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Ultrasensitive skin‐like wearable optical sensors based on glass micro/nanofibers

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Opto-Electronic Advances 2020年第3期3卷 18-24页

作者： Lei Zhang Jing Pan Zhang Zhang Hao wu ni yao Dawei Cai Yingxin Xu Jin Zhang Guofei sun Liqiang Wang Weidong Geng Wenguang Jin Wei Fang Dawei Di limin Tong State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027China Cavendish Laboratory University of CambridgeJJ Thomson AvenueCambridge CB30HEUnited Kingdom

Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological *** electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC ***,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic *** interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are ***,a five-sensor optical data glove and a 2×2-MNF tactile sensor are *** initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins.

关键词： optical micro/nanofiber pressure sensor tactile sensor wearable sensor

Sequencing and comparative analyses of Aegilops tauschii chromosome arm 3DS reveal rapid evolution of Triticeae genomes

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Journal of Genetics and Genomics 2017年第1期44卷 51-61页

作者： Jingzhong Xie Naxin Huo Shenghui Zhou Yi Wang Guanghao Guo Karin R.Deal Shuhong Ouyang Yong Liang Zhenzhong Wang Lichan Xiao Tingting Zhu Tiezhu Hu Vijay Tiwari Jianwei Zhang Hongxia Li zhongfu ni yingyin yao Huiru Peng Shengli Zhang Olin D.Anderson Patrick E.McGuire Jan Dvorak Ming-cheng Luo Zhiyong Liu Yong Q.Gu qixin sun State Key Laboratory for Agrobiotechnology China Agricultural UniversityBeijing 100193China USDA-ARS West Regional Research Center AlbanyCA 94770USA Department of Plant Sciences University of California at DavisDavisCA 95616USA Department of Plant Pathology Kansas State UniversityManhattanKS 66506USA Arizona Genomics Institute School of Plant ScienceUniversity of ArizonaTucsonAZ 85721USA

Bread wheat （Triticum aestivum, AABBDD） is an allohexaploid species derived from two rounds of interspecific hybridizations. A high-quality genome sequence assembly of diploid Aegilops tauschii, the donor of the wheat D genome, will provide a useful platform to study polyploid wheat evolution. A combined approach of BAC pooling and next-generation sequencing technology was employed to sequence the minimum tiling path （MTP） of 3176 BAC clones from the short arm ofAe. tauschii chromosome 3 （At3DS）. The final assembly of 135 super-scaffolds with an N50 of 4.2 Mb was used to build a 247-Mb pseudomolecule with a total of 2222 predicted protein-coding genes. Compared with the orthologous regions of rice, Brachypodium, and sorghum, At3DS contains 38.67% more genes. In comparison to At3DS, the short arm sequence of wheat chromosome 3B （Ta3BS） is 95-Mb large in size, which is primarily due to the expansion of the non-centromeric region, suggesting that transposable element （TE） bursts in Ta3B likely occurred there. Also, the size increase is accompanied by a proportional increase in gene number in Ta3BS. We found that in the sequence of short arm of wheat chromosome 3D （Ta3DS）, there was only less than 0.27% gene loss compared to At3DS. Our study reveals divergent evolution of grass genomes and provides new insights into sequence changes in the polyploid wheat genome.

关键词： Aegilops tauschii Genome sequencing Sequence assembly Comparative genomics Grass evolution

小麦杂种优势群研究　Ⅲ普通小麦和斯卑尔脱小麦微卫星分子标记遗传差异的研究

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农业生物技术学报 1999年第4期7卷 333-338页

作者：崔国惠倪中福刘志勇王晓玲吴利民孙其信中国农业大学小麦遗传育种研究室!北京 100094

选用15份我国不同生态区的普通小麦品种（系）及9份不同国家的斯卑尔脱小麦品种（系），利用微卫星分子标记对小麦种间、品种（系）问遗传差异进行了研究，探讨扩大杂交小麦育种亲本遗传基础的途径。所利用的18对微卫星引物在24份材料... 详细信息

