检索结果-南通市图书馆

Close association between abnormal expressed enzymes of energy metabolism and diarrhea-predominant irritable bowel syndrome

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2019年第2期132卷 135-144页

作者： Chun-Yan zhang Xin yao Gang Sun Yun-Sheng Yang Department of Gedatric gastroenterology Chinese PLA Navy general hospitalBeijing 100048China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing 100050China Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China

Background:Irritable bowel syndrome (IBS) is one of the most common functional intestinal diseases, but its pathogenesis is still *** present study aimed to screen the differentially expressed proteins in the mucosa of colon between IBS with diarrhea (IBS-D) patients and the healthy ***:Forty-two IBS-D patients meeting the Rome III diagnostic criteria and 40 control subjects from July 2007 to June 2009 in Chinese PLA General Hospital were enrolled in the present *** examined the protein expression profiles in mucosa of colon corresponding to IBS-D patients (n=5) and controls (n=5) using 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS).Secondly, Western blot and immunohistochemical analysis were carried out to validate the screened proteins in 27 IBS-D patients and 27 ***, high-performance liquid chromatography (HPLC) was further carried out to determine ATP concentration in the mucosa of colon between 10 IBS-D patients and 8 *** between 2 groups were performed by Student's t-test or mann-Whitney ***:Twelve differentially expressed proteins were screened *** α-enolase (ENOA) in the sigmoid colon (0.917 ± 0.007 vs.1.310 ± 0.100, t=2.643, P=0.017) and caecum (0.765 ± 0.060 vs.1.212 ± 0.122, t=2.225, P=0.023), Isobutyryl-CoA dehydrogenase (ACAD8) in the sigmoid colon (1.127 ± 0.201 vs.1.497 ± 0.392, t=7.093, P=0.008) of the IBS-D group were significantly lower while acetyl-CoA acetyltransferase (CT) in the caecum (2.453 ± 0.422 vs.0.931 ± 0.652, t=8.363, P=0.015) and ATP synthase subunit d (ATP5H) in the sigmoid (0.843 ± 0.042 vs.0.631 ± 0.042, t=8.613,P=0.007) of the IBS-D group was significantly higher, compared with the *** ATP concentration in the mucosa of the sigmoid colon in IBS-D group was significantly lower than that of control group (0.470 [0.180, 1.360] vs.5.350 [2.230, 7.900], U=55, Pmany proteins related to energy metabolism presented diff

关键词： ATP Irritable bowel syndrome Metabolism Proteome

Theoretical analysis of natural frequency of externally prestressed concrete beam based on rigidity correction

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2009年第1期21卷 31-35页

作者： Hui-xia xiong1,2, yao-ting zhang11.School of Civil Engineering & Mechanics, Huazhong University of Science and Technology, Wuhan 430074, China 2.Department of Civil Engineering, Nanyang Institute of Technology, Nanyang 473004, China. School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074 China Department of Civil Engineering Nanyang Institute of Technology Nanyang 473004 China

A dynamic test on externally prestressed simply supported concrete beams separately with three typical types of tendon distributions was conducted. The results show that the natural frequencies of the beams increase with the increase in the prestressing force at the tensioning stage, and the natural frequencies decrease after the cracks occur in the beams. Following the calculation formula of natural frequency of externally prestressed beam, which was reported in a literature, the natural frequencies of the experimental beams are calculated, and big errors are found between the test results and the calculated ones of natural frequency values. As a result, this paper has tried to adopt two methods to correct the rigidity parameter of the concrete beam in the formula for natural frequency calculation, and to use the corrected formula to calculate the frequencies of the experimental beams. The calculation results indicate a good consistency with the experimental ones, which verifies the feasibility of the corrected formula.

关键词： externally prestressed concrete beam natural frequency rigidity correction regression analysis

INVESTIGATIONS ON NANOMETER-SIZED ULTRAMICRO-ELECTRODES(Ⅱ)—FABRICATION, CHARACTERIZATION OF CARBON FIBER CYLINDER ULTRAMICROELECTRODES

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1993年第11期4卷 995-998页

作者： Xue Ji zhang Xing yao ZHOUDepartment of Chemistry, Wuhan University, 430072, Wuhan

Described here are the fabrication and characterization of carbon fiber cylinder ultramicroelectrodes with cylinder length of less than 100 am, total tip diameter of several hundreds nanometers. The electrodes have been fabricated by direct etching of carbon fiber using an ion beam thinner. Optical microscopy, scanning electron microscopy (SEM), cyclic voltammetry have been employed to characterize those electrodes. The experimental results obtained indicate the electrodes can be used for in vivo detection of neurotransmitters such as dopamine, 5—hydroxytryptamine in a single cell.

