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（＊）-Serial coalgebras

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Frontiers of Mathematics in china 2012年第5期7卷 955-970页

作者： hailou yao weili fan Yanru PING college of applied sciences Beijing University of TechnologyBeijing 100124China

In this paper, we introduce the notion of （＊）-serial coalgebras which is a generalization of serial coalgebras. We investigate the properties of （＊）-serial coalgebras and their comodules, and obtain sufficient a... 详细信息

关键词： Coalgebra biserial comodule (,)-serial coalgebra quiver

On adjacent-vertex-distinguishing total coloring of graphs

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science china Mathematics 2005年第3期48卷 289-299页

作者： ZHANG Zhongfu, CHEN Xiang’en, LI Jingwen, yao Bing, LU Xinzhong & WANG Jianfang college of Mathematics and Information science, Northwest Normal {4., Lanzhou 730070, china Department of Computer, Lanzhou Normal college, Lanzhou 730070, china Institute of applied Mathematics, Lanzhou Jiaotong {4., Lanzhou 730070, china college of Information and Electrical Engineering, Lanzhou Jiaotong {4., Lanzhou 730070, china Institute of applied Mathematics, Chinese Academy of sciences, beijing 100080, china 1. college of Mathematics and Information science Northwest Normal University 730070 Lanzhou China 2. Department of Computer Lanzhou Normal College 730070 Lanzhou China 3. Institute of applied Mathematics Lanzhou Jiaotong University 730070 Lanzhou China 4. college of Information and Electrical Engineering Lanzhou Jiaotong University 730070 Lanzhou China 5. Institute of applied Mathematics Chinese Academy of Sciences 100080 Beijing China

In this paper, we present a new concept of the adjacent-vertex-distinguishing total coloring of graphs (briefly, AVDTC of graphs) and, meanwhile, have obtained the adjacent-vertex-distinguishing total chromatic number... 详细信息

关键词： graph, proper total coloring, adjacent-vertex-distinguishing total coloring, adjacent-vertex-distinguishing total chromatic number.

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余代数的Krull维数

北京工业大学学报 2016年第8期42卷 1265-1269页

作者：姚海楼范维丽平艳茹北京工业大学应用数理学院北京100124

为了研究余代数的结构,基于素子余代数引进了余代数Krull维数概念,通过局部化方法对其进行了研究,得到一些有关Krull维数的等式与不等式,从而为余代数的研究提供了有用的工具.

关键词：余代数余模素余代数 Krull 维数诺特余代数

Climate and extrema of ocean waves in the East china Sea

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science china Earth sciences 2018年第7期61卷 980-994页

作者： Hailun HE Jinbao SONG Yefei BAI yao XU Juanjuan WANG fan BI State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic AdministrationHangzhou 310012China Ocean college Zhejiang UniversityZhoushan 316021China Department of Ocean and Resources Engineering University of Hawaii at ManoaHonoluluHI 96822USA School of Geographic and Oceanographic sciences Nanjing UniversityNanjing 210023China National Marine Environment Forecasting Center Beijing 100081China North china Sea Marine Forecasting Center of State Oceanic Administration Qingdao 266061China Shandong Provincial Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao 266061China

Wave climate plays an important role in the air-sea interaction over marginal seas. Extreme wave height provides fundamental information for various ocean engineering practices, such as hazard mitigation, coastal structure design, and risk assessment. In this paper, we implement a third generation wave model and conduct a high-resolution wave hindcast over the East china Sea to reconstruct a 15-year wave field from 1988 to 2002 for derivation of monthly mean wave parameters and analysis of extreme wave conditions. The numerical results of the wave field are validated through comparison with satellite altimetry measurements, low-resolution reanalysis, and the ocean wave buoy record. The monthly averaged wave height and wave period show seasonal variation and refined spatial patterns of surface waves in the East china Sea. The climatological significant wave height and mean wave period decrease from the open ocean in the southeast toward the continental area in the northwest, with the pattern generally following the bathymetry. Extreme analysis on the significant wave height at the buoy station indicates the hindcast data underestimate the extreme values relative to the observations. The spatial pattern of extreme wave height shows single peak emerges at the southwest of Ryukyu Island although a wind forcing with multi-core structure at the extreme is applied.

