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Excitonic devices based on two-dimensional transition metal dichalcogenides van der Waals heterostructures

Frontiers of Chemical Science and Engineering 2024年第2期18卷 41-67页

作者： Yulun Liu yaojie Zhu Zuowei Yan Ruixue Bai Xilin Zhang Yanbo Ren Xiaoyu Cheng Hui Ma Chongyun Jiang College of Electronic Information and Optical Engineering Nankai UniversityTianjin 300350China School of Physical Science and Technology Tiangong UniversityTianjin 300387China

Excitonic devices are an emerging class of technology that utilizes excitons as carriers for encoding, transmitting, and storing information. Van der Waals heterostructures based on transition metal dichalcogenides often exhibit a type II band alignment, which facilitates the generation of interlayer excitons. As a bonded pair of electrons and holes in the separation layer, interlayer excitons offer the chance to investigate exciton transport due to their intrinsic out-of-plane dipole moment and extended exciton lifetime. Furthermore, interlayer excitons can potentially analyze other encoding strategies for information processing beyond the conventional utilization of spin and charge. The review provided valuable insights and recommendations for researchers studying interlayer excitonic devices within van der Waals heterostructures based on transition metal dichalcogenides. Firstly, we provide an overview of the essential attributes of transition metal dichalcogenide materials, focusing on their fundamental properties, excitonic effects, and the distinctive features exhibited by interlayer excitons in van der Waals heterostructures. Subsequently, this discourse emphasizes the recent advancements in interlayer excitonic devices founded on van der Waals heterostructures, with specific attention is given to the utilization of valley electronics for information processing, employing the valley index. In conclusion, this paper examines the potential and current challenges associated with excitonic devices.

关键词： excitonic devices van der Waals heterostructures transition metal dichalcogenides interlayer excitons valley-Hall effect optoelectronics

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The AaBBX21–AaHY5 module mediates light-regulated artemisinin biosynthesis in Artemisia annua L.

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Journal of Integrative Plant Biology 2024年第8期66卷 1735-1751页

作者： Weizhi He Hang Liu Zhangkuanyu Wu Qing Miao Xinyi Hu Xin Yan Hangyu Wen yaojie Zhang Xueqing Fu Li Ren Kexuan Tang Ling Li Frontiers Science Center for Transformative Molecules Joint International ResearchLaboratory of Metabolic and Developmental SciencesKey Laboratory of Urban Agriculture(South)Ministry of AgriculturePlant Biotechnology Research CenterFudan-SJTU-Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Institute for Agri-Food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

The sesquiterpene lactone artemisinin is an important anti-malarial component produced by the glandular secretory trichomes of sweet wormwood(Artemisia annua L.).Light was previously shown to promote artemisinin production,but the underlying regulatory mechanism remains *** this study,we demonstrate that ELONGATED HYPOCOTYL5(HY5),a central transcription factor in the light signaling pathway,cannot promote artemisinin biosynthesis on its own,as the binding of AaHY5 to the promoters of artemisinin biosynthetic genes failed to activate their *** analysis and yeast two-hybrid screening revealed the B-box transcription factor AaBBX21 as a potential interactor with ***21 showed a trichome-specific expression ***,the AaBBX21–AaHY5 complex cooperatively activated transcription from the promoters of the downstream genes AaGSW1,AaMYB108,and AaORA,encoding positive regulators of artemisinin ***,AaHY5 and AaBBX21 physically interacted with the *** E3.ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1(COP1).In the dark,AaCOP1 decreased the accumulation of AaHY5 and AaBBX21 and repressed the activation of genes downstream of the AaHY5–AaBBX21 complex,explaining the enhanced production of artemisinin upon light *** study provides insights into the central regulatory mechanism by which light governs terpenoid biosynthesis in the plant kingdom.

