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Space advanced technology demonstration satellite

Science China(Technological Sciences) 2024年第1期67卷 240-258页

作者： ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI qi LI Fei liu Rui FENG ZhengGong liu liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang liu Shuo LI TianTong YU XianSheng GAO yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing yang YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI Xinqiao WEN Xiangyang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui yang JianFeng XUE HongBo SANG Peng liu JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu liu ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG xinyu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of China Beijing 100101China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Earth and Space Sciences Peking UniversityBeijing 100871China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China Shenyang Institute of Automation Chinese Academy of SciencesShenyang 110016China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Nanyang Technological University Singapore 569830Singapore Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100049China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Institute of Automation Chinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310058China

The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch *** as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,*** paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.

关键词： SATech-01 spacecraft design scientific instruments on-orbit performance

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Controllable preparation of graphene glass fiber fabric towards mass production and its application in self-adaptive thermal management

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Science Bulletin 2024年第17期69卷 2712-2722页

作者： Ruojuan liu Fan yang Shuting Cheng Xianghe Yue Fushun Liang Wenjuan Li Jingnan Wang qinchi Zhang Liangyu Zou Hao Yuan Yuyao yang Kangyi Zheng Longfei liu Mengxiong liu Wei Gu Ce Tu xinyu Mao Xiaobai Wang Yue qi Zhongfan liu Centre for Nanochemistry Beijing Science and Engineering Centre for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute(BGI) Beijing 100095China State Key Laboratory of Heavy Oil Processing College of ScienceChina University of PetroleumBeijing 102249China School of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China Soochow Institute for Energy and Materials Innovations(SIEMIS) College of EnergySoochow UniversitySuzhou 215006China Academy for Advanced Interdisciplinary Research North University of ChinaTaiyuan 030051China Department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China

Direct synthesis of graphene on nonmetallic substrates via chemical vapor deposition (CVD) has become a frontier research realm targeting transfer-free applications of CVD ***,the stable mass production of graphene with a favorable growth rate and quality remains a grand ***,graphene glass fiber fabric (GGFF) was successfully developed through the controllable growth of graphene on non-catalytic glass fiber fabric,employing a synergistic binary-precursor CVD strategy to alleviate the dilemma between growth rate and *** binary precursors consisted of acetylene and acetone,where acetylene with high decomposition efficiency fed rapid graphene growth while oxygencontaining acetone was adopted for improving the layer uniformity and ***,the bifurcating introducing-confluent premixing (BI-CP) system was self-built for the controllable introduction of gas and liquid precursors,enabling the stable production of *** features solar absorption and infrared emission properties,based on which the self-adaptive dual-mode thermal management film was *** film can automatically switch between heating and cooling modes by spontaneously perceiving the temperature,achieving excellent thermal management performances with heating and cooling power of~501.2 and~108.6 W m-2,*** findings unlock a new strategy for the large-scale batch production of graphene materials and inspire advanced possibilities for further applications.

关键词： Graphene Graphene glass fiber fabric Synergistic binary-precursor strategy Mass production Thermal management

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Paclitaxel-lipid prodrug liposomes for improved drug delivery and breast carcinoma therapy

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Chinese Chemical Letters 2024年第2期35卷 335-340页

作者： Xin Wu Xinmei Chen xinyu Wang Haisheng He Jianming Chen Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Shanghai Wei Er Lab Shanghai 201707China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Paclitaxel(PTX)is widely applied for the treatment of unresectable and metastasis breast carcinoma as well as other cancers,whereas its efficacy is always impeded by poor *** are one kind of the most successful drug carriers which are capable of solubilizing PTX and improving patients’tolerance owing to excellent biocompatibility and ***,poor compatibility between PTX and liposomes compromises the stability,drug loading and anti-tumor capacity of liposomal *** address this issue,three lipids with various chain lengths,namely,myristic acid(MA,14C),palmitic acid(PA,16C)and stearic acid(SA,18C),were conjugated to PTX via ester bonds and the synthesized prodrugs with high lipophilicity were further formulated into liposomes,*** liposomes show high stability and drug loadings,as well as sustained drug *** chain lengths of lipids are negatively correlated with drug release and enzymatic conversion rates,which further impact the pharmacokinetics,tumor accumulation,and anti-tumor efficacy of liposomal *** rapid nor slow drug release facilitates high tumor accumulation as well as anti-tumor efficacy of *** all liposomes,PTX-PA-loaded liposomes show the longest circulation and highest tumor accumulation of PTX and exert the most potent anti-tumor capacities in vivo,owing to its moderate drug release and enzymatic conversion *** its superior safety,PTX-PA liposomes hold potential for further clinical translation.

