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Unveiling the superior hydrogen evolution reaction activity of 1T-2H MoS_(2)heterointerface by on-chip microdevices

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Nano Research 2025年第1期18卷 149-156页

作者： Bowen Liu Junjie xiong Shuaishuai Xu Xinying Luo Wenyan yao Shigang Liu Yuting Du Qinghua zhang Yang Gao Bin Wang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology(NCNST)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

The identification and clarification of active sites of MoS_(2)have long been the focus of research efforts in hydrogen evolution reaction(HER).In this study,we constructed phase transition-induced 1T-2H MoS_(2)heterojunction via lithium intercalation and evaluated the HER activity using on-chip electrocatalytic microdevices(OCEMs).The heterojunction achieved an overpotential of only 226 mV at a cathodic current density of 10 mA/cm^(2),outperforming the basal planes of 1T and 2H MoS_(2).Furthermore,density functional theory(DFT)calculations demonstrated that the charge redistribution occurs at the 1T-2H MoS_(2)interface with electrons transferring from 1T to 2H MoS_(2),and the interfacial S atom at the top site of 1T MoS_(2)presents the smallest overpotential of 0.37 ***,the interference from highly active edge sites was avoided by precisely exposing specific active areas,quantitatively revealing the catalytic activity order of different types of in-plane MoS_(2)active *** work enables a systematic investigation of the HER activity of various active sites in MoS_(2),laying the foundation for quantitative analysis of activity in other lowdimensional materials.

关键词： on-chip microdevice phase transition heterojunction MoS_(2) hydrogen evolution reaction(HER)

Real Heat Flux Analysis of Continuously Casting Round Billet

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Journal of Iron and Steel Research International 2008年第1期15卷 25-29页

作者： ZHAN Hui-ying WANG Xu-dong GUO liang-liang yao man School of Material Science and Engineering Dalian University of Technology Dalian 116024 Liaoning China

The distributions of heat flux along the height and the circumferential direction of round billet mould were measured *** influence of casting speed,carbon content,powder,and pouring temperature on the average longitudinal and circumferential heat flux in the ＂high heat flux region＂ was *** experimental and analytical results provide a basis for an intelligent mould with online detection of defects,adjustment of operational parameters,optimization of the monitoring system,and even prediction of abnormal heat transfer.

关键词： continuous casting mould heat flux round billet

肌微管素相关微蛋白7在小鼠肺动脉高压中的作用及机制

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中国药理学通报 2025年第1期41卷 57-65页

作者：王嘉张黎杨耀杨曦孙雄山杨永健西南交通大学医学院四川成都610083 西部战区总医院心内科四川成都610083 西南医科大学临床医学院心血管内科四川泸州646000 西部战区总医院药剂科四川成都610083

目的探讨肌微管素相关微蛋白7(myotubularin related protein 7,MTMR7)在肺动脉高压中的作用及机制。方法健康♂小鼠、Mtmr7转基因(Mtmr7-Tg)小鼠各20只,分为对照组、Mtmr7-Tg组、野百合碱(monocrotaline,MCT)组、MCT+Mtmr7-Tg组,超声测量肺动脉血流加速时间(pulmonary artery acceleration time,PAT)和射血时间(pulmonary artery ejection time,PET),取材时分离右心室游离壁,计算右心肥厚指数,免疫染色观察肺小动脉重构。将小鼠肺动脉平滑肌细胞(pulmonary arterial smooth muscle cells,PASMCs)以低氧处理,观察其增殖和迁移情况。结果MTMR7在肺血管中表达,并且MCT处理之后,Mtmr7-Tg小鼠的PAT/PET比值降低(P<0.05),右心肥厚指数升高(P<0.01)。以Mtmr7基因过表达腺病毒转染PASMCs,可以抑制其增殖和迁移。用chemerin-9恢复p-ERK1/2的活性,过表达MTMR7对PASMCs增殖、迁移抑制作用消失。结论过表达MTMR7可减轻低氧诱导的小鼠PASMCs增殖和迁移,从而逆转肺动脉高压,机制与MTMR7降低ERK1/2磷酸化密切相关。

