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Phytochemistry and pharmacology of Allii Macrostemonis Bulbus, a traditional Chinese medicine

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Chinese Journal of Natural Medicines 2016年第7期14卷 481-498页

作者： yao Zhi-Hong QIN Zi-Fei DAI Yi yao xin-sheng College of Pharmacy Jinan University State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and Technology

Allii Macrostemonis Bulbus(Xiebai in Chinese), as a famous traditional Chinese medicine, has great medicinal and dietary values since ancient times. In China, the dry bulbs of Allium macrostemon and Allium chinense are both used as its original plants. Pharmacological studies have revealed that both of them could increase plasminogen activator activity and prolong the effect of coagulation to achieve antiplatelet aggregation which validates their traditional uses for the treatment of thoracic obstruction and cardialgia in clinics. Besides, several other significant activities, including lipid-lowering, anti-atherosclerosis, antitumor, antispasmodic, antibacterial, antioxidant, and insecticidal activities, have already been reported. The volatile oils, nitrogenous compounds, and steroidal saponins are the major beneficial compounds. Among them, steroidal saponins are considered as the characteristic constituents. In this review, the current information concerning the phytochemistry and pharmacology of Allii Macrostemonis Bulbus is summarized comprehensively. In addition, several research future perspectives are presented, especially the mechanism of bioactive components and fraction from the bulbs of Allium macrostemon and Allium chinense.

关键词： Allii Macrostemonis Bulbus Allium macrostemon Allium ehinense Phytochemistry Pharmacology Future perspectives

Strengthen the research on the medicinal and edible substances to advance the development of the comprehensive healthcare industry of TCMs

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Chinese Journal of Natural Medicines 2019年第1期17卷 1-2页

作者： GAO Hao yao xin-sheng Institute of Traditional Chinese Medicine and Natural Products College of PharmacyJinan University

Traditional Chinese medicines(TCMs)have greatly boosted the prosperity of the Chinese Nation under the direction of TCM theory system,which have centuries of clinical practice.They are not only unique health and econo... 详细信息

关键词： Strengthen research

A new lignan glycoside from Forsythia suspensa

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Chinese Journal of Natural Medicines 2014年第9期12卷 697-699页

作者： LI Chang DAI Yi DUAN Ying-Hui LIU Ming-Li yao xin-sheng College of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University

Phytochemical investigation on Forsythia suspensa(Thunb.) Vahl afforded ten compounds, including five lignan glycosides and five phenylethanoid glycosides. The compounds were isolated by using HP-20 macroporous resin, silica gel, octadecyl silica gel(ODS), size exclusion chromatography resin HW-40 chromatography, and preparative HPLC. The structures were established through application of extensive spectroscopic methods, including ESI-MS, 1D- and 2D-NMR spectroscopy. They were identified as forsythialanside E(1), 8′-hydroxypinoresinol-4′-O-β-D-glucoside(2), 8′-hydroxypinoresinol(3), lariciresinol-4′-O-β- D-glucoside(4), lariciresinol-4-O-β-D-glucoside(5), forsythoside H(6), forsythoside I(7), forsythoside F(8), plantainoside B(9), and plantainoside A(10). Compound 1 was a new lignan glycoside.

关键词： Forsythia suspensa Chemical constituents Lignan glycosides

The importance of researches on the fungal bioactive secondary metabolites in developing the comprehensive health industry

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Chinese Journal of Natural Medicines 2020年第4期18卷 241-242页

作者： CHEN Guo-Dong HU Dan GAO Hao yao xin-sheng Institute of Traditional Chinese Medicine and Natural Products College of PharmacyJinan UniversityGuangzhou 510632China

Fungi are bound up with human life. Although some species are pathogens threaten to human and plants, most of them are beneficial to human, which have been used in food(such as making of cheeses and bread), drinks (such as making of beer and wine), and medicines (e.g. Ganoderma Lucidum) for thousands of years. They have played a key role in satisfying people’s demand for healthy.Based on the latest viewpoints, the total fungal species on the earth are estimated to be about 12 million, but only about 24%of them have been described[1-2].

