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CCS Chemistry 2021年第10期3卷 2994-3004页

作者： Yang-Yang Zhou Zi-Yuan Wang Ze-fan yao Zi-Di Yu Yang Lu Xin-Yi Wang Yi Liu Qi-Yi Li Lin Zou Jie-Yu Wang Jian Pei beijing National Laboratory for Molecular sciences(BNLMS) Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter of Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 college of Chemistry Shandong Normal UniversityJinan 250014 Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621999

The mesoscopic solution-state aggregation plays a dominant role in the multilevel self-assembly of conjugated ***,its effect on solid-state microstructures and the electrical performance of conjugated polymers is still a puzzle due to the limitation of characterization ***,we have developed four isoindigo-based conjugated polymers with varied alkyl chains to reveal the relationship between solution-state aggregation,molecular doping process,and charge transport properties.

关键词： properties. conjugated aggregation

Flexible thermoelectric generator and energy management electronics powered by body heat

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Microsystems & Nanoengineering 2023年第4期9卷 293-301页

作者： Shuai Yang Yumei Li Ling Deng Song Tian Ye yao fan Yang Changlei Feng Jun Dai Ping Wang Mingyuan Gao college of Engineering and Technology Southwest University400716 ChongqingChina Chongqing Key Laboratory of Agricultural Equipment in Hilly Area 400716 ChongqingChina Gies college of Business University of Illinois at Urbana–ChampaignChampaignIL 61820USA Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopedicsRuijin HospitalShanghai Jiao Tong University School of Medicine200025 ShanghaiChina School of Mechatronical Engineering Beijing Institute of Technology100081 BeijingChina School of Civil Engineering Southwest Jiaotong University610031 ChengduChina

Uninterrupted,efficient power supplies have posed a significant hurdle to the ubiquitous adoption of wearable devices,despite their potential for revolutionizing human‒machine *** challenge is further compounded by the requirement of these devices to supply dependable energy for data-intensive sensing and *** thermoelectric solutions fail to deliver satisfactory performance under conditions of extremely low ***,we present a novel solution of a wearable thermoelectric generator integrated with an energy management system,which is capable of powering sensors and Bluetooth by harnessing body *** from previous works,our innovation lies in its ability to consistently operate even with a minimal temperature difference(i.e.,4 K)between the human skin and the ambient environment,ensuring reliable data transmission within a time as short as 1.6 ***,our system can recharge utilizing body heat under ultralow voltage conditions(30 mV).Our developed system provides a novel pathway for the continuous,reliable monitoring of self-contained wearable devices without depending on batteries.

关键词： generator utilizing body

Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5873-5886页

作者： Liangjiang Huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo Huang Yajie Li Bo Zhu Jiaqi fan Liu Wang Yani Xiao Wenjing Liu yao Tian Zhengyu fang Yingying Lv Lingfeng Xie Sheng yao Gaotan Ke Xiaolin Huang Ying Huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen Department of Rehabilitation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina National Stem Cell Resource Center State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyInstitute for Stem Cell and RegenerationChinese Academy of SciencesBeijingChina beijing Institute for Stem Cell and Regenerative Medicine BeijingChina Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Stem Cell Research Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina University of Chinese Academy of sciences BeijingChina beijing Key Lab for Pre-clinical Safety Evaluation of Drugs National Center for Safety Evaluation of DrugsNational Institutes for Food and Drug ControlBeijingChina beijing Zephyrm Biotechnologies Co. Ltd.BeijingChina

Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological *** resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains ***,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus *** injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage *** the dose-escalating phase I clinical trial(NCT038392.8)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12.months ***,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury *** summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus *** results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration.

关键词： meniscus injuries cartilage

Nitrogen doped hollow carbon nanospheres as efficient polysulfide restricted layer on commercial separators for high-performance lithium-sulfur batteries

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Chinese Chemical Letters 2023年第2期34卷 613-617页

作者： Yue Zhao Zhi Gu Wei Weng Dan Zhou Ziqiang Liu Wentong fan Shungui Deng Hao He Xiayin yao Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Department of Chemical and Environmental Engineering Faculty of Science and EngineeringUniversity of NottinghamNingbo 315100China Center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Chongqing Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology College of Materials Science and EngineeringYangtze Normal UniversityChongqing 408100China

