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Cost-benefit analysis of esophageal cancer endoscopic screening in high-risk areas of China

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World Journal of Gastroenterology 2012年第20期18卷 2493-2501页

作者： juan yang wen-Qiang wei Jin Niu Zhi-Cai Liu Chun-Xia yang You-Lin Qiao Department of Epidemiology West China School of Public Health Sichuan University Chengdu 610041 Sichuan Province China Department of Epidemiology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Thoracic-Surgery Linzhou Cancer Institute Linzhou 456550 Henan Province China

AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and the benefit-cost ratios(BCRs)of 12 EC endoscopic screening *** varied according to the targeted screening age,screening frequencies,and follow-up *** parameters were collected from population-based studies in China,published literatures,and surveillance data. RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life *** five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV(international dollar-I$55 million)and BCR(2.52).Screening six times between 40-70 years at a 5-year interval[i.e., six times(40)f-strategy]yielded the highest NPV(I$99 million)and BCR(3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR. CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of ***-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies.

关键词： Cost-benefit analysis Esophageal cancer Endoscopy Screening High-risk area

Efficacy comparison of multipoint and single point scanning panretinal laser photocoagulation in non-proliferative diabetic retinopathy treatment

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World Journal of Diabetes 2024年第8期15卷 1734-1741页

作者： yang-Zhou Zhang Hua Gong juan yang Ji-Pu Bu Hui-Ling yang Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Ophthalmology Xingsheng HospitalYiyang 413200Hunan ProvinceChina Department of Ophthalmology Boshi Eye HospitalLiuyang 410300Hunan ProvinceChina Department of Ophthalmology Hunan Children‘s HospitalChangsha 410007Hunan ProvinceChina

BACKGROUND Non-proliferative diabetic retinopathy(NPDR)poses a significant challenge in diabetes management due to its microvascular changes in the *** photocoagulation,a conventional therapy,aims to mitigate the risk of progressing to proliferative diabetic retinopathy(PDR).AIM To compare the efficacy and safety of multi-spot vs single-spot scanning panretinal laser photocoagulation in NPDR *** Forty-nine NPDR patients(86 eyes)treated between September 2020 and July 2022 were *** were randomly allocated into single-spot(n=23,40 eyes)and multi-spot(n=26,46 eyes)*** outcomes,including bestcorrected visual acuity(BCVA),central macular thickness(CMT),and mean threshold sensitivity,were assessed at predetermined intervals over 12 *** reactions were also *** Energy levels did not significantly differ between groups(P>0.05),but the multi-spot group exhibited lower energy density(P0.05).CONCLUSION While energy intensity and safety were comparable between modalities,multi-spot scanning demonstrated lower energy density and showed superior short-term improvements in BCVA and CMT for NPDR patients,with reduced laser-induced damage.

关键词： Panretinal laser photocoagulation Non-proliferative diabetic retinopathy Efficacy comparison Multipoint Single point Treatment assessment

Metaplastic breast cancer with chondrosarcomatous differentiation combined with concurrent bilateral breast cancer:A case report

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World Journal of Clinical Cases 2022年第15期10卷 5064-5071页

作者： Si-Yuan yang yang Li Jian-Yun Nie Shou-Tao yang Xiao-juan yang Mao-Hua Wang Ji Zhang Department of Breast Surgery The Third Affiliated Hospital of Kunming Medical UniversityKunming 650118Yunnan ProvinceChina Department of Digestive Medicine The First Affiliated Hospital of Kunming Medical UniversityKunming 650118Yunnan ProvinceChina

BACKGROUND Metaplastic breast carcinoma(MBC)is a rare subtype of invasive breast cancer comprising malignant epithelial and mesenchymal *** with other invasive breast cancers,MBC is not only histologically distinctly heterogeneous but also has a rapid and aggressive growth pattern,which leads to a significant risk of recurrence and *** SUMMARY In this study,we report the case of a patient with a large left breast mass diagnosed with bilateral invasive ductal carcinoma in both breasts after a preoperative core needle aspiration biopsy of the bilateral breast *** patient received neoadjuvant chemotherapy and underwent bilateral breast modified radical *** pathology suggested carcinosarcoma with predominantly chondrosarcoma in the left breast and invasive ductal carcinoma(luminal B)in the right *** the patient did not achieve complete pathological remission after six cycles of neoadjuvant chemotherapy,we administered six months of intensive capecitabine *** the patient was switched to continuous treatment with endocrine therapy using letrozole+goserelin,and the patient is currently in stable ***,as MBC of the breast is concurrently diagnosed with chondrosarcoma differentiation,our case is *** Given the variety of immunohistochemical types of bilateral breast cancer,achieving effective chemotherapy should be a key research focus.

