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Interstitial fluid flow:simulation of mechanical environment of cells in the interosseous membrane

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Acta Mechanica Sinica 2011年第4期27卷 602-610页

作者： Wei yao Guang-hong Ding Department of Mechanics and Engineering Science Fudan University Shanghai Research Center of Acupuncture 200433 Shanghai China

In vitro experiments have shown that subtle fluid flow environment plays a significant role in living biological tissues, while there is no in vivo practical dynamical measurement of the interstitial fluid flow velocity. On the basis of a new finding that capillaries and collagen fibrils in the interosseous membrane form a parallel array, we set up a porous media model simulating the flow field with FLUENT software, studied the shear stress on interstitial cells＇ surface due to the interstitial fluid flow, and analyzed the effect of flow on protein space distribution around the ceils. The numerical simulation results show that the parallel nature of capillaries could lead to directional interstitial fluid flow in the direction of capillaries. Interstitial fluid flow would induce shear stress on the membrane of interstitial cells, up to 30 Pa or so, which reaches or exceeds the threshold values of cells＇ biological response observed in vitro. Interstitial fluid flow would induce nonuniform spacial distribution of secretion protein of mast cells. Shear tress on cells could be affected by capillary parameters such as the distance between the adjacent capillaries, blood pressure and the permeability coefficient of capillary＇s wall. The interstitial pressure and the interstitial porosity could also affect the shear stress on cells. In conclusion, numerical simulation provides an effective way for in vivo dynamic interstitial velocity research, helps to set up the vivid subtle interstitial flow environment of cells, and is beneficial to understanding the physiological functions of interstitial fluid flow.

关键词： Interstitial fluid flow Porous media. Numericalsimulation - Acupoint Sheer stress

Circular RNAs:Diagnostic and Therapeutic Perspectives in CNS Diseases

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Current Medical Science 2023年第5期43卷 879-889页

作者： Ying BAI hong-hong yao Jiangsu Provincial Key Laboratory of Critical Care Medicine Department of PharmacologySchool of MedicineSoutheast UniversityNanjing 210009China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210009China

Circular RNAs(circRNAs)are a class of regulatory non-coding RNAs characterized by the presence of covalently closed ends.A growing body of evidence suggests that circRNAs play important roles in physiology and *** particular,accumulating data on circRNA functions in various central nervous system(CNS)diseases and their correlations indicate that circRNAs are critical contributors to the onset and development of brain *** this review,we focus on the regulatory and functional roles of circRNAs in CNS diseases,highlighting their diagnostic and therapeutic potential,with the aim of providing new insights into CNS diseases.

关键词： circular RNAs brain central nervous system disease diagnosis therapy

N^6-methyladenosine as a Novel Regulator of Brain Physiology and Diseases

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Current Medical Science 2020年第3期40卷 401-406页

作者： Bing HAN hong-hong yao Department of Pharmacology School of MedicineSoutheast UniversityNanjing210009China Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing210009China Co-innovation Center of Neuroregeneration Nantong UniversityNantong226019China

N^6-methyladenosine(m6A)is identified as the most widespread and abundant internal chemical modification of RNA in eukaryotes.A series of proteins including methyltransferases(also known as“writers”),demethylases(also known as“erasers”),and m6A-binding proteins(also known as“readers”)were indicated to participate in the m6A methylation.m6A has emerged as a regulator of various cellular,developmental,and disease ***,there is highest abundance of m^6A methylation in brain than in other organs,which indicates that m^6A plays an essential role in brain ***,we describe the general features,mechanisms,and functions of m^6A in the brain,and discuss the emerging roles of m6A in brain physiology and diseases.

关键词： m^6A brain physiology diseases

Restoring cosmological concordance with axion-like early dark energy and dark matter characterized by a constant equation of state?

