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Percutaneous ethanol injection, radiofrequency and their combination in treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第40期11卷 6277-6280页

作者： Bao-Ming Luo Yan-Ling Wen Hai-yun yang Hui Zhi xiao-yun xiao Bing Ou Jing-Sheng Pan Jian-Hong Ma Department of Ultrasound the Second Affiliated Hospital SunYat-sen University 107 Yanjiangxi Rd Guangzhou 510120Guangdong Province China

AIM： To evaluate the therapeutic effect and the indication of percutaneous ethanol injection （PEI）, radiofrequency ablation （RFA） and their combination in treatment of hepatocellular carcinoma （HCC）. METHODS： Two hundred and fifty-five patients with HCC received treatment of PEI, RFA or their combination. Group1 （〈 3 on in diameter, n=85） was treated with PEI, group2 （〈 3 cm in diameter, n=153） with RFA. Group3 （〉3 cm in diameter, n=86） was divided into two groups. Group 3a （/7=34） was treated with RFA, while group 3b （n=52） was treated with RFA for 2 wk after transcatheter arterial chemoembolization or PEI. Contrast-enhanced sonography was performed for 61 patients before and after RFA. Liver function and serum alpha-fetoprotein （AFP） were measured for all patients. Changes of the lesions on ultrasound and contrast-enhanced CT/HRI were evaluated for assessing the therapeutic responses. The 1-, 2-, 3- and 5-year survival rates were recorded after treatment. RESULTS： In group 1, the complete necrosis rate of lesions after 1 mo was 77.6% （66/85）. The level of AFP declined conspicuously after 1 mo. The 1-, 2-, 3- and 5-year survival rate after treatment was 80.0% （52/65）, 60.4% （32/53）, 52.5% （21/40） and 33.3% （7/21）, respectively. In group 2, the complete necrosis rate of lesions after 1 moh was 92.2% （141/153）. The level of AFP decreased conspicuously after i mo. The 1-, 2-, 3- and 5-year survival rate after treatment was 94.6% （88/93）, 73.2% （52/71）, 63.5% （33/52） and 46.4% （13/28）, respectively. In group 3a, the complete necrosis rate of lesions after 1 mo was 23.5% （8/34）. AFPdropped down to the normal level in only one patient after 1 mo. The 1-, 2- and 3-year survival rate after treatment was 47.6% （10/21）, 42.9% （6/14） and 27.3% （3/11）, respectively. Only one patient was still alive after 5 years. In group 3b, the complete necrosis rate of lesions after 1 mo was 57.7% （30/52）. The level of AFP decreased after 1 mo. The 1-, 2-, 3- and S-year survival rate after

关键词： Hepatocellular carcinoma Radiofrequencyablation Percutaneous ethanol injection Embolism Therapeutic effect

Kinematics Modeling and Experiments of Pectoral Oscillation Propulsion Robotic Fish

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Journal of Bionic Engineering 2009年第2期6卷 174-179页

作者： Shao-bo yang,Jing Qiu,xiao-yun HanInstitute of Mechatronical Engineering and Automatization,National University of Defense Technology,Changsha 410073,P.R.China Institute of Mechatronical Engineering and Automatization National University of Defense Technology Changsha P. R. China

A robotic fish driven by oscillating fins, 'Cownose Ray-I', is developed, which is in dorsoventrally flattened shape without a tail. The robotic fish is composed of a body and two lateral fins. A three-factor kinematic model is established and used in the design of a mechanism. By controlling the three kinematic parameters, the robotic fish can accelerate and maneuver. Forward velocity is dependent on the largest amplitude and the number of waves in the fins, while the relative contribution of fin beat frequency to the forward velocity of the robotic fish is different from the usual result. On the other hand, experimental results on maneuvering show that phase difference has a stronger effect on swerving than the largest amplitude to some extent. In addition, as propulsion waves pass from the trailing edge to the leading edge, the robotic fish attains a backward velocity of 0. 15 m·s^(-1).

关键词： robotic fish pectoral oscillation propulsion largest amplitude number of waves fin beat frequency phase difference

Upper Large Deviations for Mixing Random Sequence

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Communications in Mathematical Research 2010年第3期26卷 219-229页

作者： ZHANG YONG yang xiao-yun DONG ZHI-SHAN Wang De-hui College of Mathematics Jilin University Changchun 130012

In this article, we prove upper large deviations for the empirical measure generated by stationary mixing random sequence under some suitable assumptions and upper large deviations for the mixing random sequence.

