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A highly sensitive multiple-mode optical thermometer designed in Eu^(2+/3+)and Li^(+)co-doped polymorphism compound LaSc_(3)(BO_(3))_(4)

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Journal of Advanced Ceramics 2024年第6期13卷 821-833页

作者： Nan yang zhuo Li Tingxia Zhou Ziwang Zhang Wen Shi Yexiang Tong Jianxin Shi School of Chemistry IGCMESun Yat-sen UniversityGuangzhou 510006China MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry IGCMEThe Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong ProvinceSun Yat-sen UniversityGuangzhou 510006China

Noncontact optical thermometers have attracted widespread attention,but existing problems such as single-mode and low-sensitivity thermometers still urgently need to be ***,a novel multiple-mode thermometer was designed for the polymorphism LaSc_(3)(BO_(3))_(4):Eu^(2+/3+),Li^(+).X-ray diffraction(XRD)patterns revealed a slight transition betweenα-andβ-phases with the concentrations of the dopants,which is further proved by structure refinements and first-principles *** coexistence of Eu^(2+)and Eu^(3+)in the phosphors and their relative percentages were confirmed by X-ray absorption near-edge structure(XANES)*** from appropriate emissions from Eu^(2+)and Eu^(3+)without obvious energy transfer and their opposite changing trends with temperatures under 307 nm excitation,a triple-mode optical thermometer is obtained for this material within the temperature range of 150–450 *** highest sensitivities of 27.65,14.05,and 7.68%·K^(−1)are achieved based on two fluorescence intensity ratio(FIR)modes of Eu^(2+)and Eu^(3+)(5d–4f/^(5)D_(0)–^(7)F_(2,4))and the fluorescence lifetime(FL)mode of Eu^(2+),*** the best of our knowledge,the former is almost the highest in Eu^(2+)and Eu^(3+)co-doped *** results indicate that this material may be used as an excellent multiple-mode optical thermometer.

关键词： phase transition europium(Eu)ions multiple-mode optical thermometer thermal quenching properties fluorescence intensity ratio(FIR) fluorescence lifetime(FL)

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治伤巴布剂对大鼠早期骨折愈合及对炎症因子TNF-α水平的影响

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湖南文理学院学报（自然科学版） 2024年第1期36卷 51-55页

作者：李莹杨卓汪涛李平田忠游荣贺渊哲孙锋常德市第一中医医院湖南常德415000 湖南中医药大学湖南长沙410208

为了研究治伤巴布剂对大鼠早期骨折愈合及对肿瘤坏死因子-α(tumornecrosisfactor-α,TNF-α)表达的影响,将45只SPF级雄性大鼠随机分为空白组、模型组、治伤巴布剂组3个组,每组15只。空白组不造模,其余2组予以闭合造模,造模成功后治伤... 详细信息

为了研究治伤巴布剂对大鼠早期骨折愈合及对肿瘤坏死因子-α(tumornecrosisfactor-α,TNF-α)表达的影响,将45只SPF级雄性大鼠随机分为空白组、模型组、治伤巴布剂组3个组,每组15只。空白组不造模,其余2组予以闭合造模,造模成功后治伤巴布剂组在骨折标记部位予治伤巴布剂局部外敷;模型组则予等剂量赋形剂局部外敷(每天换药一次),干预7 d。造模后分别于1、3、7 d 3个时相点观测大鼠骨折肢体肿胀度、苏木精-伊红染色法(HE)观察骨折断端病理形态变化、酶联免疫吸附试验(ELISA)检测血清中TNF-α水平。结果表明:(1)与空白组对比,模型组及治伤巴布剂组在1、3、7 d 3个时相点大鼠右侧股骨明显肿胀(P<0.01),治伤巴布剂组在1、3、7 d 3个时相点肢体肿胀度较模型组明显减轻(P<0.01)。(2)HE染色结果显示模型组中可见少量软骨细胞和肉芽组织,未见骨小梁形成;治伤巴布剂可见大量软骨细胞和肉芽组织,并可见少量骨小梁形成。(3)ELISA结果显示与空白组相比,模型组及治伤巴布剂组TNF-α水平明显升高(P<0.01);与模型组相比,治伤巴布剂组TNF-α水平明显降低(P<0.01)。治伤巴布剂可以减轻大鼠股骨中段的肿胀度,对骨折的早期愈合具有一定促进作用,且降低TNF-α浓度水平抑制炎症反应。

关键词：治伤巴布剂骨折愈合炎症因子肿瘤坏死因子-α

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基于中红外光谱的中国荷斯坦牛牛奶中钠钾镁含量预测模型的建立

