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World Journal of Integrated Traditional and Western Medicine 2020年第1期6卷 37-43页

作者： JIANG Hai-jun He Bin ZHANG Tong yang yu-fei Beijing University of Chinese Medicine Beijing100029China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing100091China

Colorectal cancer is one of the common malignant tumors in *** poses a serious threat to the national health of *** advanced colorectal cancer, the main goal of treatment is to prolong survival and improve quality of *** complements other advantages, showing good therapeutic ***, how to grasp the timing of integrated Chinese and Western Medicine for the treatment of advanced colorectal cancer and use the integrated Chinese and Western Medicine treatment methods flexibly contains profound therapeutic *** yu-fei is an authoritative expert in the field of integrated Chinese and Western medicine for colorectal *** is good at accurately grasping the timing of treatment of integrated Chinese and Western Medicine, and flexibly adjusts the treatment strategy according to the specific *** this paper, we shared Professor yang yu-fei's strategy for treating advanced colorectal cancer with emphasis on integrated Chinese and Western Medicine and attached a typical case, with a view to provide reference for the treatment of advanced colorectal cancer with integrated Chinese and Western Medicine.

关键词： Integrated Chinese and western medicine Advanced colorectal cancer Treatment timing art

From Intercalation to Alloying Chemistry: Structural Design of Silicon Anodes for the Next Generation of Lithium-ion Batteries

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Chinese Journal of Structural Chemistry 2020年第1期39卷 16-19,1页

作者： yang yu-fei yang Jin-Long PAN Feng CUI Yi Department of Materials Science and Engineering Stanford UniversitySta nfordCA 94305USA School of Advanced Materials Peking UniversityShenzhen Graduate SchoolShenzhen 518055China Stanford Institute for Materials and Energy Sciences SLAC National Accelerator Laboratory2575 Sand Hill RoadMenlo ParkCA 94025USA

Lithium-ion batteries,first commercialized in 1991,have been thriving for the past 30 years and become an important basis for portable electronics and electric ***,this first generation of lithium-ion batteries built on the intercalation materials has limited energy density and can not meet the increased demand of various ***,a transition from intercalation to alloying chemistry for anodes is on ***,as the most attractive alloying anode material,has been on the research focus for next-generation highenergy density *** mechanism benefits silicon a large capacity while brings silicon the challenge of volume *** article discusses the structure design strategies to address the issues of large volume change and interface instability.

关键词： silicon anode alloying chemistry structural design lithium-ion battery

Patients with Metastatic Colorectal Cancer after Failure of Second-Line Treatment May Benefit from Low-Dose Apatinib and S-1 Combined with Jianpi Bushen Jiedu Decoction

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Chinese Journal of Integrative Medicine 2022年第10期28卷 924-929页

作者： CHEN yue XU yu-ying JIANG Hai-jun WANG Lei ZHAI Jia-wei ZHANG Tong yang yu-fei Graduate School Beijing University of Chinese MedicineBeijing(100029)China Department of Oncology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Department of Oncology Central Hospital of Ankang CityAnkangShaanxi Province(725000)China

Objective: To evaluate the effect and safety of low-dose of apatinib and S-1 combined with Jianpi Bushen Jiedu Decoction(JBJD) in patients with metastatic colorectal cancer(mCRC) who have failed second or above lines treatment, in order to provide more treatment option for mCRC patients by integrated medicine. Methods: Thirteen patients were selected from a single-arm, open-label clinical study from April 2019 to September 2020. The patients were treated with low-dose apatinib(250 mg, once a day) and S-1(20 mg, twice a day) combined with JBJD for at least one cycle and were followed up to August 2021. The primary endpoint was disease progression-free survival(PFS). Disease control rate(DCR), objective response rate(ORR), and overall survival(OS) of patients were observed as the secondary endpoints. Adverse events were recorded as well. Results: The average age of the 13 patients was 56.5±13.0 years and 76.9% were male. The median PFS and median OS were 4.6 and 8.3 months, respectively. The ORR was 7.7%(1/13) while the DCR was 61.5%(8/13). The common adverse events were hypertension, proteinuria, elevated transaminase, and thrombocytopenia. One patient experienced thrombocytopenia of grade 3. Conclusions: Patients with mCRC after failure of the second or above lines of treatment may potentially benefit from the treatment of low-dose apatinib and S-1 combined with JBJD because of its similar effect as the standard dose of target therapy and relatively better safety.(Registration No. ChiCTR1900022673)

