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Exploiting AML algorithm for multiple acoustic source 2D and 3D DOA estimations

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控制理论与应用（英文版） 2011年第1期9卷 34-43页

作者： Juo-Yu LEE Ralph E. HUDSON kung yao Electrical Engineering Department University of CaliforniaLos AngelesCalifornia 90095-1594U.S.A.

The approximate maximum likelihood (AML) algorithm shows promises for joint estimations of acoustic source spectrum and direction-of-arrival (DOA). For the multisource case, the AML algorithm remains feasible as one considers an alternating projection procedure based on sequential iterative search on single source parameters. In order to perform multisource beamforming operations, earlier, we used a two-dimensional (2D) sensor array with 2D AML to obtain the DOA estimations for sources in the far field of the array. Now, the 3D AML algorithm enables a 3D sensor array to collect acoustic data for estimation of DOA represented in azimuth and elevation angles. In this paper, we consider two acoustic sources being simultaneously active and derive Crame′r-Rao bound (CRB) on DOA estimation given by a 3D array. Also, we compare the two-source DOA estimation results of 2D AML and 3D AML, respectively. To construct reasonable constraints on sensor topology, we adopt the concept of isotropic array and decouple the interplay between azimuth and elevation angle variations. The 3D AML algorithm exhibits superior spatial separation over its 2D counterpart for multiple sources located at different azimuth and elevation angles. Although the 3D AML algorithm requires more demanding computational complexity, we have developed a number of efficiency enhancements to reduce the loading for the grid search.

关键词： Approximate maximum likelihood Direction-of-arrival Alternating projection procedure

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联想实驗及其临床应用(Ⅱ)

心理学报 1963年第2期 137-145页

作者：龔耀先

在对健康人进行联想实驗的同时,我們也对几种神經症、精神分裂症、癲癇、躁狂症和抑郁症等患者进行了研究。本文是研究神經症患者的一些資料的初步总結。自伊万諾夫-斯莫林斯基于1917年首先将联想实驗用于人类高級神經活动的研究后,許... 详细信息

在对健康人进行联想实驗的同时,我們也对几种神經症、精神分裂症、癲癇、躁狂症和抑郁症等患者进行了研究。本文是研究神經症患者的一些資料的初步总結。自伊万諾夫-斯莫林斯基于1917年首先将联想实驗用于人类高級神經活动的研究后,許多作者以此方法研究了神經症患者的皮层动力特点,他們所得結果頗不一

关键词：回答皮层薄壁组织小学程度条件刺激物电诊断图脑电图反应时疮病强迫观念反应率患者心理学报差异阳性反应临床应用

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Scan of the Issue

自动化学报 2006年第6期32卷 F0002-F0002页

作者： Professor WU Jian-Kang Institute for Infocomm Research, Singapore. 119613 Professor yao kung EE Department. University of California. Los Angeles, 90095-1594

In recent years, there have been rapid advances in sensor, sensor-on-a-chip, MEMS and wireless communication technologies. Now. massively distributed sensor networks are capable of linking people and the physical world together, providing platforms for information to be collected, shared, and processed in unprecedented ways. It is commonly recognized that sensor network research will lead to smart sentient spaces for our home and environment, work and leisure. It can help us to fight against disasters, protect us from hazards, and strengthen our defense. For the past few years, sensor networks

关键词： Scan of the Issue ENS

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梁子湖水环境时空变异分析

环境工程技术学报 2017年第2期7卷 161-167页

作者：王红姚君兰 kung Hsiang-te 李兆华李艳蔷梅新陈红兵湖北大学资源环境学院湖北武汉430062 区域开发与环境响应湖北省重点实验室湖北武汉430062 美国孟菲斯大学地球科学系田纳西州孟菲斯38152

梁子湖是湖北省第二大淡水湖,了解梁子湖水质的时间变异性和空间变异性,对梁子湖区及周边城市建设具有重要意义。以春、夏、秋、冬4次采样得到的样本数据为研究对象,利用地统计分析方法,分析了总氮(TN)、总磷(TP)、氨氮(NH_4^+-N)和高... 详细信息

