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Osteoprotegerin disrupts peripheral adhesive structures of osteoclasts by modulating Pyk2 and Src activities

畜牧与饲料科学 2015年第Z1期 71-81页

作者： ZHAO Hongyan LIU Xuezhong ZOU Hui DAI Nannan yao lulian ZHANG Xiao GAO Qian LIU Wei GU Jianhong YUAN Yan BIAN Jianchun LIU Zongping College of Veterinary Medicine Yangzhou University Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses

Osteoprotegerin has previously been shown to modulate bone mass by blocking osteoclast maturation and *** detailed mechanisms of osteoprotegerin-induced disassembly of podosomes,disruption of adhesive structures and modulation of adhesion-related proteins in osteoclasts,however,are not well *** this study,tartrate-resistant acidic phosphatase staining demonstrated that osteoprotegerin inhibited differentiation of *** use of scanning electron microscopy,real-time cell monitoring and confocal microscopy indicated that osteoclasts responded in a time and dose-dependent manner to osteoprotegerin treatments with retraction of peripheral adhesive structures and detachment from the extracellular *** imaging and Western blot studies showed that osteoprotegerin induced dephosphorylation of Tyr 402 in Pyk2 and decreased its labeling in peripheral adhesion *** induced increased intracellular labeling of Tyr 402 in Pyk2,Tyr416 in Src,increased dephosphorylation of Tyr 527 in Src,and increased Pyk2/Src association in the central region of *** evidence suggests that Src may function as an adaptor protein that competes for Pyk2 and relocates it from the peripheral adhesive zone to the central region of osteoclasts in response to osteoprotegerin *** may induce podosome reassembly and peripheral adhesive structure detachment by modulating phosphorylation of Pyk2 and Src and their intracellular distribution in osteoclasts.

关键词： osteoprotegerin osteoclast podosome Src Pyk2

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