关键词：肌微管素相关微蛋白7 ERK1/2 肺血管重构肺动脉平滑肌细胞肺动脉高压右心室肥厚

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水下爆炸气泡与海底相互作用研究

振动与冲击 2008年第3期27卷 92-98,182页

作者：张阿漫姚熊亮哈尔滨工程大学船舶工程学院哈尔滨150001

假设水下爆炸气泡阶段的流场为无粘、无旋、不可压缩的理想流体,基于势流理论,引入涡环模拟气泡的环状气泡阶段,运用边界元法模拟流场中气泡的运动,开发三维气泡动态特性模拟程序,将计算值与实验数据进行对比分析,结果表明,计算值与实... 详细信息

假设水下爆炸气泡阶段的流场为无粘、无旋、不可压缩的理想流体,基于势流理论,引入涡环模拟气泡的环状气泡阶段,运用边界元法模拟流场中气泡的运动,开发三维气泡动态特性模拟程序,将计算值与实验数据进行对比分析,结果表明,计算值与实验数据吻合较好。基于所开发的程序模拟了多种工况下气泡的动态特性,包括弱浮力、强Bjerknes力,强浮力、弱Bjerknes力以及浮力与Bjerknes力相等时水下爆炸气泡与海底的相互作用,并将各种工况的计算结果与Blake准则进行对比分析及讨论。在此基础上,进一步对比分析了不同工况下气泡的开尔文冲量(KelvinIm-pulse),射流速度以及壁压等重要特征量。旨在为近壁面气泡的动态特性研究提供参考。

关键词：水下爆炸气泡海底势流理论数值模拟

水深和药量的变化对水下爆炸气泡射流的影响研究

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工程力学 2008年第3期25卷 222-229页

作者：张阿漫姚熊亮哈尔滨工程大学船舶工程学院哈尔滨150001

假设水下爆炸气泡脉动阶段的流场是无旋、不可压缩的理想流体,运用势流理论导出气泡边界面运动的控制方程,应用气泡动力学模型,用时边界积分法求解得到气泡等边界的变形及位置,在气泡坍塌后运用环状数值模型模拟气泡的非球状回弹,并开... 详细信息

假设水下爆炸气泡脉动阶段的流场是无旋、不可压缩的理想流体,运用势流理论导出气泡边界面运动的控制方程,应用气泡动力学模型,用时边界积分法求解得到气泡等边界的变形及位置,在气泡坍塌后运用环状数值模型模拟气泡的非球状回弹,并开发了相应的计算程序,计算结果与精确解吻合很好。运用该文开发的程序计算自由场中环状气泡的运动,计算了流场中滞后流的速度以及压力随时间的变化,并讨论了水深和药量的变化对水下爆炸气泡坍塌形成的射流速度以及气泡脉动周期的影响,得到一些有规律性的曲线,旨在为相关水下爆炸气泡动态特性研究提供参考。

关键词：气泡边界积分势流理论射流环状

FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

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Science China Life Sciences 2025年

作者： Dake Xiao Haowen Ran Lishu Chen Yuanyuan Li Yan Cai Songyang zhang Qinghui Qi Huiran Wu Cheng zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan Li Tao Zhou Fangye Li Ailing Li Jianghong man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of Life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

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Mechanical properties and corrosion behavior of selective laser melted 316L stainless steel after different heat treatment processes

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Journal of Materials Science & Technology 2019年第7期35卷 1499-1507页

作者： Decheng Kong Chaofang Dong Xiaoqing Ni liang zhang Jizheng yao Cheng man Xuequn Cheng Kui Xiao Xiaogang Li Beijing Advanced Innovation Center for Materials Genome Engineering Key Laboratory for Corrosion and Protection (MOE)Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Shanghai Engineering Research Center of 3D Printing Materials Shanghai Research Institute of MaterialsShanghai 200437China School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China

