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Early Changes in Serologic Markers in Workers Exposed to Indium Compounds

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Biomedical and Environmental Sciences 2021年第3期34卷 222-226页

作者： LIU Nan GUAN Yi XUE Ling LI Bin yao san qiao School of Public Health North China University of Science and TechnologyTangshan 063000HebeiChina Institute for Occupational Health and Poison Control in China Center for Disease Prevention and Control Beijing 100050China Xinxiang Medical University Xinxiang 453003HenanChina

Case reports of lung disease among indiumexposed workers in Japan,the USA,and China over the past two decades have raised public concern about the toxicity of indium and indium *** exposure to indium compounds can result in potentially fatal indium lung disease,which is characterized by pulmonary alveolar proteinosis(PAP)and may progress to fibrosis,with or without emphysema[1].

关键词： compounds. indium raised

Expression of Thioredoxin System Protein Induced by Silica in Rat Lung Tissue

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Biomedical and Environmental Sciences 2022年第7期35卷 663-668页

作者： GUAN Yi LI Gai LIU Nan WANG Yong Heng ZHOU Qiang CHANG Mei Yu ZHAO Lin Lin yao san qiao School of Public Health North China University of Science and TechnologyTangshan 063210HebeiChina North China University of Science and Technology Affiliated Hospital Tangshan 063000HebeiChina School of Pharmacy North China University of Science and TechnologyTangshan 063210HebeiChina Xinxiang Medical University Xinxiang 453003HenanChina

Silicosis,a potentially fatal global occupational disease, is characterized by progressive deterioration of pulmonary function and irreversible fibrosis resulting from crystalline silicon dioxide or silica *** pieces of evidence[1-3]manifest that inhaled silica particles could directly or indirectly cause excess generation of reactive oxygen species(ROS),which plays a key role in the pathogenesis of *** order to maintain the cellular redox balance,the main function of thioredoxin(Trx)/thioredoxin reductase(TrxR)systems is to scavenge the ROS. TrxR, as a reductase of Trx currently known only,has the function of antioxidation and scavenging free radicals[4].In addition, recent in vitro studies demonstrate that Trx interacts directly with and inhibits the activity of apoptosis-regulating kinase-1(ASK-1)[5].The damaged cell of lung tissue caused by ROS may be an important link to ASK-1 triggered cell *** et al.[1] reported that silica could aggravate oxidative stress and promote the development of silicosis in rat lungs after silica exposure by downregulating the expression of TrxR and poor Trx activity. The specific mechanism of imbalance of reduction/oxidation status in silicosis is poorly *** previous studies[6]demonstrated that oxidative stress in rats induced by silica leads to increased peroxiredoxins(Prxs) protein reactivity to resist oxidative stress, and Trx as an electron donor is functionally associated with Prxs. Hence, we propose a hypothesis that silica exposure may lead to the disturbance of the function of the Trx/TrxR system,contributing to further oxidative damage.

关键词： oxidative irreversible maintain

Urine Metabonomic Analysis of Interventions Effect of Soy Isoflavones on Rats Exposed to Di-(2-ethylhexyl) Phthalate

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Biomedical and Environmental Sciences 2020年第2期33卷 77-88页

作者： DONG Xin Wen yao san qiao WU Hao Yu ZHANG Yun Bo WANG Cheng NA Xiao Lin WU Wei Dong Department of Environmental and Occupational Health School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina Department of Environmental Hygiene Public Health CollegeHarbin Medical UniversityHarbin 150086HeilongjiangChina

Objective Di-(2-ethylhexyl) phthalate(DEHP) is a ubiquitous environmental *** an endocrine disruptor,it seriously threatens human health and ecological environmental *** study examines the impact of intervention with soybean isoflavones(SIF) on DEHP-induced toxicity using a metabonomics *** Rats were randomly divided into control(H),SIF-treated(A,86 mg/kg body weight),DEHP-treated(B,68 mg/kg),and SIF plus DEHP-treated(D) *** were given SIF and DEHP daily through diet and gavage,*** 30 d of treatment,rat urine was tested using UPLC/MS with multivariate *** changes were also evaluated using biochemical *** Metabolomics analyses revealed that p-cresol glucuronide,methyl hippuric acid,N1-methyl-2-pyridone-5-carboxamide,lysophosphatidycholine [18:2(9 Z,12 Z)] {lyso PC [18:2(9 Z,12 Z)]},lyso PC(16:0),xanthosine,undecanedioic acid,and N6-acetyl-l-lysine were present at significantly different levels in control and treatment *** SIF supplementation partially protects rats from DEHP-induced metabolic abnormalities by regulating fatty acid metabolism,antioxidant defense system,amino acid metabolism,and is also involved in the protection of mitochondria.

关键词： Di-(2-ethylhexyl) phthalate Soy isoflavones Metabonomics UPLC-QTOF-MS/MS Urine

Long-term Di-(2-ethylhexyl) phthalate Exposure Disturbs the Lipid Metabolism Profiles and Hepatic Enzymes in Male Rats:A UPLC-MS-based Serum Metabolomics Analysis

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Biomedical and Environmental Sciences 2021年第11期34卷 920-925页

作者： DONG Xin Wen WU Wei Dong yao san qiao ZHANG Yun Bo WANG Cheng WU Hao Yu NA Xiao Lin Department of Environmental and Occupational Health School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina Department of Environmental Hygiene Public Health CollegeHarbin Medical UniversityHarbin 150086HeilongjiangChina

In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural e... 详细信息

关键词： Lipid Metab Serum

Proteomic Analysis Revealed the Involvement of Autophagy in Rat Acute Lung Injuries Caused by Gas Explosion Based on a Data-Independent Acquisition Strategy