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中国农业科学 2024年第14期57卷 2862-2873页

作者：郝磊晓褚楚温佩佩彭松悦杨卓邹慧颖樊懿楷王海童刘文举王东薇刘维华杨俊华赵娟李委奇温万周佳敏张淑君华中农业大学动物科学技术学院/动物医学院宁夏兽药饲料监察所宁夏回族自治区畜牧工作站

【背景】牛奶中钠（sodium,Na）、钾（potassium,K）和镁（magnesium,Mg）含量的准确检测有助于奶牛的健康养殖，同时也是稳定乳制品质量的前提。但目前检测牛奶中矿物质含量的常规方法昂贵且耗时，因此需要一种低成本且快速检测牛奶Na... 详细信息

【背景】牛奶中钠（sodium,Na）、钾（potassium,K）和镁（magnesium,Mg）含量的准确检测有助于奶牛的健康养殖，同时也是稳定乳制品质量的前提。但目前检测牛奶中矿物质含量的常规方法昂贵且耗时，因此需要一种低成本且快速检测牛奶Na、K和Mg含量的方法。【目的】利用中红外光谱（mid-infrared spectroscopy,MIRS）预测中国荷斯坦牛牛奶中Na、K和Mg含量的潜力，为测定牛奶中Na、K和Mg含量提供快速检测技术，为牛群饲养管理和奶牛遗传育种提供大量表型数据支撑。此外，比较不同特征波段选择算法改进预测牛奶中Na、K和Mg含量的MIRS定量预测模型的能力。【方法】以来自华北地区的255份健康中国荷斯坦牛牛奶样本为研究对象。首先，使用Milko Scan TMFT+收集牛奶样本的MIRS数据，并使用电子耦合等离子体发射光谱法测定牛奶样本中Na、K和Mg含量的真实值。随后，以MIRS数据为预测变量，Na、K和Mg含量的真实值为因变量，利用4种光谱预处理算法（一阶导数、二阶导数、SG平滑和标准正态变换）、4种特征选择算法(无信息变量消除（uninformative variable elimination,UVE）、竞争性自适应重加权算法（Competitive adaptive reweighted sampling,CARS）、遗传算法（Genetic Algorithm,GA）及最小角回归算法（Least Angle Regression,LAR）)和9种建模算法（偏最小二乘回归、支持向量机、随机森林和弹性网络等），分别建立预测牛奶中Na、K和Mg含量的MIRS定量预测模型，并选出最优模型组合（特征选择算法+光谱预处理算法+建模算法）。【结果】CARS特征波段选择算法对Na、K和Mg含量预测模型的改进效果优于UVE、GA和LAR算法。基于CARS特征选择算法、一阶导数预处理和弹性网络建模算法开发的Na含量预测模型效果最好，该模型预测集决定系数（coefficient of determination of prediction set,Rp2）=0.72，预测集均方根误差（root mean squared error of prediction,RMSEp）=63.28 mg·kg-1，预测集平均绝对误差（mean absolute error of prediction set,MAEp）=49.03 mg·kg-1，性能偏差比（ratio of performance to deviation,RPD）=1.90；基于CARS特征选择算法、原始光谱和支持向量机建模算法开发的K含量预测模型效果最好，该模型Rp2=0.57,RMSEp=141.49mg·kg-1,MAEp=116.24 mg·kg-1,RPD=1.57；基于CARS特征选择算法、原始光谱和偏最小二乘回归建模算法开发的Mg含量预测模型效果最好，该模型Rp2=0.51,RMSEp=12.08 mg·kg-1,MAEp=9.84 mg·kg-1,RPD=1.30。【结论】利用MIRS预测中国荷斯坦牛牛奶中Na和K含量的方法可行，可以较准确地预测Na含量，近似地定量预测K含量（用于区分低浓度K和高浓度K样品）。在建模之前利用CARS算法提取特征波段提高了MIRS预测模型的准确性，并大大减少了运算时间，可提高MIRS模型预测表型数据的效率。

关键词：牛奶中红外光谱矿物质钠钾镁机器学习

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Neuroprotective Nanoscavenger Induces Coaggregation of β-Amyloid and Facilitates Its Clearance in Alzheimer’s Disease Brain

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CCS Chemistry 2021年第8期3卷 2321-2335页

作者： Yu Zhao Yu Jiang Jingshan Chai Fan Huang Zhanzhan Zhang Qi Liu zhuo yang yang Liu Linqi Shi Key Laboratory of Functional Polymer Materials of Ministry of Education College of ChemistryNankai UniversityTianjin 300071 State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071 Key Laboratory of Bioactive for Materials Ministry of Education School of MedicineNankai UniversityTianjin 300071 Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192

The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent ***,we describe a nanoscavenger with novel structure that can cross the blood–brain barrier(BBB),accurately collect neurotoxic sAβs,and facilitate amounts ofβ-amyloid(Aβ)clearance.

