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Simultaneous enhancement of phosphorescence and chirality by host–guest recognition of molecular tweezers

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Chinese Chemical Letters 2022年第11期33卷 4900-4903页

作者： Diankun Jia Hua Zhong Sixun Jiang risheng yao Feng Wang School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

A novel type of host-guest recognition systems have been developed on the basis of a Au(Ⅲ) molecular tweezer receptor and chiral Pt(Ⅱ) guests. The complementary host-guest motifs display high non-covalent binding affinity (Ka: ∼10^(4) L/mol) due to the participation of two-fold intermolecular π-π stacking interactions. Both phosphorescence and chirality signals of the Pt(Ⅱ) guests strengthen in the resulting host-guest complexes, because of the cooperative rigidifying and shielding effects rendered by the tweezer receptor. Their intensities can be reversibly switched toward pH changes, by taking advantage of the electronic repulsion effect between the protonated form of tweezer receptor and the positive-charged guests in acidic environments. Overall, the current study demonstrates the feasibility to enhance and modulate phosphorescence and chirality signals simultaneously via molecular tweezer-based host-guest recognition.

关键词： Host-guest chemistry Molecular tweezer Room-temperature phosphorescence Chirality Stimuli-responsiveness

The degradation of oxadiazon by nonthermal plasma with a dielectric barrier configuration

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Plasma Science and Technology 2017年第3期19卷 15-26页

作者： Ying ZHAO risheng yao Yuedong MENG Jiaxing LI Yiman JIANG Longwei CHEN Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 People＇s Republic of China School of Medical Engineering Hefei University of Technology Hefei 230009 People＇s Republic of China

To explore the feasibility of a degradation approach by non-thermal plasma and the corresponding degradation pathways,studies on the oxadiazon removal in synthetic wastewater by a dielectric barrier discharge plasma reactor were *** loss of the nitro group,dechlorination and ring cleavage is mainly involved in the non-thermal plasma degradation pathways of oxadiazon in a solution based on the OES and LC-MS *** of EC25 and the production of the chlorine ion and nitrate ion further demonstrate the feasibility and validity of the *** conditions with a proper applied voltage,solution flow rate,oxygen flow rate,and solution pH contribute to the plasma degradation processes with a degradation ratio of over 94%.

关键词： oxadiazon wastewater degradation DBD non-thermal plasma

Degradation of 4-aminophenol by hydrogen peroxide oxidation using enzyme from Serratia marcescens as catalyst

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Frontiers of Environmental Science & Engineering 2007年第1期1卷 95-98页

作者： SUN Min yao risheng YOU Yahua DENG Shengsong GAO Wenxia College of Chemistry and Engineering Hefei University of TechnologyHefei 230009China Key Laboratory of Bio·Process of Ministry of Education Hefei 230009China

This paper reports on the degradation of 4-aminophenol using hydrogen peroxide as oxidizer and the enzyme from Serratia marcescens AB 90027 as *** effecting factors during degradation and the degrading mechanism were ***,the location of the enzyme in the cell,which could catalyze the degradation of 4-aminophenol,was *** results showed that to degrade 50 mL of 4-aminophenol whose concentration was 500 mg/L,the optimal conditions were:volume of H_(2)O_(2)=3 mL,temperature=40-60°C and pH=*** the degra-dation process,4-aminophenol was first converted to benzo-quinone and NH3,then organic acids including maleic acid,fumaleic acid,and oxalic acid were formed,and then finally CO_(2) and H2O were generated as final *** enzyme that could catalyze the degradation of 4-aminophenol was mainly extracellular enzyme.

