检索结果-南通市图书馆

同方期刊数据库

Association between triglyceride-glucose index and colorectal polyps:A retrospective cross-sectional study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 55-63页

作者： Ya-Jie Teng Ying-Xue yang jing-jing yang Qiu-Yan Lu Jia-Yi Shi Jian-Hao Xu Jie Bao Qing-Hua Wang Department of Gastroenterology The First People's Hospital of KunshanSuzhou 215300Jiangsu ProvinceChina Department of Pathology The First People's Hospital of KunshanSuzhou 215300Jiangsu ProvinceChina

BACKGROUND Colorectal polyps(CPs)are frequently occurring abnormal growths in the colorectum,and are a primary precursor of colorectal cancer(CRC).The triglyceride-glucose(TyG)index is a novel marker that assesses metabolic health and insulin resistance,and has been linked to gastrointestinal *** To investigate the potential association between the TyG index and CPs,as the relation between them has not been *** A total of 2537 persons undergoing a routine health physical examination and colonoscopy at The First People's Hospital of Kunshan,Jiangsu Province,China,between January 2020 and December 2022 were included in this retrospective cross-sectional *** excluding individuals who did not meet the eligibility criteria,descriptive statistics were used to compare characteristics between patients with and without *** regression analyses were conducted to determine the associations between the TyG index and the prevalence of *** TyG index was calculated using the following formula:Ln[triglyceride(mg/dL)×glucose(mg/dL)/2].The presence and types of CPs was determined based on data from colonoscopy reports and pathology *** A nonlinear relation between the TyG index and the prevalence of CPs was identified,and exhibited a curvilinear pattern with a cut-off point of 2.31.A significant association was observed before the turning point,with an odds ratio(95% confidence interval)of 1.70(1.40,2.06),P<***,the association between the TyG index and CPs was not significant after the cut-off point,with an odds ratio(95% confidence interval)of 0.57(0.27,1.23),P=*** Our study revealed a curvilinear association between the TyG index and CPs in Chinese individuals,suggesting its potential utility in developing colonoscopy screening strategies for preventing CRC.

关键词： Triglyceride-glucose index Colorectal polyps Colorectal cancer Insulin resistance Cross-sectional study

Rapid detection of the rice false smut fungus Ustilaginoidea virens by lateral flow strip-based recombinase polymerase amplification assay

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第11期23卷 3763-3773页

作者： Jiacheng Xi Sanlian Wan Yue Li Yuandi Xu jing yang Ting Zhang Jiajia Chen Zhengguang Zhang Danyu Shen Haifeng Zhang Sanya Institute of Nanjing Agricultural University/Key Laboratory of Integrated Management of Crop Diseases and Pests of Ministry of Education Department of Plant Pathology College of Plant Protection Nanjing Agricultural University Sanya Extension Service Center for Agricultural Technology College of Landscape Architecture Jiangsu Vocational College of Agriculture and Forestry

Rice false smut, caused by Ustilaginoidea virens, is a devastating disease that greatly reduces rice yield and ***, controlling rice false smut disease is challenging due to the unique infection mode of U. virens. Therefore,there is a need for early diagnosis and monitoring techniques to prevent the spread of this disease. Lateral flow strip-based recombinase polymerase amplification(LF-RPA) overcomes the limitations of current U. virens detection technologies, which are time-consuming, require delicate equipment, and have a high false-positive rate. In this study, we used a comparative genomics approach to identify Uv＿3611, a specific gene of U. virens, as the target for the LF-RPA assay. The designed primers and probe efffectively detected the genomic DNA(gDNA) of U. virens and demonstrated no cross-reactivity with related pathogens. Under optimal conditions, the LF-RPA assay demonstrated a sensitivity of 10 pg of U. virens gDNA. Additionally, by incorporating a simplified PEG-NaOH method for plant DNA extraction, the LF-RPA assay enabled the detection of U. virens in rice spikelets within 30 min, without the need for specialized equipment. Furthermore, the LF-RPA assay successfully detected U. virens in naturally infected rice and seed samples in the field. Therefore, the LF-RPA assay is sensitive, efficient, and convenient, and could be developed as a kit for monitoring rice false smut disease in the field.

关键词： rice false smut Ustilaginoidea virens isothermal amplification disease monitoring field diagnosis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

纵向非均匀温度下钢柱弹性屈曲荷载

工程力学 2024年第6期41卷 202-211,256页

作者：王卫永杨竞杰重庆大学土木工程学院重庆400045 重庆大学山地城镇建设与新技术教育部重点实验室重庆400045

在大空间建筑火灾中,由于热空气的上升,在纵向空间上的温度分布常常是不均匀的,上部的温度会远远高于下部的温度。该现象在火灾的轰燃发生后是十分显著的。在钢柱的抗火设计中考虑纵向温度的不均匀分布不仅符合实际情况,也更符合基于性... 详细信息

