.2)/3DOM-TiO_(2) catalyst presents the excellent low-temperature catalytic activity of nearly 100% at 100℃. Furthermore, the enhanced H_(2)O resistance is achieved, certified by the unaffected NO remove at 150℃ in the participation of 15 vol% H_(2)O. The characterizations results exhibit that the improved dispersion of the active component and enhanced redox ability are conducive to the low-temperature catalytic activity. N_(2) adsorption and desorption experiments indicate that catalyst with 3DOM support possesses a larger pore diameter and specific surface area, which may weaken the condensation of H_(2)O in the microporosity of catalysts and improved the H_(2)O resistance of the catalyst. In situ DRIFTS results manifest that Ce_(0.2)Mn_(0.2)/3DOM-TiO_(2) catalyst could not only absorb more NH_(3) and generate more surface-active sites, but inhibit the competitive adsorption between H_(2)O and SCR reactants.

关键词： 3DOM material NH_(3)-SCR H_(2)O resistance Low-temperature Cerium Rare earths

Decision Model of Transmission Capacity Based on Expected Quantile for Wind Farm

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太原理工大学学报 2024年

作者： Mst sharmin Kader Riyadzh Mahmuudh Xiaoqing Han Li Tingjun College of Electrical and Power Engineering.Taiyuan University of Technology Taiyuan University of Technology

The new energy generation represented by wind power is the most realistic strategic choice to achieve the goals of carbon peaking and carbon neutrality. To absorb renewable energy electricity in power grids a new probabilistic evaluation method for available transmission capacity in transmission systems is proposed based on joint cumulants， and a decision model for risk available transmission capacity based on expected quantiles is proposed accordingly. As a vital component of ATC calculation， the transmission reliability margin (TRM)， as a reserved transmission capacity， reflects the impact of uncertainty factors on transmission capacity. However， in traditional calculation methods， TRM is determined through deterministic or probabilistic methods， which is difficult to reflect the risks brought by large-scale wind power consumption to ATC and cannot meet the requirements for transmission capacity risk management. Firstly， to address the issue that the cumulative method requires variables to be independent of each other and cannot consider the correlation of wind power output， a joint cumulative method combined with FGM Copula function is proposed to characterize the correlation of wind power output; Secondly， for the probabilistic assessment of available transmission capacity， a probabilistic assessment model for available transmission capacity is established by combining the partition integration method and the Comish Fisher expansion; Finally， in response to the problem that decision methods based on value at risk only consider the probability achieved at the tail of the probability distribution and cannot describe the risks generated throughout the distribution， a risk available transmission capacity index based on expected quantiles is proposed， and its evaluation process is proposed. Verify the feasibility and practicality of the proposed indicators and models through case analysis.

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Detecting compromised email accounts via login behavior characterization

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Cybersecurity 2024年第1期7卷 16-36页

作者： Jianjun Zhao Can Yang Di Wu yaqin Cao Yuling Liu Xiang Cui Qixu Liu Institute of Information Engineering Chinese Academy of SciencesBeijing100085China School of Cyber Security University of Chinese Academy of SciencesBeijing100049China China Cybersecurity Review Technology and Certification Center Beijing100013China Zhongguancun Laboratory Beijing100089China

The illegal use of compromised email accounts by adversaries can have severe consequences for enterprises and *** compromised email accounts is more challenging than in the social network field,where email accounts have only a few interaction events(sending and receiving).To address the issue of insufficient features,we propose a novel approach to detecting compromised accounts by combining time zone differences and alternate logins to identify abnormal *** on this approach,we propose a compromised email account detection framework that relies on widely available and less sensitive login logs and does not require *** framework characterizes login behaviors to identify logins that do not belong to the account owner and outputs a list of account-subnet pairs ranked by their likelihood of having abnormal login *** approach reduces the number of account-subnet pairs that need to be investigated and provides a reference for investigation *** evaluation demonstrates that our method can detect most email accounts that have been accessed by disclosed malicious IP addresses and outperforms similar ***,our framework has the capability to uncover undisclosed malicious IP addresses.

关键词： Compromised account detection Mixture model Login log analysis Attribution and forensic