关键词： metastatic colorectal cancer apatinib S-1 Jianpi Bushen Jiedu Decoction Chinese medicine progression-free survival clinical trial

Li掺杂对4H-SiC光电性质影响的理论研究

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原子与分子物理学报 2025年第2期42卷 151-158页

作者：李萍尹伟潘学聪庞国旺马亚斌杨亚宏杨菲宇张盼秦彦军新疆理工学院理学院阿克苏843100 新疆理工学院机电工程学院阿克苏843100

采用基于密度泛函理论的第一性原理方法,计算了Li掺杂4H-SiC体系的电子结构及光学性质.结果表明,掺杂前后的4H-SiC均为间接带隙半导体,Li原子间隙掺杂后形成n型半导体,Li原子替位式掺杂体系的禁带中出现了杂质能级,降低了电子跃迁时所... 详细信息

采用基于密度泛函理论的第一性原理方法,计算了Li掺杂4H-SiC体系的电子结构及光学性质.结果表明,掺杂前后的4H-SiC均为间接带隙半导体,Li原子间隙掺杂后形成n型半导体,Li原子替位式掺杂体系的禁带中出现了杂质能级,降低了电子跃迁时所需的能量;对电荷差分密度图的分析表明,Li原子失去电子,导致Li-C键和Li-Si键的共价性降低,以离子性为主;在可见光区域,相比于4H-SiC体系,掺杂体系的吸收率峰值均有所提高,其中Li间隙掺杂体系吸收带边最小,吸收率峰值最大,掺杂后的4H-SiC体系对红外、可见光、紫外均能够有所吸收,说明Li掺杂能够有效拓宽4H-SiC对光的响应范围.

关键词： Li掺杂 4H-SiC 电子结构光学性质第一性原理

Effect of Jianpi Bushen Sequential Formula on Adjuvant Chemotherapy of Colon Cancer:Study Protocol for a Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2021年第12期27卷 891-895页

作者： ZHANG Tong fei yu-tong XU yun SUN Ling-yun HE Bin YAN Shao-hua TANG Mo YAN yun-zi MAO Jun yang yu-fei Department of Oncology Xiyuan Hospital of China Academy of Chinese Medicine SciencesBeijing(100091)China Centre for Evidence-Based Chinese Medicine Beijing University of Traditional Chinese MedicineBeijing(100029)China Integrative Medicine Service Memorial Sloan Kettering Cancer CenterNew York(10041 NY 212)United States

Background The side effects of chemotherapy-induced nausea and vomiting(CINV)and myelosuppression reduce the cancer patients’adherence to *** Chinese patients choose Chinese medicine(CM)during chemotherapy to reduce side effects;however,the evidence is *** efficacy of a CM herbal treatment protocol,Jianpi Bushen Sequential Formula(健脾补肾续贯方,JBSF)will be evaluated on chemotherapy completion rate among patients with colon *** A multi-center double-blind randomized controlled trial(RCT)will be conducted on 400 patients with colon cancer who will receive 8 cycles of adjuvant chemotherapy with oxaliplatin and capecitabine(CAPEOX).Patients will be randomized 1:1 to receive the JBSF or placebo *** primary outcome is the overall chemotherapy completion *** secondary outcomes include individual chemotherapy completion rate,4-cycle completion rate of chemotherapy,time to treatment failure,relative dose intensity and treatment ***-up visits will be scheduled before every and after last *** This study will provide evidence on whether JBSF can improve the chemotherapy completion rate and reduce side effects among patients with colon cancer.(Trial registration:Clinical ***,***03716518)。

关键词： Chinese medicine Jianpi Bushen Sequential Formula Liujun Anwei Formula Qitu Erzhi Formula colon cancer chemotherapy induced nausea and vomiting myelosuppression

Nondestructive testing for crack of tunnel lining using GPR

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Journal of Central South University of Technology 2005年第z1期12卷 120-124页

作者： LIU Dun-wen DENG yu yang fei XU Guo-yuan School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China

Lining craze, as a common engineering damage, affects the bearing capacity and the safety of *** improve the capabilities of the surface crack detection in the tunnel lining, ground penetrating radar(GPR) was employed. The principle and method of GPR for cracks investigation of tunnel lining were expounded. As an application example, some field measurements in order to detect the depth of cracks for the tunnel lining were achieved in a new tunnel. All GPR investigations were made with the antennae of 1 GHz. The cracks of concrete structure were located, and the distributing and depth of cracks are inspected and estimated by GPR. The results of investigation show GPR is accurate and efficient to detect cracks of tunnel lining.