选用15份我国不同生态区的普通小麦品种（系）及9份不同国家的斯卑尔脱小麦品种（系），利用微卫星分子标记对小麦种间、品种（系）问遗传差异进行了研究，探讨扩大杂交小麦育种亲本遗传基础的途径。所利用的18对微卫星引物在24份材料中均有扩增产物，共扩增出分子星小于500bp的条带495条，其中479条带（占96．78％）具有多态性，平均每个引物可扩增出26．6条多态性带。研究发现，9份斯卑尔脱小安徽卫星多态性（69．37％）略高于15份普通小麦（66．60％）。利用479条多态性带计算的遗传距离显示，斯卑尔脱小麦与普通小麦间的遗传距离平均为0．6517两者存在较大遗传差异。聚类结果显示，微卫星分子标记可将斯卑尔脱小麦与普通小麦明显划为两大不同类群。首次利用微卫星分子标记对斯卑尔脱小麦的遗传差异进行研究，从研究结果得出，利用微卫星标记可以将亲缘关系很近的品种鉴别出来。由于斯卑尔脱小麦与普通小麦之间存在较大的遗传差异，两者之间种间杂种一代育性基本正常，可以用来扩大杂交小麦亲本的遗传基础，提高小麦的杂种优势幅度。

关键词：杂种优势群普通小麦斯卑尔脱小麦微卫星标记遗传差异

The relationship of differential expression of genes in GA biosynthesis and response pathways with heterosis of plant height in a wheat diallel cross

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Chinese Science Bulletin 2009年第16期54卷 3029-3034页

作者： WANG XiuLi1,2, yao yingyin1,2, PENG HuiRu1,2, ZHANG Yi1,2, LU LaHu1,2, ni zhongfu1,2 & sun qixin1,2 1 State Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization (MOE), Key Laboratory of Crop Genomics and Genetic Improvement (MOA), and Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural Univer- sity, Beijing 100193, China 2 National Plant Gene Research Centre (Beijing), Beijing 100193, China State Key Laboratory for Agrobiotechnology Key Laboratory of Crop Heterosis and Utilization (MOE) Key Laboratory of Crop Genomics and Genetic Improvement (MOA) and Beijing Key Laboratory of Crop Genetic Improvement China Agricultural University Beijing 100193 China National Plant Gene Research Centre (Beijing) Beijing 100193 China

Heterosis in internode elongation and plant height is commonly observed in hybrid plants, but the molecular basis for the increased internode elongation in hybrids is unknown. In this study, midparent heterosis in plant height was determined in a wheat diallel cross involving 16 hybrids and 8 parents, and real-time PCR was used to analyze alterations in gene expression between hybrids and parents. Significant heterosis of plant height and the first internode in length were observed for all 16 hybrids, but the magnitude of heterosis was variable for different cross combinations. Analysis revealed that the heterosis of the first internode was significantly correlated to that of plant height (r = 0.56, P nificant difference in heterosis of gene ex- pression was observed among all cross combinations. Moreover, heterosis of the first internode in length was correlated significantly and positively with expression heterosis of KS, GA3ox2-1, GA20ox2, GA20ox1D, GA-MYB and GID1-1, but significantly and negatively with expression heterosis of GAI and GA2ox-1, which is consistent with our recently proposed model of GAs and heterosis in wheat plant height, suggesting the alteration of GA biosynthesis and response pathways might be responsible for the observed heterosis in plant height.

关键词：基因差异表达杂种优势杂交小麦反应途径生物合成遗传算法株高双列

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Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1194-1201页

作者： Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong yao Yanying Liu Chun Li Yuhui Li limin Ren Yin Su Xiaolin sun Jing He Zhanguo Li Department of Rheumatology and Immunology Peking University People’s Hospital100044 BeijingChina Department of Rheumatology and Immunology The First Affiliated Hospital of Wannan Medical College241000 WuhuAnhuiChina Department of Clinical Epidemiology and Biostatistics Peking University People’s Hospital100044 BeijingChina Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis(BZ0135) BeijingChina Peking-Tsinghua Center for Life Sciences BeijingChina State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina

Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse ***-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the *** randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active *** were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week *** cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week *** patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESRnical responses and *** primary outcomes were achieved in the perprotocol *** improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to ***-IL-2 treatment was well-tolerated in this *** results suggested that Ld-IL2 was effective and safe in *** number:NCT 02467504.

