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Efficacy and safety of dacomitinib as first-line treatment for advanced non-small cell lung cancer patients with epidermal growth factor receptor 21L858R mutation:A multicenter,case-series study in china

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Chinese Journal of Cancer Research 2024年第4期36卷 398-409页

作者： Shouzheng Wang Jiayu liu Yan Wang Ying hu Ziling liu Yu yao li liang Yutao liu lin Wang Junling li Puyuan Xing department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/CancerHospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of Medical Oncology Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Cancer Center the First Hospital of Jilin UniversityChangchun 130021China department of Medical Oncology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China department of Medical Oncology and Radiation Sickness Peking University Third HospitalBeijing 100191China

Objective:To provide real-world evidence for the application of first-line dacomitinib treatment for epidermal growth factor receptor(EGFR)21L858R mutant non-small cell lung cancer(NSCLC)patients in china and to explore the factors influencing the efficacy and ***:A longitudinal,consecutive case-series,multicenter study with mixed prospective and retrospective data was *** primary endpoint was progression-free survival(PFS),and the secondary endpoints included duration of treatment(DOT),overall survival(OS),objective response rate(ORR),disease control rate(DCR)and ***:A total of 155 EGFR 21L858R mutant patients treated with first-line dacomitinib were *** median follow-up time for these patients was 20.4 *** 134 patients with evaluable lesions,the ORR was 70.9%and the DCR was 96.3%.The median PFS was 16.3[95%confidence interval(95%CI),13.7−18.9]*** Cox regression analysis suggested that the baseline brain metastasis(BM)status[with *** BM:hazard ratio(HR),1.331;95%CI,0.720−2.458;P=0.361]and initial doses(45 mg vs.30 mg:HR,0.837;95%CI,0.427−1.641;P=0.604)did not significantly affect the median *** median DOT was 21.0(95%CI,17.5−24.6)months and the median OS was not *** tests were performed in 64 patients after progression,among whom 29(45.3%)patients developed the EGFR 20T790M *** addition,among the 46 patients who discontinued dacomitinib treatment after progression,31(67.4%)patients received subsequent third-generation EGFR-tyrosine kinase *** most common grade 3−4 adverse events were rash(10.4%),diarrhea(9.1%),stomatitis(7.1%)and paronychia(4.5%).The incidence of grade 3−4 rash was significantly higher in the 45 mg group than that in the 30 mg group(21.9%vs.7.5%,P=0.042).Conclusions:First-line dacomitinib treatment demonstrated promising efficacy and tolerable adverse events among EGFR 21L858R mutant NSCLC patients in china.

关键词： Epidermal growth factor receptor molecular targeted therapy non-small cell lung cancer safety treatment efficacy

Formation of ε-Fe_XN/BN magnetic nanocomposite and itsthermodynamic and kinetic analyses

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Chinese Science Bulletin 1998年第6期43卷 467-470页

作者： li liu bin yao Hongyan Wang fushan li bingzhe ding wenhui su department of physics Jilin University Changchun China State Key Laboratery of Rare Earth Chemistry and physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun China State Key Laboratory of Rapidly Solidified Nonequilibrium Alloys Institute of Metal Research Chinese Academy of Sciences Shenyang China

A nanocomposite of nanometer-sized magnetic granular ε-Fe-XN embedded in a nonmagnetic amorphous boron nitride matrix was prepared by ball milling mixture of α-Fe and hexagonal boron nitride in argon atmosphere. The grain size of the ε-Fe-XN alloy was about 10-20 nm. The nitrogen concentration in the ε-Fe-XN alloy increases with extending milling time. Both thermodynamic calculation and the present experiment show that iron and nitrogen atoms have higher alloying driving force than iron and boron atoms. Analyses of thermodynamics and kinetics about formation of the ε-Fe-XN alloy suggested that the formation of the ε-Fe-XN alloy is related to amorphization of the hexagonal boron nitride and refinement of the α-Fe. It was found from the present experiment that a critical grain size of the α-Fe reacting with nitrogen in the amorphous boron nitride is about 8 nm.

关键词： Fe-XN nanocomposite mechanical alloying.

Selection of dialysis methods for end-stage kidney disease patients with diabetes

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World Journal of Diabetes 2024年第9期15卷 1862-1873页

作者： yao-hua hu Ya-li liu ling-Fei Meng Yi-Xian Zhang Wen-Peng Cui department of Nephrology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

The increasing prevalence of diabetes has led to a growing population of endstage kidney disease(ESKD)patients with ***,kidney transplantation is the best treatment option for ESKD patients;however,it is limited by the lack of ***,dialysis has become the standard treatment for ESKD ***,the optimal dialysis method for diabetic ESKD patients remains *** patients with diabetes often present with complex conditions and numerous ***,these patients face a high risk of infection and technical failure,are more susceptible to malnutrition,have difficulty establishing vascular access,and experience more frequent blood sugar fluctuations than the general ***,this article reviews nine critical aspects:survival rate,glucose metabolism disorder,infectious complications,cardiovascular events,residual renal function,quality of life,economic benefits,malnutrition,and volume *** study aims to assist clinicians in selecting individualized treatment methods by comparing the advantages and disadvantages of hemodialysis and peritoneal dialysis,thereby improving patients’quality of life and survival rates.

关键词： Diabetes End-stage kidney disease Hemodialysis Peritoneal dialysis Dialysis methods selection

Two-Dimensional Conductive Metal-Organic Framework Reinforced Spinterface in Organic Spin Valves

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CCS Chemistry 2024年第1期6卷 208-217页

作者： Xiaoyu Song Chao Jin Hongliang Chen Shuaishuai ding Zhongyi liu Yang li Xiaoli Yan Wenbo Mi Long Chen Wenping hu department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic ScienceTianjin UniversityTianjin 300072 School of Chemistry and Chemical Engineering Yantai UniverisityYantaiShandong 264005 Tianjin Key Laboratory of Low Dimensional Materials physics and Processing Technology School of ScienceTianjin UniversityTianjin 300072 State Key Laboratory of supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunJilin 130012

Interface engineering in device fabrication is a significant but complicated *** great successes have been achieved by conventional physical in situ or ex situ methods,it still suffers from complicated *** this work,we present a facile method for fabricating phthalocyanine(Pc)-based two-dimensional conductive metal–organic framework(MOF)*** on PcM-Cu(M=Ni,Cu,H_(2))MOF films,spin valves with a vertical configuration of La_(0.67)Sr_(0.33)MnO_(3)/PcM-Cu MOFs/Co were constructed successfully,and exhibited notably high negative magnetoresistance(MR)up to -22% at 50 *** penetrated Co atoms coordinated with the dehydrogenated hydroxy groups in the MOFs resulting in an antiferromagnetic layer of the PcM-Cu-Co hybrid ***,a significant exchange bias effect was demonstrated at the PcM-Cu MOF/Co interface,beneficial for the MR ***,our present study provides new insights into developing high-performance organic spin valves via de novo molecular design.

关键词： two-dimensional conductive metal-organic framework two-dimensional polymer phthalocyanine spintronics organic spin valve

Roadmap for rechargeable batteries:present and beyond

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Science china Chemistry 2024年第1期67卷 13-42页

作者： Sen Xin Xu Zhang lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang huang Xinbo Zhang Yu su yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao liubing Dong Dong Zhou Feiyu Kang hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong su Yu-Guo Guo Qiang Zhang Jun Chen li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China university of Chinese Academy of Sciences.Beijing 100049 China Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChangchun 130022China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate *** to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable *** efforts are made to developing the next-generation post-li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow *** the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a *** roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable *** computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research.

关键词： energy storage rechargeable batteries battery materials electrochemistry

Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)

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Cancer Communications 2024年第9期44卷 1005-1017页

作者： Shun Lu Xiaorong Dong Hong Jian Jianhua Chen Gongyan Chen Yuping sun Yinghua Ji ZipingWang Jianhua Shi Junguo Lu Shaoshui Chen Dongqing Lv Guojun Zhang Chunling liu Juan li Xinmin Yu Zhong lin Zhuang Yu ZhehaiWang Jiuwei Cui Xingxiang Xu Jian Fang Jifeng Feng Zhi Xu RuiMa Jie hu Nong Yang Xiangdong Zhou XiaohongWu Chengping hu Zhihong Zhang You Lu Yanping hu liyan Jiang Qiming wang Renhua Guo Jianying Zhou Baolan li Chunhong hu Wancheng Tong Helong Zhang linMa Yuan Chen Zhijun Jie Yu yao Longzhen Zhang JieWeng Weidong li Jianping Xiong Xianwei Ye Jianchun Duan Haihua Yang Meili sun HongyingWei JiaweiWei Zheyu Zhang QiongWu department of Medical Oncology Shanghai Chest Hospital Shanghai JiaoTong UniversityShanghaiP.R.China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiP.R.China department of Medical Oncology-Chest Hunan Cancer Hospital&The Affiliated Cancer Hospital of Central South University Xiangya School of MedicineChangshaHunanP.R.China Thoracic OncologyMedicine HarbinMedical University Cancer HospitalHarbinHeilongjiangP.R.China department of Oncology Jinan Central HospitalJinanShandongP.R.China department of Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanP.R.China department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China department of Internal Medicine Linyi Cancer HospitalLinyiShandongP.R.China department of Respiratory Medicine Nantong Tumor HospitalNantongJiangsuP.R.China department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Breath Internal Medicine Taizhou Hospital of Zhejiang ProvinceLinhaiZhejiangP.R.China department of Respiration The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China department of Lung Internal Medicine Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiangP.R.China department of Thoracic Oncology Sichuan Cancer HospitalChengduSichuanP.R.China Thoracic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)HangzhouZhejiangP.R.China department of Thoracic Oncology The Fifth Subsidiary Sun Yat-sen University HospitalZhuhaiGuangdongP.R.China department of Oncology The Affiliated Hospital of QingdaoUniversityQingdaoShandongP.R.China department of Oncology Shandong Cancer HospitalJinanShandongP.R.China department of Oncology The First BethuneHospital of Jilin UniversityChangchunJilinP.R.China department of Respiration Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhouJiangsuP.R.China department of Internal

Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of *** study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS ***:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded *** with asymptomatic,stable CNS metastases were ***-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every *** responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;Plity of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at *** new safety findings were ***:The

关键词： aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI

A virtual thermometer for ultrahigh-temperature-pressure experiments in a large-volume press

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Matter and Radiation at Extremes 2024年第4期9卷 98-110页

作者： bingtao Feng Longjian Xie Xuyuan Hou Shucheng liu Luyao Chen Xinyu Zhao Chenyi li Qiang Zhou Kuo hu Zhaodong liu bingbing liu State Key Laboratory of superhard Materials Synergetic Extreme Condition User FacilityCollege of PhysicsJilin UniversityChangchun 130012China department of Earth Sciences University College LondonLondon WC1E 6BSUnited Kingdom Earth and Planetary Laboratory Carnegie Institute for ScienceWashingtonDistrict of Columbia 20015USA College of Earth Sciences Jilin UniversityChangchun 130012China

Ultrahigh-temperature-pressure experiments are crucial for understanding the physical and chemical properties of *** recent development of boron-doped diamond(BDD)heaters has made such melting experiments possible in large-volume ***,estimates of temperatures above 2600 K and of the temperature distributions inside BDD heaters are not well constrained,owing to the lack of a suitable ***,we establish a three-dimensional finite element model as a virtual thermometer to estimate the temperature and temperature field above 2600 *** advantage of this virtual thermometer over those proposed in previous studies is that it considers both alternating and direct current heating modes,the actual sizes of cell assemblies after compression,the effects of the electrode,thermocouple and anvil,and the heat dissipation by the pressure-transmitting *** virtual thermometer reproduces the power-temperature relationships of ultrahigh-temperature-pressure experiments below 2600 K at press loads of 2.8-7.9 MN(~19 to 28 GPa)within experimental *** temperatures above 2600 K predicted by our virtual thermometer are within the uncertainty of those extrapolated from power-temperature relationships below 2600 ***,our model shows that the temperature distribution inside a BDD heater(19-26 K/mm along the radial direction andsuch as graphite or LaCrO_(3) heaters(100-200 K/mm).Our study thus provides a reliable virtual thermometer for ultrahigh-temperature experiments using BDD heaters in Earth and material sciences.

关键词： virtual ultrahigh sizes

Synthesis and Characterization of the Large Pore Molecular Sieves VPI-5 and Si-VPI-5

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Chemical Research in Chinese Universities 1991年第1期7卷 11-17页

作者： yao Shangqing, Qiu Shilun, Pang Wenqin Yu Long (department of Chemistry, jilin university, changchun)li liyun (Wuhan Institute of physics, Wuhan)Xin Qin (Dalian Institute of Chemical physics, Dalian)

The large pore molecular sieves VPI-5 and Si VPI-5 were synthesized by using three organic amines (dipropylamine, diisopropylamine and dipentylamine) as the structure-directing agents. Compared with general alumlnophosphate molecular sieves, the synthesis of the molecular sieves of VPI-5 type ls of many unique features. Both VPI-5 and Si-VPI-5 were characterized by XRD, IR, TG-DTA, and MAS-NMR.

关键词： Aluminophosphate VPI-5 Molecular sieves

Tb￣(3+) as Fluorescent Probe in the Study of the Interaction of Other Lanthanide Ions with Trichosanthin

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Chemical Research in Chinese Universities 1995年第4期11卷 279-283页

作者： HAO Qiang li Wen-lian ZHANG Yan YU Gui YANGHong ZHAO Xu yao Qi-Zhi and li Qing-shan(department of Molecular Biofogy and National Laboratory of enzyme engineering,Jiln university,changchun, 13.02.)(changchun Institute of physics, Academia Sinica, Cha jilin UNIV DEPT MOLEC BIOLCHANGCHUN 130023PEOPLES R CHINA jilin UNIV NATL LAB ENZYME ENGNCHANGCHUN 130023PEOPLES R CHINA ACAD SINICA CHANGCHUN INST PHYSCHANGCHUN 130023PEOPLES R CHINA ACAD SINICA GRAD SCHBEIJING 100039PEOPLES R CHINA

he interaction of lanthanide (Ln￣(3+))ions with trchosanthin(TCS)was investi-gated using Tb￣(3+) as fluorescent probe. The metal-binding sites of the protein were probed by means of adding the Tb￣(3+) into the protein solutions. If other Ln￣(3+) ions exist in the Tb￣(3+) protein complex system, they would compete against Tb￣(3+) in the binding sites of the protein, and so the fluorescence intensity of Tb￣(3+) decreased,which is called quenching *** quencliing effect is related to the ionic radii of the Ln￣(3+) ions and energy transfer from Tb￣(3+) protein to Ln￣(3+) ions. Based on the ex- perimental results,a schematic of the energy transfer from protein-Tb￣(3+) complex to protein-Ln￣(3+) complex is suggested.

关键词： Trichosanthin Energy transfer Protein-Ln￣(3+) complex