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CO as a therapeutic agent: discovery and delivery forms

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Chinese Journal of Natural Medicines 2020年第4期18卷 284-295页

作者： yang xiao-xiao KE Bo-Wen LU Wen WANG Bing-He Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State UniversityAtlanta GA 30303USA Department of Anesthesiology West China HospitalChengdu 610000China

Carbon monoxide(CO) as one of the three important endogenously produced signaling molecules, termed as "gasotransmitter," has emerged as a promising therapeutic agent for treating various inflammation and cellular-stress related diseases. In this review, we discussed CO’s evolution from a well-recognized toxic gas to a signaling molecule, and the effort to develop different approaches to deliver it for therapeutic application. We also summarize recently reported chemistry towards different CO delivery forms.

关键词： Carbon monoxide Gasotransmitter CO delivery CO-RMs Organic CO prodrug

High-temperature High-pressure Hydrothermal Synthesis of Dy3＋-doped YNbO4 Single Crystal and Its Luminescence Properties

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Chemical Research in Chinese Universities 2013年第6期29卷 1050-1054页

作者： yang Min LI Qi-liang WANG Ying LIU xiao-yang WANG xiao-feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P.R.China

Single crystal Dy3＋ doped YNbO4phosphors were prepared via a high-temperature high-pressure hydrothermal procedure. Under excitation at 270 nm, the Dy3＋-doped YNbO4 phosphor shows bright white emission, which is composed of two strong bands at 492 and 576 nm corresponding to the characteristic 4F9/2→6H15/2 and aF9/2→6H13/2 transitions of Dy3＋, respectively. The dominant band was observed at 352 nm, which corresponds to the 6H15/2→6p7/2 transition of Dy3＋. Nearly white light was achieved at 2ex 270, 310 and 388 nm and the CIE（International Commission on Illumination） values were （0.3135, 0.3421）, （0.3088, 0.3380） and （0.3146, 0.3296）, respectively.

关键词： Dy-YNbO4 Single crystal High-temperature high-pressure Hydrothermal Luminescence

Highly Sensitive and Selective Amperometric Sensor for Iodate Based on 9,10-Phenanthrenequinone Derived Graphene

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Chemical Research in Chinese Universities 2013年第1期29卷 132-138页

作者： WANG Hong-juan CHENG Na-na yang xiao-yang LI xiao-meng ZHU Lian-de Faculty of Chemistry Northeast Normal University Changchun 130024 P. R. China

We reported on a new amperometric sensor for the sensitive and selective determination of iodate in table salt. The iodate sensor was constructed by the integration of a novel nanocomposite which was made from 9,10-phenanthrenequinone（PQ） and graphene（GP） with a glassy carbon electrode（GCE）. The synthesized graphene and the nanocomposite were well characterized by X-ray diffraction（XRD）, transmission electron microscopy（TEM）, Fourier transform infrared（FTIR） spectroscopy and Raman spectroscopy. We fully studied the electrochemical beha- vior and kinetic characteristics of the PQ/GP nanocomposite at GCE. The PQ/GP electrode shows a good electrochemical catalytic activity towards the reduction of iodate, which makes itself a sensitive and selective electrochemical sensor for iodate. The iodate sensor displays a high sensitivity（1.04 ***.L-1）, a low detection limit（1.0X 10-8 mol/L）, a rapid response（less than 2 s）, and a broad linear range（from 5.0X 10-8 mol/L to 6.0X 10-3 mol/L ）. In addition, the sensor is interference free. The practical application of the proposed sensor was tested by the detection of iodate in table salt.

关键词： 9,10-Phenanthrenequinone Graphene Amperometric sensor Iodate

Forkhead box protein 3 mRNA expression in the peripheral blood of kidney-transplant recipients with acute rejection

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Chinese Medical Journal 2011年第12期124卷 1775-1778页

作者： WANG Wei LI xiao-bei yang xiao-yong ZHANG xiao-dong Department of Urology Beijing Chaoyang Hospital CapitalMedical University Beijing 100020 China

Background Regulatory T cells （Tregs） are immunologically and clinically interesting not least because of the important role they play in allograft rejection. Likewise, expression of the transcription factor forkhead box protein 3 （FOXP3）, detected in transplant biopsies, is also of intere.（;t because of its role in the development of regulatory T cells. In this study, we investigated the relationship between FoxP3 mRNA expression and acute organ rejection in kidney-transplant recipients. Methods In this prospective study, FoxP3 mRNA expression levels in peripheral blood samples from 10 recipients of living relative-donor kidney transplants were measured before transplantation as well as at the 14th and 90th days post-transplantation. In addition, 46 first-time kidney-transplant recipients participated in a cross-sectional study, with 28 patients classified as having acute organ rejection; whilst the remaining 18 patients had functionally stable allografts. FoxP3 mRNA expression levels in peripheral blood samples were compared between these two different groups. Results Before transplantation mean FoxP3 mRNA levels vs. GADPH mRNA levels （Ig（FoxP3 mRNA/GADPH mRNA）） in the 10 recipients were 1.11±0.67. The mean FoxP3 mRNA expression levels measured at 14th and 90th days post-transplantation were significantly higher than before transplantation （1.69±0.38, P=0.03; 1.44±0.21, P=0.04, respectively）. Additionally, the mean FoxP3 mRNA levels vs. GADPH mRNA expression levels （Ig（FoxP3 mRNA/GADPH mRNA）） were significantly higher in recipients suffering acute rejection compared with those with stable allografts （1.77±0.61 and 1.43±0.27, respectively, P=0.03）. Conclusions After kidney transplantntion, FoxP3 mRNA levels were found to increase in the peripheral blood of all recipients. Considerably higher FoxP3 rnRNA levels were observed in recipients suffering acute rejection. These results suggest that FoxP3 mRNA levels in peripheral blood samples can be used as a diagnostic t

