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宜昌市夏季极端降水敏感性疾病和脆弱人群的筛选

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环境卫生学杂志 2024年第4期14卷 324-330,337页

作者：郭佳王姣李永红王裕何江赵程姚孝元中国疾病预防控制中心环境与人群健康重点实验室/中国疾病预防控制中心环境与健康相关产品安全所北京100021

目的分析宜昌市夏季极端降水对急诊数量的影响,筛选敏感性疾病并探究脆弱人群。方法本研究利用宜昌市2014—2019年6—8月气象数据和2家综合医院急诊数据,采用泊松广义线性模型结合分布滞后非线性模型,研究夏季极端降水(≥100 mm)与不同... 详细信息

目的分析宜昌市夏季极端降水对急诊数量的影响,筛选敏感性疾病并探究脆弱人群。方法本研究利用宜昌市2014—2019年6—8月气象数据和2家综合医院急诊数据,采用泊松广义线性模型结合分布滞后非线性模型,研究夏季极端降水(≥100 mm)与不同系统疾病急诊数的关系,筛选极端降水敏感性疾病,并进一步探讨对不同个体特征人群的滞后效应。结果共收集到研究期间宜昌市67492例急诊病例,极端降水对总人群、皮肤和皮下组织疾病、肌肉骨骼系统和结缔组织疾病、消化系统疾病的日急诊数的影响具有统计学意义,滞后天数为14 d,累积相对风险度(the cumulative relative risk,CRR)分别为1.401(95%CI:1.108~2.772)、3.267(95%CI:1.407~7.587)、2.639(95%CI:1.170~5.953)、2.435(95%CI:1.368~4.335)。男性、女性、(18~59)岁和≥60岁年龄组的CRR分别为1.403(95%CI:1.087~1.811)、1.400(95%CI:1.046~1.873)、1.329(95%CI:1.040~1.698)、1.587(95%CI:1.075~2.343)。结论极端降水可显著增加总人群的急诊风险,皮肤和皮下组织疾病、肌肉骨骼系统和结缔组织疾病、消化系统疾病为敏感性疾病,男性、女性普遍易感,18岁以上成人为脆弱人群。

关键词：极端降水敏感性疾病分布滞后非线性模型

SVM Approximate-based Internal Model Control Strategy

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自动化学报 2008年第2期34卷 172-179页

作者： WANG yao-Nan yuan xiao-Fang College of Electrical and Information Engineering Hunan University Changsha 410082 P.R. China

一台支持向量机器(SVM ) 近似底的内部模型控制(IMC ) 策略为同步发电机的蒸气 valving 控制被介绍。建议 SVM IMC 策略包括二主要部分：在内部模型结构的 SVM 近似反的控制器和无常赔偿。SVM 反的控制器经由泰勒扩大用一条输入产量近... 详细信息

一台支持向量机器(SVM ) 近似底的内部模型控制(IMC ) 策略为同步发电机的蒸气 valving 控制被介绍。建议 SVM IMC 策略包括二主要部分：在内部模型结构的 SVM 近似反的控制器和无常赔偿。SVM 反的控制器经由泰勒扩大用一条输入产量近似途径直接被导出，并且没有进一步的联机训练，它通过非线性的系统鉴定被实现。而且，一个坚韧性过滤器在内部模型结构被用于无常赔偿。模拟为蒸气 valving 控制显示出 SVM IMC 策略的有效性。

关键词：内模控制非线性控制支持向量机神经网络逼近模型

中南某市地铁站室内环境微生物污染状况及分布特征研究

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现代预防医学 2024年第9期51卷 1580-1585页

作者：罗姣苏丽琴葛覃兮邵冉起李峰奚伟豪程淑燕周纯良彭蔚桂卓嘉彭敏兰杨敏洪峰张必科王先良姚孝元贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室中国疾病预防控制中心环境与健康相关产品安全所湖南省疾病预防控制中心湘潭市疾病预防控制中心中国疾病预防控制中心传染病预防控制所

目的了解中南某市地下地铁站室内空气和公共设施物体表面微生物污染状况及分布特征。方法对中南某市三座地铁站室内不同区域、时间段空气细菌和真菌总数，重点公共设施表面细菌总数、真菌总数、大肠菌群和金黄色葡萄球菌进行采样检测... 详细信息