关键词： Wave climate East china Sea Extreme value analysis WaveWatch-lll

A Time-Varying Parameter Estimation Method for Physiological Models Based on Physical Information Neural Networks

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Computer Modeling in Engineering & sciences 2023年第12期137卷 2243-2265页

作者： Jiepeng yao Zhanjia Peng Jingjing Liu Chengxiao fan Zhongyi Wang Lan Huang college of Information and Electrical Engineering China Agricultural UniversityBeijing100083China Key Laboratory of Agricultural Information Acquisition Technology(beijing) Ministry of AgricultureBeijing100083China Key Laboratory of Modern Precision Agriculture System Integration Research Ministry of EducationBeijing100083China

In the establishment of differential equations,the determination of time-varying parameters is a difficult problem,especially for equations related to life ***,we propose a new framework named BioE-PINN based on a physical information neural network that successfully obtains the time-varying parameters of differential *** the proposed framework,the learnable factors and scale parameters are used to implement adaptive activation functions,and hard constraints and loss function weights are skillfully added to the neural network output to speed up the training convergence and improve the accuracy of physical information neural *** this paper,taking the electrophysiological differential equation as an example,the characteristic parameters of ion channel and pump kinetics are determined using *** results demonstrate that the numerical solution of the differential equation is calculated by the parameters predicted by BioE-PINN,the RootMean Square Error(RMSE)is between 0.01 and 0.3,and the Pearson coefficient is above 0.87,which verifies the effectiveness and accuracy of ***,realmeasuredmembrane potential data in animals and plants are employed to determine the parameters of the electrophysiological equations,with RMSE 0.02-0.2 and Pearson coefficient above *** conclusion,this framework can be applied not only for differential equation parameter determination of physiological processes but also the prediction of time-varying parameters of equations in other fields.

关键词： Physics-informed neural network differential equation bioelectrical signals inverse problems

Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia

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Journal of Genetics and Genomics 2017年第6期44卷 295-306页

作者： Jinsong Tang Yu fan Hong Li Qun Xiang Deng-Feng Zhang Zongchang Li Ying He Yanhui Liao Ya Wang fan He Fengyu Zhang Yin yao Shugart Chunyu Liu Yanqing Tang Raymond C.K.Chan Chuan-Yue Wang Yong-Gang yao Xiaogang Chen Institute of Mental Health National Clinical Research Center for Mental Health Disorders and National Technology Institute of Psychiatryand Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceThe Second Xiangya HospitalCentral South University Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of sciences & Yunnan Province Kunming Institute of Zoology Department of Psychiatry The First Affiliated Hospital of Zhengzhou University Kunming college of Life science University of Chinese Academy of Sciences Neuropsychology and applied Cognitive Neuroscience Laboratory and CAS Key Laboratory of Mental HealthInstitute of PsychologyChinese Academy of Sciences beijing Key Laboratory of Mental Disorders Department of PsychiatryBeijing Anding Hospitaland Center of SchizophreniaBeijing Institute for Brain Disorders and Laboratory of Brain Disorders of the Ministry of Science and TechnologyCapital Medical University Unit on Statistical Genomics Intramural Research ProgramsNational Institute of Mental HealthNIH Institute of Human Genetics University of Illinois at Chicago Department of Psychiatry The First Affiliated Hospital of China Medical University CAS Center for Excellence in Brain science and Intelligence Technology Chinese Academy of Sciences

Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still *** implemented whole-genome sequencing(WGS) analysis of 8 families with monozygotic(MZ) twin pairs discordant for schizophrenia to assess potential association of de novo mutations(DNMs) or inherited variants with susceptibility to schizophrenia. Eight non-synonymous DNMs(including one splicing site) were identified and shared by twins, which were either located in previously reported schizophrenia risk genes(p.V24.89 I mutation in TTN, p.S2506 T mutation in GCN1L1, IVS3+1G > T in DOCK1) or had a benign to damaging effect according to in silico prediction analysis. By searching the inherited rare damaging or loss-of-function(LOF) variants and common susceptible alleles from three classes of schizophrenia candidate genes, we were able to distill genetic alterations in several schizophrenia risk genes, including GAD1, PLXNA2, RELN and FEZ1. Four inherited copy number variations(CNVs; including a large deletion at 16p13.11) implicated for schizophrenia were identified in four families, respectively. Most of families carried both missense DNMs and inherited risk variants, which might suggest that DNMs, inherited rare damaging variants and common risk alleles together conferred to schizophrenia susceptibility. Our results support that schizophrenia is caused by a combination of multiple genetic factors, with each DNM/variant showing a relatively small effect size.

关键词： Whole-genome sequencing Schizophrenia Monozygotic twin De novo mutation Combined effect Susceptibility

Concise Total Synthesis of Dysoxylactam A and a Simplified Analog

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Chinese Journal of Chemistry 2022年第17期40卷 2027-2034页

作者： Guan-Zhou Yang Lei Wang yao-Yue fan Zeng-Wei Lai Xue-Ni Yu Li-Guang Lou Kun Gao Jian-Min Yue State Key Laboratory of applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou University222 Tianshui South RoadLanzhouGansu730000 China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai201203 China university of Chinese Academy of sciences No.19A Yuquan RoadBeijing100049 China

A total synthesis of 17-membered macrocyclolipopeptide dysoxylactam A,a potent agent reversing P-glycoprotein(P-gp)-mediated multidrug resistance(MDR)in cancer cells,was developed from the starting material(S)-2-methylbutanal in a linear sequence of 12 steps with 23.2%overall *** key steps include proline-catalyzed asymmetric aldol reaction,Evans aldol reaction and Krische allylation to construct the multiple stereocenters containing fragment,and ring-closing metathesis to furnish the *** total synthesis facilitates the preparation of large amount samples of dysoxylactam A and the side chain simplified derivatives for further biological tests and preliminary structure-activity relationship exploration.

