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Phosphorylation site at serine 282 of connexin 43 has a regulatory effect on survival and apoptosis of cardiomyocytes

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中国药理学与毒理学杂志 2019年第10期 778-778页

作者： yang yu-tong YAN Xin-xin XUE Jing-yi Capital Medical University The Affiliated Suzhou Hospital of Nanjing Medical University

OBJECTIVE To find out the specific serine phosphorylation site of connexin 43 which involved in regulating cardiomyocytes survival and apoptosis and its underlying mechanism. METHODS Ca;transients was performed in NRVMs transfected with connxin 43 mutants（S282A, S279A） and NRVMs exposed to anoxia and reoxygenation（A/R） and AR cells treated with cantharidinate（CA）. Lucifer Yellow Uptake Assay was detected in S282A NRVMs. Cell deaths were analyzed in all cell models. Assessment of caspase 8, 9 and 3 activity by ELISA kits, P38 and Fas/FADD expression by Western blotting, connexin 43-P38 physical interaction by Coimmunoprecipitation were carried out in both cell models and mouse models including S282A+/-mice, Ischemia/reperfusion rats and rats injected with S282A *** and electrocardiograph, evaluations of histological analysis and immunostaining of ventricular structurewere conducted on mouse models to monitor heart functions. RESULTS Deficiency in phosphorylation of S282 in NRVMs transfected with connxin 43 mutants（S282A, S279A） and AR cells induced cardiomyocyte death and blockaded intercellular coupling. Markedly activated caspase 3, 8 and increased Fas/FADD expression were found in S282A and AR cells. But CA, an inhibitor of PP2A-A which regulates Cx43 serine dephosphorylation, restored decreased phosphorylation of S282 and completely inhibited FAS/FADD apoptotic pathway in A/R cells. Cx43 S282A;mice, ischemia/reperfusion rats and rats injected with S282A adenovirus with S282 dephosphorylation exhibited arrhythmias and dispersed myocardial damage including disarranged myocardium,fibrosis, apoptosis of cardiomyocytes, and impaired cardiac output. CONCLUSION Deficiency in serine 282 phosphorylation is linked to ventricular arrhythmias and also triggers cardiomyocyte death via activation of P38 MAPK and Fas/FADD pathway.

关键词： connexin 43 phosphorylation ischemia/reperfusion apoptosis arrhythmia

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Design of hadronic calorimeter for DarkSHINE experiment

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Nuclear Science and Techniques 2024年第9期35卷 155-167页

作者： Zhen Wang Rui yuan Han-Qing Liu Jing Chen Xiang Chen Kim Siang Khaw Liang Li Shu Li Kun Liu Qi-Bin Liu Si-yuan Song tong Sun Xiao-Long Wang yu-Feng Wang Hai-Jun yang Jun-Hua Zhang yu-Lei Zhang Zhi-yu Zhao Chun-Xiang Zhu Xu-Liang Zhu Yi-Fan Zhu Tsung-Dao Lee Institute Shanghai Jiao Tong University1 Lisuo RoadShanghai 201210China Institute of Nuclear and Particle Physics School of Physics and Astronomy800 Dongchuan RoadShanghai 200240China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200443China Institute of Modern Physics Fudan UniversityShanghai 200443China

The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used and the design of the detector *** paper presents the optimized design of the hadronic calorimeter(HCAL)used in the DarkSHINE experiment,which is studied using a GEANT4-based simulation *** geometry is optimized by comparing a traditional design with uniform absorbers to one that uses different thicknesses at different locations on the detector,which enhances the efficiency of vetoing low-energy neutrons at the sub-GeV *** overall size and total amount of material used in the HCAL are optimized to be lower,owing to the load and budget requirements,whereas the overall performance is studied to satisfy the physical objectives.