关键词： Paclitaxel Lipids Prodrugs Liposomes Drug release Chemotherapy

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Determining an optimal control strategy for anthropogenic VOC emissions in China based on source emissions and reactivity

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Journal of Environmental Sciences 2024年第2期136卷 248-260页

作者： Ruipeng Wang Xiaoqi Wang Shuiyuan Cheng Jiaxian Zhu xinyu Zhang Long Cheng Kai Wang Key Laboratory of Beijing on Regional Air Pollution Control Faculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

An evidence-based control strategy for emission reduction of VOC sources can effectively solve the regional PM2.5and O3compound pollution in *** estimated the anthropogenic VOC emission inventory in China in 2018 and established a source profile database containing 129 sources based on localized detection and the latest research ***,the distribution of the ozone formation potential(OFP)and secondary organic aerosol formation potential(SOAFP)for emission sources was ***,priority control routes for VOC emission sources were proposed for different *** VOC emissions in China reached 27,211.8 Gg in 2018,and small passenger cars,industrial protective coatings,biomass burning,heavy trucks,printing,asphalt paving,oil storage and transportation,coking,and oil refining were the main *** protective coatings,small passenger cars,and biomass burning all contributed significantly to OFP and *** in emission reduction control should be given to industrial protective coatings,small passenger cars,heavy trucks,coking,printing,asphalt paving,chemical fibers,and basic organic chemical sources over the medium and long term in *** addition,the priority control route for VOC emission sources should be adjusted according to the variations in VOC emission characteristics and regional differences,so as to obtain the maximum environmental benefits.

关键词： Volatile organic compounds Anthropogenic emission inventory Reactivity Emission projection Priority control route

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Comprehensive Risk Assessment of Sea Level Rise and Tropical Cyclones in Dongzhaigang Mangroves,China

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Chinese Geographical Science 2024年第4期34卷 631-646页

作者： DING Ruyi CAI Rongshuo YAN Xiuhua LI Cuihua WANG Cui NIE xinyu Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China

Mangroves play a pivotal role in tropical and subtropical coastal ecosystem,yet they are highly vulnerable to the effects of climate change,particularly the accelerated global sea level rise(SLR)and stronger tropical cyclones(TCs).However,there is a lack of research addressing future simultaneous combined impacts of the slow-onset of SLR and rapid-onset of TCs on China's *** order to develop a comprehensive risk assessment method considering the superimposed effects of these two factors and analyze risk for mangroves in Dongzhaigang,Hainan Island,China,we used observational and climate model data to assess the risks to mangroves under low,intermediate,and very high greenhouse gas(GHG)emission scenarios(such as SSP1-2.6,SSP2-4.5,and SSP5-8.5)in 2030,2050,and 2100,and compiled a risk assessment scheme for mangroves in Dongzhaigang,*** results showed that the combined risks from SLR and TCs will continue to rise;however,SLRs will increase in intensity,and TCs will *** comprehensive risk of the Dongzhaigang mangroves posed by climate change will remain low under SSP1-2.6 and SSP2-4.5 scenarios by 2030,but it will increase substantially by *** under SSP5-8.5 scenario,the risks to mangroves in Dongzhaigang are projected to increase considerably by 2050,and approximately 68.8%of mangroves will be at very high risk by *** risk to the Dongzhaigang mangroves is not only influenced by the hazards but also closely linked to their exposure and *** therefore propose climate resilience developmental responses for mangroves to address the effects of climate *** study for the combined impact of TCs and SLR on mangroves in Dongzhaigang,China can enrich the method system of mangrove risk assessment and provide references for scientific management.