关键词： Total synthesis Dysoxylactam A Macrocyclolipopeptide Reversing multidrug resistance Structure-activity relationship

Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere

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Research 2023年第4期2023卷 595-608页

作者： Yue Yin Yaping Yan Biao fan Wenping Huang Jie Zhang Hai-Yan Hu Xiaoqiong Li Dongbin Xiong Shu-Lei Chou yao Xiao Hai Wang School of Medical Technology Beijing Institute of TechnologyBeijing 100081China college of Materials Engineering Henan University of EngineeringXinzheng 451191China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China university of Chinese Academy of sciences Beijing 100049China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Life science Beijing Institute of TechnologyBeijing 100081China Institute of Advanced Materials Hubei Normal UniversityHuangshi 415000China State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi'an Jiaotong UniversityXi'anShaanxiChina

Triple-negative breast cancer(TNBC)is a subtype of breast cancer with high mortality,and the efficacy of monotherapy for TNBC is still ***,we developed a novel combination therapy for TNBC based on a multifunctional nanohollow carbon *** intelligent material contains a superadsorbed silicon dioxide sphere,sufficient loading space,a nanoscale hole on its surface,a robust shell,and an outer bilayer,and it could load both programmed cell death protein 1/programmed cell death ligand 1(PD-1/PD-L1)small-molecule immune checkpoints and small-molecule photosensitizers with excellent loading contents,protect these small molecules during the systemic circulation,and achieve accumulation of them in tumor sites after systemic administration followed by the application of laser irradiation,thereby realizing dual attack of photodynamic therapy and immunotherapy on ***,we integrated the fasting-mimicking diet condition that can further enhance the cellular uptake efficiency of nanoparticles in tumor cells and amplify the immune responses,further enhancing the therapeutic ***,a novel combination therapy“PD-1/PD-L1 immune checkpoint blockade+photodynamic therapy+fasting-mimicking diet”was developed with the aid of our materials,which eventually achieved a marked therapeutic effect in 4.1-tumor-bearing *** concept can also be applied to the clinical treatment of human TNBC with guiding significance in the future.

关键词： eventually thereby dioxide

基于中国全科医生的糖尿病医患沟通技能培训设计与开发

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中国全科医学 2024年第7期27卷 816-821页

作者：姚弥林恺樊洁婷纪欣鑫王颖董爱梅韩晓宁齐建光迟春花 Shamil Haroon Dawn Jackson KK Cheng Richard Lehman 北京大学第一医院全科医学科北京市100034 北京大学医学部全科医学系北京市100191 汕头大学医学院第一附属医院全科医学中心广东省汕头市515041 火箭军特色医学中心内分泌科北京市100088 汕头大学医学院广东省汕头市515041 北京大学第一医院教育处北京市100034 北京大学第一医院内分泌科北京市100034 北京大学第一医院心血管科北京市100034 北京大学第一医院儿科北京市100034 北京大学第一医院健康管理中心北京市100034 英国伯明翰大学应用健康研究院伯明翰B152TT 英国伯明翰大学医学院伯明翰B152TT

全科医生作为居民健康“守门人”,在基层糖尿病等慢性疾病管理中发挥着重要作用。糖尿病管理可以延缓病情进展、减少糖尿病并发症和改善患者健康结局,这需要患者和医生之间的有效沟通并互相协作。全科医生具备良好的沟通能力有助于与糖... 详细信息

全科医生作为居民健康“守门人”,在基层糖尿病等慢性疾病管理中发挥着重要作用。糖尿病管理可以延缓病情进展、减少糖尿病并发症和改善患者健康结局,这需要患者和医生之间的有效沟通并互相协作。全科医生具备良好的沟通能力有助于与糖尿病患者建立长期的照护关系、帮助患者建立有效的自我管理技能。本文总结了本研究团队在多种理论框架指导下的全科医生糖尿病沟通技能培训的设计和开发:基于系统综述发现的循证依据,通过定性研究进一步探索糖尿病患者与全科医生的沟通体验和想法,以及混合方法研究设计理念获取全科医学对于医患沟通培训内容的优先排序,旨在为高质量的基层糖尿病管理提供新思路,并为基于证据和医学教育框架设计全科医生相关培训项目提供借鉴。

关键词：糖尿病沟通技能在职培训培训设计全科医生

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