The polysulfide shuttle limits the development of lithium-sulfur(Li-S) batteries with high energy density and long lifespan. Herein, nitrogen doped hollow carbon nanospheres(NHCS) derived from polymerization of dopamine on SiO_(2.nanospheres are employed to modify the commercial polypropylene/polyethylene/polypropylene tri-layer separators(PP/PE/PP@NHCS). The abundant nitrogen heteroatoms in NHCS exhibit strong chemical adsorption toward polysulfides, which can effectively suppress the lithium polysulfides shuttle and further enhance the utilization of active sulfur. Lithium-sulfur batteries employing the PP/PE/PP@NHCS deliver an initial discharge capacity of 1355 mAh/g and retain high capacity of 92. mAh/g after 100 cycles at 0.2.C. At a high rate of 2.C, the lithium-sulfur batteries exhibit capacity of 461 mAh/g after 1000 cycles with a capacity fading rate of 0.049% per cycle. This work demonstrates that the NHCS coated PP/PE/PP separator is promising for future commercial applications of lithium-sulfur batteries with improved electrochemical performances.

关键词： Nitrogen doped hollow carbon nanospheres Separator modification Shuffle effect Polysulfides Lithium-sulfur batteries

Relationship between High-quality Tea and the Geological Background in Qionglai Mountains

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Agricultural science & Technology 2011年第6期12卷 908-913页

作者： ZENG Qi-guo MA Xiao-jun PENG Pei-hao LUO fan WANG Yun HU yao-wen college of Geoscience Chengdu University of Technology Chengdu 610059 Institute of Medicinal Plant Development Chinese Acad-emy of Medical Sciences Beijing 100193 Tea Research Institute of Sichuan Academy of Agricultural sciences Chengdu 610066 college of Resource and Environmental sciences Chongqing University Chongqing 400030

[Objective] Many strata emerge in the high-quality tea producing area in Qionglai Mountains,which belongs to Mesozoic Cretaceous(K),Mingshan Fm(E1-2.n)and Dayi conglomerate Team(N)of Cenozoic Tertiary System as well as Quaternary System(Q).Analysis on the migrating features of soil heavy metal from each stratum to tea leaves showed that the enrichment ability of elements was Cu>Cd>Zn>Ni>Hg>As>Cr>*** comparing the soil background values with the soil base values of Sichuan hilly area and Chengdu economic region,it could be concluded that Cd,Hg,Mo,Pb and Se were enriched,and other metal elements existed at a level close to that of the comparing *** pH was a little acidic,and high quality tea cultivation could be developed here at *** the increase of human activities,the environment of study area tends to ***,land planning and use should be *** government should control the environment nearby and prevent pollution.

关键词： Qionglai Mountains High-quality tea Geological background

Tricuspid regurgitation following pacemaker implantation for bradycardia:a two-year study comparing different pacing strategies

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Chinese Medical Journal 2023年第20期136卷 2508-2510页

作者： Xiaofei Li Xiaohan fan Qian Wang Zhao Wang Haojie Zhu Hui Li Hao Wang Zhimin Liu Yan yao Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Echocardiography Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

To the Editor:Tricuspid regurgitation(TR)is a known complication of cardiac implantable electrical device(CIED)implantation with a prevalence of up to 10–30%.Due to the detrimental effects of right ventricular pacing(RVP)on cardiac function,His bundle pacing(HBP)and left bundle branch area pacing(LBBAP)have been increasingly used as physiological pacing *** observational study aimed to assess the lead-related significant TR(moderate and severe)in patients with HBP,LBBAP,right ventricular apical pacing(RVAP),and right ventricular septal pacing(RVSP)in bradycardia patients during the two-year follow-up.

关键词： pacing ventricular cardia

Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer

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Cancer Communications 2023年第11期43卷 1275-1279页

