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Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue wei Wen-Bo Cao Sai-Jun Mo Zhi-Yan sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

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浅析美国海波皮处理厂污水资源化

节能 2002年第4期21卷 34-36页

作者：杨维孙炳双李亚峰沈阳建筑工程学院沈阳110015 辽宁省城市节约用水办公室沈阳110001

以美国海波皮处理厂的污水处理工程为例 ,阐述了美国现行的集现代先进的污水处理技术、固体废物处理技术及废气处理技术为一体的污水资源化技术路线。结合辽河流域城市污水处理厂的建设 ,从坚持走可持续发展道路的宏观角度提出污水资源... 详细信息

以美国海波皮处理厂的污水处理工程为例 ,阐述了美国现行的集现代先进的污水处理技术、固体废物处理技术及废气处理技术为一体的污水资源化技术路线。结合辽河流域城市污水处理厂的建设 ,从坚持走可持续发展道路的宏观角度提出污水资源化的几点认识。

关键词：污水处理污水回用技术路线美国海波皮处理厂生物处理污水资源化皮革

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao wei Panpan Zhao Yongchun Wang Mingxi Li Li sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

计算机化OSCE在口腔临床实践技能考核中的应用

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上海口腔医学 2017年第3期26卷 349-352页

作者：聂蓉蓉朱锋谢思静吴丽杨洁孙卫斌南京大学医学院附属口腔医院修复科江苏南京210008 南京大学医学院附属口腔医院口腔颌面外科江苏南京210008 南京大学医学院附属口腔医院教育科江苏南京210008

目的 :针对我国目前口腔医学生临床技能考核中存在的弊端,构建和实施口腔临床客观结构化考核体系(objective structured clinical examination,OSCE)。方法 :OSCE采用计算机信息化作业,考核方式为多站式考核,共分为3大部分、8个站点,考... 详细信息

目的 :针对我国目前口腔医学生临床技能考核中存在的弊端,构建和实施口腔临床客观结构化考核体系(objective structured clinical examination,OSCE)。方法 :OSCE采用计算机信息化作业,考核方式为多站式考核,共分为3大部分、8个站点,考核内容包括基础知识选择题、辅助检查结果评判、病例分析测试题、医患沟通以及基本技能操作考核等。结果:运用OSCE,能够在较短时间内对口腔医学生分析、解决临床表现和问题的能力进行测试;从多方面、多目的评估应试者的临床实践能力、学习能力及职业素质;信息化操作平台也更加方便、环保。结论:计算机化OSCE有助于学生提早适应执业医师考试,提高学生的临床综合技能,值得在口腔教学中推广应用。

关键词：计算机化客观结构化临床水平考试口腔医学

Numerical simulation of axial liquid film cooling in rocket combustor

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航空动力学报 2013年第2期28卷 459-465页

作者： yang wei sun bing ZHENG Li-ming School of Astronautics Beijing University of Aeronautics and Astronautics

Numerical simulation has been done for liquid film cooling in liquid rocket *** species of axial Navier-Stokes equations have been solved for liquid-film / hot-gas flow field,and k-εequations have been used for compressible turbulent *** results of the model agree well with the results of software *** results show that :(1) Liquid film can decrease the wall heat flux and temperature effectively,and the cold border area formed by the film covers the whole combustor and nozzle wall.(2) The turbulent viscosity is higher than the physical viscosity,and its biggest value is in the border area of the convergent area in *** effect of turbulent flow on the whole simulation field can not be ignored.(3) The mass fraction of kerosene at the film inlet is 1,but it decreases along the nozzle wall and achieves its lowest value at the ***,the mass fraction of kerosene near the wall is the biggest at any axial location.

关键词： liquid rocket engine liquid film cooling heat flux numerical simulation turbulent flow

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Study on fluid-structure interaction in liquid oxygen feeding pipe systems using finite volume method

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Acta Mechanica Sinica 2011年第5期27卷 706-712页

作者： Xin wei bing sun Institute of Telecommunication Satellite China Academy of Space Technology100194 Beijing China School of Astronautics Beihang University 100191 Beijing China

The fluid-structure interaction may occur in space launch vehicles,which would lead to bad performance of vehicles,damage equipments on vehicles,or even affect astronauts＇ *** this paper,analysis on dynamic behavior of liquid oxygen （LOX） feeding pipe system in a large scale launch vehicle is performed,with the effect of fluid-structure interaction （FSI） taken into *** pipe system is simplified as a planar FSI model with Poisson coupling and junction *** tests on pipes between the tank and the pump are solved by the finite volume *** show that restrictions weaken the interaction between axial and lateral *** reasonable results regarding frequencies and modes indicate that the FSI affects substantially the dynamic analysis,and thus highlight the usefulness of the proposed *** study would provide a reference to the pipe test,as well as facilitate further studies on oscillation suppression.

关键词： Fluid-structure interaction · Liquid oxygen · Finite volume method

Study on pressure wave propagation in two-phase flow in liquid oxygen feed pipe between pumps

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航空动力学报 2010年第10期25卷 2352-2357页

作者： wei Xin sun bing FANG Jie School of Astronautics Beijing University of Aeronautics and Astronautics Beijing 100191 China

A study on the character of pressure wave propagation was proposed for the gas liquid oxygen two-phase flow in the pipe between *** to the practical working conditions,the homogenous model based on the compressibility theory regarding a single bubble in an infinite liquid,and Redlich-Kwong gas equation was derived a model for the low temperature and high pressure case,especially considering the change of the ratio of density of gas to one of *** numerical tests were *** results not only show the agreement between numerical simulation for this model and experiment at the normal temperature and pressure is good,but also show that the modifications of the model for the low temperature and high pressure condition are *** study is of reference to further study of oscillation restrain and relative pipe tests.

关键词： two-phase flow pressure wave pipe between pumps phase velocity attenuation

Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min Xu Hai-Ying Jin Feng-Li sun wei-Dong Jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury