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Combination treatment with chondroitinase ABC in spinal cord injury—breaking the barrier

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Neuroscience Bulletin 2013年第4期29卷 477-483页

作者： rong-rong Zhao James W Fawcett Brain Repair Centre University of Cambridge

After spinal cord injury （SCl）, re-establishing functional circuitry in the damaged central nervous system （CNS） faces multiple challenges including lost tissue volume, insufficient intrinsic growth capacity of adult neurons, and the inhibitory environment in the damaged CNS. Several treatment strategies have been developed over the past three decades, but successful restoration of sensory and motor functions will probably require a combination of approaches to address different aspects of the problem. Degradation of the chondroitin sulfate proteoglycans with the chondroitinase ABC （ChABC） enzyme removes a regeneration barrier from the glial scar and increases plasticity in the CNS by removing perineuronal nets. Its mechanism of action does not clash or overlap with most of the other treatment strategies, making ChABC an attractive candidate as a combinational partner with other methods. In this article, we review studies in rat SCI models using ChABC combined with other treatments including cell implantation, growth factors, myelin-inhibitory molecule blockers, and ion channel expression. We discuss possible ways to optimize treatment protocols for future combinational studies. To date, combinational therapies with ChABC have shown synergistic effects with several other strategies in enhancing functional recovery after SCI. These combinatorial approaches can now be developed for clinical application.

关键词： spinal cord injury combination treatment chondroitinase ABC chondroitin sulfate proteoglycan rehabilitation plasticity axon regeneration

Meso-scale Discovery Assay Detects the Changes of Plasma Cytokine Levels in Mice after Low or High LET Ionizing Irradiation

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Biomedical and Environmental Sciences 2021年第7期34卷 540-551页

作者： JIA rong CHEN Ya Xiong DU Ya rong HU Bu rong Key Laboratory of Space Radiobiology of Gansu Province&CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000GansuChina School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100039China Department of Radiation Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhou 325035ZhejiangChina

Objective To obtain precise data on the changes in the levels of 29 cytokines in mice after high or low linear energy transfer(LET)irradiation and to develop an accurate model of radiation exposure based on the cytokine levels after *** Plasma samples harvested from mice at different time points after carbon-ion or X-ray irradiation were analyzed using meso-scale discovery(MSD),a high-throughput and sensitive electrochemiluminescence measurement *** estimation equations were set up using multiple linear regression *** The relative levels of IL-6 at 1 h,IL-5 and IL-6 at 24 h,and IL-5,IL-6 and IL-15 at 7 d after irradiation with two intensities increased *** minimum measured levels of IL-5,IL-6 and IL-15 were up to 4.0076 pg/mL,16.4538 pg/mL and 0.4150 pg/mL,*** addition,dose estimation models were established and *** The MSD assay can provide more accurate data regarding the changes in the levels of the cytokines IL-5,IL-6 and *** cytokines could meet the essential criteria for radiosensitive biomarkers and can be used as radiation *** prediction models can conveniently and accurately estimate the exposure dose in irradiated organism.

关键词： MSD assay Low or high LET irradiation Mouse plasma Cytokines Dose estimation model

Symmetry Restoring Phase Transitions at High Density in a 4D Nambu-Jona-Lasinio Model with a Single Order Parameter

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Communications in Theoretical Physics 2003年第6X期40卷 669-674页

作者： ZHOUBang-rong DepartmentofPhysics GraduateSchooloftheChineseAcademyofSciencesBeijing100039China

High density phase transitions in a 4-dimensional Nambu-Jona-Lasinio model containing a single symmetry breaking order parameter coming from the fermion-antifermion condensates are researched and expounded by means of both the gap equation and the effective potential approach. The phase transitions are proven to be second-order at a high temperature T; however at T = 0 they are first- or second-order, depending on whether A/m(0), the ratio of the momentum cutoff A in the fermion-loop integrals to the dynamicalfermion mass m(0) at zero temperature, is less than 3.387 or not. The former condition cannot be satisfied in some models. The discussions further show complete effectiveness of the critical analysis based on the gap equation for second order phase transitions including determination of the condition of their occurrence.

关键词： Nambu-Jona-Lasinio模位相转变单阶参数高密度对称恢复有效势间隙方程

Critical Analyses of Order Parameter and Phase Transitions at High Density in Gross－Neveu Model

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Communications in Theoretical Physics 2003年第1X期40卷 67-72页

作者： ZHOUBang-rong DepartmentofPhysics GraduateSchooloftheChineseAcademyofSciencesBeijing100039China

By critical analyses of the order parameter of symmetry breaking, we have researched the phase transitions at high density in D = 2 and D = 3 Gross-Neveu (GN) model and shown that the gap equation obeyed by the dynamical fermion mass has the same effectivenesss as the effective potentials for such analyses of all the second order and some specJal first order phase transitions. In the meantime we also further ironed out a theoretical divergence and proven that in D = 3 GN model a first order phase transition does occur in the case of zero temperature and finite chemical potential.