目的了解中南某市地下地铁站室内空气和公共设施物体表面微生物污染状况及分布特征。方法对中南某市三座地铁站室内不同区域、时间段空气细菌和真菌总数，重点公共设施表面细菌总数、真菌总数、大肠菌群和金黄色葡萄球菌进行采样检测。采用多元线性回归和logistic回归进行影响因素分析。结果地铁站室内空气细菌和真菌总数中位数分别为194.35和346.29CFU/m3；物表细菌和真菌总数中位数分别为15.00CFU/25cm2和0CFU/50cm2，大肠菌群和金黄色葡萄球菌阳性率分别为2.22%和11.11%。地铁站室内空气微生物水平存在时空分布差异，其中站厅内细菌总数最高，站台内真菌总数最高；早高峰时段细菌总数最高，晚高峰时段真菌总数最高。检票机表面细菌和真菌总数均高于其他公共设施，中午公共设施表面真菌总数低于晚高峰时段，大肠菌群阳性率低于早高峰时段。地铁站室内空气细菌总数与温度（β=-0.06,95%CI:-0.11～-0.01）和风速（β=-0.28,95%CI:-0.55～-0.01）呈负相关关系；空气真菌总数与相对湿度（β=0.01,95%CI:0～0.02）呈正相关关系，与PM2.5（β=-0.01,95%CI:-0.02～-0.01）呈负相关关系；物表细菌总数与PM2.5（β=-0.04,95%CI:-0.07～-0.02）呈负相关关系。结论中南某市三座地铁站室内环境微生物水平较低，公共设施物体表面存在致病菌的污染。地铁站细菌和真菌浓度在不同区域和时间段的分布规律存在差异，且与温度、湿度、风速及PM2.5有关。

关键词：地铁站微生物污染室内空气物体表面时空分布

Realizing quantum imaginary time evolution in experiment

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 167-168页

作者： xiao yuan Center on Frontiers of Computing Studies Peking UniversityBeijing 100871China School of Computer Science Peking UniversityBeijing 100871China

NISQ,or Noisy Intermediate-Scale Quantum computing,represents a pivotal and the state-of-the-art quantum technology[1].Characterized by intermediate-scale quantum devices that are beyond classical computational capabilities yet fall short of the error-correction thresholds required for fault-tolerant quantum computing,NISQ devices exhibit both promise and *** devices hold immense potential in solving certain computational problems that surpass classical capabilities,with wide applications in optimization,machine learning,and quantum chemistry.

关键词： quantum imaginary correction

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A novel current-sharing scheme based on magamp

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第8期9卷 1150-1156页

作者： Wen-xi yao xiao-yuan HONG Zheng-yu LU School of Electrical Engineering Zhejiang University Hangzhou 310027 China

The magamp (magnetic amplifier) is widely used in power supplies due to its low cost, simplicity and other advan-tages. This paper discusses a novel application of the magamp in switching power supplies, where the magamp is used to regulate pulse width modulation (PWM) instead of power signal in the main circuit. This method extends the application of the magamp in power supplies, and makes it possible to further regulate control signal when PWMs have been generated. Based on this applica-tion, a new current-sharing (CS) scheme using the magamp is proposed, which uses a modified inner loop CS structure. In this scheme PWMs are generated by one main controller, and CS is achieved by regulating PWMs using a magamp in each module. Compared with traditional application of the magamp, the new CS scheme can be used in most topologies and only requires magamps of low power capacity. Then a test circuit of parallel power supply is developed, in which CS is achieved by a PWM regulator with the magamp. The proposed scheme is also used to upgrade an electroplate power to make it capable of paralleling supplies. Experimental results show that the proposed scheme has good CS performance.

关键词：脉冲技术电气化电流分配磁性放大技术

Highly Conductive Ag/pCF/MVQ Composite Rubber for Efficient Electromagnetic Interference Shielding

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Chinese Journal of Polymer Science 2024年第6期42卷 864-873页

作者： Yang Chen xiao-Ming Shao Liang He Yi-Nuo Xu Qi-yuan yao Ding Feng Wen-Cai Wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Key Laboratory of Beijing City for Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing100029China Sino-german School of Engineering Qingdao University of Science and TechnologyQingdao266400China

In this study,flexible and highly conductive composite rubber at low filler content was successfully prepared through polydopamine-assisted electroless silver plating plus mechanical ***,carbon fibers(CF)were activated by polydopamine(PDA)to improve the surface activity by self-polymerization ***,because of the metal chelating ability of PDA,silver layer was firmly deposited on the surface of CF through a facile electroless silver plating ***,flexible silver-plated carbon fibers(Ag/pCF)silicone rubber composites prepared by mechanical *** using X-ray photoelectron spectroscopy(XPS)and X-ray diffraction(XRD),the chemical composition and crystal structure of Ag/pCF were examined,and scanning electron microscopy(SEM)was used to assess the surface morphology of the Ag/*** results showed that a uniform and dense silver layer was formed on the surface of the CF,and the conductivity of the Ag/pCF could reach 7885 S/*** was noteworthy that the composite rubber filled with only 45 phr Ag/pCF had a high electromagnetic interference shielding effectiveness(100 dB)due to the low density and high aspect ratio of Ag/*** composite rubber has excellent potential for application in the field of electromagnetic interference shielding.