梁子湖是湖北省第二大淡水湖,了解梁子湖水质的时间变异性和空间变异性,对梁子湖区及周边城市建设具有重要意义。以春、夏、秋、冬4次采样得到的样本数据为研究对象,利用地统计分析方法,分析了总氮(TN)、总磷(TP)、氨氮(NH_4^+-N)和高锰酸盐指数(COD_(Mn))4个水质因子的时空特性。结果发现:水体中TN浓度的年变化特征为冬季高于春季,北部较高;TP浓度季节变化较小,从东到西呈片状降低;NH_4^+-N浓度夏季低于冬季,冬季个别区域高于秋季,总体趋势是东高西低;COD_(Mn)在冬春两季较低,而夏秋季节较高,主要集中在西梁子湖和东梁子湖中部。在时间上,梁子湖冬春季水质优于夏秋季;在空间上,梁子湖区中心水质较好,东梁子湖和入湖口附近水质较差。

关键词：梁子湖水质因子克里金(Kriging)插值时空分析

Impact of gut–brain interaction in emerging neurological disorders

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World Journal of Clinical Cases 2023年第1期11卷 1-6页

作者： Muh-Shi Lin yao-Chin Wang Wei-Jung Chen Woon-Man kung Division of Neurosurgery Department of SurgeryKuang Tien General HospitalTaichung 43303Taiwan Department of Biotechnology and Animal Science College of BioresourcesNational Ilan UniversityYilan 26047Taiwan Department of Biotechnology College of Medical and Health CareHung Kuang UniversityTaichung 43302Taiwan Department of Health Business Administration College of Medical and Health CareHung Kuang UniversityTaichung 43302Taiwan Department of Emergency Min-Sheng General HospitalTaoyuan 33044Taiwan Graduate Institute of Injury Prevention and Control College of Public HealthTaipei Medical UniversityTaipei 11031Taiwan Division of Neurosurgery Department of SurgeryTaipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan Department of Exercise and Health Promotion College of Kinesiology and HealthChinese Culture UniversityTaipei 11114Taiwan

The central nervous system(CNS)is a reservoir of immune *** immune glial cells are responsible for maintenance and defense against foreign *** blood–brain barrier(BBB)prevents detrimental pathogens and potentially overreactive immune cells from entering the *** the double-edged neuroinflammatory response is overloaded,it no longer has the protective function of promoting ***,microbiota and its derivatives may emerge as pathogen-associated molecular patterns of brain pathology,causing microbiome–gut–brain axis dysregulation from the *** dysbiosis of the gastrointestinal flora leads to subsequent alterations in BBB permeability,peripheral immune cells are recruited to the *** results in amplification of neuroinflammatory circuits in the brain,which eventually leads to specific neurological *** treatment strategies for gastrointestinal disorders may protect against specific immune responses to gastrointestinal disorders,which can lead to potential protective effects in the ***,this study investigated the mutual effects of microbiota and the gut–brain axis,which may provide targeting strategies for future disease treatment.

关键词： Neuroinflammation Blood–brain barrier Microbiota Gut–brain axis Neurological disorders

Suppressing tumor growth of nasopharyngeal carcinoma by hTERTC27 polypeptide delivered through adeno-associated virus plus adenovirus vector cocktail

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Chinese Journal of Cancer 2012年第12期31卷 588-597页

作者： Xiong Liu Xiang-Ping Li Ying Peng Samuel S.Ng Hong yao Zi-Feng Wang Xiao-Mei Wang Hsiang-Fu kung Marie C.M. Lin Department of Otolaryngology Nanfang Hospital Nanfang Medical UniversityGuangzhou Guangdong 510515 P. R. China Department of Neurology The Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou Guangdong 510120 P. R. China Brain Tumor Center Divison of Neurosurgery Department of Surgery The Chinese University of Hong KongShatin Hong Kong China Center for Emerging Infectious Diseases The Chinese University of Hong Kong ShatinHong Kong P. R. China Medical College Shenzhen UniversityShenzhen Guangdong 518061 P. R. China

