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Mucosa color and size may indicate malignant transformation of chicken skin mucosa-positive colorectal neoplastic polyps

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 750-760页

作者： Ying-Jie Zhang Meng-Xia Yuan Wu Wen Fan Li Yi Jian Chuan-Ming Zhang ye yang Feng-Lin Chen Department of Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND Lipid metabolism reprogramming is suspected to exist in pre-cancerous lesions,including colorectal *** colonoscopy frequently reveals chicken skin mucosa(CSM;white or yellow-white speckled mucosa)surrounding colo-rectal polyps,caused by macrophages engulfing and accumulating the lipids decomposed by colon cells or adjacent ***-positive colorectal polyps are associated with various diseases;however,their prognosis varies *** snare polypectomy is commonly used to resect lesions up to 10 to 15 mm in diameter without signs of submucosal invasion but is controversial for CSM-positive colorectal *** imaging is required to diagnose and treat CSM-positive colorectal *** This retrospective cohort study included 177 patients with CSM-positive colorectal polyps diagnosed using *** patient-related information was extracted from the Goldisc soft-clinic DICOM system or electronic medical record *** on the pathological results,patients were classified as non-neoplastic polyps(five juvenile polyps),neoplastic polyps,non-invasive high-grade neoplasia(NHGN),or submucosal invasive carcinoma(SM stage cancer).We analyzed and compared the clinical features,suspected risk factors for malignant transformation of neoplastic polyps,and early infiltration of sub-mucosal *** The diameters of NHGN and SM polyps were much smaller than those of neoplastic *** NHGN polyps had a deeper red mucosal *** logistic regression analyses,diameter and deeper red mucosal color were independent risk factors for malignant transformation of neoplastic *** 1 CSM was more common in high-grade intraepithelial neoplasia and SM;type 2 CSM was more common in neoplastic *** regression analyses revealed no significant differences in the malignant transformation of neoplastic polyps or early submucosal invasion of CSM-positive colorectal *** in the CSM mucosa surrounding neoplastic

关键词： Chicken skin mucosa Colorectal cancer Colorectal polyps Endoscopic resection Malignant transformation White light endoscopy

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Effects and mechanisms of Panax notoginseng-steamed chicken on uterine involution in mice

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Food Science and Human Wellness 2024年

作者： Zhuowen Chen Yue Dang Lanping Guo Yuan Qu Yuan Liu Xiaoyan yang Xiuming Cui Chengxiao Wang ye yang School of Life Science and Technology， Kunming University of Science and Technology Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province China Academy of Chinese Medical Sciences

Panax notoginseng-steamed chicken (PNSC) is a common medicinal diet in China. In this study， we conducted comprehensive analysis to determine the effect of PNSC on uterine involution in postpartum mice and human umbilical vein endothelial cells. The role of the PI3K/AKT/mTOR pathway in this process was explored. Results showed that PNSC promoted the recovery of endometrial hyperplasia and uterine index in postpartum mice. In vitro and in vivo experiments indicated that PNSC activated PI3K/AKT/mTOR signaling pathway， promoted the proliferation of human umbilical vein endothelial cells (HUVEC)， up-regulated the expression of VEGF， and its binding to VEGFR2. Moreover， it increased the expression of PCNA， MMP9， and CyclinD1 in the nucleus. Moreover， it up-regulated the secretion of hormones， such as prolactin (PRL)， progesterone (P)， as well as the level of vascular endothelial growth factor (VEGF) in mice， and down-regulated the secretion of endothelin-1 hormones (ET-1)， thereby promoting uterine involution. In conclusion， this study demonstrates that PNSC can regulate angiogenesis to promote uterine involution by activating the PI3K/AKT/mTOR pathway.

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Application of mesenchymal stem cell therapy for premature ovarian insufficiency: Recent advances from mechanisms to therapeutics

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World Journal of Stem Cells 2024年第1期16卷 1-6页

作者： Hang-Qi Hu Xi-Yan Xin Yu-Tian Zhu Rui-Wen Fan Hao-Lin Zhang yang ye Dong Li Department of Traditional Chinese Medicine Peking University Third HospitalBeijing 100191China

The incidence of premature ovarian insufficiency(POI)is increasing worldwide,particularly among younger women,posing a significant challenge to *** addition to menopausal symptoms,POI leads to several complications that profoundly affect female reproductive function and overall ***,current clinical treatment strategies for this condition are limited and often yield unsatisfactory *** approaches typically involve hormone repla-cement therapy combined with psychological ***,mesenchymal stem cell(MSC)therapies for POI have garnered considerable attention in global *** can restore ovarian reproductive and endocrine functions through diverse mechanisms,including controlling differentiation,promoting angiogenesis,regulating ovarian fibrosis,inhibiting apoptosis,enhancing autocrine and paracrine effects,suppressing inflammation,modulating the immune system,and genetic *** editorial offers a succinct summary of the application of MSC therapy in the context of POI,providing evidence for groundbreaking medical approaches that have potential to enhance reproductive health and overall well-being for women.

