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Fabrication strategies and supramolecular interactions of polymer-lipid complex nanoparticles as oral delivery systems

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Nano Research 2021年第12期14卷 4487-4501页

作者： Taoran Wang yangchao Luo Department of Nutritional Sciences University of ConnecticutStorrsCT06269USA

Oral administration of nutrient/drug is the most common and preferred route. However, a number of barriers are encountered after ingestion, limiting efficient oral nutrient/drug absorption. Both lipid-based (e.g., nanoemulsion, solid lipid nanoparticles) and polymer-based (e.g., protein and polysaccharide nanoparticles) nanoscale delivery systems have demonstrated capability to overcome some of these physiological barriers during transportation and metabolism stages. To better deal with those barriers, polymer-lipid complex nanoparticles are being explored and developed to merge the beneficial features and overcome the respective shortcomings of lipid-based and polymer-based nanoparticles. This paper aims to provide an overview of the various preparation strategies and supramolecular interactions of orally administered polymer-lipid complex nanoparticles by reviewing recent studies. Two types of polymer-lipid complex nanoparticles have been developed, i.e., lipid core with polymer shell nanoparticles and polymer core with lipid shell nanoparticles (lipid-polymer hybrid nanoparticles). Besides, both natural and synthetic polymers used for fabrication are discussed and their advantages and disadvantages are highlighted. Further research work is needed to optimize the fabrication and scaling up processes, so that these versatile polymer-lipid complex nanoparticles could have a significant impact on the oral delivery of nutrient/drug.

关键词： oral delivery nanoparticles polymer-lipid complex core-shell interactions

Parametric study on seismic performance of selfcentering reinforced concrete column with bottom-placed rubber layer

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Frontiers of Structural and Civil Engineering 2023年第8期17卷 1145-1162页

作者： yangchao RU Liusheng HE Huanjun JIANG Department of Disaster Mitigation for Structures College of Civil EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China

To realize seismic-resilient reinforced concrete(RC)moment-resisting frame structures,a novel selfcentering RC column with a rubber layer placed at the bottom(SRRC column)is proposed *** the column,the longitudinal reinforcement dissipates seismic energy,the rubber layer allows the rocking of the column,and the unbonded prestressed tendon enables self-centering capacity.A refined finite element model of the SRRC column is developed,the effectiveness of which is validated based on experimental *** show that the SRRC column exhibits stable energy dissipation capacity and no strength degradation;additionally,it can significantly reduce permanent residual deformation and mitigate damage to *** parametric studies pertaining to SRRC columns have been conducted to investigate the critical factors affecting their seismic performance.

关键词： seismic resilience self-centering rubber layer flag-shaped hysteresis loop parametric study

Colloidal nanoparticles prepared from zein and casein:interactions,characterizations and emerging food applications

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Food Science and Human Wellness 2023年第2期12卷 337-350页

作者： Yi Wang Wusigale yangchao Luo Department of Nutritional Sciences University of ConnecticutStorrs 06269USAKey Laboratory of Dairy Biotechnology and EngineeringMinistry of Education Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China

Protein colloidal nanoparticles(NPs)are ubiquitous present in nature and function as building blocks with multiple functions in both food formulations and biological *** scientists are inspired by naturally occurring proteins to induce self-assembly behavior of protein by manipulating environmental parameters,providing opportunities to construct special and expected *** and casein,the main proteins derived from corn and milk,are two examples of the most prevalently studied food proteins for nanoarchitectures in recent *** this article,the compositions,structures,and physicochemical properties of these two proteins and casein derivatives are summarized as well as their interactions and *** to fabricate zein-sodium caseinate based NPs are critically highlighted and ***,applications such as encapsulation and delivery of bioactive compounds,producing food packaging for enhanced antioxidative and antimicrobial effects,and stabilization of emulsions to achieve fat *** to the imperative role of food proteins in diet composition,this review not only provides cutting-edge knowledge for nanoparticle construction but also opens new avenues for efficient utilization and exploitation of food proteins.

关键词： Zein Casein Nanoparticles Interactions Applications

Relay Selection Scheme for AF System with Partial CSI and Optimal Stopping Theory

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Tsinghua Science and Technology 2020年第2期25卷 302-312页

作者： Rui Zhu Tao Li Jianxin Guo yangchao Huang School of Information Engineering Xijing InstituteXi’an 710123China Institute of Information and Navigation Air Force Engineering UniversityXi’an 710008China Beijing Institute of Information Engineering Beijing 100085China Institute of Information and Navigation Air Force Engineering UniversityXi'an 710008China

Relay selection for Relay Assisted(RA)networks is an economical and effective method to improve the spectrum *** selection performs especially well when the source node has accurate and timely Channel State Information(CSI).However,since perfect CSI knowledge is rarely available,research of relay selection with partial(statistical)CSI is of paramount *** this paper,relay selection for RA networks with statistical CSI is formulated as a Multiple-Decision(MD)***,the cost of obtaining the CSI is also considered in the formulated *** relay selection schemes,Maximal Selection Probability(MSP)and Maximal Spectrum Efficiency Expectation(MSEE),are proposed to solve the formulated MD problem under different optimal criteria assumptions based on the optimal stopping *** MSP scheme maximizes the probability that the Best Assisted Relay Candidate(BARC)can be selected,whereas the MSEE scheme provides the maximal expectation of the spectrum *** results show that the proposed schemes effectively improve the spectrum efficiency,and the MSEE scheme is more suitable for stable communication ***,the MSP scheme is more suitable for burst communication cases.

关键词： Relay-Assisted(RA)network relay selection optimal stopping

基于新特征参数的再入滑翔飞行器机动模式智能辨识

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空军工程大学学报 2024年第2期25卷 32-38页

作者：贺杨超李炯邵雷周池军张锦林空军工程大学防空反导学院西安710038

再入滑翔飞行器的机动模式辨识问题是拦截方实现对其轨迹预测的关键。提出了一组与飞行器轨迹机动特点贴合的特征参数,根据构建的RGV机动模式轨迹库,搭建了LSTM深度学习神经网络,实现了对RGV机动模式的智能辨识。与传统模式辨识方法和... 详细信息

再入滑翔飞行器的机动模式辨识问题是拦截方实现对其轨迹预测的关键。提出了一组与飞行器轨迹机动特点贴合的特征参数,根据构建的RGV机动模式轨迹库,搭建了LSTM深度学习神经网络,实现了对RGV机动模式的智能辨识。与传统模式辨识方法和其他典型特征参数的辨识网络进行对比,结果显示文中所提特征参数在LSTM机动模式辨识网络训练中具有收敛速度快、辨识精度高和鲁棒性好的特点。

关键词：再入滑翔飞行器特征参数机动模式智能辨识

考虑产运环节碳排放的生鲜低碳供应链运营决策

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系统管理学报 2024年第1期33卷 1-15页

作者：冯颖冯仰超张景雄宣彪张炎治中国矿业大学经济管理学院江苏徐州221116

考虑零售商将物流外包给第三方物流服务商(TPL)且生产商进行碳减排的情形,探究了碳排放环节及碳政策变化对于生鲜低碳供应链运营决策的影响。假设TPL的物流服务水平影响生鲜农产品新鲜度且消费者具有低碳偏好意识,在单独考虑生产碳排放... 详细信息

考虑零售商将物流外包给第三方物流服务商(TPL)且生产商进行碳减排的情形,探究了碳排放环节及碳政策变化对于生鲜低碳供应链运营决策的影响。假设TPL的物流服务水平影响生鲜农产品新鲜度且消费者具有低碳偏好意识,在单独考虑生产碳排放和同时考虑产运碳排放两种情形下,分别构建了碳税政策和碳交易政策下的博弈模型。研究发现:单独考虑生产碳排放时,TPL的物流服务水平决策不受碳政策变化的影响;产运同时存在碳排放时,运输环节的碳排放由于产生了额外的成本,抑制了TPL提升物流服务水平的动力;若碳税价格低于(高于)碳交易价格,则碳税政策下TPL的物流服务水平也相应低于(高于)碳交易政策的情形。进一步考虑物流服务成本、新鲜度和碳减排成本均为幂函数的情形,研究发现:供应链成员的碳排放行为会间接削弱减排企业的碳减排力度;在减排技术较为成熟的经济发达阶段,政府更倾向于实行碳交易政策;非减排企业均存在“搭便车”现象,其受益于减排企业减排导致的消费者支付意愿和市场需求的上升;供应链成员利润并非一定受损于运输环节的碳排放,特定情形下会因市场需求上涨而受益。

