检索结果-南通市图书馆

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

具有特应性体质的腺病毒肺炎患儿临床特征及影像学改变

在线全文

学校读者我要写书评

暂无评论

国际儿科学杂志 2020年第11期47卷 806-810页

作者：李淼韩晓华刘立云姚慧生伊丽丽中国医科大学附属盛京医院小儿呼吸内科沈阳110004

目的探讨具有特应性体质的腺病毒肺炎患儿临床特征及影像学改变。方法选取中国医科大学附属盛京医院小儿呼吸科2018年6月至2019年12月收治的腺病毒肺炎患儿120例,根据有无特应性体质及肺炎严重程度分为有特应性体质组42例(轻型肺炎30例... 详细信息

目的探讨具有特应性体质的腺病毒肺炎患儿临床特征及影像学改变。方法选取中国医科大学附属盛京医院小儿呼吸科2018年6月至2019年12月收治的腺病毒肺炎患儿120例,根据有无特应性体质及肺炎严重程度分为有特应性体质组42例(轻型肺炎30例,重症肺炎12例)及无特应性体质组78例(轻型肺炎50例,重症肺炎28例)。住院期间按照腺病毒肺炎诊治指南进行治疗,出院1个月后进行随访,并对患儿住院期间化验检查、临床表现、临床特征、入院、出院时及随访时肺部影像学改变进行统计分析。结果在轻型肺炎患儿中,具有特应性体质的患儿与无特应性体质患儿相比,严重咳嗽的比例、出现喘息比例差异有统计学意义(分别为P=0.041,P=0.004);两组间入院时及出院后1个月肺CT提示小气道改变的患者比例差异无统计学意义(P>0.05);其中有特应性体质患儿住院期间出现喘息的风险是无特应性体质患儿的2.32倍;出现严重咳嗽的风险是无特应性体质患儿的1.72倍。在重症肺炎患儿中,有特应性体质患儿与无特应性体质患儿相比,入院时及出院后喘息比例差异有统计学意义(分别为P=0.002,P=0.034)。两组间入院时及出院时出现小气道改变的比例差异显著(分别为P=0.001,P=0.009);其中有特应性体质患儿住院期间出现喘息的风险是无特应性体质重症肺炎患儿的1.94倍;出院后出现喘息风险是无特应性体质患儿的1.98倍;有特应性体质的重症肺炎患儿入院时出现小气道改变风险为无特应性体质肺炎患儿的1.25倍;出院后一个月仍有小气道改变的风险为无特应性体质患儿的2.31倍。结论患有特应性体质的腺病毒轻型肺炎患儿住院期间咳嗽症状重,易出现喘息;重症腺病毒肺炎的特应性体质患儿肺部影像学易出现小气道改变,肺部影像学恢复时间长,需定期随访,应引起临床医生重视。

关键词：儿童特应性体质腺病毒肺炎临床特征影像学改变

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Development of a general circumferentially nonuniform heat transfer fuel rod model for subchannel analysis and application to helical fuel rods

在线全文

学校读者我要写书评

暂无评论

Science China Technological Sciences 2025年

作者： Junsen FU Junlong LI Xiaowen WANG Qi ZHANG yao XIAO Hanyang GU School of Mechanical Engineering Shanghai Jiao Tong University Key Laboratory of Nuclear Power Systems and Equipment of the Ministry of Education Shanghai Jiao Tong University National Key Laboratory of Nuclear Reactor Technology Nuclear Power Institute of China State Key Laboratory of Nuclear Power Safety Technology and Equipment Shanghai Jiao Tong University