关键词： Carbon fibers Polydopamine Electroless plating Silver Electromagnetic interference shielding

Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreaticβ-cell Dysfunction

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Current Medical Science 2024年第2期44卷 346-354页

作者： Kai-yuan WANG Shi-mei WU Zheng-jian yao Yun-xia ZHU xiao HAN Key Laboratory of Human Functional Genomics of Jiangsu Province Department of Biochemistry and Molecular BiologyNanjing Medical UniversityNanjing 211166China

Objective:While the reduction of transient receptor potential channel subfamily M member 5(TRPM5)has been reported in islet cells from type 2 diabetic(T2D)mouse models,its role in lipotoxicity-induced pancreaticβ-cell dysfunction remains *** study aims to study its ***:Pancreas slices were prepared from mice subjected to a high-fat-diet(HFD)at different time points,and TRPM5 expression in the pancreaticβcells was examined using immunofluorescence ***-stimulated insulin secretion(GSIS)defects caused by lipotoxicity were mimicked by saturated fatty acid palmitate(Palm).Primary mouse islets and mouse insulinoma MIN6 cells were treated with Palm,and the TRPM5 expression was detected using qRT-PCR and Western ***-induced GSIS defects were measured following siRNA-based Trpm5 *** detrimental effects of Palm on primary mouse islets were also assessed after overexpressing Trpm5 via an adenovirus-derived Trpm5(Ad-Trpm5).Results:HFD feeding decreased the mRNA levels and protein expression of TRPM5 in mouse pancreatic *** reduced TRPM5 protein expression in a time-and dose-dependent manner in MIN6 *** also inhibited TRPM5 expression in primary mouse *** of Trpm5 inhibited insulin secretion upon high glucose stimulation but had little effect on insulin *** of Trpm5 reversed Palm-induced GSIS defects and the production of functional maturation molecules unique toβ***:Our findings suggest that lipotoxicity inhibits TRPM5 expression in pancreaticβcells both in vivo and in vitro and,in turn,drivesβ-cell dysfunction.

关键词： type 2 diabetes β-cell dysfunction lipotoxicity TRPM5

Efficient removal of Cr(VI) by polydopamine-modified lignin from aqueous solution: Batch and XAFS studies

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Water Science and Engineering 2024年第1期17卷 51-61页

作者： xiao-jie Guo Wei-kang Fu Jing-yuan Ma Bo-jun Xi Chen Wang Meng-yao Guan College of Materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018China College of Textile and Garment Shaoxing UniversityShaoxing 312000China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Lignocellulose has the potential to become a bio-based adsorbent due to its biodegradability and *** this study,a novel polydopamine functionalized-lignin(lignin@PDA),prepared via self-polymerization of dopamine(PDA)on lignin,was used as a bio-based adsorbent for rapid scavenging of hexavalent chromium(Cr(VI)).The morphology,functional groups,crystalline structure,and chemical composition of lignin@PDA were characterized with a scanning electron microscope-energy dispersive spectrometer,Fourier transform infrared spectroscopy,X-ray diffraction,and X-ray photoelectron *** Cr(VI)adsorption process of lignin@PDA was studied using batch experiments as a function of pH,ionic strength,adsorbent dose,and contact time at room *** adsorption rate of lignin@PDA was five times greater than that of the unmodified lignin,with a maximum adsorption capacity of 102.6 mg/g in an acidic *** adsorption of Cr(VI)on lignin@PDA fit the pseudo-secondorder equation and the Freundlich model,indicating that the adsorption process was mainly dominated by chemisorption and surface *** thermodynamic parameters showed that adsorption of Cr(VI)on lignin@PDA was an endothermic and spontaneous *** X-ray absorption fine structure results showed that sorption and reduction of Cr(VI)into Cr(II)occurred simultaneously on ***,PDA coating not only improved the reactivity of lignin but also promoted the complete reduction of Cr(VI)by *** to these results,polydopamine functionalized-lignin is a promising bio-based adsorbent for immobilization of Cr(VI)from wastewater.

关键词： Lignin Polydopamine Hexavalent chromium EXAFS Adsorption mechanism

A Trust Evaluation Mechanism Based on Autoencoder Clustering Algorithm for Edge Device Access of IoT

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Computers, Materials & Continua 2024年第2期78卷 1881-1895页

作者： xiao Feng Zheng yuan Cyber Security Academy Beijing University of Posts and TelecommunicationsBeijing100876China Department of Cyberspace Security Beijing Electronic Science and Technology InstituteBeijing100070China State Grid Info-Telecom Great Power Science and Technology Co. Ltd.Beijing102211China

First,we propose a cross-domain authentication architecture based on trust evaluation mechanism,including registration,certificate issuance,and cross-domain authentication processes.A direct trust evaluation mechanism based on the time decay factor is proposed,taking into account the influence of historical interaction *** weight the time attenuation factor to each historical interaction record for updating and got the new historical record *** refer to the beta distribution to enhance the flexibility and adaptability of the direct trust assessment model to better capture time trends in the historical *** we propose an autoencoder-based trust clustering *** perform feature extraction based on *** leibler(KL)divergence is used to calculate the reconstruction *** constructing a convolutional autoencoder,we introduce convolutional neural networks to improve training efficiency and introduce sparse constraints into the hidden layer of the *** sparse penalty term in the loss function measures the difference through the KL *** clustering is performed based on the density based spatial clustering of applications with noise(DBSCAN)clustering *** the clustering process,edge nodes have a variety of trustworthy attribute *** assign different attribute weights according to the relative importance of each attribute in the clustering process,and a larger weight means that the attribute occupies a greater weight in the calculation of ***,we introduced adaptive weights to calculate comprehensive trust *** experiments prove that our trust evaluation mechanism has excellent reliability and accuracy.

关键词： Cross-domain authentication trust evaluation autoencoder