在大空间建筑火灾中,由于热空气的上升,在纵向空间上的温度分布常常是不均匀的,上部的温度会远远高于下部的温度。该现象在火灾的轰燃发生后是十分显著的。在钢柱的抗火设计中考虑纵向温度的不均匀分布不仅符合实际情况,也更符合基于性能化的抗火设计理念。该文先以无端部约束钢柱为研究对象并假定其横截面上的温度均匀分布,基于能量法推导了其在一般场模型火灾条件下的弹性屈曲荷载;在简化的双区域火灾模型条件下,分别基于平衡微分方程以及能量法推导其弹性屈曲荷载,并采用数值分析对推导结果进行验证。发现基于平衡微分方程推导的精确解相较于数值模拟结果,误差均小于3%,而基于能量法推导的结果则在部分情况下显著偏大。此外,研究结果表明:如果忽略温度的纵向不均匀分布,对于受热长度与非受热长度等长的钢柱,其弹性临界荷载会被严重低估,甚至达到约37%。考虑柱端轴向约束的作用,该文给出了不均匀温度分布条件下约束柱的弹性屈曲荷载计算方法。

关键词：钢结构弹性屈曲能量法抗火轴向约束非均匀温度

Research progress on the mechanism of exercise fatigue and the role of probiotics in counteracting it

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Food and Health 2024年第3期6卷 33-41页

作者： Zi-Xia Chen jing yang Jia-Jia Song Hua-Yi Suo College of Food Science Southwest UniversityChongqing400715China Chongqing Engineering Research Center for Processing&Storage of Distinct Agricultural Products Chongqing Technology and Business UniversityChongqing 400067China

Exercise fatigue is a physiological phenomenon where the body cannot maintain a specific level after being stimulated by excessive *** five main theories include“energy depletion”,“accumulation of metabolites”,“homeostasis disorder of the internal environment”,“free radicals”,and“central nervous system protection inhibition”.The imbalance of intestinal flora caused by vigorous exercise can further lead to ***,maintaining healthy intestinal flora is crucial for athlete health and *** studies have demonstrated that probiotics can regulate intestinal flora and alleviate exercise fatigue;however,there are no systematic reviews on the anti-fatigue effects of *** on the mechanisms of exercise-induced fatigue,this article summarizes the effects and mechanisms by which probiotics combat exercise fatigue,aiming to provide research ideas for the development of probiotics that prevent exercise fatigue.

关键词： probiotics gut microbiota exercise fatigue mechanism

Amelanotic primary cervical malignant melanoma:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第7期15卷 953-960页

作者： Jin-Lin Duan jing yang Yong-Long Zhang Wen-Tao Huang Department of Pathology The Affiliated Tongren HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200332China Laboratory of Targeted Therapy and Precision Medicine Department of Clinical LaboratoryShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Primary malignant melanoma of the cervix(PMMC)is an extremely rare disease that originates from primary cervical malignant melanoma and frequently re-presents a challenge in disease diagnosis due to unclarified clinical and histo-logical presentations,particularly those without *** SUMMARY Here,we report a case of amelanotic PMMC,with a history of breast cancer and thyroid *** patient was finally diagnosed by immunohistochemical staining and staged as IB2 based on the International Federation of Gynecology and Obstetrics with reference to National Comprehensive Cancer Network guide-lines and was treated with radical hysterectomy,bilateral salpingo-oophorectomy and pelvic *** then received combination therapy consisting of immunotherapy with tislelizumab and radiofrequency *** has remained free of disease for more than 1 *** The differential diagnosis process reenforced the notion that immunohisto-chemical staining is the most reliable approach for amelanotic PMMC *** to the lack of established therapeutic guidelines,empirical information from limited available studies does not provide the rationale for treatment-decision *** integrating'omics'technologies and patient-derived xenografts or mini-patient-derived xenograft models this will help to identify selective thera-peutic window(s)and screen the appropriate therapeutics for targeted therapies,immune checkpoint blockade or combination therapy strategies effectively and precisely that will ultimately improve patient survival.

关键词： Primary cervical malignant melanoma MelanA Immunotherapy Patient management Case report

直接酯化法合成月桂酸单甘油酯及对金黄色葡萄球菌的抑菌性能研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

功能材料 2024年第7期55卷 7015-7021页

作者：张轩杨婧陕西科技大学环境科学与工程学院西安710021

选择月桂酸和甘油为原料、对甲苯磺酸为催化剂,通过单因素试验测定了反应温度、反应时间、搅拌速度、原料摩尔比、催化剂用量等对月桂酸单甘油酯(GML)纯度的影响,研究了GML浓度和pH值变化对金黄色葡萄球菌的抑制效果。结果表明,在n(甘油... 详细信息