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Biomedical and Environmental Sciences 2023年第2期36卷 206-212页

作者： HONG Shan DING Chun Jie ZHOU Qiang SUN Yun Zhe ZHANG Miao LI Ning DONG Xin Wen GUAN Yi ZHANG Lin TIAN Lin Qiang CAO Jia yao Wu REN Wen Jie yao san qiao School of Public Health Xinxiang Medical UniversityXinxiang 453003HenanChina Department of Nephrology Xinxiang Second People’s HospitalXinxiang 453003HenanChina School of Public Health North China University ofScience and TechnologyTangshan 063210HebeiChina Clinical Medical Research Center for Women and ChildrenDiseases Maternal and Child Health Care Hospital of Shandong ProvinceShandong UniversityJinan 250001ShandongChina Institute of Trauma and Orthopedics Xinxiang Medical UniversityXinxiang 453003HenanChina ToxicologyResearch Institute PLA Army Medical UniversityChongqing 400038China School of Public Health ZhengzhouUniversityZhengzhou 450000HenanChina

Gas explosion injury is a compound injury caused by a shock wave,high-temperature flame,or toxic gas directly or indirectly acting on the human body,resulting in multiple organ *** a hyperaerated tissue,the lung is the primary organ that experiences an early *** pathological manifestations of gas-explosion-induced acute lung injury(ALI)include pulmonary tissue edema.

关键词： lung Lung acute

Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis

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Biomedical and Environmental Sciences 2013年第11期26卷 930-933页

作者： yao san qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang LU yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun Department of Occupational and Environmental Health School of Public Health Hebei Union University Division of Pneumoconiosis School of Public Health China Medical University Department of Pneumoconiosis Beidaihe Sanitarium for China Coal Miners Department of Community Medicine Tangshan Workers’ Hospital

The role of Fas/Fas ligand （FasL） in mediating alveolar macrophage （AM）-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied. It showed that the serum levels of IL-1β, TNF-a, IL-8, MIP-la, MCP-1, and TGF-β1 were higher in silicosis patients than in controls, and increased with the progression of silicosis except TGF-β1 and IL-8. TGF-β1, IL-8, MCP-1,

关键词： FasL AM

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职业应激对女性月经的影响及其机制

中华劳动卫生职业病杂志 2006年第8期24卷 496-498页

作者：吴清峰姚三巧华北煤炭医学院预防医学系唐山063000

据报道,2000年我国女性从业人员已过3亿,占社会总从业人员的44.96%,高于世界平均水平.由于职业女性担负着事业和家庭的双重任务,经常工作家庭“两班倒”,任务重、压力较大,易产生心理应激.研究表明,各种各样的环境应激如生活和工作暴露... 详细信息

据报道,2000年我国女性从业人员已过3亿,占社会总从业人员的44.96%,高于世界平均水平.由于职业女性担负着事业和家庭的双重任务,经常工作家庭“两班倒”,任务重、压力较大,易产生心理应激.研究表明,各种各样的环境应激如生活和工作暴露均可干扰女性内分泌功能,影响女性的生殖内分泌,危害女性的生殖健康和月经功能.

关键词：女性从业人员月经功能职业应激内分泌功能生殖内分泌双重任务职业女性平均水平心理应激环境应激

凋亡蛋白及其配体系统介导的细胞凋亡与尘肺的关系

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中国职业医学 2007年第3期34卷 237-240页

作者：张喜英姚三巧华北煤炭医学院劳动卫生与环境卫生学科河北唐山063000

尘肺是生产过程中长期吸入含游离二氧化硅(SiO2)的粉尘而发生的以肺组织纤维化为主的疾病.近年来关于石英引起的细胞功能改变、崩解死亡和肺泡结构及其细胞受损破坏,进而导致肺组织纤维化病变的机制的研究不断深入并取得许多重要的进展.

关键词：凋亡蛋白细胞凋亡尘肺肺纤维化

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氯氰菊酯对雌性大鼠生殖器官的影响

环境与健康杂志 2008年第8期25卷 708-710页

作者：李海斌李君姚三巧新乡医学院公共卫生学系劳动卫生与环境卫生教研室河南新乡453003

目的研究氯氰菊酯(CP)对雌性大鼠生殖器官的影响。方法选择刚断乳的清洁级健康雌性 SD 大鼠50只,体重为90～110 g,按体重随机分为溶剂对照组(花生油)、CP 低(20 mg/kg)、中(40 mg/kg)、高剂量组(80 mg/kg)和阳性对照组(100μg/kg 雌二醇... 详细信息

目的研究氯氰菊酯(CP)对雌性大鼠生殖器官的影响。方法选择刚断乳的清洁级健康雌性 SD 大鼠50只,体重为90～110 g,按体重随机分为溶剂对照组(花生油)、CP 低(20 mg/kg)、中(40 mg/kg)、高剂量组(80 mg/kg)和阳性对照组(100μg/kg 雌二醇)。采用灌胃染毒方式,灌胃量为5 ml/kg,每天1次,连续染毒28 d。从染毒第1天起,观察并记录各组大鼠阴道开口只数和时间,计算阴道开口率。第29天处死动物,分离卵巢、子宫、阴道并称重,计算脏器系数。结果与溶剂对照组比较,CP 高、中、低剂量组大鼠染毒后第1周阴道开口率差异有统计学意义(P<0.05),阴道开口时间提前。各剂量组大鼠的卵巢、子宫、阴道重量及其系数均随染毒剂量增加而增高,与溶剂对照组比较,差异均有统计学意义(P<0.05)。结论 CP 对大鼠的生殖器官具有一定的影响。

关键词：农药氯氰菊酯大鼠生殖器官