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A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2324-2340页

作者： Xin Wang Qian Liu hai-tao Yu Jia-zhao Xie jun-ning Zhao Zhi-ting Fang Min Qu yao Zhang Ying Yang Jian-Zhi Wang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Fundamental Medicine Wuxi School of MedicineJiangnan UniversityWuxiJiangsu 214122China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and PreventionHubei Provincial Academy of Preventive MedicineWuhan 430000China Endocrine Department of Liyuan Hospital Key Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease(AD);however,the fundamental mechanism is *** this study,we found a substantial decline in isocitrate dehydrogenase 3β(IDH3β)levels,a critical tricarboxylic acid cycle enzyme,in AD patients and AD-transgenic mice’s *** investigations demonstrated that the knockdown of IDH3βinduced oxidation-phosphorylation uncoupling,leading to reduced energy metabolism and lactate *** resulting increased lactate,a source of lactyl,was found to promote histone lactylation,thereby enhancing the expression of paired-box gene 6(PAX6).As an inhibitory transcription factor of IDH3β,the elevated PAX6 in turn inhibited the expression of IDH3β,leading to tau hyperphosphorylation,synapse impairment,and learning and memory deficits resembling those seen in *** AD-transgenic mice,upregulating IDH3βand downregulating PAX6 were found to improve cognitive functioning and reverse AD-like ***,our data suggest that impaired oxidative phosphorylation accelerates AD progression via a positive feedback inhibition loop of IDH3β-lactate-PAX6-IDH3β.Breaking this loop by upregulating IDH3βor downregulating PAX6 attenuates AD neurodegeneration and cognitive impairments.

关键词： metabolism Alzheimer impaired

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两种丙烯酸酯类二元共聚物的合成及降凝影响因素探讨

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现代化工 2011年第S2期31卷 80-83,85页

作者：姚海军马君刚新疆维吾尔自治区产品质量监督检验研究院新疆乌鲁木齐830046

针对新疆西北局原油,主要合成丙烯酸酯类系列原油降凝剂:丙烯酸酯-马来酸酐和丙烯酸酯-苯乙烯二元共聚物类降凝剂,对其合成和降凝影响因素进行探讨并找出最优化结果。

关键词：丙烯酸酯降凝剂马来酸酐苯乙烯原油

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Strong ferroelectric and luminescence properties of 0-3 type 0.8BaTiO_(3)-0.2CaTiO_(3):Pr^(3+)composite ceramics prepared by cold sintering process

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Journal of Advanced Ceramics 2024年第7期13卷 1002-1010页

作者： Xiaocui Rao Xueling Yang Renbing Sun Peng Du hai Jiang yao Huang Laihui Luo Department of Microelectronics Science and Engineering School of Physical Science and TechnologyNingbo UniversityNingbo 315211China College of Materials Science and Engineering Ningbo University of TechnologyNingbo 315016China

0-3 type ferroelectric-phosphor composite ceramics cannot be prepared by the traditional solid-state sintering(SSS)method due to the strong chemical reaction between ferroelectrics and phosphors during high-temperature *** cold sintering process(CSP)may solve this issue by densifying ceramics at ultralow sintering *** this work,dense 0-3 type 0.8BaTiO_(3)-0.2CaTiO_(3):Pr^(3+)(0.8BT-0.2CT:Pr^(3+))binary composite ceramics were fabricated at an ultralow temperature of 225℃via CSP with the Ba(OH)2·8H2O hydrated *** effects of the Ba(OH)_(2)·8H2O content,sintering temperature,and sintering time on the microstructure and densification of the ceramics were *** density of the composite ceramics prepared by the optimized sintering parameters reaches 89%.Both energy-dispersive X-ray(EDX)spectroscopy and X-ray diffraction(XRD)confirm the existence of BT and CT:Pr^(3+)phases in the prepared ceramics.A strong ferroelectric performance is obtained,and the luminescent properties of CT:Pr^(3+)are preserved for the ***,the 0.8BT-0.2CT:Pr^(3+)composite ceramics prepared by CSP have stronger photoluminescence and photo-stimulated luminescence than their counterparts prepared by cold sintering assistance(CSA)and SSS ***,CSP is a promising method for combining luminescent and ferroelectric properties into 0-3 type composite ceramics.