Irregular grains, high interfacial stresses and anisotropic properties widely exist in 3D-printed metallic materials, and this paper investigated the effects of heat treatment on the microstructural, mechanical and corrosion properties of 316 L stainless steel fabricated by selective laser melting. Sub-grains and low-angle boundaries exist in the as-received selective laser melted(SLMed) 316 L stainless steel. After heat treatment at 1050℃, the sub-grains and low-angle boundaries changed slightly, and the stress state and strength decreased to some extent due to the decrease of dislocation density. After heat treatment at 1200℃, the grains became uniform, and the dislocation cells vanished, which led to a sharp decline in the hardness and strength. However, the ductility was improved after recrystallization heat *** passive film thickness and corrosion potential of the SLMed 316 L stainless steel decreased after heat treatment, and the pitting potential also decreased due to the accelerated transition from metastable to steady-state pitting;this accelerated transition was caused by the presence of weak passive films at the enlarged pores after heat treatment, especially for an adequate solid solution treatment.

关键词： 316L stainless steel Selective laser melting Heat treatment Microstructure Mechanical property Corrosion behaviour

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近边界三维水下爆炸气泡动态特性研究

爆炸与冲击 2008年第2期28卷 124-130页

作者：张阿漫姚熊亮哈尔滨工程大学船舶工程学院黑龙江哈尔滨150001

模拟了近壁、近自由面的水下爆炸气泡的非线性动态特性,假定水下爆炸气泡脉动阶段的流场是无旋、不可压缩的,采用高阶曲面三角形单元离散三维气泡表面,用边界积分法求解气泡的运动,在计算奇异积分时通过重新构造双层位势的主值积分消除... 详细信息

模拟了近壁、近自由面的水下爆炸气泡的非线性动态特性,假定水下爆炸气泡脉动阶段的流场是无旋、不可压缩的,采用高阶曲面三角形单元离散三维气泡表面,用边界积分法求解气泡的运动,在计算奇异积分时通过重新构造双层位势的主值积分消除双层奇异积分的奇异性,得到更精确的结果,并通过合理的加权方法精确的求解边界面上各节点的真实速度,结合弹性网格技术(elastic mesh technique,EMT)得到优化速度,在整个模拟过程中不需要采用数值光顺。将本文的三维模型与轴对称模型进行的对比分析表明,两种模型计算结果吻合很好,并用三维模型模拟了气泡与自由表面及圆筒的相互作用,水下爆炸气泡在自由表面及圆筒的联合作用下呈现出强非线性。

关键词：爆炸力学非线性动态特性边界积分水下爆炸气泡自由表面圆筒 EMT 三维

Modeling and Trajectory Tracking Control for Flapping-Wing Micro Aerial Vehicles

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 148-156页

作者： Wei He Xinxing Mu liang zhang yao Zou the Institute of Artificial Intelligence University of Science and Technology Beijingand also with the School of Automation and Electrical EngineeringUniversity of Science and Technology BeijingBeijing 100083China

This paper studies the trajectory tracking problem of flapping-wing micro aerial vehicles(FWMAVs)in the longitudinal *** of all,the kinematics and dynamics of the FWMAV are established,wherein the aerodynamic force and torque generated by flapping wings and the tail wing are explicitly formulated with respect to the flapping frequency of the wings and the degree of tail wing *** achieve autonomous tracking,an adaptive control scheme is proposed under the hierarchical ***,a bounded position controller with hyperbolic tangent functions is designed to produce the desired aerodynamic force,and a pitch command is extracted from the designed position ***,an adaptive attitude controller is designed to track the extracted pitch command,where a radial basis function neural network is introduced to approximate the unknown aerodynamic perturbation ***,the flapping frequency of the wings and the degree of tail wing inclination are calculated from the designed position and attitude controllers,*** terms of Lyapunov's direct method,it is shown that the tracking errors are bounded and ultimately converge to a small neighborhood around the *** are carried out to verify the effectiveness of the proposed control scheme.

关键词： Flapping-wing micro aerial vehicles(FWMAVs) modeling neural networks trajectory tracking