关键词：碳税碳交易碳减排生鲜低碳供应链第三方物流服务商

Generation and characterization of orthogonal FH sequences for the cognitive network

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Science China(Information Sciences) 2015年第2期58卷 140-150页

作者： GUAN Lei LI Zan SI JiangBo HUANG yangchao State Key Laboratory of Integrated Services Networks Xidian University

The existing orthogonal frequency hopping(FH) sequence cannot support the high throughput and high spectrum efficient cognitive FH(CFH) network due to its small family size, high computational complexity and short period. To overcome these disadvantages, this paper investigates the generation of the orthogonal FH sequence and analyzes its multiple accessibility performance based on the CFH frequency division multipleaccess(FDMA) network model. By the random mapping and cyclical shift replacement(CSR) scheme, a large family size of orthogonal FH sequence with dynamic frequency slot number is generated. In this case, the external interference could be eliminated by avoiding the interfered frequencies, and blocking mutual interference incurred for the packet by the orthogonal frequencies. Moreover, the theoretical relationships of the throughput and transmission delay with respect to the user number and the packet arrival rate are given, which shows that our proposed orthogonal FH sequence could support high throughput and short packet transmission delay in CFH-FDMA network. The simulation results validate our theoretical analysis of the CFH-FDMA network performance, and show that our proposed sequence outperforms the widely used no hit zone FH sequences in terms of uniformity, randomness, Hamming correlation, complexity and sensitivity, etc.

关键词： cognitive frequency hopping orthogonal frequency hopping sequence frequency hopping network frequency division multiple access throughput

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煤系战略性金属锂镓的富集分离研究进展

金属矿山 2024年第1期 233-243页

作者：方丹夏阳超李永改邢耀文苗真勇桂夏辉中国矿业大学炼焦煤资源绿色开发全国重点实验室江苏徐州221116 中国矿业大学国家煤加工与洁净化工程技术研究中心江苏徐州221116 中国矿业大学化工学院江苏徐州221116

煤系物中存在丰富的锂、镓等战略性金属矿物,从中提取利用这些金属,既促进了资源再利用还可以增加我国战略性金属储备。由于锂镓的富集分离必经以厘清煤系锂、镓的赋存状态为前提,故先阐述了锂、镓含量检测和赋存形态研究,继而提出锂镓... 详细信息

煤系物中存在丰富的锂、镓等战略性金属矿物,从中提取利用这些金属,既促进了资源再利用还可以增加我国战略性金属储备。由于锂镓的富集分离必经以厘清煤系锂、镓的赋存状态为前提,故先阐述了锂、镓含量检测和赋存形态研究,继而提出锂镓的预富集方法和分离提取方法,详细分析了物理分选法、化学分选法等富集方法,以及化学沉淀法、溶剂萃取法、离子交换吸附法和膜分离法等分离方法的技术原理和适用性。针对煤系锂、镓富集分离研究现状,提出了未来的发展方向,包括探清目标元素与有害元素的组合形式和成矿机理,提高煤系锂、镓的活化适应性和选择性,突破金属分离的技术瓶颈并优化生产工艺,实现酸碱溶液循环利用。研究成果可为煤系物的资源化利用和其他战略性金属的提取利用提供有益参考。

关键词：煤系物锂镓赋存状态物理分选化学活化提取分离

数字化背景下思政元素融入《眼镜光学技术》课程教学路径研究

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玻璃搪瓷与眼镜 2024年第5期52卷 27-31页

作者：蔡佳妤周向军李杨超海南卫生健康职业学院海口571100

数字化背景下,研究思政元素融入高校《眼镜光学技术》课程的教学路径,详细探讨如何结合课程特点,通过数字化教学手段提升课程的思政育人效果。旨在促进思政教育与专业教育的有机结合,培养既具备专业知识又具有良好思政素养的技能型人才。

关键词：数字化思政元素眼镜光学技术教学方法课程融合

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