关键词： Gross-Neveu模型有序参数分析间隙方程有效势高密度对称恢复高压相变

Numerical Investigation of Three-dimensional Aeroacoustic Characteristics of Owl-inspired Trailing-edge Fringes

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Journal of Bionic Engineering 2023年第3期20卷 1103-1120页

作者： Jiaxin rong Hao Liu Shanghai Jiao Tong University and Chiba University International Cooperative Research Center(SJTU-CU ICRC) Shanghai200240China Graduate School of Engineering Chiba University1-33Yayoi-choInage-kuChiba263-8522Japan

Owls are widely known for their silent flight,which is attributed to their unique wing morphologies comprising leading-edge(LE)serrations,trailing-edge(TE)fringes,and a velvety *** aeroacoustic characteristics of owl-inspired TE fringes have been widely investigated through two-dimensional(2D)modeling,but remain yet poorly studied in association with their three-dimensional(3D)***,we present a numerical study of the 3D aeroacoustic characteristics of owl-inspired TE fringes in which we combined large-eddy simulations(LES)with the Ffowcs Williams‒Hawkings *** constructed a clean wing model and three wing models with TE fringes that were distributed differently *** aerodynamic forces and 3D acoustic characteristics reveal that,like the 2D results of our previous studies,the 3D TE fringes enable remarkable sound reduction spatially while having aerodynamic performance comparable to the clean *** of the near-field 3D flow structures,vortex dynamics,and flow fluctuations show that TE fringes can robustly alter the 3D flow by breaking 3D TE vortices into small eddies and mitigating 3D flow ***,it is verified that TE fringes alter spanwise flows,thus dominating the 3D aeroacoustic characteristics in terms of passive flow control and flow stabilizations,whereas the fringes are inefficient in suppressing the acoustic sources induced by wingtip ***,the TE fringes distributed at midspan have better acoustic performance than those in the vicinity of the wingtip,indicating the importance of a spanwise distribution in enhancing aeroacoustic performance.

关键词： Owl Three-dimensional trailing-edge fringes Aeroacoustics Large-eddy simulation Ffowcs Williams‒Hawkings equation

Distribution of Traditional Chinese Medicine syndromes in diabetic kidney disease chronic kidney disease 1-5: a correlation study

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Journal of Traditional Chinese Medicine 2024年第3期44卷 572-580页

作者： LI Shuang DUAN Shuwei DONG Zheyi QU Yilun LUO Yayong KE Jianghua WANG Conghui PENG yangzhi ZHOU Xuefeng CHEN Xiangmei Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People's Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China School of Clinical Medicine Guangdong Pharmaceutical Universityjuangzhou510006China Basic Medical College Chengdu University of Traditional Chinese MedicineChengdu610075China

OBJECTIVE: To analyze the distribution of Traditional Chinese medicine(TCM) syndromes in patients with diabetic kidney disease(DKD) and its related ***: We enrolled 435 patients with DKD, who were not undergoing dialysis, admitted to the Department of Nephrology, First Medical Center, Chinese PLA General Hospital from April 2020 to August *** of their TCM syndromes and related factors was carried ***: The 435 patients included 109, 117, 86, and 123 chronic kidney disease(CKD) 1-2, CKD3, CKD4, and CKD5 cases, respectively. With the progression of CKD1-5, the proportion of Yin deficiency and dry heat syndrome,and that of Qi and Yin deficiency syndrome showed a downward trend, whereas the proportion of spleen-kidney Yang deficiency, blood deficiency, blood stasis, water stagnation, and phlegm turbidity syndromes showed an upward trend;the differences were statistically significant(P < 0.05). Multivariate logistic regression analysis showed that Yin deficiency and dry heat syndrome was positively correlated with hemoglobin [odds ratio(OR) =1.022, P = 0.005], albumin(OR = 1.058, P = 0.006), and estimated glomerular filtration rate(eGFR)(OR = 1.020,P < 0.001) but negatively correlated with male sex(OR =0.277, P = 0.004). Qi and Yin deficiency syndrome was positively correlated with albumin(OR = 1.056, P < 0.001)and eGFR(OR = 1.008, P = 0.022) but negatively correlated with age(OR = 0.977, P = 0.023). Liver-kidney Yin deficiency syndrome was positively correlated with age(OR = 1.028, P = 0.021) and glycosylated hemoglobin(OR = 1.223, P = 0.007) but negatively correlated with total cholesterol(OR = 0.792, P = 0.006).Spleen-kidney Yang deficiency syndrome was negatively correlated with hemoglobin(OR = 0.977, P < 0.001),albumin(OR = 0.891, P < 0.001), and eGFR(OR = 0.978,P < 0.001) but positively correlated with high density lipoprotein(OR = 3.376, P = 0.001). CONCLUSION: With CKD1-5 progression, TCM syndromes changed from Yin deficiency and dry

关键词： diabetic nephropathies syndrome and complex hemoglobins albumins glomerular filtration rate correlation of data

Seismic attenuation relationship with homogeneous and heterogeneous prediction-error variance models

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Earthquake Engineering and Engineering Vibration 2014年第1期13卷 1-11页