关键词： Figure CHARACTERIZATION OF CARBON FIBER CYLINDER ULTRAMICROELECTRODES FABRICATION INVESTIGATIONS ON NANOMETER-SIZED ULTRAMICRO-ELECTRODES

MoS2 Nanosheets Sensitized with Quantum Dots for Room-Temperature Gas Sensors

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2020年第5期12卷 20-32页

作者： Jingyao Liu Zhixiang Hu Yuzhu zhang Huayao Li Naibo Gao Zhilai Tian Licheng Zhou Baohui zhang Jiang Tang Jianbing zhang Fei Yi Huan Liu School of Optical and Electronic Information Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology1037 Luoyu RoadWuhan 430074People’s Republic of China

The Internet of things for environment monitoring requires high performance with low power-consumption gas sensors which could be easily integrated into large-scale sensor *** semiconductor gas sensors have many advantages such as excellent sensitivity and low cost,their application is limited by their high operating ***-dimensional(2D)layered materials,typically molybdenum disulfide(MoS2)nanosheets,are emerging as promising gas-sensing materials candidates owing to their abundant edge sites and high in-plane carrier *** work aims to overcome the sluggish and weak response as well as incomplete recovery of MoS2 gas sensors at room temperature by sensitizing MoS2 nanosheets with PbS quantum dots(QDs).The huge amount of surface dangling bonds of QDs enables them to be ideal receptors for gas *** sensitized MoS2 gas sensor exhibited fast and recoverable response when operated at room temperature,and the limit of NO2 detection was estimated to be 94 *** strategy of sensitizing 2D nanosheets with sensitive QD receptors may enhance receptor and transducer functions as well as the utility factor that determine the sensor performance,offering a powerful new degree of freedom to the surface and interface engineering of semiconductor gas sensors.

关键词： Gas sensor Room temperature Molybdenum disulfide Quantum dot Nitrogen dioxide

Identification of retinal thickness and blood flow in agerelated macular degeneration with reticular pseudodrusen

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2023年第8期16卷 1268-1273页

作者： Yong-Zhao Wei Hao Huang Xiang zhang Hong-Hua Yu Bao-Yi Liu Yu-yao Diao Lu Cheng Hao Cheng Department of Ophthalmology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Guangdong Eye Institute Department of OphthalmologyGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina

AIM:To investigate thickness characteristics and vascular plexuses in retinas with reticular pseudodrusen(RPD)as an early detection strategy for age-related macular degeneration(AMD).METHODS:This retrospective study included 24 subjects(33 eyes)with RPD and 25 heathy control subjects(34 eyes).The superficial capillary plexus(SCP)and the deep capillary plexus(DCP)of the retinal posterior poles were investigated with optical coherence tomography angiography(OCTA).Retinal thicknesses and vessel densities were analyzed ***:The general retinal thicknesses of RPD eyes were significantly decreased(95%CI-14.080,-0.655;P=0.032).The vessel densities of DCP in RPD eyes were significantly increased in the global(95%CI 1.067,7.312;P=0.027),parafoveal(95%CI 0.417,5.241;P=0.022),and perifoveal(95%CI 0.181,6.842;P=0.039)***,the vessel densities of the SCP were rarely increased in the eyes with ***:The thinning of retinas in the RPD group suggests a reduction in the number of ***,the increased vessel density of the DCP in retinas with RPD indicates a greater demand for blood supply,possibly due to the hypoxia induced RPD compensation caused by RPD in the outer *** study highlights the pathological risks associated with RPD and emphasizes the importance of early intervention to retard the progression of AMD.

关键词： reticular pseudodrusen age-related macular degeneration retinal thickness retinal vessel density optical coherence tomography angiography

基于插值算法的立体显示的图像合成与嵌入式实现

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

发光学报 2016年第10期37卷 1237-1244页

作者：杨兰曾祥耀邹卫东张永爱周雄图郭太良集美大学理学院福建厦门361021 福州大学物理与信息工程学院福建福州350116 厦门市产品质量监督检验院福建厦门361021

在多视点自由立体显示中,针对柱透镜光栅参数与显示器像素不匹配造成的串扰问题,提出利用图像插值的合成方法对图像进行缩放处理。以9视点为例,提出缩放比例系数k,实现双线性插值算法的改进。嵌入式样机测试结果表明,该方法能够满足显... 详细信息

在多视点自由立体显示中,针对柱透镜光栅参数与显示器像素不匹配造成的串扰问题,提出利用图像插值的合成方法对图像进行缩放处理。以9视点为例,提出缩放比例系数k,实现双线性插值算法的改进。嵌入式样机测试结果表明,该方法能够满足显示器像素宽度与柱透镜参数的完全匹配,串扰度从13.55%降低到1.40%,降低了12.15%,图像分辨率明显提高,立体显示效果更好。

关键词：柱透镜光栅自由立体显示技术插值算法嵌入式

Anti-inflammatory effects of amarogentin on 2,4-dinitrochlorobenzene-induced atopic dermatitis-like mice and in HaCat cells

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2023年第3期6卷 255-265页

作者： Qian zhang Hanlin Wang Cheng Ran Yansi Lyu Fei Li Yihang yao Shaojun Xing Li Wang Si Chen Department of Dermatology The Sixth Affiliated Hospital of Shenzhen University and Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenChina Department of Immunology Shenzhen University Health Science CenterShenzhenChina Department of Otolaryngology Affiliate Hospital of Hebei UniversityBaodingChina Department of Dermatology Shenzhen University General HospitalShenzhen UniversityShenzhenChina Department of Pathogen Biology Shenzhen University Health Science CenterShenzhenChina