关键词： solubleβ-amyloid aggregates nanoscavengers cross the BBB coaggregate microglial clearance

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《投教基地投资者教育服务规范》团体标准解读

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中国标准化 2024年第17期 185-188页

作者：张舰顾颖杨晨茁邱蕾张玉婷常丽艳北京基金小镇控股有限公司北京市房山区基金小镇发展促进中心北京正河山标准化咨询事务所(有限合伙)

本文主要分析《投教基地投资者教育服务规范》(T/CFSCC 001—2023)的编制背景与意义,重点解读其适用范围、术语和定义及标准要求,并结合北京基金小镇投资者教育基地实际进行案例分析。本文将为清晰地理解和把握该标准,以及标准的贯彻实... 详细信息

本文主要分析《投教基地投资者教育服务规范》(T/CFSCC 001—2023)的编制背景与意义,重点解读其适用范围、术语和定义及标准要求,并结合北京基金小镇投资者教育基地实际进行案例分析。本文将为清晰地理解和把握该标准,以及标准的贯彻实施提供一定参考,为投教基地的建设与运营提供指导。

关键词：投资者教育投教基地标准

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Facile Synthesis of 7-epi-Taxane and Its Derivatives and Preliminary Evaluation of Anticancer Activity

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Chinese Journal of Chemistry 2016年第11期34卷 1165-1176页

作者： Zhao Li Jia Feng Kun Zou zhuo yang Yong Zhang Zhijian Xu Bo Li Jiye Shi Yiming Li Weiliang Zhu Kaixian Chen School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai 201203 China CAS Key Laboratory of Receptor Research Drug Discovery and Design Centre Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Nano Science and Technology Institute University of Science and Technology of China Suzhou Jiangsu 215123 China UCB Biopharma SPRL Chemin du Foriest Braine-l'Alleud Belgium Kellogg College University of Oxford 60-62 Banbury Road Oxford OX2 6PN United Kingdom

7-epi-Taxane has been achieved efficiently in gram scale from natural taxane via inversion of the 7-hydroxyl group simply using Ag20 as catalyst and DMF as solvent. The catalyst could he quantitatively recovered by filtra- tion without loss of catalytic activity. This condition is also applicable to the direct epimerization of taxane derivatives （e.g., docetaxel and paclitaxel） to 7-epi-taxane derivatives （e.g., 7-epi-docetaxel and 7-epi-paclitaxel）. Furthermore, 33 ester derivatives of 7-epi-taxane with different amino acid moieties at the position of C-13 were successfully synthesized via esterification without protecting C-7-OH. Bioassay results revealed that compounds 13 and 18 have good selectivity against prostatic cancer cell line DU145, with ICs0 value as low as 15.9 nmol/L for 18.

关键词： taxane 7-epi-taxane silver oxide amino acid C-13 derivative of taxane anticancer activity

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New common bile duct morphological subtypes:Risk predictors of common bile duct stone recurrence

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World Journal of Gastrointestinal Surgery 2022年第3期14卷 236-246页

作者： Xu Ji zhuo yang Shu-Ren Ma Wen Jia Qian Zhao Lu Xu Ying Kan yang Cao Yao Wang Bao-Jun Fan Department of Digestive Endoscopy General Hospital of Northern Theater CommandShenyang 110840Liaoning ProvinceChina Postgraduate College Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is the primary treatment for removing common bile duct(CBD)*** risk factors for CBD stone recurrence after ERCP have been discussed for many ***,the influence of CBD morphology has never been *** To evaluate CBD morphology and other predictors affecting CBD stone recurrence in average *** A retrospective analysis of 502 CBD stone patients who underwent successful therapeutic ERCP for stone extraction at our centre from February 2020 to January 2021 was *** morphology and other predictors affecting CBD stone recurrence were examined by univariate analysis and multivariate logistic regression *** CBD morphology(P<0.01),CBD diameter≥1.5 cm[odds ratio(OR)=2.20,95%CI:1.08-4.46,P=0.03],and endoscopic biliary sphincterotomy with balloon dilation(ESBD)(OR=0.35,95%CI:0.17-0.75,P<0.01)are three independent risk factors for CBD stone ***,the recurrence rate of patients with the S type was 6.61-fold that of patients with the straight type(OR=6.61,95%CI:2.61-16.77,P<0.01).The recurrence rate of patients with the polyline type was 2.45-fold that of patients with the straight type(OR=2.45,95%CI:1.14-5.26,P=0.02).The recurrence rate of S type patients was 2.70-fold that of patients with the polyline type(OR=2.70,95%CI:1.08-6.73,P=0.03).Compared with no-ESBD,ESBD could decrease the risk of *** CBD diameter≥1.5 cm and CBD morphology,especially S type and polyline type,were associated with increased recurrence of CBD *** addition,ESBD was related to decreased *** with these risk factors should undergo periodic surveillance and standard prophylactic therapy.