关键词： patients placebo methotrexate

基于ABAQUS平台对球冠结构焊接变形的数值试验

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焊接学报 2007年第6期28卷 89-92,117-118页

作者：姚熊亮刘庆杰孙谦周其新哈尔滨工程大学船舶工程学院哈尔滨150001 海军装备部北京100814

球冠结构在焊接过程中产生的焊接变形是关系到结构安全性能的重要指标。为了保证球冠焊接构件的可靠性,准确推断球冠结构焊接变形,有必要针对球冠结构的焊接变形进行数值试验分析。基于大型有限元软件ABAQUS开发相应的焊接程序,对焊接... 详细信息

球冠结构在焊接过程中产生的焊接变形是关系到结构安全性能的重要指标。为了保证球冠焊接构件的可靠性,准确推断球冠结构焊接变形,有必要针对球冠结构的焊接变形进行数值试验分析。基于大型有限元软件ABAQUS开发相应的焊接程序,对焊接过程中温度场、结构变形进行了数值模拟,并将模拟结果与相关理论值及试验值进行对比分析。结果表明,数值试验结果与理论结果基本吻合,满足工程要求。在此基础上,对球冠结构的焊接过程进行三维有限元分析,得到了球冠结构焊接变形随球冠壁厚、焊接坡口形式及焊接顺序的变化规律,为控制结构的焊接变形提供了依据。

关键词：球冠结构焊接变形焊接数值试验

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浒苔多糖的结构、制备与降解研究进展

现代食品科技 2022年第6期38卷 343-353页

作者：宁利敏姚忠朱本伟孙芸南京中医药大学医学院·整合医学院江苏南京210023 南京工业大学食品与轻工学院江苏南京211816

浒苔多糖作为浒苔的主要功能成分,具有多种生物活性,如免疫调节、抗氧化、抗肿瘤、降血脂等。但是由于其分子量较大,浒苔多糖具有溶解性差、生物利用率低等缺陷,这极大地限制了浒苔多糖资源的高值化开发和利用。浒苔多糖降解后得到的低... 详细信息

浒苔多糖作为浒苔的主要功能成分,具有多种生物活性,如免疫调节、抗氧化、抗肿瘤、降血脂等。但是由于其分子量较大,浒苔多糖具有溶解性差、生物利用率低等缺陷,这极大地限制了浒苔多糖资源的高值化开发和利用。浒苔多糖降解后得到的低分子量产物,在保持了多糖的多种生物活性的基础上,大大提升了其溶解性、生物利用度等,因而浒苔多糖降解产物的制备与活性研究已成为海洋生物资源开发研究领域的热点。目前,浒苔寡糖的制备主要是通过对浒苔多糖的降解实现的,主要方法包括化学降解法、物理降解法和酶降解法等。该研究综述了浒苔多糖的化学组成、结构、提取和纯化方法,并对浒苔多糖降解产物的制备方法和活性等进展进行了总结和展望,以期为浒苔多糖及其降解产物的研究提供理论基础,为推动海洋藻类多糖资源的高值化利用和开发提供参考。

关键词：浒苔多糖提取纯化降解产物活性

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径向流吸附器流体流动特性及其结构参数优化

化工学报 2014年第9期65卷 3395-3402页

作者：陈瑶张学军陆军亮邱利民张小斌孙大明甘智华浙江大学制冷与低温研究所浙江杭州310027

径向流吸附器通常存在流体沿轴向床层分布不均匀,从而导致吸附剂利用率下降和空分系统运行安全性问题。通过对表征Z型径向流吸附器流动特性的微分控制方程中包含的结构参数进行量纲1化,系统地研究了各结构参数对吸附器内流体分布的影响... 详细信息