关键词： mangrove climate change risk assessment combined hazards sea level rise(SLR) tropical cyclones(TCs) resilience development Dongzhaigang China

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Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging

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Genes & Diseases 2024年第5期11卷 407-427页

作者： Wenchao Wang Junjie qian Mingge Shang Yiting qiao Jiacheng Huang Xinxin Gao Zhou Ye xinyu Tong Kangdi Xu Xiang Li Zhengtao liu Lin Zhou Shusen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China NHC Key Laboratory of Combined Multi-organ Transplantation HangzhouZhejiang 310003China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic CancerChinese Academy of Medical Sciences(2019RU019)HangzhouZhejiang 310003China Key Laboratory of Organ Transplantation Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesHangzhouZhejiang 310003China Shulan International Medical College Zhejiang Shuren UniversityHangzhouZhejiang 310015China Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College HangzhouZhejiang 310000China

Aging is a contributor to liver ***,the concept of liver aging has become prominent and has attracted considerable interest,but its underlying mechanism remains poorly *** our study,the internal mechanism of liver aging was explored via multi-omics analysis and molecular experiments to support future targeted *** aged rat liver model was established with D-galactose,and two other senescent hepatocyte models were established by treating HepG2 cells with D-galactose and *** then performed transcriptomic and metabolomic assays of the aged liver model and transcriptome analyses of the senescent hepatocyte *** livers,genes related to peroxisomes,fatty acid elongation,and fatty acid degradation exhibited down-regulated expression with aging,and the hepatokine Fgf21 expression was positively correlated with the down-regulation of these *** senescent hepatocytes,similar to the results found in aged livers,FGF21 expression was also ***,the expressions of cell cycle-related genes were significantly down-regulated,and the down-regulated gene E2F8 was the key cell cycle-regulating transcription *** then validated that FGF21 overexpression can protect against liver aging and that FGF21 can attenuate the declines in the antioxidant and regenerative capacities in the aging *** successfully validated the results from cellular and animal experiments using human liver and blood *** study indicated that FGF21 is an important target for inhibiting liver aging and suggested that pharmacological prevention of the reduction in FGF21 expression due to aging may be used to treat liver aging-related diseases.

关键词： Antioxidant capability FGF21 Liver aging Liver regeneration Multiomics analysis

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DNA methylation of SMPD3-based diagnostic biomarkers of NASH and mild fibrosis

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Genes & Diseases 2024年第1期11卷 99-102页

作者： Na Wu Mofan Feng Siran Yue xinyu Shi Nan Tang Yalan Xiong Jianying Wang Lei Zhang Hualing Song Yi Shi Guang He Guang Ji Baocheng liu Shanghai Innovation Center of Traditional Chinese Medicine Health Service School of Public HealthShanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China

Non-alcoholic fatty liver disease(NAFLD)is a liver condition that is widely prevalent across the world.A considerable number of people with NAFLD have the potential to progress to a more severe form of the condition known as nonalcoholic steatohepatitis(NASH),accompanied by bridging *** advancement is more likely if the patient has metabolic risk factors such as obesity or type 2 diabetes that deteriorate over ***,even slight inflammation or fibrosis in NAFLD can significantly increase the likelihood of progression compared to steatosis *** underscores the importance of revising the present methods of monitoring NAFLD patients to ensure early detection and effective management of the disease.