选择月桂酸和甘油为原料、对甲苯磺酸为催化剂,通过单因素试验测定了反应温度、反应时间、搅拌速度、原料摩尔比、催化剂用量等对月桂酸单甘油酯(GML)纯度的影响,研究了GML浓度和pH值变化对金黄色葡萄球菌的抑制效果。结果表明,在n(甘油)∶n(月桂酸)=3∶1,反应温度为180℃,反应时间为3.5 h,搅拌速度为250 r/min,对甲苯磺酸用量为0.4%(质量分数)条件下制备出的GML纯度最高,该工艺为最优合成工艺;正交试验测试表明,合成温度对GML纯度的影响最大,最优合成工艺下制备出的GML初始纯度为47.7%,提纯后纯度可达97.2%。抑菌性能测试表明,GML对金黄色葡萄球菌的抑制效果与其浓度呈正相关,当浓度达到12 mg/mL时,抑菌圈的直径达到了最大值16.1 mm;GML对金黄色葡萄球菌的抑菌率均随着时间的增加逐渐降低,在pH值=5.7和7.2的条件下,GML对金黄色葡萄球菌的抑菌半衰期分别为54和49 h,可见弱酸条件下GML对金黄色葡萄球菌的抑菌半衰期更大,抑菌效果更佳。

关键词：月桂酸单甘油酯最优工艺单因素试验金黄色葡萄球菌抑菌性能

在线全文

学校读者我要写书评

暂无评论

数字劳动的理论化研究新进展

经济学动态 2024年第5期 143-160页

作者：杨静郑嵘中国社会科学院大学马克思主义学院 102488 中国社会科学院马克思主义研究院

国外学者主要以“数字劳动”这一术语来涵盖在数字技术变革背景下出现的在线产消实践和经过数字技术改造的传统劳动实践。数字劳动是理解当代资本主义发展新动态的一把新钥匙,将数字劳动这一新现象进行系统的理论化,是数字经济时代理论... 详细信息

国外学者主要以“数字劳动”这一术语来涵盖在数字技术变革背景下出现的在线产消实践和经过数字技术改造的传统劳动实践。数字劳动是理解当代资本主义发展新动态的一把新钥匙,将数字劳动这一新现象进行系统的理论化,是数字经济时代理论研究的前沿问题之一。本文系统梳理了国外社会科学界涉及数字劳动理论化研究的最新进展,从国外数字劳动理论化研究的三个重要方面来进行归纳总结和深入分析。首先,扎根理论学者从对数字劳动现象的直接经验观察中建构扎根理论模型,以扎根理论为方法论,主要对零工平台与数字劳动者之间的互动实践进行多维度理论阐释,以填补既有社会科学理论无法对数字劳动新实践提供直接适用理论的空白。其次,传播政治经济学者主张复兴马克思的劳动价值理论,以此来解释在线产消实践与社交媒体平台的价值创造和价值实现之间的关系,并引发了如何正确理解和应用马克思的劳动价值理论的相关争论。再次,劳动过程理论学者主张将数字劳动研究的焦点转移到零工劳动实践上来,在独立的劳动过程理论框架下研究零工劳动者遭受的平台控制及其反抗实践。最后,本文对相关研究进展进行了评述并对未来研究方向进行了展望。

关键词：数字劳动扎根理论劳动价值理论劳动过程理论

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu jing yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Whole-genome Sequencing Reveals Autooctoploidy in Chinese Sturgeon and Its Evolutionary Trajectories

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第1期22卷 51-65页

作者： Binzhong Wang Bin Wu Xueqing Liu Yacheng Hu Yao Ming Mingzhou Bai Juanjuan Liu Kan Xiao Qingkai Zeng jing yang Hongqi Wang Baifu Guo Chun Tan Zixuan Hu Xun Zhao Yanhong Li Zhen Yue Junpu Mei Wei Jiang Yuanjin yang Zhiyuan Li Yong Gao Lei Chen Jianbo Jian Hejun Du Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Yichang 443100China Chinese Sturgeon Research Institute China Three Gorges CorporationYichang 443100China yangtze River Biodiversity Research Center China Three Gorges CorporationWuhan 430014China BGI-Shenzhen Shenzhen 518083China BGI Genomics BGI-ShenzhenShenzhen 518083China Department of Biotechnology and Biomedicine Technical University of DenmarkLyngby 2800Denmark River Basin Complex Administration Center China Three Gorges CorporationYichang 443100China BGI-Sanya BGI-ShenzhenSanya 572025China yangtze Eco-Environment Engineering Research Center China Three Gorges CorporationBeijing 100038China

The order Acipenseriformes,which includes sturgeons and paddlefishes,represents“living fossils”with complex genomes that are good models for understanding whole-genome duplication(WGD)and ploidy evolution in ***,we sequenced and assembled the first high-quality chromosome-level genome for the complex octoploid Acipenser sinensis(Chinese sturgeon),a critically endangered species that also represents a poorly understood ploidy group in *** results show that *** is a complex autooctoploid species containing four kinds of octovalents(8n),a hexavalent(6n),two tetravalents(4n),and a divalent(2n).An analysis taking into account delayed rediploidization reveals that the octoploid genome composition of Chinese sturgeon results from two rounds of homologous WGDs,and further provides insights into the timing of its ploidy *** study provides the first octoploid genome resource of Acipenseriformes for understanding ploidy compositions and evolutionary trajectories of polyploid fishes.

关键词： Chinese sturgeon Whole-genome sequencing Autooctoploid Polyploidization and diploidization Whole-genome duplication