径向流吸附器通常存在流体沿轴向床层分布不均匀,从而导致吸附剂利用率下降和空分系统运行安全性问题。通过对表征Z型径向流吸附器流动特性的微分控制方程中包含的结构参数进行量纲1化,系统地研究了各结构参数对吸附器内流体分布的影响。同时针对实验室已有的一台Z型径向流吸附器,采用理论求解和实验数据对照的方法验证了模型的可靠性。结果表明,减小吸附床层轴向高度和吸附剂颗粒直径能显著提高Z型径向流吸附器内流体分布的均匀性;当空气的运动黏度和其他结构参数不变时,吸附器的空气处理量在一定范围内变化对吸附床层内流体的均匀性影响不大。

关键词：径向流吸附流动特性结构参数优化模型

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小麦种质资源耐热性评价

中国农业科学 2019年第23期52卷 4191-4200页

作者：王小波关攀锋辛明明汪永法陈希勇赵爱菊刘曼双李红霞张明义逯腊虎魏亦勤刘旺清张金波倪中福姚颖垠胡兆荣彭惠茹孙其信中国农业大学农学院/农业生物技术国家重点实验室/杂种优势研究与利用教育部重点实验室/作物遗传改良北京市重点实验室河北省农林科学院粮油作物研究所/河北省作物遗传育种实验室西北农林科技大学农学院山西省农业科学院小麦研究所宁夏农林科学院农作物研究所新疆农业科学院农作物品种资源研究所

【目的】利用热感指数作为耐热性鉴定指标,分别对冬、春小麦种质资源进行高通量耐热性鉴定,筛选耐热种质资源,为小麦耐热性育种提供材料基础。【方法】冬小麦材料采用延期播种、春小麦材料种植在温度有显著差异的地理环境下,人为致使小... 详细信息

【目的】利用热感指数作为耐热性鉴定指标,分别对冬、春小麦种质资源进行高通量耐热性鉴定,筛选耐热种质资源,为小麦耐热性育种提供材料基础。【方法】冬小麦材料采用延期播种、春小麦材料种植在温度有显著差异的地理环境下,人为致使小麦灌浆期遭遇高温胁迫。根据不同环境处理的千粒重值计算冬、春小麦各个材料的热感指数。依据热感指数,对来自中国不同小麦生态区和国外不同地区和组织的1 325份小麦种质资源,包括688份冬小麦和637份春小麦,分别进行耐热性评价。热感指数小于0.5为极耐热材料、大于等于0.5小于1为中等耐热材料、大于等于1小于1.5为中等热敏感材料、大于等于1.5为极敏感材料。【结果】冬小麦和春小麦热胁迫处理组灌浆期平均最高温度分别高于对照组1.91℃和7.09℃,且热胁迫处理组千粒重与对照组相比均有显著降低。根据热感指数分级评价结果,极耐热冬、春小麦材料31和48份,占供试材料的4.51%和7.54%;极敏感冬、春小麦材料19和58份,占供试材料的2.76%和9.11%;其余大多数材料为中间类型(中等耐热材料和中等热敏感材料)。从中国小麦生态区域的地理分布来看,来自南部麦区(西南冬麦区、青藏春冬麦区、长江中下游冬麦区)的冬小麦材料耐热性整体高于来自北部麦区(北部冬麦区、黄淮冬麦区)的冬小麦材料。对于春小麦,来自新疆春冬麦区的材料耐热性最强,平均热感指数为0.70,且其中88.00%的材料属于耐热材料(极耐热材料或中等耐热材料);此外,来自国际干旱地区农业研究中心的春小麦平均热感指数为0.88,也表现出较强的耐热性。来自CIMMYT的人工合成六倍体材料耐热性最弱,平均HSI为1.18,其中69.58%的材料为热敏感材料(中等热敏感材料和极敏感材料)。【结论】采用延期播种或在高温的地理环境下种植能使小麦在灌浆期遭遇高温胁迫。以千粒重热感指数作为评价指标,对1 325份小麦种质资源进行高通量耐热性鉴定,综合考虑正常条件下的产量潜力和高温条件下的耐热性,筛选出优异耐热资源103份,可用于相应生态区小麦的耐热性遗传改良。

关键词：小麦种质资源耐热性热感指数生态区