The subchannel analysis method is one of the most crucial transient safety analysis methods in the thermal design of nuclear reactors. The nonuniformity of circumferential heat transfer is slight in conventional pressurized water reactor (PWR)cores, but it is significant in advanced reactors with wire-wrapped or helical fuel rods. Predicting circumferentially nonuniform heat transfer behavior can be challenging owing to the complex geometry of helical fuel rods. In this study, a general circumferentially nonuniform heat transfer fuel rod (GCNF) model is developed to predict the fuel central temperature and circumferential heat flux and wall temperature. This model incorporates a refined two-dimensional fuel conduction model and circumferential nonuniform shape factor, addressing the dual factors contributing to the circumferential nonuniformity of helical fuel rods. An empirical correlation for the nonuniform shape factor is developed based on the computational fluid dynamics (CFD) results, and it is implemented to the subchannel code. The newly developed model is applied to a helical fuel annulus and validated by comparing the prediction results with CFD data. The maximum wall temperature predicted by the code is 1.15°C lower than the value calculated through CFD. In terms of the heat flux, the maximum value at the inner corner is22 kW lower than that obtained from the CFD prediction. The accurate prediction of circumferentially nonuniform heat transfer in helical fuel, concerning the surface heat flux and cladding temperature, addresses existing shortcomings in helical fuel subchannel analysis methods. Additionally, the capability to predict the fuel central temperature is essential for the safety analysis to determine whether fuel rods are melting. The generality of the model framework allows it to be used for the prediction of circumferential nonuniform heat transfer behavior in other types of fuel assemblies.

关键词：

Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 265-276页

作者： yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen Jin He Jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

姜黄素对哮喘小鼠体内NF-κB、IκB及p-IκB含量的影响

在线全文

学校读者我要写书评

暂无评论

国际儿科学杂志 2017年第6期44卷 423-425,封3页

作者：刘立云王佳李淼姚慧生韩晓华尚云晓中国医科大学附属盛京医院小儿呼吸科沈阳110004

目的了解姜黄素对哮喘小鼠核因子(NF)-κB、IκB、p-IκB的含量的影响.方法对30只Balb/c小鼠随机分组,分为正常对照组、哮喘组及姜黄素干预哮喘小鼠.应用卵清蛋白溶液建立哮喘小鼠模型;对各组小鼠进行肺功能的检测;检测各组肺组织中的... 详细信息

目的了解姜黄素对哮喘小鼠核因子(NF)-κB、IκB、p-IκB的含量的影响.方法对30只Balb/c小鼠随机分组,分为正常对照组、哮喘组及姜黄素干预哮喘小鼠.应用卵清蛋白溶液建立哮喘小鼠模型;对各组小鼠进行肺功能的检测;检测各组肺组织中的NF-κB、IκB及p-IκB的含量.结果哮喘组胞浆内NF-κB较对照组减少(P＜0.01),而姜黄素干预组胞浆内NF-κB含量较哮喘组明显增加,具有统计学意义(P＜0.05).哮喘组胞核内NF-κB较对照组明显增加(P＜0.01),而姜黄素干预组胞核内NF-κB较哮喘组明显减少,差异具有统计学意义(P＜0.05).哮喘组胞浆内的p-IκB含量显著高于对照组(P＜0.01),而姜黄素干预组胞浆内的p-IκB含量显著低于哮喘组,差异具有统计学意义(P＜0.01).哮喘组胞浆内的IκB含量显著低于对照组(P＜0.01),而姜黄素干预组IκB含量较哮喘组显著增高,差异具有统计学意义(P＜0.01).结论姜黄素通过减轻IκB的磷酸化抑制NF-κB转录入核内,从而减轻哮喘小鼠的气道高反应性.

关键词：姜黄素哮喘小鼠 NF-κB IκB p-IκB

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Trimetallic mesoporous PdCuRu for efficient formate electrosynthesis from polyethylene terephthalate recycling

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Yuting Li Huiqin yao Lizhi Sun Shu Han Xiaoxiang Xu Guangyin Fan Ben Liu College of Chemistry and Materials Science Sichuan Normal University Key Laboratory of Green Chemistry and Technology of Ministry of Education College of Chemistry Sichuan University School of Basic Medical Sciences Ningxia Medical University Department of Otorhinolaryngology-Head and Neck Surgery Zhongnan Hospital of Wuhan University

