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Chemokine-like factor 1 (CKLF1) is expressed in myocardial ischemia injury in vivo and in vitro

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BIOCELL 2024年第6期48卷 981-990页

作者： JULING FENG HAODONG CHEN yangBO LIU QIDI AI yantao yang LEI ZHAO SHIFENG CHU NAIHONG CHEN School of Pharmacy Department of PharmacyHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction PiecesHunan University of Chinese MedicineChangsha410208China Department of Pharmacology State Key Laboratory of Bioactive Substances and Functions of Natural MedicinesInstitute of Materia Medica&Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Department of Diagnostics Research Lab of Translational Medicine Hengyang Medical CollegeUniversity of South ChinaHengyang421001China Department of Gastrointestinal Surgery The First Affiliated HospitalHengyang Medical CollegeUniversity of South ChinaHengyang421001China

Introduction:Chemokine-like factor 1(CKLF1)is a chemokine that is overexpressed in several *** previousﬁndings revealed a signiﬁcant increase in CKLF1 expression in the ischemic brain,suggesting its potential as a therapeutic target for ischemic ***:In this study,we examined the expression dynamics of CKLF1 in both in vivo and in vitro models of ischemic cardiac *** infarction(MI)was induced in vivo by ligation of the left anterior descending artery(LAD)of the rat *** levels of CKLF1,Creatine Kinase MB Isoenzyme(CK-MB),and Lactate dehydrogenase(LDH)in the serum were detected using Enzyme-linked immunosorbent assay(ELISA).The expression of CKLF1 in the infarcted area was detected by immunohistochemistry,immunoﬂuorescence,quantitative PCR(qPCR),and Western blotting(WB).H9C2 and AC16 cardiomyocytes cultured in vitro were subjected to oxygen and glucose deprivation(OGD).LDH was used to detect cell damage,and CKLF1 expression was detected by qPCR and ***:CKLF1 mRNA and protein expression were signiﬁcantly increased in h9c2 cells at 1.5 h and in AC16 cells at 4 h after *** serum CK-MB in rats increased signiﬁcantly on theﬁrst day after infarction,while the LDH concentration increased signiﬁcantly on the third day after ***1 blood levels signiﬁcantly increased on theﬁrst day following MI in ***1 expression notably increased in the infarct area on days 1,3,and 7 *** MI tissue,CKLF1 colocalizes with cardiomyocytes,macrophages,and ***:CKLF1 was substantially expressed during myocardial ischemia injury both in vivo and in vitro and was colocalized with macrophages and neutrophils,indicating that CKLF1 is expected to be a biomarker and a drug target for the treatment of myocardial infarction.

关键词： Chemokine-like factor 1 Overexpression Myocardial infarction

Double diffusive convection in the finger regime for different Prandtl and Schmidt numbers

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Acta Mechanica Sinica 2020年第4期36卷 797-804页

作者： yantao yang SKLTCS and Department of Mechanics and Engineering Science BIC-ESATCollege of Engineeringand Institute of Ocean ResearchPeking UniversityBeijing 100871China

In this work fingering double diffusive convection,*** buoyancy-driven flow with fluid density being affected by two different scalar components,is investigated numerically with special efforts on the influences of the physical properties of two scalar *** show that different scalar properties can affect the global transport *** concentration flux exhibits different exponents in their power-law scalings for different combinations of scalar *** scaling exponents of heat flux,however,depend mainly on the ratio of the diffusivities of two *** one uses the local parameters of the finger layer in the bulk,the behaviors are very similar to those found in the fully periodic *** horizontal width of the fingers is consistent with the wavelength of the fast growing *** one case we observe evidences of the thermohaline staircase,namely,the typical width of the flow structures changes significantly in different layers within the flow domain.

关键词： Double diffusive convection Convection turbulence Hirbulent mixing

我国玉米生产与消费时空格局演变及匹配性分析

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中国农业科技导报 2024年第5期26卷 1-10页

作者：曹炎杨艳涛王国刚中国农业科学院农业经济与发展研究所北京100081

玉米是我国第一大粮食作物,对我国粮食安全影响深远。依据重心模型,运用地理信息系统(geographic information system,GIS)测算了1999—2022年我国玉米生产重心与消费重心的移动方向、距离、速度等变化特征,利用耦合模型分析玉米生产与... 详细信息

玉米是我国第一大粮食作物,对我国粮食安全影响深远。依据重心模型,运用地理信息系统(geographic information system,GIS)测算了1999—2022年我国玉米生产重心与消费重心的移动方向、距离、速度等变化特征,利用耦合模型分析玉米生产与消费的空间匹配性,并结合自然、经济、政治等因素,研究其变动原因。结果表明,1999—2022年我国玉米生产重心整体呈现从西南-东北移动的特点,共移动了148.55 km,平均移动速度为6.46 km·a^(-1);玉米消费重心总体呈现从西南-东北-东南-西南-东北环形变动的特点,阶段性特征明显;生产与消费重心的耦合距离呈先升高后降低的总体特点,但增幅远大于降幅。耦合距离由471.02 km(1999年)变为513.02 km(2022年),其中2013年二者的重心耦合距离达最大值,为557.91 km。2020年以来,玉米生产与消费的耦合距离又出现增加趋势,空间匹配性再度下降,为新时代粮食安全带来了挑战。因此,提出优化玉米区域利益协调机制、构建多主体利益联结机制和支持政策体系、优化玉米区域生产与消费空间格局、实施区域差异性的粮食政策等政策建议。