关键词： AaBBX21 AaHY5 AaCOP1 Artemisia annua L. artemisinin biosynthesis light

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Baosteel Technical Research 2024年第1期18卷 8-13页

作者： ZHANG Yalin WANG yaojie WANG Xuemin Cold Rolling Plant Baoshan Iron&Steel Co.Ltd.Shanghai 201900China School of Mechanical Engineering and Automation Northeastern UniverstiyShenyang 110819China Research Institute Baoshan Iron&Steel Co.Ltd.Shanghai 201999China

An internal defect meter is an instrument to detect the internal inclusion defects of cold-rolled strip *** detection accuracy of the equipment can be evaluated based on the similarity of the multiple detection data obtained for the same steel *** on the cosine similarity model and eigenvalue matrix model,a comprehensive evaluation method to calculate the weighted average of similarity is *** show that the new method is consistent with and can even replace artificial evaluation to realize the automatic evaluation of strip defect detection results.

关键词： internal defect inclusion similarity evaluation model repeatability detection equipment strip steel

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The Effect of Ginkgo Biloba Leaf Dropping Pill Combined with Butylphthalide Capsule on Cognitive Dysfunction in Patients after Acute Ischemic Stroke and Its Impact on Serum Cytokines

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Journal of Biosciences and Medicines 2024年第7期12卷 252-262页

作者： yaojie Cai Yuping He Gang Yang Yan Chen Department of Neurology Zhuji Peoples Hospital of Zhejiang Province Shaoxing China Department of Neurosurgery Zhuji Peoples Hospital of Zhejiang Province Shaoxing China

Objective: To investigate the therapeutic effect of Ginkgo biloba extract dropping pills combined with butylphthalide capsules on cognitive dysfunction in patients after acute ischemic stroke (AIS) and its impact on serum cytokines CRP, IL-6, and Hcy. Methods: This study selected 76 patients with cognitive dysfunction after ischemic stroke who were hospitalized at Zhuji People’s Hospital from January 2023.to January 2024. The patients were divided into two groups. The control group was treated with butylphthalide capsules, while the combination group received Ginkgo biloba extract dropping pills in addition to the treatment given to the control group. The neurological function, cognitive function, activities of daily living, and levels of serum cytokines CRP, IL-6, and Hcy were compared between the two groups after 1 month and 3.months of treatment. Results: The NIHSS scores, MMSE scores, ADL scores, and levels of CRP, IL-6, and Hcy in both groups showed statistically significant differences compared to before treatment (P Conclusion: The combination of Ginkgo biloba extract dropping pills and butylphthalide capsules has a better therapeutic effect on cognitive dysfunction in patients after ischemic stroke. It can improve the neurological function and cognitive function of patients, enhance their ability to perform daily activities, and reduce inflammatory responses.

关键词： Acute Ischemic Stroke Ginkgo Biloba Leaf Drop Pills Butylphthalein Cognitive Impairment

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Application of Time-Tracking Platform in the Reperfusion Treatment of Patients with Acute Ischemic Stroke in Primary Hospitals

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Journal of Biosciences and Medicines 2024年第7期12卷 230-238页

作者： yaojie Cai Yan Chen Feng Fu Yuping He Department of Neurology Zhuji Peoples Hospital of Zhejiang Province Shaoxing China

Objective To explore the application effect of time tracking platform in improving the reperfusion treatment of patients with acute ischemic stroke in primary hospitals. Methods and Results Patients with acute ischemic stroke who carried out emergency intravenous thrombolysis and arterial thrombectomy in our hospital in 2021, 2022 and 2023.were selected. The time tracking mode was implemented, and the patients were recorded at each time node of the hospital and the whole-process digital management was conducted. Compared the mean DNT (Door to Needle Time) of intravenous thrombolysis in emergency stroke patients in 2021, 2022 and 2023. the total number of hospital cases within 4.5 h of onset, the total number of thrombolysis cases within 4.5 h of onset, the number of intravenous thrombolysis in 60 minutes of acute ischemic stroke, and the number of thrombolysis cases. The results show that from 2021 to 2023.our emergency stroke patients with intravenous thrombolysis average DNT shortened year by year, to the hospital within 4.5 h after the onset of the difference is statistically significant (all P < 0.05) conclusion through the application of stroke time tracking platform, is beneficial to shorten the treatment time of each link, can effectively reduce the hospital time delay, improve the rate of thrombolysis, improve the reperfusion of stroke centers in primary hospitals.