Electrochemical recycling of waste polyethylene terephthalate（PET） plastics represents a green and sustainable route to produce valuable fuels and address serious environmental issues. Despite some encouraged achievements, their progress is still slower because of the lack of highly active and selective electrocatalysts. Here, we reported an efficient PET recycling route with trimetallic PdCuRu mesoporous nanospheres（MSs） as a high-performance electrocatalyst that achieved selective electrosynthesis of valuable formate from PET hydrolysate（PETH） electrooxidation. Penetrated metal mesopores and trimetallic compositions of PdCuRu MSs synergistically optimized electronic structures of Pd sites and changed chemisorption properties of intermediates, which disclosed a high formate Faradic efficiency of 97% and impressive yield rate of 0.49 mmol h-1cm-2in an alkaline solution. Meanwhile, this electrocatalyst held good electrocatalytic stability, retaining high formate Faradic efficiency and yield rate even being performed for 10 cycles, which highlighted its potential applications for practical PET recycling. Our study provides a powerful strategy for designing high-performance electrocatalysts toward selective electro-synthesis of valuable fuels from various waste plastics.

关键词：

肺炎支原体耐药基因检测与难治性肺炎支原体肺炎的相关性分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际儿科学杂志 2016年第6期43卷 492-496页

作者：姚慧生张睿刘立云王佳伊丽丽韩晓华中国医科大学附属盛京小儿呼吸内科沈阳110004 第四军医大学附属第一医院西安710032

目的了解肺炎支原体对大环内酯类耐药基因的检测与临床难治性肺炎支原体肺炎的相关性。方法（1）对我院血清肺炎支原体抗体及咽试子标本肺炎支原体DNA均阳的97例住院肺炎患儿，行大环内酯类耐药基因DNA测序分析，筛选突变株，比较耐药... 详细信息

目的了解肺炎支原体对大环内酯类耐药基因的检测与临床难治性肺炎支原体肺炎的相关性。方法（1）对我院血清肺炎支原体抗体及咽试子标本肺炎支原体DNA均阳的97例住院肺炎患儿，行大环内酯类耐药基因DNA测序分析，筛选突变株，比较耐药基因组与无耐药基因突变组的临床表现。（2）将97例肺炎支原体肺炎（Mycoplasma pneumoniae pneumonia，MPP）患儿分为耐药组和非耐药组、普通MPP组和难治性MPP（RMPP）组，回顾性总结分析并比较各组患儿的临床表现、实验室检查及影像学表现的差别，对RMPP的表现行多因素Logistic回归分析，总结耐药基因的突变与RMPP是否具有相关性。结果（1）97例MPP中17例无基因突变（17．5％），80例存在耐药基因突变（82．5％）。（2）耐药基因突变组中，CRP值更高，发热时间、住院时间、大环内酯类药物应用时间、应用大环内酯类药物后退热时间及咳嗽时间更长，大叶性肺炎发生率更高，经统计学分析具有统计学意义。（3）RMPP组与普通MPP组相比，耐药基因突变率更高，外周血中性粒百分百分比、CRP、降钙素原及乳酸脱氢酶的值更高，发热时间、住院时间、大环内酯类药物应用时间、应用大环内酯类药物后退热时间及咳嗽时间更长，差异有统计学意义（P〈0．05）。（4）Logistic回归分析结果大环内酯类药物应用时间以及耐药基因的突变与RMPP具有相关性。结论MPP中耐药基因普遍存在；耐药基因的突变组临床症状持续时间长、恢复慢，CRP值更高，大叶性肺炎发生率高；RMPP与普通MPP组相比：耐药基因突变率更高，炎性指标及乳酸脱氢酶的值更高，应用大环内酯类药物后退热时间及咳嗽时间更长，其中大环内酯类药物应用时间及耐药基因的突变与RMPP具有相关性，为RMPP的危险因素。

关键词：难治性肺炎支原体肺炎耐药性 23SrRNA基因突变