关键词：玉米生产时空格局消费时空格局匹配性分析

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基于UHPLC-Q-Orbitrap HRMS技术的肾康注射液在大鼠体内代谢产物的鉴定及代谢途径分析

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中草药 2024年第3期55卷 730-745页

作者：杨彦涛李卓伦周霖康建程旭孙志郑州大学第一附属医院药学部河南郑州450052 河南省精准医学临床质谱工程研究中心河南郑州450052 复旦大学药学院上海201203

目的采用UHPLC-Q-Orbitrap HRMS技术鉴定肾康注射液(Shenkang Injection,SKI)在大鼠体内的代谢产物,并提出可能的代谢途径。方法 SD大鼠经尾iv SKI后,收集其血浆、尿液和粪便样本。以0.1%甲酸水溶液(A)-乙腈(B)为流动相,梯度洗脱,Water... 详细信息

目的采用UHPLC-Q-Orbitrap HRMS技术鉴定肾康注射液(Shenkang Injection,SKI)在大鼠体内的代谢产物,并提出可能的代谢途径。方法 SD大鼠经尾iv SKI后,收集其血浆、尿液和粪便样本。以0.1%甲酸水溶液(A)-乙腈(B)为流动相,梯度洗脱,Waters BEH C18柱进行色谱分离;使用Q Exactive HRMS和加热电喷雾离子源(HESI)进行正、负离子模式下的质谱扫描分析。根据“提取-化合物筛选-鉴定-验证”的大鼠体内代谢产物的鉴定策略对质谱数据进行分析。结果在大鼠血浆、尿液和粪便中共鉴定出121种外源化合物,包括29种原型化合物和92种代谢产物。这些代谢产物主要经历的生物转化有羟基化、还原和去饱和等Ⅰ相代谢反应,以及甲基化、乙酰化、磺酸化、葡萄糖醛酸化、甘氨酸结合、半胱氨酸结合和牛磺酸结合等Ⅱ相代谢反应。结论为SKI的体内药理学和作用机制的进一步研究提供了物质基础,所提出的鉴定策略为中药的体内药效物质研究提供了一种系统、全面、可靠的方法。

关键词：肾康注射液代谢产物代谢途径 UHPLC-Q-Orbitrap HRMS 丹参素羟基红花黄色素A 5-羟甲基糠醛

Neural network as a function approximator and its application in solving differential equations

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Applied Mathematics and Mechanics(English Edition) 2019年第2期40卷 237-248页

作者： Zeyu LIU yantao yang Qingdong CAI State Key Laboratory for Turbulence and Complex System Peking University Department of Mechanics and Engineering Science College of EngineeringPeking University Center for Applied Physics and Technology College of EngineeringPeking University

A neural network(NN) is a powerful tool for approximating bounded continuous functions in machine learning. The NN provides a framework for numerically solving ordinary differential equations(ODEs) and partial differential equations(PDEs)combined with the automatic differentiation(AD) technique. In this work, we explore the use of NN for the function approximation and propose a universal solver for ODEs and PDEs. The solver is tested for initial value problems and boundary value problems of ODEs, and the results exhibit high accuracy for not only the unknown functions but also their derivatives. The same strategy can be used to construct a PDE solver based on collocation points instead of a mesh, which is tested with the Burgers equation and the heat equation(i.e., the Laplace equation).

关键词： neural network(NN) function approximation ordinary differential equation(ODE)solver partial differential equation(PDE)solver

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温度对废弃生物质热解规律及产物分布的影响

太阳能学报 2024年第7期45卷 745-750页

作者：刘鹏李学琴李艳玲孙堂磊杨延涛雷廷宙常州大学城乡矿山研究院常州市生物质绿色安全高值利用技术重点实验室常州213164 华东理工大学资源与环境工程学院上海200237

为探究有机固体废弃物热解规律及产物分布,以不同原料(木屑、污泥、生活垃圾)为研究对象,利用一级固定床反应系统研究持续升温下不同生物质热解性能的变化规律。结果表明:高温有利于促进生物质热解、提高热解气产率、降低焦油产率,尤其... 详细信息