作者： Yongzhan Nie Xianchun Gao Xiqiang Cai Zhen Wu Qiaoyi Liang Guobing Xu Na Liu Peng Gao Jingyu Deng Hongzhi Xu Zhanlong Shen Changqi Cao Fenrong Chen Nannan Zhang Yongxi Song Mingjun Sun Chengyin Liu Guangpeng Zhou weili Han Jianhua Dou Huahong Xie Liping yao Zhiguo Liu Gang Ji Xin Wang Qingchuan Zhao Lei Shang Daiming {2. Xiaoliang Han Jianlin Ren Han Liang Zhenning Wang Jinhai Wang Qi Wu Jun Yu Kaichun Wu the MAGIS Study Group State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi'anShaanxiP. R. China Department of Gastroenterology Tangdu HospitalFourth Military Medical UniversityXi'anShaanxiP. R. China BioChain (beijing) science & Technology Inc. BeijingP. R. China Department of Medicine and Therapeutics Institute of Digestive DiseasePrince of Wales HospitalThe Chinese University of Hong KongHong KongP. R. China Department of Endoscopy Center Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationBeijingP. R. China Department of Gastroenterology the Second Affiliated HospitalXi'an Jiaotong UniversityXi'anShaanxiP. R. China Department of Surgical Oncology and General Surgery Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal TumorsThe First Affiliated Hospital of China Medical UniversityShenyangLiaoningP. R. China Department of Gastric Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjinP. R. China Department of Gastroenterology Zhongshan HospitalXiamen UniversityXiamenFujianP. R. China Department of Gastrointestinal Surgery Peking University People's HospitalBeijingP. R. China Department of Endoscope The First Hospital Affiliated to China Medical UniversityShenyangLiaoningP. R. China Department of Health Statistics School of Preventive MedicineFourth Military Medical UniversityXi'anShaanxiP. R. China 不详

Dear Editor,Early diagnosis is critical for successful treatment of gastric adenocarcinoma(GA).However,the sensitivities of tumor markers carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9)and CA72.4 for GA detection are approximately 2.%[1],and the sensitivities of all markers combined for early gastric cancer detection is still very low[2..DNA methylation plays a major role in tumorigenesis and therefore has obvious potential as a non-invasive biomarker for cancer detection[3].Through genome-wide methylation analysis and histological verification,we previously identified ring finger protein 180(RNF180)as a novel preferentially methylated gene in GA[4,5].

关键词： RNF180 diagnosis gastric

Nationwide survey analysis of esophagogastric varices in portal hypertension based on endoscopic management in china

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Portal Hypertension & Cirrhosis 2024年第3期3卷 129-138页

作者： Xing Wang Bing Hu Yiling Li Weichun Lin Zhijie Feng Yanjing Gao Zhining fan Feng Ji Bingrong Liu Jinhai Wang Wenhui Zhang Tong Dang Hong Xu Derun Kong Lili Yuan Liangbi Xu Shengjuan Hu Liangzhi Wen Ping yao Yunxiao Liang Xiaodong Zhou Huiling Xiang Xiaowei Liu Xiaoquan Huang Yinglei Miao Xiaoliang Zhu De‐An Tian Feihu Bai Jitao Song Ligang Chen Yangzhen Bian Ba Yingcai Ma Yifei Huang Bin Wu Xiaolong Qi CHESS‐Endoscopyconsortium Department of Gastroenterology The Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouGuangdongChina Guangdong Province Engineering and Technology Research Center of Digestive Endoscopy GuangzhouGuangdongChina Department of Gastroenterology and Hepatology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyangLiaoningChina Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Gastroenterology Qilu Hospital of Shandong UniversityJinanShandongChina Department of Digestive Endoscopy The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiangChina Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Gastroenterology Beijing Daxing District People's HospitalBeijingChina Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical CollegeBaotouInner MongoliaChina Department of Gastroenterology The First Hospital of Jilin UniversityChangchunJilinChina Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Department of Digestive Endoscopy The Second Hospital of Shanxi Medical UniversityTaiyuanShanxiChina Digestive Endoscopy Center The Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhouChina Department of Gastroenterology People's Hospital of Ningxia Hui Autonomous RegionNingxia Medical UniversityYinchuanNingxiaChina Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqingChina Department of Gastroenterology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Gastroente

Aims:The endoscopic treatment of esophagogastric varices is challenging,and the nationwide application of endoscopic therapies for various types of esophagogastric varices and different clinical scenarios remains *** study investigated the use of endoscopic therapy for portal hypertension in ***:This study used a questionnaire survey initiated by the Liver Health Consortium in china to investigate the use of endoscopic therapies for portal *** were released online from January 30,2.2. to February 2.,2.2. and filled out by chief physicians or senior instructors responsible for endoscopic therapies in participating hospitals across 31 provinces(autonomous regions and municipalities)in *** of guideline adherence between primary and referral medical centers were performed using the chi‐square test or Fisher's exact ***:In total,836 hospitals participated in the *** primary and secondary prophylaxis of esophagogastric variceal bleeding(EGVB),adherence to the national guidelines was 72.5%(606/836)and 39.2.(32./836),*** differences were observed in the rate of adherence between the primary and referral centers for primary(79.9%[111/139]vs.71.0%[495/697],p=0.033)and secondary prophylaxis(2..3%[38/139]vs.41.6%[2.0/697],p=0.002..Of the hospitals,78.2.(654/836)preferred endoscopic therapies for acute EGVB,and the timing of endoscopy was usually within 12.h(48.5%,317/654)and 12.2. h(36.9%,2.1/654)after *** therapy was more likely to be the first choice of treatment for acute EGVB in referral centers than in primary centers(82.6%[576/697]vs.56.1%[78/139],p2.and isolated gastric varices type 1,the most prevalent procedures were cyanoacrylate injection combined with sclerotherapy(48.2.[403/836]and 2..9%[2.0/836],respectively);however,substantial hospitals preferred clip-assisted therapies(12.4%[104/836]and 2