关键词： Metaplastic breast cancer Invasive ductal carcinoma Carcinosarcoma Chondrosarcoma differentiation Bilateral breast cancer Case report

Role of Ni(NO_3)_2 in the preparation of a magnetic coal-based activated carbon

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Mining Science and Technology 2011年第4期21卷 599-603页

作者： ZhangJun Xie Qiang Liu juan yang Mingshun Yao Xing School of Chemical and Environmental Engineering China University of Mining Technology Beijing 100083 China

The role of Nil（NO3）2 in the preparation of a magnetic activated carbon is reported in this paper. Magnetic coal-based activated carbons （MCAC） were prepared from Taixi anthracite with low ash content in the presence of Ni（NO3）2. The MCAC materials were characterized by a vibrating sample magnetometer （VSM）, X-ray diffraction （XRD）, a scanning electric microscope （SEM）, and by N2 adsorption. The cylindri- cal precursors and derived char were also subjected to thermogravimetric analysis to compare their behavior of weight losses during carbonization. The results show that MCAC has a larger surface area （1074 m21g） and a higher pore volume （0.5792 cm3/g） with enhanced mesopore ratio （by about 10~）. It also has a high saturation magnetization （1.6749 emu/g） and low coercivity （43.26 Oe）, which allows the material to be magnetically separated. The MCAC is easily magnetized because the nickel salt is con- vetted into Ni during carbonization and activation. Metallic Ni has a strong magnetism on account of electrostatic interaction. Added Ni（NO3）2 catalyzes the carbonization and activation process by accelerat- ing burn off of the carbon, which contributes to the development of mesopores and macropores in the activated carbon.

关键词： Magnetic coal-based activated carbon Ni(NO3)2 Magnetic properties Pore structure

Genotypic and environmental variation in barley limit dextrinase activity and its relation to malt quality

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第5期7卷 386-392页

作者： WANG Xu-dong yang juan ZHANG Guo-ping Department of Agronomy Zhefiang University Hangzhou 310029 China

Variation in the limit dextrinase activity of barley malt, and the relationships between limit dextrinase activity and malt quality parameters were investigated using eight cultivars grown at seven diverse locations in China for two successive years. Limit dextrinase activity varied with genotype and location, with the levels ranging from 0.245 U/g to 0.980 U/g. The results showed that the variation in limit dextrinase activity was more attributable to the environment (location and year) than to the genotype. The response of limit dextrinase activity to the environment differed markedly among cultivars, and was reflected by large difference in coefficient of variation of cultivars across diverse locations. Regression analysis showed that limit dextrinase activity was negatively correlated with malt viscosity (r=?0.52, P<0.01), positively correlated with Kolbach index (r=0.38, P<0.01) and malt extract (r=0.30, P<0.05), but had no significant correlation with malt protein content and diastatic power.

关键词： Barley (Hordeum vulgare L.) Limit dextrinase activity Genotype Environment Malt quality

Radial deformation of single-walled carbon nanotubes on quartz substrates and the resultant anomalous diameter-dependent reaction selectivity

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Nano Research 2015年第9期8卷 3054-3065页

作者： juan yang Yu Liu Daqi Zhang Xiao Wang Ruoming Li Yan Li Beijing National Laboratory for Molecular Sciences Key Laboratory for the Physics and Chemistry of Nanodevices State KeyLaboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871 China

Owing to the unique conjugated structure, the chemical-reaction selectivity of single-walled carbon nanotubes （SWNTs） has attracted great attention. By utilizing the radial deformation of SWNTs caused by the strong interactions with the quartz lattice, we achieve an anomalous diameter-dependent reaction selectivity of quartz lattice-oriented SWNTs in treatment with iodine vapor; this is distinctly different from the widely reported and well accepted higher reaction activity in small-diameter tubes compared to large-diameter tubes. The radial deformation of SWNTs on quartz substrate is verified by detailed Raman spectroscopy and mappings in both G-band and radial breathing mode. Due to the strong interaction between SWNTs and the quartz lattice, large-diameter tubes present a larger degree of radial deformation and more delocalized partial electrons are distributed at certain sidewall sites with high local curvature. It is thus easier for the carbon--carbon bonds at these high-curvature sites on large-diameter tubes to break down during reaction. This anomalous reaction activity offers a novel approach for selective removal of small-band^aD large-diameter tubes.