为探究有机固体废弃物热解规律及产物分布,以不同原料(木屑、污泥、生活垃圾)为研究对象,利用一级固定床反应系统研究持续升温下不同生物质热解性能的变化规律。结果表明:高温有利于促进生物质热解、提高热解气产率、降低焦油产率,尤其木屑热解受温度变化作用显著;木屑、污泥、生活垃圾经高温热解后焦油所含有机物的分布差异明显,其中木屑热解油中未检测出酸类物质,酚类、醇类物质占比随温度变化明显增加,酮类化合物占比变化不大;进一步通过不同指标论证了生物质热解制备高值燃气的可行性,得出生物质高温热解气具有很好的协同作用和良好的应用前景,是生物质高值化利用的重要方向,也是绿氢产生的重要途径。

关键词：生物质能废弃生物质热解规律产物分布高值燃气高效利用

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Recent progress in compressible turbulence

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Acta Mechanica Sinica 2015年第3期31卷 275-291页

作者： Shiyi Chen Zhenhua Xia Jianchun Wang yantao yang State Key Laboratory for Turbulence and Complex Systems Center for Applied Physics and Technology College of Engineering Peking University Physics of Fluids Group Faculty of Science and TechnologyMESA+ Research Institute and J.M.Burgers Centre for Fluid Dynamics University of Twente

In this paper, we review some recent studies on compressible turbulence conducted by the authors＇ group, which include fundamental studies on compressible isotropic turbulence （CIT） and applied studies on developing a con- strained large eddy simulation （CLES） for wall-bounded turbulence. In the first part, we begin with a newly pro- posed hybrid compact-weighted essentially nonoscillatory （WENO） scheme for a CIT simulation that has been used to construct a systematic database of CIT. Using this database various fundamental properties of compressible turbulence have been examined, including the statistics and scaling of compressible modes, the shocklet-turbulence interac- tion, the effect of local compressibility on small scales, the kinetic energy cascade, and some preliminary results from a Lagrangian point of view. In the second part, the idea and for- mulas of the CLES are reviewed, followed by the validations of CLES and some applications in compressible engineering problems.

关键词： Compressible turbulence Hybrid compact-WENO scheme Compressibility effect. Lagrangian studyConstrained large eddy simulation

Macroscopic damping model for structural dynamics with random polycrystalline configurations

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Acta Mechanica Sinica 2018年第3期34卷 493-506页

作者： yantao yang Junzhi Cui Yifan Yu Meizhen Xiang Academy of Mathematics and Systems Science Chinese Academy of Sciences Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics

In this paper the macroscopic damping model for dynamical behavior of the structures with random polycrystalline configurations at micro-nano scales is established. First, the global motion equation of a crystal is decomposed into a set of motion equations with independent single degree of freedom （SDOF） along normal discrete modes, and then damping behavior is introduced into each SDOF motion. Through the interpolation of discrete modes, the continuous representation of damping effects for the crystal is obtained. Second, from energy conservation law the expression of the damping coefficient is derived, and the approximate formula of damping coefficient is given. Next, the continuous damping coefficient for polycrystalline cluster is expressed, the continuous dynamical equation with damping term is obtained, and then the concrete damping coefficients for a polycrystalline Cu sample are shown. Finally, by using statistical two-scale homogenization method, the macroscopic homogenized dynamical equation containing damping term for the structures with random polycrystalline configurations at micro-nano scales is set up.

关键词： Polycrystalline cluster Dynamical equation Damping coefficient Two-scale homogenization method Atomic-Continuum Coupled Model

Effects of the actuation waveform on the drop size reduction in drop-on-demand inkjet printing

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Acta Mechanica Sinica 2020年第5期36卷 983-989,I0001页

作者： Anas Bin Aqeel Muhammad Mohasan Pengyu Lv yantao yang Huiling Duan SKLTCS and Department of Mechanics and Engineering Science BIC-ESATCollege of EngineeringPeking UniversityBeijing 100871China Department of Mechatronics Engineering National University of Sciences and TechnologyIslamabadPakistan Key Laboratory of High Energy Density Physics Inertial Fusion Sciences and Application Collaborative Innovation Center of Ministry of EducationPeking UniversityBeijing 100871China

In this study the effects of the actuation waveforms on the droplet generation in a drop-on-demand inkjet printing are studied systematically by numerical *** different types of waveforms,namely the unipolar and bipolar actuations,are investigated for three fluids with different physical *** focus on two key parameters,which are the dwell time and the velocity *** the unipolar driving,the ejection velocity and the ejected liquid volume are both increased as the velocity amplitude becomes *** dwell time only has minor effects on both the ejection velocity and the ejected liquid *** ejection velocity decreases significantly for large liquid viscosity,while the influences of viscosity on the ejected liquid volume are much *** different droplet morphologies and the corresponding parameter ranges are *** droplet radius can be successfully reduced to about 40%e of the nozzle exit *** the bipolar waveforms,same droplet morphologies are observed but with shifted boundaries in the phase *** minimal radius of stable droplet produced by the bipolar waveforms is even smaller compared to the unipolar ones.

关键词： Drop-on-demand inkjet printing Actuation waveform optimization Droplet ejection-Printability range