Background:Amarogentin(AMA)is a secoiridoid glycoside extracted from Swertia and Gentiana roots and exhibits many biological effects such as antioxidative,antiinflammatory,and antitumor *** dermatitis(AD)is a chronic inflammatory skin disease caused by disorders in the regulation of multiple inflammatory *** effective cure has been found for AD ***:We constructed the HaCat and splenocyte model and tested the inhibitory effect of AMA on IL-4,IL-6,and IL-13 secretions using enzyme-linked immunosorbent assay(ELISA).The AD mouse model was constructed and treated with AMA,the severity of skin lesions was observed,epidermal tissue was collected,and epidermal thickness and mast cell infiltration were observed using hematoxylin and eosin and toluidine blue staining,*** expression of kallikrein-related peptidase 7(KLK7)and filaggrin(FLG)was detected using immunostaining and Western blot *** mRNA expression of KLK7 and FLG was detected using quantitative polymerase chain reaction(qPCR).Blood immunoglobulin E(IgE)secretion was ***:AMA inhibited IL-6 secreted by tumor necrosis factor(TNF)-α-induced HaCaT cells and reduced IL-4 and IL-13 secreted by phytohemagglutinin(PHA)-induced primary cells in the mice *** was found that the treatment of AMA with 2,4-din itrochlorobenzene-induced AD-like mice could promote the recovery of dermatitis,reduce the score of dermatitis severity and the scratching frequency,treat the skin lesions,reduce the epidermal thickness,decrease the infiltration of mast cells,reduce the IgE level in serum,decrease the expression levels of AD-related cytokines,increase protein and mRNA expression of FLG,and reduce the protein and mRNA expression of KLK7 in the skin tissues of AD-like ***:In conclusion,AMA inhibits inflammatory response at the cellular level,and AMA reduces the validation response of specific dermatitis mice,relieves pruritus,and repairs the damaged skin barrie

关键词： amarogentin atopic dermatitis-like mice cytokines HaCaT

6061铝合金表面激光熔覆温度场的模拟与验证

在线全文

学校读者我要写书评

暂无评论

焊接学报 2007年第10期28卷 1-4页

作者：张松张春华张宁于莉丽刘常升 man H C 沈阳工业大学材料科学与工程学院沈阳110023 东北大学材料与冶金学院沈阳110004 香港理工大学工业及系统工程学系

根据激光熔覆的特点,建立了移动激光高斯热源作用下三维激光熔覆温度场的计算模型,利用有限元软件ANSYS对温度场分布进行了动态模拟。结果表明,激光熔覆温度场模拟等温线呈椭圆形,在移动热源的前方等温线密集,温度梯度较大,热源后方的... 详细信息

根据激光熔覆的特点,建立了移动激光高斯热源作用下三维激光熔覆温度场的计算模型,利用有限元软件ANSYS对温度场分布进行了动态模拟。结果表明,激光熔覆温度场模拟等温线呈椭圆形,在移动热源的前方等温线密集,温度梯度较大,热源后方的等温线稀疏,温度梯度较小。采用高功率连续波Nd:YAG激光在6061铝合金表面激光熔覆SiC陶瓷粉末,形成SiCp/Al金属基复合材料改性层,熔覆层除含有Al,SiC之外,还含有少量的Al4C3,Al4SiC4相,通过熔覆层组织形貌观察及相结构分析验证了模拟结果的准确性和可靠性,为陶瓷—金属基复合材料激光熔覆工艺参数的优化提供了理论依据。

关键词：激光熔覆金属基复合材料温度场有限元法

Thoughts on studies of China continental geology and tectonics

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2006年第10期16卷 1022-1026页

作者： zhang Guowei, GUO Anlin and yao Anping (Ministry of Education Key Laboratory of Continental Dynamics, Department of Geology, Northwest University, Xi’an 710069, China) [a]Ministy if Education Key Laboratory of Dynamics Department of Geology Northwest University Xi an China

As an important part of the global continents, China continent has long been situated in the peculiar tectonic position and experienced extremely complicated activities, which resulted in the regional unique characteristics for China continent on the global common geological background. These characteristics contain abundant information regarding scientific key issues of modern geological frontier. Thus, China continent can be a natural laboratory and excellent arena for the modern geosciences. The modern earth sciences have started entering the era featured with earth systematic science and beyond plate tectonics. How to take the regional advantage and exploit the treasure resource to participate the new theoretical and methodological creation is a historic opportunity and great challenge we are facing. This paper generalizes research priorities in four fields on China continental geology and tectonics for discussion. They are: China continental tectonics and dynamics; Mesozoic-Cenozoic crustal deformation and deep-seated processes in China continent and the adjacent regions; deep-seated dynamic background and evolutionary trend of crustal tectonic activities on the time scale of human existence; deep-seated background and processes of conjunction and transformation of different tectonic systems.

关键词： China continental geology and continental tectonics plate tectonics continental dynamics key scientific issues.