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Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke

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Neural Regeneration Research 2024年第2期19卷 409-415页

作者： Hongmei Duan Shulun li Peng Hao Fei Hao Wen Zhao Yudan Gao hui {2. Yiming Gu yang Lv Xinjie Bao Kin Chiu Kwok-Fai So {2. yang xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Department of Epidemiology and Statistics School of Public Health and ManagementNingxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Physical Education Capital University of Economics and BusinessmBeijingChina Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Psychology State Key Lab of Brain and Cognitive SciencesThe University of Hong KongHong Kong Special Administration RegionChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain ***,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still *** this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in *** gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional *** study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.

关键词： adult endogenous neurogenesis angiogenesis basic fibroblast growth factor-chitosan gel chitosan functional recovery ischemic stroke neural stem cell newborn neuron

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Effects of the CNTF-collagen gel-controlled delivery system on rat neural stem/progenitor cells behavior

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science China(life sciences) 2010年第4期53卷 504-510页

作者： yang zhaoyang1, qiao hui2.& li xiaoguang1,{2., beihang university, beijing 100191, China 2.ublic Heath school, Ningxia medical university, Yinchuan 750004, China 3beijing Institute for Neuroscience, Capital medical university, beijing 100069, China 1. school of biological {2. and medical engineering Beihang University Beijing 100191 China2. Public Heath School Ningxia Medical University Yinchuan 750004 China3. Beijing Institute for Neuroscience Capital Medical University Beijing 100069 China

The injury of central nervous system (CNS) usually causes the cavity formation. Although transplantation of neural stem/precursor cells (NSPCs) into the lesioned area of CNS has been shown to be implicated in the functional restoration, the therapeutic result is limited by the poor survival of NSPCs as well as their insufficient proliferation and differentiation abilities. Type-1 collagen is considered as a candidate scaffold or drug delivery system to overcome the aforementioned obstacle. This study observed the effects of the CNTF (ciliary neurotrophic factor)-collagen gel-controlled delivery system and daily addition of soluble-form CNTF on the NSPC survival, migration, proliferation and differentiation. The results showed that, within 12.h of the initial co-culture, CNTF was released in a burst pattern, then the CNTF-collagen gel-controlled delivery system stably released CNTF for up to 12.d. The cell viability test, together with immunohistochemistry, RT-PCR and Western blotting, showed that the CNTF-collagen gel-controlled delivery system supported the NSPCs seeded on the surface of collagen gel survival and facilitated their migration and proliferation. The daily addition of soluble-form CNTF to the medium had similar effects to the CNTF-collagen gel-controlled delivery system, but large quantities of soluble-form CNTF were consumed during the entire process. Taken together, the CNTF-collagen gel-controlled delivery system not only provides a physical scaffold for the transplanted NSPCs to adhere and migrate, but also facilitates the NSPC survival, growth and proliferation, simultaneously reducing the consumption of the expensive growth factors. This system may be used to enhance the microenvironment in the lesioned area of CNS.

关键词： spinal cord neural stem/progenitor cells control release type-1 collagen CNTF

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Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors

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Biomedical and Environmental sciences 2024年第2期37卷 133-145页

作者： liU Xiao CAO Ying liN Xiao Wan GAO Dan {2. MIAO hui hui li Tian Zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ***,the underlying mechanism is yet *** study aimed to explore the changes in metabolites in three specific brain regions and saliva of older mice with postoperative delirium behavior and to identify potential non-invasive *** Eighteen-month-old male C57/BL6 mice were randomly assigned to the anesthesia/surgery or control *** tests were conducted 2. h before surgery and 6,9,and 2. h after *** C3(C3)and S100 calcium-binding protein B protein(S100beta)levels were measured in the hippocampus,and a metabolomics analysis was performed on saliva,hippocampus,cortex,and amygdala *** In total,43,33,38,and 14 differential metabolites were detected in the saliva,hippocampus,cortex,and amygdala,respectively.“Pyruvate”“alpha-linolenic acid”and“2.oleoyl-1-palmitoy-snglycero-3-phosphocholine”are enriched in one common pathway and may be potential non-invasive biomarkers for *** changes were observed in the three brain regions,with the upregulation of 1-methylhistidine and downregulation of *** Dysfunctions in energy metabolism,oxidative stress,and neurotransmitter dysregulation are implicated in the development of *** identification of changes in the level of salivary metabolite biomarkers could aid in the development of noninvasive diagnostic methods for POD.