关键词： single-step densification cold sintering composite ceramics ferroelectric luminescence

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基于均匀化理论的页岩基岩运移机制尺度升级研究

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中国科学：物理学、力学、天文学 2017年第11期47卷 115-124页

作者：孙海姚军 YALCHIN Efendiev 中国石油大学(华东)石油工程学院青岛266580 Department of Mathematics Texas A & M University

基岩孔隙是页岩气藏的主要储集空间.页岩有机质孔隙和非有机孔隙具有不同的赋存方式和传输机制:有机质孔隙存在吸附气、游离气两种赋存方式,无机质内仅存在游离气,气体在有机质孔隙存在吸附解吸和吸附气的表面扩散.传统的数值模拟方法... 详细信息

基岩孔隙是页岩气藏的主要储集空间.页岩有机质孔隙和非有机孔隙具有不同的赋存方式和传输机制:有机质孔隙存在吸附气、游离气两种赋存方式,无机质内仅存在游离气,气体在有机质孔隙存在吸附解吸和吸附气的表面扩散.传统的数值模拟方法未考虑页岩基岩内不同孔隙介质储集方式和运移机制的差异性,未考虑有机质分布结构特征的影响.本文基于均匀化理论建立了考虑页岩基岩有机质分布特征和相应运移机制的尺度升级数学模型,在小尺度模型中考虑有机质和无机质赋存方式和运移机制的差异性.数值模拟结果表明,传统上具有相同宏观运移参数的基岩,若其有机质分布不同,采用尺度升级后的宏观模型计算的压力变化和产量均不同,必须进行尺度升级才能实现复杂结构分布的页岩基岩模拟的准确性.

关键词：页岩气均匀化理论运移机制尺度升级

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Supermassive black holes triggered by QCD axion bubbles

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Communications in Theoretical Physics 2024年第5期76卷 134-139页

作者： hai-jun Li Ying-Quan Peng Wei Chao Yu-Feng Zhou Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Center for Advanced Quantum Studies Department of PhysicsBeijing Normal UniversityBeijing 100875China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Beijing/HangzhouChina

Supermassive black holes(SMBHs)are ubiquitous in the center of galaxies,although the origin of their massive seeds is still *** this paper,we investigate the formation of SMBHs from the quantum chromodynamics(QCD)axion *** this case,primordial black holes(PBHs)are considered as the seeds of SMBHs,which are generated from the QCD axion bubbles due to an explicit Peccei–Quinn(PQ)symmetry breaking after *** QCD axion bubbles are formed when the QCD axion starts to oscillate during the QCD phase *** consider a general case in which the axion bubbles are formed with the bubble effective angle θ_(eff)∈(0,π],leading to the minimum PBH mass∼■(10^(4)−10^(7))M⊙for the axion decay constant f_(a)∼■(10^(16))*** PBHs at this mass region may account for the seeds of SMBHs.

关键词： supermassive black holes primordial black holes quantum chromodynamics axion

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Proppant transport in rough fracture networks using supercritical CO_(2)

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Petroleum Science 2024年第3期21卷 1852-1864页

作者： Yong Zheng Meng-Meng Zhou Ergun Kuru Bin Wang jun Ni Bing Yang Ke Hu hai Huang hai-Zhu Wang School of Petroleum Engineering Xi'an Shiyou UniversityXian710065ShaanxiChina Shaanxi Key Laboratory of Carbon Dioxide Sequestration and Enhanced Oil Recovery Xi'an710075ShaanxiChina State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China School of Mining and Petroleum Engineering University of AlbertaEdmontonTG2W2AlbertaCanad Shaanxi Yanchang Petroleum(Group)Co. Ltd.Xi'an710075ShaanxiChina

Proppant transport within fractures is one of the most critical tasks in oil,gas and geothermal reservoir stimulation,as it largely determines the ultimate performance of the operating *** transport in rough fracture networks is still a relatively new area of research and the associated transport mechanisms are still *** this study,representative parameters of rough fracture surfaces formed by supercritical CO_(2) fracturing were used to generate a rough fracture network model based on a spectral synthesis *** fluid dynamics(CFD)coupled with the discrete element method(DEM)was used to study proppant transport in this rough fracture *** reveal the turning transport mechanism of proppants into branching fractures at the intersections of rough fracture networks,a comparison was made with the behavior within smooth fracture networks,and the effect of key pumping parameters on the proppant placement in a secondary fracture was *** results show that the transport behavior of proppant in rough fracture networks is very different from that of the one in the smooth fracture *** turning transport mechanisms of proppant into secondary fractures in rough fracture networks are gravity-driven sliding,high velocity fluid suspension,and fracture structure *** the same injection conditions,supercritical CO_(2)with high flow Reynolds number still has a weaker ability to transport proppant into secondary fractures than *** of the supercritical CO_(2)needs to be increased beyond a certain value to have a significant effect on proppant carrying,and under the temperature and pressure conditions of this paper,it needs to be increased more than 20 times(about 0.94 m Pa s).Increasing the injection velocity and decreasing the proppant concentration facilitates the entry of proppant into the branching fractures,which in turn results in a larger stimulated reservoir *** results help to understand the pro