关键词： NAFLD inflammation NASH

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基于改进EfficientNet的红外图像光伏组件故障识别研究

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仪器仪表学报 2024年第4期45卷 175-184页

作者：吕游郑茜齐欣宇房方刘吉臻华北电力大学新能源电力系统国家重点实验室北京102206 华北电力大学控制与计算机工程学院北京102206

光伏组件的故障会影响光伏阵列的输出性能,从而降低电站的发电效率,严重时甚至会危害电站的安全运行。传统的方法无法满足目前光伏组件故障检测快速性和正确率需求。因此,本文提出了一种基于改进EfficientNet的光伏组件故障识别方法。首... 详细信息

光伏组件的故障会影响光伏阵列的输出性能,从而降低电站的发电效率,严重时甚至会危害电站的安全运行。传统的方法无法满足目前光伏组件故障检测快速性和正确率需求。因此,本文提出了一种基于改进EfficientNet的光伏组件故障识别方法。首先,利用采集到的光伏组件红外图像建立故障数据集,并利用图像分割和数据增强对数据集进行预处理;其次,基于EfficientNet网络构建故障识别模型,同时在模型中引入双通道注意力模块(CBAM),该模块能够抑制不必要特征的识别,增强模型对空间特征信息的提取能力,进而提高模型的识别准确率;最后,通过对比仿真实验证明模型的有效性和先进性。实验结果表明,该模型的故障识别准确率达到了90.83%,相较于原始的EfficientNet模型提高了2.83%,且模型大小仅为20.3 M,具有良好的实用性,能够满足光伏电站实际应用的需求。

关键词：光伏组件红外图像故障识别 CBAM注意力机制

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Low-cost dopant-free fluoranthene-based branched hole transporting materials for efficient and stable n-i-p perovskite solar cells

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Chinese Chemical Letters 2024年第10期35卷 213-219页

作者： xinyu Yu Fei Wu Xianglang Sun Linna Zhu Baoyu Xia Zhong'an Li Key Laboratory for Material Chemistry of Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energy Faculty of Materials & Energy Southwest University

It has been widely recognized that hole transporting materials(HTMs) play a key role in the rapid progress of perovskite solar cells(PVSCs). However, common organic HTMs such as spiro-OMe TAD not only suffer from high synthetic costs, but also usually require the additional chemical doping process to improve their hole transport ability, which unfortunately induces the terrible stability issue. Therefore, it is urgent to develop low-cost dopant-free HTMs for efficient and stable PVSCs. In this work, we have successfully developed a new class of efficient dopant-free fluoranthene-based HTMs(TPF1–5) with quite low lab synthetic costs by combining donor-acceptor and branched structure designs. The detailed structure-property study revealed that tuning the twisted arms at different substitution sites would regulate the intermolecular interactions and film-forming ability, thereby significantly affecting the performance of the HTMs. By applying these HTMs in conventional PVSCs, the dopant-free TPF1-based devices not only achieved the best efficiency of 21.76%, which is comparable to that of the doped spiro-OMeTAD control devices, but also showed much better operational stability, which maintained over 87% of the initial efficiency under maximum power point tracking after 1038 h.

关键词： Dopant-free Fluoranthene Hole transporting materials Low-cost Perovskite solar cells

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Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

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Genes & Diseases 2024年第5期11卷 198-218页

作者： Han Sun Yafang Gao xinyu Ma Yizhou Deng Lintao Bi Lisha Li Department of Hematology and Oncology China-Japan Union HospitalJilin UniversityChangchunJilin 130021China The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchunJilin 130021China

Mechanical stimulation is the key physical factor in cell *** acts as a fundamental regulator of cell behavior,regulating cell proliferation,differentiation,apoptosis,and exhibiting specific signature alterations during the pathological *** research continues,the role of epigenetic science in mechanotransduction is attracting ***,the molecular mechanism of the synergistic effect between mechanotransduction and epigenetics in physiological and pathological processes has not been *** focus on how histone modifications,as important components of epigenetics,are coordinated with multiple signaling pathways to control cell fate and disease ***,we propose that histone modifications can form regulatory feedback loops with signaling pathways,that is,histone modifications can not only serve as downstream regulators of signaling pathways for target gene transcription but also provide feedback to regulate signaling *** and epigenetic changes could be potential markers and therapeutic targets in clinical practice.

关键词： FAK Histone modifications MAPK Mechanotransduction RhoA WNT/b-catenin YAP/TAZ

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