关键词： Metabolomic Postoperative delirium(POD) Mechanism biological marker

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Responses of osteoblasts under varied tensile stress types induced by stretching basement materials

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International Journal of Smart and Nano Materials 2024年第2期15卷 279-295页

作者： Xuezheng Geng qiao li Yan Yao lizhen Wang Yubo Fan beijing Advanced Innovation Center for Biomedical {2. School of Biological Science and Medical EngineeringKey Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of EducationBeijingChina school of engineering Medicine Beihang UniversityBeijingChina

Osteoblasts are mechanosensitive *** stress with different conditions,including loading time,frequency,magnitude,*** cause varied responses in ***,it was not clarified that the effect of the loading types on the *** this study,we focused on the effect of varied tensile stress types on osteoblasts,including isotropic stretch,biaxial stretch,and uniaxial stretch with the negative ratio of transverse strain to axial strain(NR)-1,0,and 0.2.*** proliferation was determined to be most efficient when stimulated by 6%strain at a frequency of 1 Hz and a negative value of 0 for 1 h/*** varied strain resulted in a thickening of the F-actin cytoskeleton and a thinning of the *** flattening caused Yes-associated protein(YAP)to be transported to the *** was suggested that the influence of loading types on the mechanobiology responses must be *** mechanism of cell mechanical sensitivity under varied loading types was explored,which would provide good sugges-tions for designing microstructures to control deformation patterns in bone tissue engineering.

关键词： MC3T3-E1 tensile stress negative poisson’s ratio cell proliferation YAP

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DNA methylation clocks for estimating biological age in Chinese cohorts

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Protein & Cell 2024年第8期15卷 575-593页

作者： Zikai Zheng Jiaming li Tianzi liu Yanling Fan qiao-Cheng Zhai Muzhao Xiong qiao-Ran Wang Xiaoyan Sun Qi-Wen Zheng Shanshan Che Beier jiang Quan Zheng Cui Wang lixiao liu Jiale Ping Si Wang Dan-Dan Gao Jinlin Ye Kuan {2. Yuesheng Zuo Shuai Ma Yun-Gui{2. Jig Qu Feng Zhang Peilin Jia Guang-hui liu Weiqi Zhang CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China university of Chinese Academy of sciences Beijing 100049China CAS Key Laboratory of Computational Biology Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China Division of Orthopaedics Quzhou Affliated Hospital of Wenzhou Medical UniversityQuzhou 324000China The Joint Innovation Center for engineering in Medicine Quzhou Affliated Hospital of Wenzhou Medical UniversityQuzhou 324000China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerXuanwu HospitalCapital Medical UniversityBeijing 100053China Aging Biomarker Consortium Beijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China nstitute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China

Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG ***,a systematic comparison between DNA methylation data and other omics datasets has not yet been ***,available DNAm age predictors are based on datasets with limited ethnic *** address these knowledge gaps,we generated and analyzed DNA methylation datasets from two independent Chinese cohorts,revealing age-related DNAm ***,a DNA methylation aging clock(iCAS-DNAmAge)and a group of DNAm-based multi-modal clocks for Chinese individuals were developed,with most of them demonstrating strong predictive capabilities for chronological *** clocks were further employed to predict factors influencing aging *** DNAm aging clock,derived from multi-modal aging features(compositeAge-DNAmAge),exhibited a close association with multi-omics changes,lifestyles,and disease status,underscoring its robust potential for precise biological age *** findings offer novel insights into the regulatory mechanism of age-related DNAm changes and extend the application of the DNAm clock for measuring biological age and aging pace,providing the basis for evaluating aging intervention strategies.

关键词： DNA methylation aging clock aging age prediction

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Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors

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Chinese medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 48-55页

作者： Yeming Wang li Guo Guohui Fan {2. Han qiao Zhang lili Ren hui Zhang Geng Wang Xue{2. Zhang Tingxuan Huang Wei{2. Wang Lan Chen lixue Huang Xiaoying Gu Xinming Wang Jingchuan Zhong Ying Wang hui li Jiapei Yu Zhibo liu Chaolin Huang Bin Cao Jianwei Wang National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesChina-Japan Friendship HospitalBeijing 100029China National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100029China school of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeState Key Laboratory of Respiratory Health and MultimorbidityKey Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College)Ministry of EducationBeijing 100730China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical research and Data managementCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Jin Yin-tan Hospital WuhanHubei 430023China Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology and Clinical Immunology Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Ministry of Science&TechnologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(PUMCH)Key Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospsitalInstitute of Respiratory MedicineChinese