关键词： kidney transplantation rejection forkhead box protein 3

Preparation and characterization of solid dispersions of Quercetin with PEG4000

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沈阳药科大学学报 2008年第S1期25卷 129-130页

作者： yang xiao-zhan,LI xiao-hui(Institute of Materia Medica,Third Military Medical University,Chongqing 400038,China)

Objective To enhance the solubility,quicken the speed of digesting and absorption,and increase the bioavailability of quercetin(3,3',4',5,7-pentahydroxyflavone).Methods A series of Quercetin-PEG4000 solid dispersions were prepared by fusion *** configuration and property of solid dispersion were characterized by solubility tests,dissolution tests,FTIR spectra,differential scanning calorimetry(DSC)and *** *** to solubility tests the the mass ratio of quercetin to PEG4000 affected strongly on the solubility of solid dispersions,on the whole,the relation of the solubility of solid dispersions to the mass ratio presented linear *** preparation temperature had little effect on the solubility of solid *** surface-active agent,polysorbate80 increased strongly the solubility of solid *** to the dissolution tests,the mass ratio of quercetin to PEG4000 affected strongly on the dissolution of solid dispersions,the preparation temperature had little effect on the dissolution of solid *** surface-active agent,polysorbate80 increased strongly the dissolution of solid dispersions,and after addition polysorbate80,the dissolution of solid dispersions was two times of the dissolution of solid dispersions without *** to the DSC results,except that a little of quercetin molecular existed as crystalline state in the solid dispersion with the mass ratio was qu:PEG=1:2,quercetin existed as amorphous phase in other mass ratio solid *** to the FTIR spectra and microphotograph results,the relation of quercetin and PEG4000 was mainly physical mixing in quercetin-PEG4000 solid *** was just like solute in solution,and PEG4000 was just like solvent in *** force between quercetin and PEG4000 was mainly hydrogen bonding,so the biological activity of quercetin would not be influenced greatly after the formation solid *** Th

关键词： quercetin PEG4000 solid dispersion solubility dissolution

Rapamycin instead of mycophenolate mofetil or azathioprine in treatment of post-renal transplantation urothelial carcinoma

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Chinese Medical Journal 2009年第1期122卷 35-38页

作者： HU xiao-peng MA Lin-lin WANG Yong YIN Hang WANG Wei yang xiao-yong ZHANG xiao-dong Department of Urology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Background Malignant tumor is the most common complication occurred in transplant recipients. It is widely recognized that immunosuppressive treatments increase the risk of cancer in transplant recipients. The efficacy and safety of rapamycin （RPM） in combination with low-dose calcineurin inhibitor （CNI） in treating 15 renal allograft recipients which developed urothelial carcinoma were observed.Methods Immunosuppressive regimen in all recipients was altered with rapamycin to replace mycophenolate mofetil （MMF） or azathioprine （Aza）. The initial loading dosage was 2 mg/d, and the next dosage was 1 mg/d. The dosage of rapamycin was carefully adjusted according to the blood drug level and concentration of the drug was maintained at 4-6 μg/L. In all the 15 patients, the calcineurin inhibitor was reduced down to one third of the original dosage after the rapamycin blood concentration became stable. Surgical treatment and intravesical instillation chemotherapy were carried out in all patients. Recurrence of the tumor was monitored throughout the study. Post-transplant renal function and side effects were also closely monitored.Results Among the 15 patients, 9 had no tumor recurrence in 2 years, 2 had tumor recurrences twice, and 4 had once. There was no acute rejection observed during RPM treatment. Post-transplant renal function in 11 patients was improved with a decreased creatinine level. Hyperlipoidemia and thrombocytopenia were the most frequent adverse events which responded well to corresponding treatments.Conclusion Among the renal allograft recipients with urothelial carcinoma, combination of rapamycin and low dose calcineurin inhibitor treatment is effective and safe.

关键词： renal transplantation urothelial carcinoma rapamycin

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MSVL语言的公理系统的程序验证

西安电子科技大学学报 2010年第1期37卷 96-101页

作者：杨潇潇段振华西安电子科技大学计算理论与技术研究所陕西西安710071

MSVL语言是一种用于模拟、建模和验证程序的区间时序逻辑程序设计语言.为了证明区间时序逻辑程序的正确性,提出了MSVL语言的一个公理系统:包括正则形转换的状态公理和状态推演规则,以及将程序从一个状态转换到另一个状态的区间公理和区... 详细信息

MSVL语言是一种用于模拟、建模和验证程序的区间时序逻辑程序设计语言.为了证明区间时序逻辑程序的正确性,提出了MSVL语言的一个公理系统:包括正则形转换的状态公理和状态推演规则,以及将程序从一个状态转换到另一个状态的区间公理和区间推演规则.最后给出验证实例说明基于该公理系统的程序验证方法.

关键词：形式验证时序逻辑正则形安全性公理系统

Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

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Science China Chemistry 2025年第1期 273-287页

作者： Shuguang yang Lijun Hu Hong xiao Zecong xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing yang Jinghui Chen Xingyue xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery