检索结果-南通市图书馆

Confirmation of susceptibility gene loci on chromosome 1 in Northern China Han families with type 2 diabetes

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2001年第8期114卷 93-95,112页

作者：杜玮南孙红霞熊墨淼左瑾方福德王■ 孙琦强伯勤沈岩姚志建顾军黄薇陈竺华秀峰高伟中国医学科学院中国协和医科大学基础医学研究所北京100005 中国医学科学院中国协和医科大学北京协和医院内分泌科北京100730 国家人类基因组北方研究中心北京100176 国家人类基因组南方研究中心上海201203 山东烟台毓璜顶医院内分泌科烟台264006

Objective　To confirm previous effort to identify type 2 diabetes susceptibility genes in a Northern Chinese population by conducting a new genome scan with both an increased number of type 2 diabetes families and a new set of microsatellite markers within the previously localized ***　A genome scan method was applied. After multiplexed PCR, electrophoreses, genescan and genotyping analysis, we obtained size information for all loci , and then a further study was done by both parametric and non-parametric linkage analysis to investigate the P values and Z values of these ***　We surveyed 34 microsatellite markers which distributed within 5 regions along chromosome 1, and a total of 12?000 genotypes were screened. Evidence of linkage with diabetes was identified for 8 of the 34 loci. All P values of the 8 loci were lower than 0.05, and the highest Z value was 2.17. A very interesting finding is that all 5 markers at the p- terminal 1p36.3-1p36.23 region, spanning a long range of 16.9?cM, were identified to have a low P value of less than 0.05, which suggests that this region may contain multiple susceptibility genes. Regions 4 and 5 also confirmed the previous findings, and we narrowed these two regions to a 2.7?cM and 2.5?cM regions, ***　We further confirmed the results gained in the previous genome-wide scan using an increased number of NIDDM families and a new set of microsatellite markers lying within the initially localized regions. The fact that all 5 loci at the p- terminal region displayed a low P value of less than 0.05 suggests that more than 1 susceptibility gene may reside in this region.

关键词： type 2 diabetes · microsatellte mark ers · genome screening · susceptibility genes · gene mapping

Two New Glycosides from Rubus amabilis

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2000年第10期11卷 897-900页

作者： Chen, XC Jia, zj Lanzhou Univ Natl Lab Appl Organ Chem Dept Chem Lanzhou 730000 Peoples R China

A pregnane glycoside and a lignan glycoside were isolated from the aerial parts of Rubus amabilis. Their structures were elucidated as 3-O-beta-D-glucopyranosyl-3 beta.15 alpha-dihydroxypregn-5-en-20-one and (-)-secoi... 详细信息

关键词： Rubus amabilis Rosaceae pregnane lignan glycoside

A New Benzofuranosesquiterpene Dimer from Ligularia Virgaurea

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1997年第4期8卷 315-316页

作者： Wang, BG Jia, zj LANZHOU UNIV DEPT CHEMNATL LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

A new benzofuranosesquiterpene dimer, named virgaurin B, has been isolated from the roots of Ligularia virgaurea and its structure has been elucidated by spectroscopic evidence.

关键词： Chen A New Benzofuranosesquiterpene Dimer from Ligularia Virgaurea

NEOLIGNAN GLUCOSIDES FROM PEDICULARIS TORTA

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1996年第2期7卷 145-148页

作者： Wang, CZ Jia, zj LANZHOU UNIV INST ORGAN CHEMLANZHOU 730000PEOPLES R CHINA LANZHOU UNIV STATE KEY LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

Two new neolignan glucosides, tortosides D and E were isolated from plants of Pedicularis torta. On the basis of spectral evidence, tortosides D and E were determined as (7R.8S)-dehydrodiconiferyl-9-O-beta-D-4 ''-O-methyl-glucopyranoside and (7R,8S)-5-methoxy-dihydrodehydrodiconiferyl alcohol-9'-O-beta-D-glucopyranoside, respectively.

关键词：

NEOLIGNAN GLUCOSIDES FROM PEDICULARIS LONGIFLORA

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1996年第2期7卷 141-144页

作者： Wang, CZ Jia, zj LANZHOU UNIV INST ORGAN CHEMLANZHOU 730000PEOPLES R CHINA LANZHOU UNIV STATE KEY LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

Two new neolignan glucosides, longiflorosides A and B were isolated from whole plants of Pedicularis lungiflora. On the basis of spectral evidence, longiflorosides A and B were determined as (7R, 8S)-4-O-methyl-dehydrodiconiferyl alcohol-9'-O-beta-D-glucopyranoside and (erythro)-1-(4-O-beta-D-glucopyranosyl-3,5-dimethoxy-phenyl)-2-:2-methoxy-4-[1-(E)-propene-3-ol]-phenoxyl}-propane-1,3-diol, respectively.

关键词：

ANALYSIS ON SMALL SCALE BRIDGING IN FIBROUS MONOLITHIC CERAMICS

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 1999年第3期12卷 227-238页

作者： Wu, zj Cai, QH Tsing Hua Univ Dept Mech Engn Beijing 100084 Peoples R China

Based on shear lag model of interface between fiber and matrix, a new formula that relates the crack opening displacement and bridging force in fibrous monolithic ceramics was constructed under the framework of small scale bridging. This formula was applied to predict the fracture resistance or R-curve response of a three-point bending specimen made of fibrous monolithic ceramics. A parametric investigation on the influences of fiber volume fraction, fiber radius, characteristics of constituents, BN's fracture toughness and specimen's geometry on the bridging forces and fracture resistance in Si3N4/BN composite was carried out. The upper and lower limits of the R-curve of Si3N4/BN in small scale bridging were derived. This research revealed the role played by the above parameters in the fracture toughness of fibrous monolithic ceramics.

关键词： fibrous monolithic ceramics fiber bridging R-curve fracture toughness

The rotation and the phase transition in solid C60

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1996年第6期14卷 481-489页

作者： Xu, zj Yan, JM CHINESE ACAD SCI INST CHEMBEIJING 100080PEOPLES R CHINA

The interaction between C-60's in solid C-60 has been calculated by (exp-6-1) potential, and the cause and the controlled factor of the high rapid rotations of C-60's were discussed. In order to describe the disordered degree of C-60 rotation, an equivalent M is introduced. The phase transitions at the similar to 260 K and at the similar to 90 K are studied from the viewpoint of C-60 rotation. The potential barriers of the ordered rotation below the similar to 260 K and the disordered rotation above the similar to 260 K have been given, and the effect of the external pressure on the temperature of phase transition has also been given.

关键词： fullerene C-60 molecular rotation phase transition

ON THE CONVERGENCE OF THE BRENT METHOD

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 1994年第1期12卷 1-20页

作者： WANG, DR HUANG, zj SHANGHAI UNIV SCI & TECHNOL DEPT MATHSHANGHAIPEOPLES R CHINA FUDAN UNIV DEPT STAT & OPERAT RESSHANGHAIPEOPLES R CHINA

In this paper, we establish the semi-local convergence theorem of the rent method with regional estimation. By an in-depth investigation in to the algorithm structure of the method, we convert the Brent method into an approximate Newton method with a special error term. Bsaed on such equivalent variation, under a similar condition of the Newton-Kantorovich theorem of the Newton method, we establish a semi-local convergence theorem of the Brent method. This theorem provides a sufficient theoretical basis for initial choices of the Brent method.

关键词： holds Choice vergence convergent elimination otherwise Brent Dennis Cornell approximate

Phase Structure Change of Mo-Si System duringMechanical Alloying

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 1999年第5期15卷 423-426页

作者： Liu, SJ Qu, XH Liu, zj Huang, BY Cent S Univ Technol State Key Powder Met Changsha 410083 Peoples R China

The structure of Mo-15.16 Si, Mo-30 Si and Mo-36.3 Si (wt pct) elemental powder mixture during mechanical alloying was studied using electron microscopy and X-ray diffraction. It had been found that, in all the systems under study, silicon disappeared initially during mechanical alloying (MA). In the Mo-Si systems all products were in form of amorphous state after long time milling, but there were different intermediate products. MoSi2 and Mo5Si3 intermetallic compounds in the Mo-30Si and Mo-36.3Si (wt pct) were directly synthesized from elements through inter-diffussion process. The high density of defects and interface of nano-crystal lines induced by ball milling would promote the reaction process. Only in the Mo-15.16Si (wt pct) system was Mo(Si) supersaturated solid solution formed as an intermediate product. Schematic free-energy diagram of Mo-Si system based on the thermodynamics was used to analyze the difference among the intermediate state products.

关键词： Molybdenum alloys