Background:The impact of corticosteroids on humoral responses in coronavirus disease 2.19(COVID-19)sur-vivors during the acute phase and subsequent 6-month period remains *** study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-19 survivors 6 months after infection ***:We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2.2.,which involved adults hospitalized with severe COVID-19(LOTUS,ChiCTR2.0002.308).Anti-body samples were collected from 192.patients during hospitalization,and kinetic antibodies were monitored at all available time points after ***,plasma samples were collected from 101 COVID-19 survivors for comprehensive humoral immune measurement at the half-year follow-up *** main focus was comparing the humoral responses between patients treated with systemic corticosteroid therapy and the non-corticosteroid ***:From illness onset to day 30,the median antibody titre areas under the receiver operating characteristic curve(AUCs)of nucleoprotein(N),spike protein(S),and receptor-binding domain(RBD)immunoglobulin G(IgG)were significantly lower in the corticosteroids *** AUCs of N-,S-,and RBD-IgM as well as neutralizing antibodies(NAbs)were numerically lower in the corticosteroids group compared with the non-corticosteroid ***,peak titres of N,S,RBD-IgM and-IgG and NAbs were not influenced by *** 6-month follow-up,we observed a delayed decline for most binding antibodies,except N-IgM(𝛽−0.05,95%CI[−0.10,0.00])in the corticosteroids group,though not reaching statistical *** significant difference was observed for ***,for the half-year seropositive rate,corticosteroids significantly accelerated the decay of IgA and IgM but made no difference to N-,S-,and RBD-IgG or ***,corticosteroids group showed a trend towards d

关键词： COVID-19 Corticosteroid Immunity Antibody Humoral response

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Intra-amygdala antagonism ofβ-adrenergic receptors mediates the reconsolidation of drug-associated memory

Intra-amygdala antagonism ofβ-adrenergic receptors mediates...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yan WU~(1,2.,Yong-hui li~1,Xiao-Yan {2.~1,Nan SUI~(1,*) 1 Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of sciences,{2. 100101,China 2.Graduate university of Chinese Academy of science,{2. 100101,China

＜正＞Increasing number of experiments has proved the reconsolidation of drug ***,the reconsolidation of the reward and aversion emotional arouse induced by drug is an important reason of the psychology *** precise mechanism of the reconsolidation of drug-related memory remains *** role ofβnoradrenergic receptors in the basolateral amygdala was examined in the reconsolidation of other emotional ***,few of their mechanisms are known about drug-associated emotional memory *** the present series of studies aiming to elucidate the differential neural substrates of the two opposite emotional aroused memory reconsolidation induced by drug,the role ofβ-adrenergic receptors of basolateral amygdale（BLA） on the reconsolidation of morphine associated reconsolidation was investigated in conditioned place preference（CPP） and conditioned place aversion（CPA） paradigm. The main results are as follows:（1） Reactiveation with a contextual recall destabilized an established mCPA,but morphine CPP（mCPP） needs contextual and drug to reactive.（2.β-Adrenergic receptors in the BLA mediate reconsolidation of mCPA,but not mCPP.（3） No effect was observed on a-adrenergic receptors on drug-related memory *** of B-adrenergic receptors of BLA are different on the reconsolidation of mCPA and mCPP.

关键词： drug addiction reconsolidation basolateral amygdale adrenergic receptors reward memory negative affection

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物理生物医学——原创交叉研究的新领域

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科学通报 2024年第15期69卷 2008-2014页

作者：杜全生粟硕戴慧李舟国家自然科学基金委员会交叉科学部北京100085 中国科学院北京纳米能源与系统研究所北京101400 上海市重大传染病和生物安全研究院复旦大学公共卫生学院上海200032 北京大学基础医学院免疫学系北京100191

物理生物医学是物理学与生物医学深度融合的新兴交叉研究领域,融入了材料学、化学、信息科学、机械工程等多个领域物质科学的知识和技术.它的科学内涵在于揭示生命现象的物理规律,并利用物理的方法和技术实现对生命过程的调控.因此,物... 详细信息

物理生物医学是物理学与生物医学深度融合的新兴交叉研究领域,融入了材料学、化学、信息科学、机械工程等多个领域物质科学的知识和技术.它的科学内涵在于揭示生命现象的物理规律,并利用物理的方法和技术实现对生命过程的调控.因此,物理生物医学既要解析伴随生命活动所产生的内源性物理信号的奥秘.