关键词： Mesenchymal stem cell therapy Mechanism Premature ovarian insufficiency Therapeutic Women

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Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

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Science China Earth Sciences 2024年

作者： ye yang Steven A.BINNIE Sheng XU Cong-Qiang LIU Tibor J.DUNAI Institute of Surface-Earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on Earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646+777744mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography,and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau,high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

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Changes in visual performance after implantation of different intraocular lenses

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1273-1282页

作者： Bo-Wen Li Hao Huang Man-Sha Huang Shuang-Lin Guo Lu Gao Yu-Ying Zeng Lu Cheng Si-yang Yao Jian-Qiang Lin Lin Liu ye yang Xiao-Ming Lu Hao Cheng Department of Ophthalmology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Eye Center of Xiangya Hospital Hunan Key Laboratory of OphthalmologyCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Ophthalmology Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 412000Hunan ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Department of Ophthalmology Guangzhou Red Cross HospitalJinan UniversityGuangzhou 510000Guangdong ProvinceChina AIER Eye Hospital Jinan UniversityGuangzhou 510180Guangdong ProvinceChina

AIM:To evaluate the trending visual performance of different intraocular lenses(IOLs)over time after ***:Ninety-one patients received cataract surgery with implantations of monofocal(Mon)IOLs,segmental refractive(SegRef)IOLs,diffractive(Dif)IOLs,and extendeddepth-of-focus(EDoF)IOLs were *** aberrations and optical quality collected with iTrace and OQAS within postoperative 6mo were followed and ***:Most of the visual parameters improved over the postoperative *** postoperative visual acuity(POVA)of the Mon IOL,SegRef IOL,and EDoF IOL groups achieved relative stability in earlier states compared with the Dif IOL ***,the overall visual performance of the 3 IOLs continued to upturn in small extents within the postoperative *** optical quality initially improved in the EDoF IOL group,then in the Mon IOL,SegRef IOL,and Dif IOL *** and objective visual performance of the Mon IOL and EDoF IOL groups,as well as POVA and visual quality of the Dif IOL group,improved in the postoperative 1mo and *** the postoperative 6mo,gradual improvements were observed in the visual acuity and objective visual performance of the SegRef IOL group,as well as in the postoperative optical quality of the Dif IOL ***:The visual performance is different among eyes implanted with different *** findings of the current study provide a potential reference for ophthalmologists to choose suitable IOLs for cataract patients in a personalized solution.

关键词： intraocular lenses visual performance changing characteristics high-order wavefront aberration

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准噶尔盆地卡姆斯特地区石树沟群砂岩地球化学特征及其对源岩的指示

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东华理工大学学报（自然科学版） 2024年第1期47卷 22-33页

作者：杨烨核工业北京地质研究院北京100029 中核集团铀资源勘查与评价技术重点实验室北京100029

为揭示卡姆斯特地区石树沟群的源岩性质和构造背景,探讨其对砂岩型铀成矿作用的影响,对该区的石树沟群砂岩开展了岩石学及地球化学研究。结果表明,石树沟群砂岩以岩屑砂岩为主,成熟度低,富集Cs、U、Cr、Hf,亏损Nb、Ta、Th;整体具轻稀土... 详细信息

为揭示卡姆斯特地区石树沟群的源岩性质和构造背景,探讨其对砂岩型铀成矿作用的影响,对该区的石树沟群砂岩开展了岩石学及地球化学研究。结果表明,石树沟群砂岩以岩屑砂岩为主,成熟度低,富集Cs、U、Cr、Hf,亏损Nb、Ta、Th;整体具轻稀土富集、重稀土亏损、Eu负异常特征,与卡拉麦里造山带中酸性岩浆岩稀土元素特征具有相似性;沉积物源为卡拉麦里造山带,源岩主要为富铀的中酸性岩浆岩,形成构造背景为活动大陆边缘-大陆岛弧环境。石树沟群的源岩为砂岩型铀成矿提供了物质来源。

关键词：地球化学特征沉积源岩石树沟群准噶尔盆地卡姆斯特地区

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Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica

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Chinese Journal of Natural Medicines 2024年第06期 568-576页

作者： WANG Min LI Han HU Bintao TANG Chunping XU Hui KE Changqiang XIE Zuoquan ye yang YAO Sheng State Key Laboratory of Drug Research&Natural Products Research Center Shanghai Institute of Materia Medica Chinese Academy of Sciences University of Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences

Nine new germacranolides, sylvaticalides A-H（1–9）, and three known analogues（10–12） were isolated from the aerial part of Vernonia sylvatica. Their structures were established using comprehensive spectroscopic analysis, including high-resolution electrospray ionization mass spectroscopy（HR-ESI-MS） and 1D and 2D nuclear magnetic resonance（NMR） spectra. Their absolute configurations were determined by X-ray diffraction experiments. The anti-inflammatory activities of all isolated compounds were assessed by evaluating their inhibitory effects on the nuclear factor kappa B（NF-κB） pathway, which was activated by lipopolysaccharide（LPS）-stimulated human THP1-Dual cells, and the interferon-stimulated gene（ISG） pathway, activated by STING agonist MSA-2 in the same cell model. Compounds 1, 2 and 6 showed inhibitory effects on the NF-κB and ISG signaling pathways, with IC50values ranging from 4.12 to 10.57 μmol·L-1.