关键词： Serratia marcescens enzyme hydrogen peroxide 4-aminophenol degradation

Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors

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Science China Chemistry 2014年第6期57卷 823-832页

作者： ZOU DingBiao QIU YaTao TU ZhengChao LIAO ChenZhong LUO JinFeng MENG QingQing yao risheng LI Zheng JIANG Sheng Laboratory of Medicinal Chemistry Guangzhou Institute of Biomedicine and HealthChinese Academy of Sciences School of Medical Engineering Hefei University of Technology Department of Radiology the Methodist Hospital Research Institute

We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping *** synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I *** 7u showed very potent kinase inhibitory activities against Bcr-Abl WT,Bcr-Abl E255K,Bcr-Abl Q252H,Bcr-Abl G250E and Bcr-Abl T315I,with IC50 values of 0.13 nM,0.17 nM,0.24 nM,0.19 nM and 0.65μM,*** compound also displayed anti-proliferation activity against K562 cell line with an IC50 value of 1.1 nM,thus representing a new lead for further optimization.

关键词： chronic myeloid leukemia(CML) anticancer agents Bcr-Abl imatinib resistance

Dex/PVA复合凝胶的制备及其对辅酶A的控制释放

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东南大学学报（自然科学版） 2011年第6期41卷 1330-1336页

作者：尹双青吉民姚日生东南大学化学化工学院南京211189 马鞍山丰原制药有限公司马鞍山243011 合肥工业大学医学工程学院合肥230009

以葡聚糖-20(Dex)为原料,运用冷冻干燥法,在水相体系中制得粒径为100～200 nm的微凝胶.采用微波-冻融、冷冻干燥法在聚乙烯醇(PVA)凝胶中嵌入Dex微凝胶,生成Dex/PVA的复合凝胶,并用红外光谱、X-粉末衍射和透射电镜表征了Dex微凝胶的结构... 详细信息

以葡聚糖-20(Dex)为原料,运用冷冻干燥法,在水相体系中制得粒径为100～200 nm的微凝胶.采用微波-冻融、冷冻干燥法在聚乙烯醇(PVA)凝胶中嵌入Dex微凝胶,生成Dex/PVA的复合凝胶,并用红外光谱、X-粉末衍射和透射电镜表征了Dex微凝胶的结构,用扫描电镜表征了Dex/PVA复合凝胶的微观形貌.溶胀试验和力学性能测试表明,Dex/PVA复合凝胶具有Dex微凝胶的环境响应性和PVA凝胶的力学性能.在不同温度、不同pH值条件下,用复合凝胶在辅酶A质量分数为0.80%的缓冲溶液中制得样品进行药物控制释放试验.结果显示,复合凝胶对辅酶A的控制释放具有温度和pH值敏感性,在温度10℃,pH=4.5的磷酸缓冲溶液中,含有30%Dex微凝胶的PVA复合凝胶能较好地控制辅酶A的释放,释药动力学方程为Rc=100t0.27/(1.47+6.56t-0.23),R2=0.998 9.

关键词： Dex/PVA复合凝胶辅酶A 控制释放温度敏感性

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辅酶A的冻干工艺及其性状结构

化工学报 2011年第11期62卷 3236-3241页

作者：尹双青吉民姚日生东南大学化学化工学院江苏南京210096 马鞍山丰原制药有限公司安徽马鞍山243000 合肥工业大学医学工程学院安徽合肥230009

引言辅酶A(coenzyme A,CoA)是生物体内乙酰化酶的辅酶,也是人体内最重要的酶之一,参与三羧酸循环,起着传递乙酰基的作用,对糖、蛋白质和脂类的代谢起重要作用[1-2]。大量的研究证明辅酶A能促进脂类的正常代谢,抑制过氧化脂质的形成,阻... 详细信息

引言辅酶A(coenzyme A,CoA)是生物体内乙酰化酶的辅酶,也是人体内最重要的酶之一,参与三羧酸循环,起着传递乙酰基的作用,对糖、蛋白质和脂类的代谢起重要作用[1-2]。大量的研究证明辅酶A能促进脂类的正常代谢,抑制过氧化脂质的形成,阻止血小板的凝集。

