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Effects of chitosan/collagen substrates on the behavior of rat neural stem cells

science china(life sciences) 2010年第2期53卷 215-222页

作者： yang zhaoyang1,mo linhong2.duan hongmei2.& li xiaoguang1,2.1 school of biological science and medical engineering,beihang university,beijing 100191,china 2 beijing Institute for Neuroscience,Capital medical university,beijing 100069,china 1. school of biological science and medical engineering Beihang University Beijing 100191 China2. Beijing Institute for Neuroscience Capital Medical University Beijing 100069 China

Spinal cord and brain injuries usually lead to cavity *** transplantation by combining stem cells and tissue engineering scaffolds has the potential to fill the cavities and replace the lost neural *** chitosan and collagen have their unique *** this study,the effects of chitosan and collagen on the behavior of rat neural stem cells (at the neurosphere level) were tested in vitro in terms of cytotoxicity and supporting ability for stem cell survival,proliferation and *** the serum-free condition,both chitosan membranes and collagen gels had low cytotoxicity to *** is,cells migrated from neurospheres,and processes extended out from these neurospheres and the differentiated *** with the above two materials,chitosan-collagen membranes were more suitable for the co-culture with rat neural stem cells,because,except for low cytotoxicity and supporting ability for the cell survival,in this group,a large number of cells were observed to migrate out from neurospheres,and the differentiating percentage from neurospheres into neurons was significantly *** modification of chitosan-collagen membranes may shed light on in vivo nerve regeneration by transplanting neural stem cells.

关键词： chitosan collagen neural stem cells biocompatibility differentiation

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