关键词：信息科学生物医学深度融合物理规律物理信号机械工程交叉研究物理学

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Allele-specific genome editing of imprinting genes by preferentially targeting non-methylated loci using Staphylococcus aureus Cas9(SaCas9)

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science Bulletin 2019年第21期64卷 1592-1600页

作者： Yajing liu Jianan li Chang{2. Zhou Bin Meng Yu Wei Guang {2. Zong{2. Lu Qingmei Shen Yu Zhang hui {2. Yunbo qiao school of life {2. and Technology ShanghaiTech UniversityShanghai 201210China Institute of Biochemistry and Cell Biology Chinese Academy of SciencesShanghai 200031China university of Chinese Academy of sciences Beijing 100049China Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech UniversityShanghai 200031China Precise Genome engineering Center School of Life SciencesCuangzhou UniversityGuangzhou 510006China

Allele-specific DNA methylation is the most important imprinting marker localized to differentially methylated regions(DMRs),and aberrant genomic imprinted DNA methylation is associated with some human diseases,including Prader-Willi syndrome and ***,the development of an effective strategy for the precise editing of allele-specific methylated genes is essential for the functional clarification of imprinting elements and the correction of imprinting disorders in human *** discover a feasible allele-specific genome editing tool based on the CRISPR/Cas system,which is an efficient genetargeting technique in various organisms,we examined the targeting efficiency of Staphylococcus aureus Cas9(SaCas9)and Streptococcus pyogenes Cas9(SpCas9)in response to DNA methylation *** found that the targeting efficiency of SaCas9,but not SpCas9,was enhanced by targeted DNA demethylation using the d Cas9-Tet1 catalytic domain(CD)but suppressed by targeted DNA methylation using Dnmt3l-Dnmt3a-d *** in vitro cleavage assay further demonstrated that SaCas9 nuclease activity was inhibited by 5-methylcytosine(5mC)in a synthesized Cp G-containing *** analysis with Ch IP-Q-PCR demonstrated that the non-methylated sequence targeting of Sa Cas9 depends on the binding preference of SaCas9 to non-methylated *** advantage of this feature of SaCas9,we have successfully obtained non-methylated allele-biased targeted embryos/mice for two imprinting genes,H19 and Snrpn,with relatively high efficiencies of 2..6%and 47.4%,*** results indicate that the targeting efficiency of SaCas9 was strongly reduced by DNA *** using SaCas9,we successfully achieved allele-specific genome editing of imprinting genes by preferentially targeting non-methylated loci.

关键词： Allele-specific DNA methylation SaCas9 Imprinting gene

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Bioinformatics Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of Gastric Cancer

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Current medical science 2022年第2期42卷 357-372页

作者： Dan-wen WANG Fei SU li-jie yang li-wen SHI Tie-cheng yang Hua-{2. WANG Xuan-fei li Mao-hui FENG Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan443071China Clinical medical Research Center of Peritoneal Cancer of Wuhan Wuhan443071China Clinical Cancer Study Center of Hubei Provence Wuhan443071China Hubei Key Laboratory of Tumor biological Behaviors Wuhan443071China Department of Oncology the First Hospital of Lanzhou UniversityLanzhou730000China

Objective Gastric cancer(GC)is a deadly cancer and a challenging public health problem *** study aimed to analyze potential genes associated with pathogenesis and prognosis of gastric *** This work selected the overlapping differentially expressed genes(DEGs)in GC from four datasets,the GSE2.2.2.GSE2.998,GSE5412. and GSE118916 Gene Expression Omnibus *** DEGs were used to carry out comprehensive bioinformatic analysis to analyze the related functions and pathways enriched,the relative expression levels and immune infiltrates,the prognostic characteristics and the interaction *** In total,55 DEGs increased while 98 decreased in their expression *** those DEGs with increased expression,they were mostly concentrated on“focal adhesion”and“ECM-receptor interaction”,whereas DEGs with decreased expression were mostly associated with“gastric acid secretion”and“drug metabolism cytochrome P450”.MCODE and ClueGO results were then integrated to screen 10 hub genes,which were FN1,COL1A1,COL3A1,BGN,TIMP1,COL1A2.LUM,VCAN,COL5A2.and *** analysis revealed that higher expression of the ten hub genes significantly predicted lower overall survival of GC ***1 was most significantly related to neutrophils,CD8+T cells,as well as dendritic cells,while LUM was most significantly related to *** Immunohistochemistry results and functional testing showed that the expression of COL5A2.was elevated in GC and that it might be a key gene in GC tumorigenesis.

关键词： gastric cancer differentially expressed genes bioinformatics analysis prognosis immune infiltrate

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