关键词：辅酶A 冻干工艺性状与结构纯度稳定性

Research Progress on the Development and Application of New Natural Tobacco Humectants

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Agricultural Science & Technology 2016年第5期17卷 1261-1267页

作者： Xiaojing MA Xinge LIU Zhiqiang XU Yingbo XU Huai WANG risheng yao Anhui Key Laboratory of Tobacco Chemistry (China Tobacco Anhui Industrial CO. LTD) School of Biological and Medical Engineering Hefei University of Technology

The research progress on the development and application of new natural tobacco humectants was reviewed in the ***,animals and microbes contain special moisturizing substances,showing distinctive advantages and outstanding effects in respect of the tobacco moisture content maintaining and cigarette suction comfort *** development necessity,major types,functional mechanism and influence on cigarette quality of new natural tobacco humectants development were compared and ***,the prospect of new natural tobacco humectants development and application was forecasted.

关键词： Natural humectants Tobacco Moisture retentivity Cigarette quality Moisturizing mechanism

mPEG-g-Dex微凝胶偶联羟基喜树碱的制备及性质

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高分子材料科学与工程 2011年第4期27卷 143-146,150页

作者：刘璐姚日生尤启冬陶丽合肥工业大学化学工程学院安徽合肥230009 中国药科大学药学院江苏南京210009

以大分子右旋糖酐(Dex)为载体,丁二酸酐(SA)为交联剂,二环己基碳化亚胺(DCC)为缩合剂制备右旋糖酐基微凝胶,同步接枝单甲氧基聚乙二醇(mPEG)、偶联羟基喜树碱(HCPT)-丁二酸单酯。结果表明,缩短了反应时间;mPEG-g-Dex微凝胶偶联HCPT形成... 详细信息

以大分子右旋糖酐(Dex)为载体,丁二酸酐(SA)为交联剂,二环己基碳化亚胺(DCC)为缩合剂制备右旋糖酐基微凝胶,同步接枝单甲氧基聚乙二醇(mPEG)、偶联羟基喜树碱(HCPT)-丁二酸单酯。结果表明,缩短了反应时间;mPEG-g-Dex微凝胶偶联HCPT形成了内疏水外亲水的胶束结构,粒径分布在200nm^300nm,可实现对肿瘤组织的被动靶向富集;羟基喜树碱在水中的溶解度由3.9μg/mL提高到400μg/mL,水溶性增加了约100倍,有利于生物利用度的提高;在pH=7.4缓冲溶液中的释放符合Rc=100t1.96/(1166.71+0.08t3.08)动力学方程,20h内偶联物释放HCPT只有20%左右,呈现显著缓释特性。

关键词：微凝胶偶联物制备体外释放右旋糖酐羟基喜树碱单甲氧基聚乙二醇

聚甲醛/聚醚型聚氨酯共混体系的溶混性及微晶结构

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高分子材料科学与工程 1999年第1期15卷 97-99页

作者：姚日生边侠玲安徽省化工研究院

用ＤＳＣ法研究了聚甲醛（ＰＯＭ）和聚醚型聚氨酯（ＰＥＵ）共混体系的溶混性，ＷＡＸＤ分析表明，ＰＥＵ未能进入ＰＯＭ的晶胞及晶粒中，两者仅在ＰＯＭ的无定形区域形成可溶混结构，且ＰＯＭ的（１１０）晶面法向微晶粒尺寸Ｌ１１０... 详细信息

用ＤＳＣ法研究了聚甲醛（ＰＯＭ）和聚醚型聚氨酯（ＰＥＵ）共混体系的溶混性，ＷＡＸＤ分析表明，ＰＥＵ未能进入ＰＯＭ的晶胞及晶粒中，两者仅在ＰＯＭ的无定形区域形成可溶混结构，且ＰＯＭ的（１１０）晶面法向微晶粒尺寸Ｌ１１０是随组分的增加而增大的。

关键词：聚甲醛聚醚型聚氨酯溶混性微晶结构共混