关键词： Time-Tracking Platform Acute Ischemic Stroke Thrombolysis Thrombectomy

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Beneficial effects of lacquer seed oil on bromocriptine-induced postpartum hypogalactia in rats

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Food Science and Human Wellness 2024年

作者： Mengting Li Xiaoyu Song Lin Shi Jie Li Mayira·Ahat yaojie Liu Chen Hou Jianke Li University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization， Shaanxi Normal University College of Food Engineering and Nutritional Science， Shaanxi Normal University

The high incidence of postpartum hypogalactia hinders the healthy development of postpartum women and the next generation. Lacquer seed oil (LSO)， the oil extracted from the seeds of the lacquer tree， has been traditionally used as a dietary supplement for promoting postpartum lactation and recovery in some districts of China. However， its physiological effects have not been verified， and the mechanism and active components of LSO have not been analyzed. Thus， we applied LSO to bromocriptine-induced postpartum hypogalactia rats. The results showed that LSO supplement effectively improves bromocriptine-induced postpartum hypogalactia. LSO also increased prolactin levels reduced by bromocriptine， promoted JAK2/STAT5 and PI3./AKT pathways and several gene expression levels of milk synthesis in mammary gland. Moreover， metabolomic and network pharmacological analysis further revealed that JAK2/STAT5， PI3./AKT， and estrogen signaling pathway are the potential main regulatory sites for the beneficial effects of LSO on postpartum hypogalactia， and that quercetin， kaempferol， arachidonic acid， epicatechin， and β-sitosterol are the top 5 main active ingredients of LSO. Our results suggested that LSO has great potential in the application of the improvement of postpartum hypogalactia.

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Unveiling the therapeutic potential:KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitro

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Oncology Research 2024年第11期32卷 1791-1802页

作者： JINXIA CHEN SULI DAI GENG ZHANG SISI WEI XUETAO ZHAO YANG ZHENG yaojie WANG XIAOHAN WANG YUNJIANG LIU LIANMEI ZHAO Research Center The Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Key Laboratory of Tumor Gene Diagnosis Prevention and TherapyClinical Oncology Research CenterShijiazhuang050000China Department of Blood Transfusion The Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Breast Center Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Hebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance Hebei Medical UniversityShijiazhuang050000China

Background:Triple-negative breast cancer(TNBC)is a heterogeneous,recurring cancer characterized by a high rate of metastasis,poor prognosis,and lack of efficient ***2046,a small molecule inhibitor,can inhibit cell motility in malignant tumors,including breast ***,the specific targets and the corresponding mechanism of its function remain ***:In this study,we employed(3.(4,5-dimethylthiazol-2-yl)-5-(3.carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium)(MTS)assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in ***-Seq was used to explore the targets of KBU2046 that inhibit the motility of ***,confirmed the predicted important signaling pathways through RT-qPCR and western ***:In this study,we found that KBU2046 functioned as a novel transforming growth factor-β(TGF-β1)inhibitor,effectively suppressing tumor cell motility in ***,it directly down-regulated leucine-rich repeat-containing 8 family,member E(LRRC8E),latent TGFβ-binding protein 3.LTBP3.,dynein light chain 1(DNAL1),and MAF family of bZIP transcription factors(MAFF)genes,along with reduced protein expression of the integrin ***,KBU2046 decreased phosphorylation levels of Raf and *** deactivation of the ERK signaling pathway impeded cancer invasion and ***:In summary,these findings advocate for the utilization of TGF-β1 as a diagnostic and prognostic biomarker and as a therapeutic target in ***,our data underscore the potential of KBU2046 as a novel therapeutic strategy for combating cancer metastasis.

关键词： KBU2046 TGF-β1(transforming growth factor-β1) LRRC(leucine-rich repeat-containing) LTBP(leucine-rich repeat-containing) Breast cancer(BC) Integrinαv Integrinα6

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Analysis of wheel-rail adhesion redundancy considering the thirdbody medium on the rail surface

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Railway Sciences 2024年第2期3卷 156-176页

作者： Chun Tian Gengwei Zhai Mengling Wu Jiajun Zhou yaojie Li Institute of Rail Transit Tongji UniversityShanghaiChina

Purpose–In response to the problem of insufficient traction/braking adhesion force caused by the existence of the third-body medium on the rail surface,this study aims to analyze the utilization of wheel-rail adhesion coefficient under different medium conditions and propose relevant measures for reasonable and optimized utilization of adhesion to ensure the traction/braking performance and operation safety of ***/methodology/approach–Based on the PLS-160 wheel-rail adhesion simulation test rig,the study investigates the variation patterns of maximum utilized adhesion characteristics on the rail surface under different conditions of small creepage and large *** statistical analysis of multiple sets of experimental data,the statistical distribution patterns of maximum utilized adhesion on the rail surface are obtained,and a method for analyzing wheel-rail adhesion redundancy based on normal distribution is *** study analyzes the utilization of traction/braking adhesion,as well as adhesion redundancy,for different medium under small creepage and large slip *** on these findings,relevant measures for the reasonable and optimized utilization of adhesion are ***–When the third-body medium exists on the rail surface,the train should adopt the low-level service braking to avoid the braking skidding by extending the braking *** with the current adhesion control strategy of small creepage,adopting appropriate strategies to control the train’s adhesion coefficient near the second peak point of the adhesion coefficient-slip ratio curve in large slip can effectively improve the traction/braking adhesion redundancy and the upper limit of adhesion utilization,thereby ensuring the traction/braking performance and operation safety of the ***/value–Most existing studies focus on the wheel-rail adhesion coefficient values and variation patterns under different medium conditions,without considering wheth

关键词： Wheel-rail adhesion redundancy PLS-160 wheel-rail adhesion simulation test rig Normal distribution Utilized adhesion coefficient

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基于N-Unet视网膜血管分割

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计算机应用与软件 2024年第4期41卷 219-223页

作者：田红陈姚节武汉科技大学计算机科学与技术学院湖北武汉430065 智能信息处理与实时工业系统湖北省重点实验室湖北武汉430065 冶金工业过程国家级虚拟仿真实验教学中心湖北武汉430065

针对在现阶段视网膜血管分割过程中存在的分支断裂问题,提出一种非局部Unet的模型Non-local Unet(N-Unet)。N-Unet模型保留了编码器-解码器的对称结构,在编码器阶段引入非局部块,使模型在提取特征的过程中关注非局部信息,能更好地捕捉... 详细信息

针对在现阶段视网膜血管分割过程中存在的分支断裂问题,提出一种非局部Unet的模型Non-local Unet(N-Unet)。N-Unet模型保留了编码器-解码器的对称结构,在编码器阶段引入非局部块,使模型在提取特征的过程中关注非局部信息,能更好地捕捉图像中非相邻像素之间的关系。该模型在公开的DRIVE数据集上进行评估,得到的准确性、敏感性、特异性、曲线下面积分别为0.9523.0.8021、0.9743.0.8949。实验结果表明,该方法在解决血管分割过程中的分支断裂问题表现良好,具有研究意义。

关键词： Unet网络 Non-local 血管分割医学图像

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抑制船尾拖纹的长时段船舶跟踪方法

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计算机应用与软件 2024年第6期41卷 161-168页

作者：何水陈黎陈姚节武汉科技大学计算机科学与技术学院湖北武汉430081 武汉科技大学湖北省智能信息处理与实时工业系统重点实验室湖北武汉430081

船舶跟踪任务中水面拖纹干扰和目标遮挡会影响船舶跟踪的效果。提出一种抑制船尾拖纹的长时段船舶跟踪方法。对图像预处理,提升图像清晰度;使用离线训练的拖纹检测器检测水面拖纹,实时校正船舶跟踪框;根据感知哈希算法判断是否发生目标... 详细信息

船舶跟踪任务中水面拖纹干扰和目标遮挡会影响船舶跟踪的效果。提出一种抑制船尾拖纹的长时段船舶跟踪方法。对图像预处理,提升图像清晰度;使用离线训练的拖纹检测器检测水面拖纹,实时校正船舶跟踪框;根据感知哈希算法判断是否发生目标遮挡,遮挡时使用在线检测器对目标区域进行检测,找回船舶位置并初始化跟踪器,实现长时段跟踪。实验结果表明,该方法能有效抑制船尾拖纹对跟踪的影响,提高船舶跟踪精度,实现长时段船舶跟踪。

关键词：船舶跟踪拖纹检测孪生网络长时段重检测

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