关键词： mixing sequence empirical measure large deviation

Down-regulation of human leukocyte antigens class I on peripheral T lymphocytes and NK cells from subjects in region of high-incidence gastrointestinal tumor

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Chinese Medical Journal 2011年第12期124卷 1813-1817页

作者： ZHANG Zhi-mian LI Ying-jie GUAN xiao yang xiao-yun GAO Xi-mei yang xiao-jing WANG Li-shui ZOU Xiong Department of Health Examination Center Qilu Hospital of Shandong University Jinan Shandong 250012 China Department of Laboratory Medicine Qilu Hospital of Shandong University Jinan Shandong 250012 China

Background Many types of human tumors can suppress the immune system to enhance their survival. Loss or down-regulation of human leukocyte antigens （HLA） class I on tumors is considered to be a major mechanism of tumor immune escape. Our previous studies found that HLA class I on peripheral-blood mononuclear cells was significantly lower in gastric cancer patients. The present study made an analysis of HLA class I expression on peripheral-blood T lymphocytes and NK cells from subjects of Lijiadian village, a village with high-incidence gastrointestinal tumor. Methods A total of 181 villagers from Lijiadian village and 153 normal controls from the Department of Health Examination Center were enrolled in this study. Using a multi-tumor markers detection system, these villagers were divided into two groups： high-risk group （tumor markers positive group） and low-risk group （tumor markers negative group）. The percentage of T lymphocytes and NK cells and levels of HLA class I on their surface were determined in these subjects by flow cytometry. Results Percentages of T lymphocytes and NK cells in peripheral-blood mononuclear cells did not vary with age. The expression level of HLA class I on peripheral T lymphocytes and NK cells was not affected by age or gender, but was significantly down-regulated in Lijiadian villagers （P 〈0.05）, with the low-risk group, there was a significant reduction of cells （P 〈0.05） in the high-risk group. especially on the surface of NK cells （P 〈0.01）. Compared HLA class I on peripheral T lymphocytes （P 〈0.05） and NK Conclusions HLA class I on peripheral T lymphocytes and NK cells may be involved in tumorigenesis and development of gastrointestinal tumor, and understanding their changes in expression may provide new insights into the mechanism of tumor immunity.

关键词： histocompatibility antigens class I T-lymphocytes killer cells, natural gastrointestinal neoplasms

溶血磷脂酸在皮肤损伤疾病中的作用及其分子机制

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中国生物化学与分子生物学报 2020年第4期36卷 364-369页

作者：牟笑笑杨晓杨晓云潍坊医学院临床医学院生物化学与分子生物学系山东潍坊261053 潍坊医学院护理学院护理学系山东潍坊261053

皮肤作为人体最大器官覆盖于全身,能阻挡有害物质的侵入,保护人体内环境稳态,参与人体代谢过程。皮肤损伤、炎症和纤维化等,都会导致皮肤屏障功能的减退,影响正常的生命活动。溶血磷脂酸(lysophosphatidic acid,LPA)是十分活跃的磷脂信... 详细信息

皮肤作为人体最大器官覆盖于全身,能阻挡有害物质的侵入,保护人体内环境稳态,参与人体代谢过程。皮肤损伤、炎症和纤维化等,都会导致皮肤屏障功能的减退,影响正常的生命活动。溶血磷脂酸(lysophosphatidic acid,LPA)是十分活跃的磷脂信号分子,参与多种生理和病理生理过程。LPA是维持体内平衡所必需的生物活性脂质介质,在皮肤中通过不同的信号通路发挥多功能磷脂信使作用。本文综述了皮肤中溶血磷脂酸受体(lysophosphatidic acid receptor,LPA1-6)及其细胞信号通路的作用及机制,综述了LPA在皮肤创面愈合、皮肤瘢痕、皮肤黑色素瘤、硬皮病、皮肤瘙痒、过敏性皮炎、皮肤屏障、皮肤疼痛,皮肤毛发生长中的作用及分子机制,有助于了解LPA在皮肤中的生理和病理生理作用。深入研究LPA的作用机制将有助于挖掘其在皮肤治疗中的作用,开发以LPA为靶点的药物。

关键词：溶血磷脂酸皮肤溶血磷脂酸受体细胞信号通路

联合检测血清25羟基维生素D及肿瘤标志物在结直肠癌诊断中的应用

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中国中西医结合外科杂志 2016年第5期22卷 445-449页

作者：杨晓云刘蕊天津市人民医院检验科天津300191

目的：探讨联合检测血清25羟基维生素D[25（OH）D]及肿瘤标志物在结直肠癌（CRC）诊断中的应用价值。方法：检测150例正常对照者及150例CRC患者血清25（OH）D、CEA、CA19-9等指标;收集CRC患者肿瘤临床病理特征资料,进行统计分析。结果：... 详细信息