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Real-time detection of methane concentration based on TDLAS technology and 1D-WACNN

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Optoelectronics Letters 2024年第11期 663-670页

作者： KAN Lingling MIAO Kai LIANG Hongwei NIE Rui ye yang School of Electrical and Information Engineering Northeast Petroleum University

In order to further reduce the cost of manually screening suitable second harmonic signals for curve fitting when detecting methane concentration by tunable diode laser absorption spectroscopy(TDLAS) technology, as well as the influence of certain human factors on the amplitude screening of second harmonic signals, and improve the detection accuracy, a one-dimensional wide atrous convolutional neural network(1D-WACNN) method for methane concentration detection is proposed, and a real-time detection system based on TDLAS technology to acquire signal and Jetson Nano to process signal is built.

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Dialectical study of disulfidptosis and clinical outcome in patients with colorectal cancer

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Traditional Medicine Research 2024年第10期9卷 52-63页

作者： Hua-Mei Zhu Yu-Tao Chen yang ye Yue-Feng Hu Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000China The Second School of Medicine Wenzhou Medical UniversityWenzhou 325000China

Background:Colorectal cancer(CRC)is a leading cause of cancer mortality *** study aims to develop a prognostic model based on disulfidptosis-related genes to assess survival outcomes in CRC,highlighting the tumor microenvironment’s ***:The thought of traditional Chinese medicine syndrome differentiation and treatment runs through the whole *** analyzed CRC tissue data from The Cancer Genome Atlas and the Gene Expression Omnibus using single-sample gene set enrichment and weighted gene correlation network analyses to identify prognostic markers and evaluate immune *** also investigated predictive drug ***:We identified seven disulfidptosis-related markers–complement C1q A chain(C1QA),solute carrier family 11 member 1(SLC11A1),cluster of differentiation 36(CD36),cluster of differentiation 6(CD6),interleukin 1 receptor associated kinase 3(IRAK3),S100 calcium binding protein A8(S100A8),and CD8 subunit alpha(CD8A)–that significantly influence *** classified in the low-risk group demonstrated improved overall survival compared to those in the high-risk group across training(P=0.0026)and validation cohorts(P=0.032).Differential gene expression was significant in the high-risk group(P<0.001),and prevalent mutations included APC regulator of WNT signaling pathway(APC),tumor protein P53(TP53),Titin(TTN),and Kirsten rat sarcoma viral oncogene(KRAS).The risk score correlated linearly with tumor microenvironment *** results of drug analysis showed that some traditional drugs may have anticancer effects through the vertical action of ***:Our prognostic model,integrating seven disulfidptosis-related genes,categorizes CRC patients by survival probability and underscores these genes as potential biomarkers linked to the tumor *** findings support their use in refining therapeutic strategies for CRC.

关键词： colorectal cancer tumor microenvironment disulfidptosis WGCNA LASSO regression

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“亲近”还是“疏远”?———联合投资伙伴的社会期望绩效反馈与联合风险投资关系

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管理工程学报 2024年第1期38卷 128-144页

作者：杨晔刘冰毅杜衡上海财经大学公共经济与管理学院上海200433

风险投资是支持创新创业的重要活动,但风险投资的不确定性催生了“抱团”行为的出现,与风险投资联合投资伙伴选择相关的研究也开始逐渐丰富。本文借鉴企业行为理论中的绩效反馈,以2000—2020年CVSource中记录的投资交易数据,分析了风险... 详细信息

风险投资是支持创新创业的重要活动,但风险投资的不确定性催生了“抱团”行为的出现,与风险投资联合投资伙伴选择相关的研究也开始逐渐丰富。本文借鉴企业行为理论中的绩效反馈,以2000—2020年CVSource中记录的投资交易数据,分析了风险投资机构联合投资伙伴的社会期望绩效反馈对双方联合关系强度的影响。研究发现,当联合投资伙伴处于社会期望绩效落差状态时,为得到互惠交易流,风险投资机构与期望绩效水平较高的联合投资伙伴之间的关系变得亲近。当联合投资伙伴处于社会期望绩效顺差状态时,高期望绩效水平的联合投资伙伴为避免摊薄收益,选择不进行联合投资,因而与风险投资机构之间的关系变得疏远。此外,风险投资机构与联合投资伙伴之间的绩效差距也是进一步导致双方联合关系强度降低的重要因素。本研究从绩效反馈理论视角拓展了风险投资联合行为的相关研究,打开了联合投资伙伴之间关系动态性的黑箱,揭示了风险投资联合行为的内在规律。

关键词：风险投资联合投资绩效反馈社会期望

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