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Communications in Theoretical Physics 2024年第7期76卷 74-82页

作者： Yan-hong yao Xin-He Meng School of Physics and Astronomy Sun Yatsen University 2 Daxue RoadTangjiaZhuhaiChina School of Physics Nankai University 94 Weijin RoadNankaiTianjinChina

The Hubble tension persists as a challenge in *** early dark energy(EDE)models,initially considered the most promising for alleviating the Hubble tension,fall short of addressing the issue without exacerbating other tensions,such as the S_(8)*** that a negative dark matter(DM)equation of state(EoS)parameter is conducive to reduce the value of the σ_(8)parameter,we extend the axion-like EDE model in this paper by replacing the cold dark matter(CDM)with DM characterized by a constant EoS w_(dm)(referred to as WDM hereafter).We then impose constraints on this axion-like EDE extension model,along with three other models:the axion-like EDE model,ΛWDM,and Λ*** constraints are derived from a comprehensive analysis incorporating data from the Planck 2018 cosmic microwave background,baryon acoustic oscillations,and the Pantheon compilation,as well as a prior on H_(0)(i.e.H_(0)=73.04±1.04,based on the latest local measurement by Riess et al)and a Gaussianized prior on S_(8)(i.e.S_(8)=0.766±0.017,determined through the joint analysis of KID1000+BOSS+2dLenS).We find that although the new model maintains the ability to alleviate the Hubble tension to~1.4σ,it still exacerbates the S_(8)tension to a level similar to that of the axion-like EDE model.

关键词： Hubble tension early dark energy noncold dark matter S8 tension

Inhibitive effects of chlortetracycline on performance of the nitritation-anaerobic ammonium oxidation(anammox)process and strategies for recovery

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Journal of Environmental Sciences 2018年第8期30卷 29-36页

作者： hong yao Huayu Li Jing Xu Lushen Zuo Beijing Key Laboratory of Aqueous Typical Pollutants Control and Water Quality Safeguard Department of Municipal and Environmental Engineering Beijing Jiaotong University

The short-and long-term effects of chlortetracycline（CTC） on the nitritation-anaerobic ammonium oxidation（anammox） process were evaluated. The half maximal inhibitory concentration of CTC in the batch tests of the nitritation-anammox process was 278.91 mg/L at an exposure time of 12 hr. The long-term effects of CTC on the process were examined in a continuous-flow nitritation-anammox reactor. Within 14 days, the nitrogen removal rate significantly decreased from 0.61 to 0.25 kg N/m^3/day with 60 mg/L CTC in the *** performance suppressed by CTC barely recovered, even after CTC was removed from the influent. Furthermore, the inhibition of CTC also reduced the relative abundance of ammonium oxidizing bacteria（AOB） and anaerobic ammonium oxidizing bacteria（An AOB）in the reactor, resulting in both a decreased amount of and an imbalance between AOB and An AOB. When fresh anammox sludge was reseeded into the nitritation-anammox reactor,the nitrogen removal rate recovered to 0.09 ± 0.03 kg N/m3/day.

关键词： Nitritation-anammox process Anaerobic ammonium oxidizing bacteria (AnAOB) Ammonium oxidizing bacteria (AOB) Chlortetracycline

Autler-Townes splitting in photoelectron spectra of K_2 molecule

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Chinese Physics B 2012年第2期21卷 259-265页

作者： yao hong-Bin Zheng Yu-Jun School of Physics Shandong UniversityJinan 250100China

We investigate Autler-Townes splitting in the photoelectron spectra of K2 molecule driven by pump-probe pulses via employing the time-dependent wave packet approach. It is found that the magnitude of Aulter-Townes splitting varies with the wavelength of the intense laser pulse. In particular, the phenomenon of Aulter-Townes splitting vanishes for the far-off resonance of the pump pulse. Also, the split peaks of Autler Townes in the case of resonant pump pulse give us an approach to directly obtaining the transition dipole moment of a molecule.