目的：探讨联合检测血清25羟基维生素D[25（OH）D]及肿瘤标志物在结直肠癌（CRC）诊断中的应用价值。方法：检测150例正常对照者及150例CRC患者血清25（OH）D、CEA、CA19-9等指标;收集CRC患者肿瘤临床病理特征资料,进行统计分析。结果：CRC患者血清25（OH）D水平[（33.17±15.75）nmmol/L]低于正常对照者[（41.18±11.59）nmmol/L],P〈0.01;CEA及CA19-9水平[分别为3.67（2.14,7.20）ng/m L、8.10（3.10,18.90）U/m L],高于正常对照者[分别为2.26（1.75,3.09）ng/m L、4.82（2.90,7.35）U/m L],P〈0.01;CRC患者血清25（OH）D及CEA水平一致性较差,（Kappa=0.174,P〈0.05）;肿瘤大体类型为非溃疡型、细胞为高中分化、临床分期为Ⅰ~Ⅱ期及无淋巴结转移的CRC患者血清CEA水平均低于大体类型为溃疡型、肿瘤细胞为低分化、临床分期为Ⅲ-Ⅳ期及发生淋巴结转移者（P〈0.05）,但血清25（OH）D水平在各组间的比较均未见统计学差异（P〉0.05）。结论：联合检测患者血清25（OH）D与肿瘤标志物浓度,对早期诊断CRC及评估病情具有临床应用意义。

关键词：结直肠癌 25羟基维生素D 肿瘤标志物

Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

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Science China Chemistry 2025年第1期68卷 273-287页

作者： Shuguang yang Lijun Hu Hong xiao Zecong xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

关键词： fluorescent molecular probes self-amplifying myeloperoxidase photodynamic therapy

Anti-tumor effects of polybutylcyanoacrylate nanoparticles of diallyl trisulfide on orthotopic transplantation tumor model of hepatocellular carcinoma in BALB/c nude mice

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Chinese Medical Journal 2007年第15期120卷 1336-1342页

作者： ZHANG Zhi-mian yang xiao-yun DENG Shu-hai XU Wei GAO Hai-qing Health Examination Center Qilu Hospital of Shandong University Jinan 250012 China Department of Health Care Qilu Hospital of Shandong University Jinan 250012 China Department of Pharmaceutics College of Pharmacy Shandong University Jinan 50012 China

Background Hepatocellular carcinoma （HCC） ranked the second among the causes of cancer mortality in China since the 1990s. Up to now, medication still plays an important role in the treatment of HCC. The therapies based on the allicin as a potential chemopreventive analog although is in its infancy at the present time, may have a significant role in the future management of HCC. Diallyl trisulfide （DATS） is a natural compound derived from garlic. In this study, we investigated the inhibitory effects of hepatic targeted polybutylcyanoacrylate nanoparticles of diallyl trisulfide （DATS-PBCA-NP） on orthotopic transplanted HepG2 hepatocellular carcinoma in nude mice. Methods DATS-PBCA-NP were detected by transmission electron microscope （TEM） and high-performance liquid chromatography （HPLC）. The orthotopic transplantation HCC models were established by implanting HCC HepG2 xenograft bits under the envelope of the mice liver. Successful models （n=29） were divided into 4 groups： normal saline （NS）, empty nanoparticles （EN）, DATS and DATS-PBCA-NP were intravenously administered to the mice respectively for 2 weeks. In vivo antitumor efficacy was evaluated by the measurement of tumor volume. Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling （TUNEL） assay and protein levels of apoptosis and cell proliferation proteins by immunoblotting in tumor tissues were performed to elucidate the possible mechanism. Results DATS-PBCA-NP possessed smooth and round appearance, dispersed well, and released in vitro in accord with double phase kinetics model. DATS-PBCA-NP changed the tissue/organ distribution of DATS in vivo. The successful rate of tumor implantation was 100%. Intravenous administration of DATS-PBCA-NP significantly retarded the growth of orthotopically transplanted hepatoma in BALB/c nude mice （compared with the other three groups, all P〈0.05） without causing weight loss （P〉0.05）. TUNEL staining showed that the tumors from DATS-PBCA-NP treated mice e

关键词： hepatocellular polybutylcyanoacrylate nanoparticles model animal orthotopic transplantation

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中国共产党作风建设百年历史经验研究

湘潭大学学报（哲学社会科学版） 2022年第3期46卷 125-132页

作者：杨小云长沙学院湖南长沙410022

100年来,中国共产党在作风建设方面积累了丰富的历史经验:将作风建设视为关系党的形象、关系人心向背、关系党和国家生死存亡的大事,始终予以高度重视;加强思想教育和理论武装;坚持党对作风建设的领导;建立完善“不敢腐、不能腐、不想... 详细信息

100年来,中国共产党在作风建设方面积累了丰富的历史经验:将作风建设视为关系党的形象、关系人心向背、关系党和国家生死存亡的大事,始终予以高度重视;加强思想教育和理论武装;坚持党对作风建设的领导;建立完善“不敢腐、不能腐、不想腐”的长效机制。

关键词：中国共产党作风建设历史经验从严治党