Nasopharyngeal carcinoma(NPC) is a metastatic carcinoma that is highly prevalent in Southeast Asia. Our laboratory has previously demonstrated that the C-terminal 27-kDa polypeptide of human telomerase reverse transcriptase (hTERTC27) inhibits the growth and tumorigenicity of human glioblastoma and melanoma cells. In this study, we investigated the antitumor effect of hTERTC27 in human C666-1 NPC cells xenografted in a nude mouse model. A cocktail of vectors comprising recombinant adeno-associated virus (rAAV) and recombinant adenovirus (rAdv) that each carry hTERTC27 (rAAV-hTERTC27 and rAdv- hTERTC27; the cocktail was abbreviated to rAAV/rAdv-hTERTC27) was more effective than either rAAV- hTERTC27 or rAdv-hTERTC27 alone in inhibiting the growth of C666-1 NPC xenografts. Furthermore, we established three tumors on each mouse and injected rAAV/rAdv-hTERTC27 into one tumor per mouse. Although hTERTC27 expression could only be detected in the injected tumors, reduced tumor growth was observed in the injected tumor as well as the uninjected tumors, demonstrating that the vector cocktail could provoke an antitumor effect on distant, metastasized tumors. Further studies showed the observed antitumor effects included inducing necrosis and apoptosis and reducing microvessel density. Together, our data suggest that the rAAV/rAdv-hTERTC27 cocktail can potently inhibit NPC tumor growth in both local and metastasized tumors and should be further developed as a novel gene therapy strategy for NPC.

关键词：重组腺相关病毒抑制肿瘤生长抑制腺病毒载体鸡尾酒鼻咽癌多肽人端粒酶逆转录酶

Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations

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World Journal of Gastroenterology 2007年第14期13卷 2100-2103页

作者： Bing-Ying Xu Li-Ping Guo Shui-Shan Lee Qing-Ming Dong Yi Tan Hong yao Li-Hua Li Che-Kit Lin Hsiang-Fu kung Ming-Liang He Kunming Medical College Kunming 650032 Yunnan Province China Stanley Ho Center for Emerging Infectious Diseases and Li Ka Shing Institute of Health Sciences The Chinese University ofHong Kong Hong Kong China Department of Microbiology Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Hong Kong Red Cross Blood Transfusion Service Hong Kong China

AIM： To investigate the genotype and allelic frequencies of Cytochrome P450 2B6 polymorphisms in four southern Chinese populations.METHODS： DNA was obtained from blood samples from Han Chinese from Hong Kong and three minority groups,the Wa, Bulang and Lahu from Yunnan in southern China. Genotyping was performed using real-time PCR and confirmed by direct sequencing.RESULTS： A total of 507 subjects from southern China were studied. Results showed there is a high prevalence of 516G 〉 T （34.5%） in ethnic Chinese compared to literature reports on other Asian populations and Caucasians. The frequency of the 516TT genotype is higher in the Hah majority （23.1%） than in three other ethnic minority groups （i.e., 7.4%, 9.1% and 15.8%） in southern China.CONCLUSION： This was the first study to document the spectrum of CYP2B6 allelic variants and genotypes in a southern Chinese population. The 516G 〉 T allele is associated with a defective metabolism of efavirenz （EFV）, which therefore may predispose to drug *** regimens for human immunodeficiency virus （HIV） and heroin addiction may need to be optimized in different populations because of the marked variability of the key metabolizing enzyme.

关键词： Polymorphism Allele Genotype Ethnicity Discrimination PCR

一种新颖的光纤Bragg光栅小电流传感器设计

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传感技术学报 2006年第1期19卷 267-269页

作者：丰明坤陈曜李晓勇浙江科技学院信息与电子工程学院杭州310012 中国计量学院计量技术工程学院杭州310012

利用光纤Bragg光栅的应变传感原理设计了一种新颖的小电流传感器,通过检测光栅反射峰峰值波长的位移来实现小电流的检测。实验结果表明,室温下检测电流在10mA^10A范围内时,传感曲线具有良好的线性,且测量值与理论值较吻合。与微弯效应... 详细信息

利用光纤Bragg光栅的应变传感原理设计了一种新颖的小电流传感器,通过检测光栅反射峰峰值波长的位移来实现小电流的检测。实验结果表明,室温下检测电流在10mA^10A范围内时,传感曲线具有良好的线性,且测量值与理论值较吻合。与微弯效应光纤电流传感器相比,该方案具有更好的稳定性和较高的精度。

关键词：光纤Bragg光栅应变效应传感器

Investigation of Planar Shock Reflection on a Wedged Surface Loaded with Low Temperature Plasmas

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Investigation of Planar Shock Reflection on a Wedged Surface...