关键词： Endoscopic retrograde cholangiopancreatography Common bile duct stones Recurrence Common bile duct morphology Risk factors

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Fertility achieved through in vitro fertilization in a male patient with 48,XXYY syndrome

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Asian Journal of Andrology 2018年第2期20卷 208-209页

作者： De-Feng Liu Lian-Ming Zhao Kai Hong Jia-Ming Mao Yu-zhuo yang Zhe Zhang Hui Jiang Reproduetive Medical Center Peking University Third Hospital Beijing 100191 China Department of Urology Peking University Third Hospital Beijing 100191 China

The 48,XXYY syndrome is a rare sex chromosome aneuploidy with an incidence of 1：18 000-1：40 000 male births and is associated with hypergonadotropic hypogonadism as an endocrine disorder. Most men with this syndrome are never diagnosed in China. Due to sex chromosome aneuploidies and limited effective communication, these patients suffer from infertility.

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基于制冷季逐时能耗模拟的地铁车站冷源方案分析方法

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暖通空调 2024年第6期54卷 167-170,166页

作者：鲍帅阳杨卓武雪都李晓锋任继乐刘畅洛阳市轨道交通集团有限责任公司洛阳北京清华同衡规划设计研究院有限公司北京清华大学北京

提出了一种综合室外典型年逐时气象参数、列车发车对数、客流量变化等因素,在制冷季逐时负荷基础上进行能耗模拟的冷源方案分析思路。首先建模计算得到地铁车站制冷季逐时空调负荷,然后基于逐时室外气象条件修正冷水机组的实际性能。以... 详细信息

提出了一种综合室外典型年逐时气象参数、列车发车对数、客流量变化等因素,在制冷季逐时负荷基础上进行能耗模拟的冷源方案分析思路。首先建模计算得到地铁车站制冷季逐时空调负荷,然后基于逐时室外气象条件修正冷水机组的实际性能。以某地铁车站公共区为例,对水冷螺杆式冷水机组和水冷涡旋式模块化冷水机组2种空调冷源方案进行了对比。结果显示,虽然水冷螺杆式冷水机组的额定COP高于水冷涡旋式模块化冷水机组,但针对该地铁车站的负荷特点,采用水冷涡旋式模块化冷水机组方案制冷站年能耗比采用水冷螺杆式冷水机组方案低11.6%。

关键词：地铁车站能耗模拟空调冷源渗风量气象参数发车对数螺杆式冷水机组涡旋式冷水机组

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Biochar-based materials as remediation strategy in petroleum hydrocarbon-contaminated soil and water:Performances,mechanisms,and environmental impact

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Journal of Environmental Sciences 2024年第4期138卷 350-372页

作者： zhuo Wei YiWei yang Liu Shuai Niu Yaxi Xu Jong-Hwan Park Jim J.Wang Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China School of Plant Environment&Soil SciencesLouisiana State University AgCenter.Baton RougeLA 70803USA Department of Life Resources Industry Dong-A University37Nakdong-daero 550 beon-gilSaha-guBusan 49315South Korea

Petroleum contamination is considered as a major risk to the health of humans and *** as low-cost and eco-friendly carbon materials,have been widely used for the removal of petroleum hydrocarbon in the *** purpose of this paper is to review the performance,mechanisms,and potential environmental toxicity of biochar,modified biochar and its integration use with other materials in petroleum contaminated soil and ***,the use of biochar in oil-contaminated water and soil as well as the factors that could influence the removal ability of biochar were systematically *** addition,the modification and integrated use of biochar for improving the removal efficiency were summarized from the aspects of sorption,biodegradation,chemical degradation,and ***,the functional impacts and associated ecotoxicity of pristine and modified biochars in various environments were ***,some shortcoming of current approaches,and future research needs were provided for the future direction and challenges of modified biochar ***,this paper gain insight into biochar application in petroleum remediation from the perspectives of performance enhancement and environmental sustainability.

关键词： Petroleum contamination Adsorbent Bioremediation Biochar modification Ecotoxicity

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