关键词： Autler-Townes splitting photoelectron spectra K2 molecule wave packet

Phase Structure and Crystallization Behavior of Polyethylene in Its Blends with cis-1,4-Butadiene Rubber

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Chinese Journal of Polymer Science 2015年第3期33卷 386-394页

作者： hong yao Jun-teng Liu Li-qun Zhang 闫寿科 Beijing Key Laboratory of Membrane Science & State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology

Phase structure and crystallization behavior of polyethylene （PE） in its blends with cis-1,4-butadiene rubber （BR） at different blend ratios and sample preparation conditions were studied. The PE is finely dispersed in the BR matrix. For samples hot pressed at 145 ℃, circular PE microdomains with randomly oriented PE lamellar aggregates were produced. The domain size and number increase with increasing PE content. When the PE content is over 10 wt%, most of the PE domains impinged each other. The separated PE domains are connected by PE stripes with parallel arranged lamellar aggregates. For samples hot pressed at 140 ℃, elongated PE microdomains with oriented PE lamellar aggregates were obtained due to the shear flow. The crystallization of PE in the blends depends on the phase structure. Confined crystallization of PE occurs in small microdomains at relatively low temperature. With the increase of domain size, the crystallization ability of PE increases while the confined crystallization decreases.

关键词： Polyethylene cis-1,4-Butadiene rubber Blend Crystallization Morphology.

A robust viscoelastic surfactant tolerating 20% HCl up to 150℃ for oil well stimulation

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Petroleum Science 2024年第3期21卷 1865-1874页

作者： Ji Wang Ning Qi hong-yao Yin Yu-Jun Feng Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065SichuanPR.China Tianfu Yongxing Laboratory New Theory and Technology of CO_(2) Capture Research CenterChengdu610065SichuanPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Viscoelastic surfactants(VES)are often used as viscous diverters in acidizing stimulation to prolong the acid consumption time and maximize zonal coverage of the acid for improving well ***,the ceiling temperature of commercial VES cannot exceed 120℃in practical use because of the poor thermal stability and fragile molecular structure,hindering their implementation in hightemperature oil reservoirs,i.e.,≥150℃.Here we synthesized a novel C22-tailed diamine,N-erucaminopropyl-N,N-dimethylamine(EDPA),and examined comparatively its rheological behavior,assemblies morphology and molecular stability in 20 wt%HCl with a commercial VES,erucyl dimethyl amidopropyl betaine(EDAB).The feasibility of EDPA for acidizing stimulation was assessed by acid etching of carbonate rock with its HCl solution at 150℃.Rheological results showed that the 2.5 wt%EDPA—20 wt%HCl solution maintains stable viscosity of 90 m Pa s at 150℃for 60 min,while that of 2.0 wt%EDAB HCl solution is just 1 m Pa s under identical conditions.1H NMR spectra and cryo-TEM observations revealed that the chemical structure and self-assembled architectures of EDPA remained intact in such context,but the EDAB suffered from degradation due to the hydrolysis of the amide group,accounting for the poor heat-resistance and *** reaction rate of 2.5 wt%EDPA HCl solution with carbonate rock was one order of magnitude lower than that of 20 wt%HCl solution at 150℃,underpinning the potential of EDPA to be used in the high-temperature reservoirs *** work improved the thermal tolerance of VES in highly concentrated HCl solution,paving a feasible way for the acidization of high-temperature reservoir environments(~150℃).

关键词： Viscoelastic surfactants Thermal stability Self-diverting acid Wormlike micelles Acidizing stimulation

Structure and properties of low-dielectric-constant poly(acetoxystyrene-co-octavinyl-polyhedral oligomeric silsesquioxane) hybrid nanocomposite

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Chinese Chemical Letters 2010年第4期21卷 488-491页

作者： Zhang, Chao Xu, hong yao Zhao, Xian Donghua Univ State Key Lab Modificat Chem Fibers & Polymer Mat Shanghai 201620 Peoples R China Donghua Univ Coll Mat Sci & Engn Shanghai 201620 Peoples R China Shandong Univ State Key Lab Crystal Mat Jinan 250100 Peoples R China

Low-dielectric-constant poly(acetoxystyrenezhi-co-octavinyl-polyhedral oligomeric silsesquioxane)(PAS-POSS) organicinorganic hybrid nanocomposite was successfully synthesized via one-step free radical polymerization and characterized by FTIR,high-resolution ~1H NMR,^(29)Si NMR,DSC,TGA,AFM,spectroscopic elhpsometry and dielectric constants measurements. The results show T_g and T_(dec) were elevated dramatically due to the incorporation of inorganic POSS *** ellipsometry and dielectric consta...

关键词： Low-dielectric-constant Hybrid nanocomposite POSS