关键词： endoscopy esophagogastric varices guideline adherence portal hypertension questionnaire survey

Total liquid ventilation reduces oleic acid-induced lung injury in piglets

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Chinese Medical Journal 2013年第22期126卷 4282-4288页

作者： ZHU yao-bin LIU Dong-hai ZHANG Yan-bo LIU Ai-jun fan Xiang-ming QIAO Chen-hui WANG Qiang LIU Ying-long Department of Pediatric Heart Center Beijing Anzhen Hospital. Capital Medical University Beijing 100029 China Department of Pediatric Heart Center State Key Laboratory ol Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Peking Union Medical college Beijing 100037 China

Background Pediatric patients are susceptible to lung injury that does not respond to traditional therapies. Total liquid ventilation has been developed as an alternative ventilatory strategy for severe lung injury. The aim of this study is to investigate the effect of total liquid ventilation on oleic acid （OA）-induced lung injury in piglets. Methods Twelve Chinese immature piglets were induced acute lung injury by OA. Twelve piglets were randomly treated with conventional gas ventilation （control group） or total liquid ventilation （study group） for 2.0 minutes. Samples for blood gas analysis were collected before, and at 60-minute intervals after OA-induced lung injury. The degree of lung injury was quantified by histologic examination. The inflammatory cells and the levels of IL-1β, IL-6, IL-10 and TNF-α in plasma, tissue and bronchoalveolar lavage were analyzed. Results Neutrophil and macrophage counts in bronchoalveolar lavage were significantly decreased in the study group （P〈0.05）. The total lung injury score was also reduced in the study group （P〈0.05）. The concentrations of IL-1β, IL-6, IL-10 and TNF-α in plasma, tissue and bronchoalveolar lavage were significantly reduced in the study group （P〈0.05）. Conclusions Total liquid ventilation reduces biochemical and histoloaic OA-induced luna iniurv in nialets.

关键词： total liquid ventilation, perfluorocarbons acute lung injury, oleic acid, cytokines

Hypercompact CRISPR–Cas12.2.(CasF) enables genome editing, gene activation, and epigenome editing in plants

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Plant Communications 2022年第6期3卷 131-134页

作者： Shishi Liu Simon Sretenovic Tingting fan Yanhao Cheng Gen Li Aileen Qi Xu Tang Yang Xu Weijun Guo Zhaohui Zhong yao He Yanling Liang Qinqin Han Xuelian Zheng Xiaofeng Gu Yiping Qi Yong Zhang Department of Biotechnology School of Life Sciences and TechnologyCenter for Informational BiologyUniversity of Electronic Science and Technology of ChinaRoom 216Main BuildingNo.4Section 2North Jianshe RoadChengdu 610054China Department of Plant science and Landscape Architecture University of MarylandCollege ParkMD 20742USA Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Institute for Bioscience and Biotechnology Research University of MarylandRockvilleMD 20850USA

CRISPR-Cas9,-Cas12.,-Cas12.,and-Cas13 have been harnessed for genome engineering in human and plant cells(Liu et al.,2.2.).However,the large size of these Cas proteins(e.g.190 kDa for SpCas9)makes them difficult to deliver into cells via a viral *** development of smaller Cas proteins will lead to reduced viral vector sizes that can be more widely adopted in versatile genome engineering ***,a CRISPR-Cas12.2.CasF)system was discovered in huge phages and developed into a hypercompact genome editor due to the small size of Cas12.2.80 kDa)(Pausch et al.,2.2.).Unfortunately,the gene editing efficiency of Cas12.2.in Arabidopsis protoplasts using ribonucleoprotein delivery was less than one percent(Pausch et al.,2.2.).Further optimization of this system is clearly required if CRISPR-Cas12.2.mediated editing in plant genomes is to be adopted by the plant sciences community.

关键词： CRISPR activation system