关键词： single-walled carbonnanotubes,reaction selectivity,interaction,quartz substrate,radial deformation

High spatial resolution spectroscopy of G292.0+1.8 with Chandra

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Research in Astronomy and Astrophysics 2014年第10期14卷 1279-1288页

作者： Xue-juan yang Xiao-Qin Liu Shun-Yu Li Fang-Jun Lu Faculty of Materials Optoelectronics and PhysicsXiangtan University Particle Astrophysics Center Institute of High Energy PhysicsChinese Academy of Sciences

We present high spatial resolution X-ray spectroscopy of supernova rem- nant G292.0＋1.8 made with Chandra observations. The X-ray emitting region of this remnant was divided into 25 × 25 pixels with a scale of 20＂ × 20＂ each. Spectra of 328 pixels were created and fitted with an absorbed one component non-equilibrium ionization model. With the spectral analysis results, we obtained maps of absorbing column density, temperature, ionization age and abundances for O, Ne, Mg, Si, S and Fe. The abundances of O, Ne and Mg show tight correlations between each other in the range of about two orders of magnitude, suggesting that they are all from explo- sive C/Ne burning. Meanwhile, the abundances of Si and S are also well correlated, indicating that they are the ashes of explosive O-burning or incomplete Si-burning. The Fe emission lines are not prominent in the whole remnant, and their abundance is significantly reduced, indicating that the reverse shock may not have propagated to the Fe-rich ejecta. Based on relative abundances of O, Ne, Mg, Si and Fe to Si, we suggest a progenitor mass of 25 - 30 M⊙ for this remnant.

关键词： ISM supernova remnants -- ISM individual G292.0+1.8

Determination of optimal grid opening width for herringbone water-sediment separation structures based on sediment separation efficiency

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Journal of Mountain Science 2019年第3期16卷 619-629页

作者： XIE Xiang-ping WEI Fang-qiang WANG Xiao-jun yang Hong-juan Anyang Institute of Technology Chongqing Institutes of Green and Intelligent Technology Chinese Academy of Science Institute of Mountain Hazards and Environment Chinese Academy of Sciences

The herringbone water-sediment separation structure(HWSSS) was developed to prevent debris flows. This paper mainly focuses on evaluating the sediment separation efficiency of HWSSS in debris flow prevention and determining the grid opening width D, a crucial structure parameter for HWSSS design. Theoretical analysis on the total sediment separation rate Pt reveals that the efficiency of sediment separation is much related with sediment grain size distribution(GSD) and grid opening width. The lower limit of Pt is deduced from the perspective of safety consideration by transforming debris flow into sediment-laden flow. Hydraulic model tests were carried out. Based on the regression analysis of the experimental data, the quantitative relationships between Pt and D and GSD characteristic values were finally established. A procedure for determining optimal grid opening width is proposed based on these analyses. These results are of significance in evaluating sediment separation effect by HWSSS in debris flow prevention and contribute to a more explicit methodology for design of HWSSS.

关键词： Debris flow Water-sediment separation Structure design Sediment separation efficiency Grid opening width

Effect of early stepwise cardiopulmonary rehabilitation on function and quality of life in sepsis patients

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World Journal of Clinical Cases 2024年第4期12卷 729-736页

作者： Ming-Hui Zheng Wen-Jun Liu juan yang Division of Cardiovascular First Ward Departments of Internal Medicine Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Department of Respiratory Medicine PuRen Hospital Affiliated to Wuhan University of Science and Technology/Respiratory MedicineWuhan 430000Hubei ProvinceChina Department of Cardiology Huanggang Central HospitalHuanggang 438000Hubei ProvinceChina

BACKGROUND Sepsis,as a non-limiting host infection disease,can be accompanied by serious complications such as organ failure,which seriously threatens patient quality of *** To investigate the effect of early stepwise cardiopulmonary rehabilitation on cardiopulmonary function and quality of life in patients evacuated from mechanical ventilation with *** A total of 80 patients with sepsis who were hospitalized in our hospital from January 2021 to January 2022 were selected and divided into the observation group(n=40)and the control group(n=40)according to the random number table *** observation group was treated with early stepwise cardiopulmonary rehabilitation,and the control group was treated with a conventional treatment *** function indexes(central venous pressure,cardiac troponin I,B-type brain natriuretic peptide),lung function indicators(diaphragmatic mobility,changes in central venous oxygen saturation,oxygenation index),and quality of life(Quality of Life Evaluation Scale)were compared between the two groups after *** After treatment,the central venous pressure,diaphragm mobility,central venous oxygen saturation,oxygenation index,and Quality of Life Evaluation Scale scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The observation group was less than that of the control group for other parameters,and the differences were statistically significant(P<0.05).CONCLUSION Early stepwise cardiopulmonary rehabilitation can effectively enhance cardiac and pulmonary function and improve the quality of life in patients evacuated from mechanical ventilation with sepsis.

关键词： Stepwise cardiopulmonary rehabilitation Sepsis Evacuation of mechanical ventilation Cardiopulmonary function Quality of life