关键词： tunnel lining nondestructive testing(NDT) cracks ground penetrating radar

Cohort Study on Prognosis of Patients with Metastatic Colorectal Cancer Treated with Integrated Chinese and Western Medicine

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Chinese Journal of Integrative Medicine 2018年第8期24卷 573-578页

作者： ZHANG Tong HE Wen-ting ZI Ming-jie SONG Gang YI Dan-hui yang yu-fei Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical Sciences Second Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University Ethics Committee Xiyuan Hospital of China Academy of Chinese Medical Sciences Department of Digestive Oncology Beijing Cancer Hospital School of Statistics Renmin University of China

Objective： To investigate the efficacy of integrated Chinese and Western medicine（IM） in the treatment of metastatic colorectal cancer（m CRC） in a cohort ***： The survival outcome of patients receiving IM was compared with that of patients receiving Western medicine *** study design was adopted with ＂continuous administration of Chinese medicine for 3 months＂ as the exposure *** who met this exposure factor were assigned to the IM cohort（Group A,110 patients）.Patients who did not meet this exposure factor were assigned to the Western medicine cohort（Group B,225 patients）.The overall survival（OS）,progression-free survival（PFS）,and 1 st year,2 nd year,and 3 rd year survival in the two cohorts were ***： The median OS in Group A and B were 18 months [95% confidence interval（CI） 15-21] and 16 months（95% CI 14-18）,respectively,and the median PFS in Group A and B were 6 months（95% CI 4-7） and 5 months（95% CI 4-6）,*** statistically significant differences were observed between the groups（P=0.186,P=0.223）.Group A demonstrated significantly longer OS and PFS than Group B in the following subgroups： female patients,patients with lesions in the right half of the colon,and those who received first-line treatment（P〈0.05）.In the subgroup of elderly patients（age〉65 years）,the OS in Group A was longer than that in Group B（P〈0.05）.Conclusion： IM could prolong the survival of patients with m CRC.（Registry *** CTR-IOR-17010497）

关键词： cohort study metastatic colorectal cancer integrative medicine

Efficacy of Quxie Capsule in Metastatic Colorectal Cancer:Long-Term Survival Update of A Double-Blind,Randomized,Placebo Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第11期28卷 971-974页

作者： ZHANG Tong XU yun SUN Ling-yun HE Bin HAO Jie ZHANG Da yang yu-fei Department of Oncology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China

Objective:To verify the efficacy of Quxie Capsule in patients with metastatic colorectal cancer(m CRC).Methods:It was a block randomized,double-blind,placebo-controlled *** patients with m CRC were randomized into 2 groups at a 1:1 *** patients in the treatment group received conventional therapy including chemotherapy,radiotherapy,targeted therapy and supportive care,and Chinese herbal medicine combined with Quxie Capsule(each capsule of 0.4 g was orally administered at 50 mg/kg,twice daily,day 1–20,in a 30-day course)for 3 *** patients in the control group received conventional therapy and Chinese herbal medicine combined with placebo for 3 *** outcome measures were overall survival(OS)and progression-free survival(PFS).Subgroup analysis was performed according to therapy lines,right or left-sided colon,targeted therapy and RAS gene status to determine the differences in PFS and OS between the two *** were followed up every 3 months until December 31st,***:Median follow-up time was 19.4 *** median OS was 23.9 months in the treatment group[95%confidence interval(CI)15.9-28.5]vs.14.3 months in the control group(95%CI 11.3-21.4,P0.05).In the subgroups of second-line therapy,non-targeted therapy,RAS gene wild type and left-sided colon,the treatment group showed a significant survival benefit compared with the control group(P<0.05 or P<0.01),***:Quxie Capsule can reduce the risk of death and prolong the OS of patients with m CRC.(Registration *** CTR-IOR-16009733).