关键词： Hadronic calorimeter GEANT4 simulation Neutron background Scintillation detector Dark photon

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The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury

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Neural Regeneration Research 2024年第5期19卷 1084-1091页

作者： Yijing Zhao tong Li Zige Jiang Chengcheng Gai Shuwen yu Danqing Xin Tingting Li Dexiang Liu Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China Maternal and Child Health Care Hospital of Shandong Province Affiliated to Qingdao UniversityJinanShandong ProvinceChina

We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal ***,the precise mechanism underlying the role of H2S in this situation remains *** this study,we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine,a H2S precursor,attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionineβsynthase(a major H2S synthetase in the brain)in the prefrontal *** also found that an miR-9-5p inhibitor blocked the expression of cystathionineβsynthase in the prefrontal cortex in mice with brain injury caused by hypoxia and ***,miR-9-5p overexpression increased cystathionine-β-synthase and H2S expression in the injured prefrontal cortex of mice with hypoxic ischemic brain injury.L-cysteine decreased the expression of CXCL11,an miR-9-5p target gene,in the prefrontal cortex of the mouse model and in lipopolysaccharide-stimulated BV-2 cells and increased the levels of proinflammatory cytokines BNIP3,FSTL1,SOCS2 and SOCS5,while treatment with an miR-9-5p inhibitor reversed these *** findings suggest that H2S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p/CXCL11 axis and restoringβ-synthase expression,thereby playing a role in reducing neuroinflammation in hypoxic ischemic brain injury.

关键词： chemokine(C-X-C motif)ligand 11 cystathionineβsynthase H2S hypoxic ischemic brain injury inflammation L-cysteine lipopolysaccharide microglia miR-9-5p neuroprotection

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基于Hausdorff距离的图像配准快速算法

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计算机工程 2011年第12期37卷 193-195,198页

作者：杨通钰彭国华西北工业大学理学院西安710129

在图像配准过程中,传统Hausdorff距离算法的计算量较大。针对该问题,提出一种基于Hausdorff距离的图像配准快速算法。将参考图像和待配准图像进行边缘检测,在待配准图像上任意选取一个模板,通过设定一个变化的阈值对Hausdorff距离算法... 详细信息

在图像配准过程中,传统Hausdorff距离算法的计算量较大。针对该问题,提出一种基于Hausdorff距离的图像配准快速算法。将参考图像和待配准图像进行边缘检测,在待配准图像上任意选取一个模板,通过设定一个变化的阈值对Hausdorff距离算法进行改进,以减少不必要点的计算,实现快速匹配,并根据匹配数据,对图像进行尺度变换及旋转操作,使2幅图像能在空间上配准。实验结果表明,与传统的配准算法相比,该算法的计算复杂度较低。

关键词：模板匹配图像配准边缘检测二值化 Hausdorff距离算法

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Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

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Journal of Genetics and Genomics 2024年第1期51卷 75-86页

作者： Boxun Zhang Xuan Zhang Zhen Luo Jixiang Ren Xiaotong yu Haiyan Zhao Yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou Ding Haoyu yang Zishan Jin Xiaolin tong Jun Wang Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Faculty of Biological Science and Technology Baotou Teacher's CollegeBaotouInner Mongolia 014030China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Infinitus(China)Company Ltd GuangzhouGuangdong 510405China Affiliated Hospital of Changchun University of Chinese Medicine ChangchunJilin 130021China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xinjiekou Community Health Service Center in Xicheng District Beijing 100035China Department of Spleen and Stomach Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China University of Chinese Academy of Sciences Beijing 100049China Beijing University of Chinese Medicine Beijing 100105China Northeast Asia Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchunJilin 130117China

Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are ***,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to *** of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT *** addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

关键词： Impaired glucose tolerance Diabetes mellitus Gut microbiota Metabolomics

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Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 852-860页

作者： Hai-Jian Hu Ping Li Bin tong yu-Lian Pang Hong-Dou Luo Fei-Fei Wang Chan Xiong yu-Lin yu Hai He Xu Zhang Affiliated Eye Hospital of Nanchang University Jiangxi Research Institute of Ophthalmology and Visual ScienceJiangxi Clinical Research Center for Ophthalmic DiseaseJiangxi Branch of National Clinical Research Center for Ocular DiseasesNanchang 330006Jiangxi ProvinceChina Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430015Hubei ProvinceChina

AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced ***:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were *** relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were *** with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were ***:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without *** area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal ***:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level.