关键词： fungal satisfying viewpoint

Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities

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Chinese Journal of Natural Medicines 2019年第1期17卷 27-32页

作者： MEI Yu-Dan ZHANG Nan ZHANG Wei-Yang TANG Jin-Shan ZHOU Hua YU Yang yao xin-sheng Institute of Traditional Chinese Medicine&Natural Products College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan University XiangXue Academician workstation Xiangxue Pharmaceutical Co.Ltd. College of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Faculty of Chinese Medicine Macao University of Science and Technology and State Key Laboratory of Quality Research in Chinese Medicine(Macao University of Science and Technology)

The flower buds of Lonicera macranthoides(Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids(1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid(1) and 2α, 4α-dihydroxy-23-nor-ursolic acid(2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L^(-1).

关键词： Lonicerae Flos Lonicera macranthoides Ursane-type nortriterpenes Anti-inflammation iNOS

Isolation and Structure Elucidation of an Antifungal Antibiotics A73 Produced by a Soil Fungus Strain No.131

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Chemical Research in Chinese Universities 1999年第1期15卷 85-88页

作者： YANG Jun QI Xiu-lan SHAO Gang yao xin-sheng Susumu Kitanaka Department of Natural Products Chemistry Department of Microbiology Shenyang Pharmaceutical UniversityShenyang110015 Department of Pharmacognosy College of PharmacyNihon UniversityJapan Chiba274

ＩｎｔｒｏｄｕｃｔｉｏｎＭｏｒｐｈｏｌｏｇｉｃａｌｄｅｆｏｒｍａｔｉｏｎｏｆｍｙｃｅｌｉａｏｒｃｏｎｉｄｉａｏｆｍｉｃｒｏｏｒｇａｎｉｓｍｓ，ｓｕｃｈａｓｃｕｒｌｉｎｇ，ｓｗｅｌｉｎｇ，ｈｙｐｅｒ－ｄｉｖｅｒｇｅｎｃ... 详细信息

ＩｎｔｒｏｄｕｃｔｉｏｎＭｏｒｐｈｏｌｏｇｉｃａｌｄｅｆｏｒｍａｔｉｏｎｏｆｍｙｃｅｌｉａｏｒｃｏｎｉｄｉａｏｆｍｉｃｒｏｏｒｇａｎｉｓｍｓ，ｓｕｃｈａｓｃｕｒｌｉｎｇ，ｓｗｅｌｉｎｇ，ｈｙｐｅｒ－ｄｉｖｅｒｇｅｎｃｙ，ｂｅａｄｆｏｒｍａｔｉｏｎ，ａ...

关键词： Antifungal antibiotics Isolation Structure elucidation A73

A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

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Chinese Journal of Natural Medicines 2019年第12期17卷 906-911页

作者： ZHANG JieD WANG Chuan-XiD SONG Xiao-Jun LI Shuang ZHAO Huan CHEN Guo-Dong HU Dan GAO Hao yao xin-sheng College of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China Institute of Traditional Chinese Medicine&Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China

A pair of new tirucallane triterpenoid epimers,picraquassins M and N(1 and 2),were isolated from the stems of Picrasma quassioides(D.Don)Benn.Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses.In addition,their ACh E inhibitory activity,cytotoxicity against five human tumour cell lines(SW480,MCF-7,HepG2,Hela,and PANC-1),and antimicrobial activity against two bacteria(Staphylococcus.aureus 209 P and Escherichia coli ATCC0111)and two fungi(Candida albicans FIM709 and Aspergillus niger R330)were evaluated.