关键词： Quxie capsule metastatic colorectal cancer randomized controlles trial Chinese medicine

Dynamic Treatment Strategy of Chinese Medicinefor Metastatic Colorectal Cancer Based on Machine Learning Algorithm

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Chinese Journal of Integrative Medicine 2024年第11期30卷 993-1000页

作者： XU yu-ying LI Qiu-yan YI Dan-hui CHEN yue ZHAI Jia-wei ZHANG Tong SUN Ling-yun yang yu-fei Department of Oncology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China School of Statistics Renmin University of ChinaBeijing 100872China Graduate School Beijing University of Chinese MedicineBeijing 100029China

Objective:To establish the dynamic treatment strategy of Chinese medicine(CM)for metastatic colorectal cancer(mCRC)by machine learning algorithm,in order to provide a reference for the selection of CM treatment strategies for ***:From the outpatient cases of mCRC in the Department of Oncology at Xiyuan Hospital,China Academy of Chinese Medical Sciences,197 cases that met the inclusion criteria were *** to different CM intervention strategies,the patients were divided into 3 groups:CM treatment alone,equal emphasis on Chinese and Western medicine treatment(CM combined with local treatment of tumors,oral chemotherapy,or targeted drugs),and CM assisted Western medicine treatment(CM combined with intravenous regimen of Western medicine).The survival time of patients undergoing CM intervention was taken as the final evaluation *** affecting the choice of CM intervention scheme were screened as decision *** dynamic CM intervention and treatment strategy for mCRC was explored based on the cost-sensitive classification learning algorithm for survival(CSCLSurv).Patients'survival was estimated using the Kaplan-Meier method,and the survival time of patients who received the model-recommended treatment plan were compared with those who received actual treatment ***:Using the survival time of patients undergoing CM intervention as the evaluation index,a dynamic CM intervention therapy strategy for mCRC was established based on *** CM intervention strategies for mCRC can be selected according to dynamic decision variables,such as gender,age,Eastern Cooperative Oncology Group score,tumor site,metastatic site,genotyping,and the stage of Western medicine treatment at the patient's first *** median survival time of patients who received the model-recommended treatment plan was 35 months,while those who receive the actual treatment plan was 26.0 months(P=0.06).Conclusions:The dynamic treatment strategy of CM,bas

关键词： metastatic colorectal cancer Chinese medicine dynamic treatment strategy cost sensitive classificationlearningforsurvival

Chinese Medicine Combined with Adjuvant Chemotherapy for Improving Myelosuppression in Colorectal Cancer Patients:A Systematic Review and Network Meta-Analysis

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Chinese Journal of Integrative Medicine 2024年第7期30卷 643-652页

作者： LI Rui ZHANG Tong YAN Shao-hua YAN yun-zi DING Ya-cong WANG Yan-song yang yu-fei Department of Oncology China Academy of Chinese Medical SciencesXiyuan HospitalBeijing100091China Department of Oncology Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To assess the effectiveness of Chinese herbal medicine(CHM)combined with adjuvant chemotherapy on myelosuppression for colorectal cancer(CRC)patients using network meta-analysis(NMA).Methods Literature searches in both international(PubMed,Embase,Web of Science,and Cochrane Library)and Chinese(China Science and Technology Journal Database,Wanfang Data,China National Knowledge Infrastructure)databases for relevant randomized controlled trials(RCTs)were conducted from inception until October 10,*** included RCTs of patients who received CHM combined with chemotherapy,including FOLFOX,XELOX,FOLFIRI,and other relevant regimens in the CHM treatment *** outcomes included the incidence of myelosuppression,leukopenia,hemoglobin reduction,and *** reviewers independently screened the databases,extracted the data,and assessed the risk of bias and credibility of *** 5.4.1 software and STATA 14.0 were used to perform the *** A total of 31 RCTs were included,published from 2008 to 2021 in *** these,2,314 participants comparing the following 9 CHMs were identified:Shengbai Recipe(SBR),Bazhen Decoction(BZD),Jianpi Jiedu Recipe(JJR),Jianpi Recipe(JR),Compound Cantharis Capsule(CCC),Zaofan Pill(ZFP),Guilu Erxian Gel(GL),Buzhong Tiaogan Decoction(BZ),and Qiamagu Capsule(QM).The results of NMA found an indirect *** on the surface under the cumulative ranking curve(SUCRA),the ZFP+chemotherapy group had the lowest incidence of myelosuppression,with an odds ratio(OR)of 0.08[95%confidence interval(CI):0.01,0.76],whereas the GL+chemotherapy group had the lowest incidence of leukopenia,hemoglobin reduction,and thrombocytopenia,with an OR of 5.25(95%CI:2.41,11.43),4.66(95%CI:2.23,9.72),and 0.27(95%CI:0.13,0.54),***,BZD+chemotherapy could alleviate leukopenia,hemoglobin reduction,and thrombocytopenia(P<0.01).Pairwise comparison showed that there was no difference in the efficacy among the 8 CHMs+c

关键词： Chinese herbal medicine colorectal cancer network meta-analysis systematic review myelosuppression chemotherapy