作者： He-Qing Mu rong-rong Xu Ka-Veng Yuen Faculty of Science and Technology University of Macao

Peak ground acceleration(PGA) estimation is an important task in earthquake engineering *** of the most well-known models is the Boore-Joyner-Fumal formula,which estimates the PGA using the moment magnitude,the site-to-fault distance and the site foundation *** the present study,the complexity for this formula and the homogeneity assumption for the prediction-error variance are investigated and an effi ciency-robustness balanced formula is *** this purpose,a reduced-order Monte Carlo simulation algorithm for Bayesian model class selection is presented to obtain the most suitable predictive formula and prediction-error model for the seismic attenuation *** this approach,each model class(a predictive formula with a prediction-error model) is evaluated according to its plausibility given the *** one with the highest plausibility is robust since it possesses the optimal balance between the data fi tting capability and the sensitivity to noise.A database of strong ground motion records in the Tangshan region of China is obtained from the China Earthquake Data Center for the *** optimal predictive formula is proposed based on this *** is shown that the proposed formula with heterogeneous prediction-error variance is much simpler than the attenuation model suggested by Boore,Joyner and Fumal(1993).

关键词： Bayesian inference Boore-Joyner-Fumal formula heterogeneity variance input-dependent variance model class selection peak ground acceleration seismic attenuation

A Uniqueness Theorem of a System of Nonlinear Equations and Its Applications

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Acta Mathematicae Applicatae Sinica 2015年第1期31卷 111-120页

作者： rong LIU College of Computer and Information Science Fujian Agriculture and Forestry University College of Mathematics and Computer Science Hunan Normal University

A uniqueness theorem of a solution of a system of nonlinear equations is given. Using this result uniqueness theorems for power orthogonal polynomials, for a Gaussian quadrature formula of an extended Chebyshev system... 详细信息

关键词： uniqueness theorems power orthogonal polynomials Gaussian quadrature formula extendedChebyshev system Gaussian Birkhoff quadrature formula

新型抗癫痫发作药物吡仑帕奈添加治疗0~18岁儿童难治性癫痫的临床观察研究

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中国全科医学 2025年第2期28卷 250-256页

作者：马湖萍任蓉侯梅苑爱云青岛大学附属妇女儿童医院神经康复科山东省青岛市266034 山东省潍坊市寿光市人民医院新生儿科 262700

背景目前儿童难治性癫痫(RE)仍是癫痫的治疗难点,国内吡仑帕奈(PER)治疗儿童RE尚属新药,缺少PER对儿童RE添加治疗的建议,且国内报道中使用PER治疗的RE患儿样本量较少。因此PER对于儿童RE,尤其低年龄RE患儿的疗效仍需大样本、进一步研究... 详细信息

背景目前儿童难治性癫痫(RE)仍是癫痫的治疗难点,国内吡仑帕奈(PER)治疗儿童RE尚属新药,缺少PER对儿童RE添加治疗的建议,且国内报道中使用PER治疗的RE患儿样本量较少。因此PER对于儿童RE,尤其低年龄RE患儿的疗效仍需大样本、进一步研究。目的探究PER添加治疗儿童RE的疗效、可能的适应证、不良反应及耐受性。方法对2022年1月—2023年1月在青岛大学附属妇女儿童医院诊治的0~18岁RE患儿进行自身对照、回顾性分析,对比PER添加治疗前后不同观察时点的癫痫发作频率的变化,评估PER的治疗效果,记录药物不良反应及药物保留率,并分析PER有效组与无效组的临床特征。结果共纳入192例研究对象,PER添加治疗后,第12、24、36周的有效率分别为56.3%(108/192)、62.1%(113/182)、69.7%(122/175),无发作率分别为19.3%(37/192)、21.4%(39/182)、24.6%(43/175)。不良反应发生率为16.1%(31/192),主要为头晕、暴躁易怒、无力嗜睡等,末次随访药物保留率为91.1%(175/192)。PER添加治疗的RE患儿连续用药12周时,治疗总有效与无效/恶化患儿起病年龄、抗癫痫治疗病程、起源类型、发作形式、添加PER前发作频率、联合其他抗癫痫发作药物(ASMs)数量、生酮饮食/外科治疗情况,差异有统计学意义(P<0.05)。此外,178例患儿进行了脑电图检查,167例患儿进行了头颅磁共振检查;治疗总有效与无效/恶化患儿脑电图检查结果、头颅磁共振检查结果比较,差异有统计学意义(P<0.05)。脑电图检查结果中以脑前部(前、中、颞前、中部)放电总有效占比较高;头颅影像学检查结果中以正常者总有效占比较高,其次为以脑白质损伤为主的患儿。结论PER添加治疗儿童RE整体有效率及保留率较高,不良反应轻微,药物耐受情况好。对于起病年龄晚、发作形式为运动性发作、局灶性起源、抗癫痫治疗病程短、联合用药数量及发作频率少的RE患儿更为有效。脑电图中以脑前部(前、中、颞前、颞中部)放电、头颅磁共振结果正常者总有效占比较高。

关键词：难治性癫痫儿童吡仑帕奈治疗结果药物不良反应

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