关键词： Tirucallane triterpenoid Epimers Picrasma quassioides AChE inhibitory activity Cytotoxicity Antimicrobial activity

Biotransformation ofα-asarone by Alternaria longipes CGMCC 3.2875

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Chinese Journal of Natural Medicines 2021年第9期19卷 700-705页

作者： ZOU Jian ZHANG Shuai ZHAO Huan WANG Yong-Heng ZHOU Zheng-Qun CHEN Guo-Dong HU Dan LI Ning yao xin-sheng GAO Hao Institute of Traditional Chinese Medicine&Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents ofTCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China College of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China

Biotransformation ofα-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans,(+)(7 S,8 S,7’S,8’R)iso-magnosalicin(1 a)/(-)(7 R,8 R,7’R,8’S)iso-magnosalicin(1 b)and(+)(7 R,8 R,7’S,8’R)magnosalicin(2 a)/(-)(7 S,8 S,7’R,8’S)magnosalicin(2 b),and four known metabolites,(±)acoraminol A(3),(±)acoraminol B(4),asaraldehyde(5),and 2,4,5-trimethoxybenzoic acid(6).Their structures,including absolute configurations,were determined by extensive analysis of NMR spectra,X-ray crystallography,and quantum chemical ECD calculations.The cytotoxic activity and Aβ_(42)aggregation inhibitory activity of all the compounds were evaluated.Compound 2 displayed significant anti-Aβ_(42)aggregation activity with an inhibitory rate of 60.81%(the positive control EGCG:69.17%).In addition the biotransformation pathway ofα-asarone by Alternaria longipes CGMCC 3.2875 was proposed.

关键词： Biotransformation α-Asarone Alternaria longipes CGMCC 3.2875 Anti-Aβ_(42)aggregation activity

Expression of recombination-activating genes and T cell receptor gene recombination in the human T cell leukemia cell line

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Chinese Medical Journal 2007年第5期120卷 410-415页

作者： ZOU Hong-yun MA Li MENG Min-jie yao xin-sheng LIN Ying WU Zhen-qiang HE Xiao-wei WANG Ju-fang WANG Xiao-ning Institute of Molecular Immunology School of Biotechnology Southern Medical University Guangzhou 510515China School of Bioscience and Bioengineering South China University of TechnologyGuangzhou 510641 China School of Life Science and Biopharmacology Guangdong Pharmaceutical University Guangzhou 510006 China

Background Recent studies have suggested that mature T cells can change their specificity through reexpression of recombination-activating genes （RAG） and RAG-mediated V（D）J recombination. This process is named receptor revision and has been observed in mature peripheral T cells from transgenic mice and human donors. However, whether the receptor revision in mature T cells is a random or orientated process remains poorly understood. Here we used the Jurkat human T cell line, which represents a mature stage of T cell development, as a model to investigate the regulation of T cell receptor （TCR） gene recombination. Methods TCR Dβ-Jβ signal joint T cell receptor excision DNA circles （sjTRECs） were determined by nested and seminested PCR. Double-strand DNA breaks at recombination signal sequences （RSSs） in the TCRVβ chain locus were detected by ligation-mediated-PCR. Further analysis of the complementarity-determining region 3 （CDR3） size of the TCRVβ chain was examined by the TCR GeneScan technique. Results RAG1, RAG2, and three crucial components of the nonhomologous DNA end-joining （NHEJ） pathway were readily detected in Jurkat. Characteristics of junctional diversity of Dβ2-Jβ2 signal joints and ds RSS breaks associated with the Dβ2 5＇ and Dβ 2 3＇ sites were detected in DNA from Jurkat cells. CDR3 size and the gene sequences of the TCRVβ chain did not change during cell proliferation. Conclusions RAG1 and RAG2 and ongoing TCR gene recombination are coexpressed in Jurkat cells, but the ongoing recombination process may not play a role in modification of the TCR repertoire.However, the results suggest that Jurkat could be used as a model for studying the regulation of RAGs and V（D）J recombination and as a ＂special＂ model of the coexistence of TCR gene rearrangements and ＂negative＂ receptor revision.

关键词： recombination-activating genes T cell receptor gene recombination receptor revision TCR GeneScan