关键词： 10-2 visual field ganglion cell-inner plexiform layer retinal nerve fiber layer thickness glaucoma

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聚丙烯纤维与TG固化剂对水泥石灰土强度及稳定性的影响

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科学技术与工程 2017年第14期17卷 302-308页

作者：杨林刘雨彤东北林业大学土木工程学院哈尔滨150040

为提高水泥石灰综合稳定土的基层性能,选用聚丙烯纤维、TG土壤固化剂改良水泥石灰土。根据水泥和石灰含量、聚丙烯纤维掺量、TG固化剂剂量对水泥石灰土无侧限抗压强度的影响规律,从而确定水泥和石灰含量均为4%,聚丙烯纤维和TG固化剂掺... 详细信息

为提高水泥石灰综合稳定土的基层性能,选用聚丙烯纤维、TG土壤固化剂改良水泥石灰土。根据水泥和石灰含量、聚丙烯纤维掺量、TG固化剂剂量对水泥石灰土无侧限抗压强度的影响规律,从而确定水泥和石灰含量均为4%,聚丙烯纤维和TG固化剂掺量分别取0.2%、0.02%。在此基础上,研究了纤维与固化剂对水泥石灰土劈裂强度、收缩性、水稳定性及冻稳定性的影响。试验结果表明:经聚丙烯纤维与TG固化剂复合固化的水泥石灰土强度及稳定性提高效果最显著,优于高石灰掺量的水泥石灰土。

关键词：水泥石灰土聚丙烯纤维 TG土壤固化剂强度抗裂性稳定性

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Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

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Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma Li-Na Sheng Xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-Jin Ong Zhi-yu Sun Shu-Wen Tang yu-Hong yu Xin-tong Du Xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement Lifetime

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Protein C deficiency with venous and arterial thromboembolic events

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World Journal of Clinical Cases 2024年第12期12卷 2000-2003页

作者： Nan Zhang Dong-Kun Sun Xu Tian Xin-yu Zheng tong Liu Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of CardiologyThe Second Hospital of Tianjin Medical UniversityTianjin 300211China

Protein C(PC)is a key component of the vitamin K-dependent coagulation *** exerts anticoagulant effects by inactivating factors V and *** or inherited PC deficiency results in a prothrombotic state,with presentations varying from asymptomatic to venous ***,there has been an increasing number of reports linking PC deficiency to arterial thromboembolic events,such as myocardial infarction and ischemic *** editorial focuses on the association between PC deficiency and thromboembolism,which may provide some insights for treatment strategy and scientific research.

关键词： Protein C deficiency Venous thromboembolism Myocardial infarction Editorial Arterial thromboembolism

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Efficacy and safety of Xileisan combined with mesalazine for ulcerative colitis:A meta-analysis and trial sequential analysis

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World Journal of Clinical Cases 2024年第21期12卷 4703-4716页

作者： Xin-yu yang yun-Feng yu Ke-Ke tong Gang Hu Rong yu Lian-Jun Su School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The benefits and risks of Xileisan(XLS)in the treatment of ulcerative colitis(UC)remain *** The present study aimed to evaluate the efficacy and safety of the combination of XLS and mesalazine when treating *** We searched eight databases for clinical trials evaluating the combination of XLS and mesalazine in the treatment of UC,up to January ***-analysis and trial sequential analysis(TSA)were performed using Revman 5.3 and TSA 0.***.5.10 beta,*** The present study included 13 clinical studies involving 990 patients,of which 501 patients received XLS combined with mesalazine while 489 patients received mesalazine *** meta-analysis showed that,in terms of efficacy,the combination of XLS and mesalazine significantly improved the clinical efficacy rate by 22%[risk ratio(RR)=1.22;95%CI:1.15–1.28;P0.05).The TSA showed non conclusive findings in the meta-analysis of the safety ***’s test showed no publication bias(P=0.734).CONCLUSION Treatment with XLS alleviated the clinical symptoms,intestinal mucosal injury,and inflammatory response in patients with UC,while demonstrating good safety.

关键词： Xileisan Mesalazine Ulcerative colitis Meta-analysis Trial sequential analysis

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