关键词： Reservoir stimulation CCUS Rough fracture network Supercritical CO_(2) Proppanttransport

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Cuproptosis mediates copper-induced testicular spermatogenic cell death

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Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang Xu-jun Yu jun-jun Li yao Xiao Guang-Sen Li Fang Yang Liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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Investigating the causal link between gut microbiota and dry age-related macular degeneration:a bidirectional Mendelian randomization study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1723-1730页

作者： hai-Yan Huang Jing Wang Bo Qin yao Tan Clinical Medical College of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Postdoctoral Station of Clinical Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina The Third Xiangya Hospital Central South UniversityChangsha 410000Hunan ProvinceChina

AIM:To assess the causal link between 211 gut microbiota(GM)taxa and dry age-related macular degeneration(dAMD)***:Mendelian randomization using instrumental factors taken from a genome-wide association study(GWAS)were *** variance weighted(IVW)analysis and sensitivity analysis were performed on the FinnGen project,which included 5095 cases and 222590 ***:The IVW analysis showed substantial genusand family-level relationships between GM taxa and dAMD ***,the family Peptococcaceae(P=0.03),genus Bilophila(P=3.91×10^(-3)),genus Faecalibacterium(P=6.55×10^(-3)),and genus Roseburia(P=0.04)were linked to a higher risk of developing dAMD,while the genus Candidatus Soleaferrea(P=7.75×10^(-4)),genus Desulfovibrio(P=0.04)and genus Eubacterium ventriosum group(P=0.04)exhibited a protective effect against *** significant causal relationships were observed at higher taxonomic ***,in the reverse IVW analysis,no meaningful causal effects of the 7 GM ***:These findings give support for the gutretina axis participation in dAMD and shed light on putative underlying *** on the connection between GM and dAMD have not yet revealed the underlying mechanism.

关键词： dry age-related macular degeneration gut microbiota mendelian randomization gut-retina axis genome-wide association study

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Cycloaddition Reactions of Epoxides and CO_(2)Catalyzed by Bifunctional Rare-Earth Metal Complexes Bearing Amino-Bridged Tris(phenolato)Ligands

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Chinese Journal of Chemistry 2024年第14期42卷 1571-1581页

作者： Yongjie Chen Yanwei Wang jun Nong Dan Yuan Yingming yao Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceDushu Lake CampusSoochow UniversitySuzhouJiangsu215123 China

Eight zwitterionic rare earth metal complexes stabilized by amino-bridged tris(phenolato)ligands bearing quaternary ammonium side-arms were synthesized and *** complexes were used as single-component catalysts for the cycloaddition of CO_(2)and epoxides,and their catalytic activities are obviously higher than those of their binary *** studies revealed that the halide anions(Cl^(–),Br^(–),I^(–))and the metal complexes influenced the catalytic activity,and the lanthanum complex bearing iodide anion showed the highest catalytic activity for this addition reaction.A variety of mono-substituted epoxides were converted to cyclic carbonates in good to excellent yields(55%—99%)with high selectivity(>99%)at 30℃and 1 bar CO_(2),whereas internal epoxides required higher both reaction temperatures(60—120℃)and catalyst loading(2 mol%)for high *** catalyst was recyclable for four times without noticeable loss of catalytic *** on the results of kinetic studies and in℃situ IR reactions,a plausible reaction mechanism was proposed.

关键词： Bifunctional catalyst Carbon dioxide Cyclic carbonate Rare-earth metal Tris(phenolato)ligand Insertion Cycloaddition C1 building blocks

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Theoretical study on the effect of H_(2)O on the formation mechanism of NO_(x) precursors during indole pyrolysis

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 99-112页

作者： Ziqi Wang jun Shen Xuesong Liu Sha Wang Shengxiang Deng hai Zhang Yun Guo School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The incineration technology of kitchen waste is one of the effective technologies to achieve the resource utilization of municipal solid *** is an important stage of *** is a rich initial product in the pyrolysis process of kitchen waste,and the presence of H_(2)O has a significant impact on the decomposition of indole to form NO_(x) ***,this study uses density functional theory method to study the effect of H_(2)O on the thermal decomposition of indole to produce NH_(3),HNCO,and *** H_(2)O participates in the reaction,it can provide oxidative groups to generate a new product HNCO,which is different from the previous findings by indole pyrolysis without the presence of H_(2)***,this study theoretically proves that NH_(3) is easier to form than *** is consistent with the phenomenon that NH_(3) release is higher than HCN release in pyrolysis *** addition,compared with the individual pyrolysis of indole,the participation of H_(2)O reduces the energy barriers for the formation of NH_(3) and HCN during indole pyrolysis,thereby promoting the formation of NH_(3) and HCN.

关键词： indole pyrolysis H_(2)O NO_(x)precursors DFT

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