检索结果-南通市图书馆

Discovery of anti-cancer stem cells drug:synthesis and biological evaluation of a library of natural products and their analogues

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discovery of anti-cancer stem cells drug:synthesis and biolo...

第一届《药学学报》药学前沿论坛暨2015年中国药学会中药与天然药物专业委员会会议

作者： SANG Feng yang zhan-tao DING Ya-hui ZHAI Jia-dai LU Ya-xin yang Guang zhanG Quan 陈悦 State Key Laboratory of Medicinal Chemical Biology College of PharmacyCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)

It is widely reported that cancer stem cells play a key role in carcinogenesis,cancer disease progression,relapse,and drug ***,compounds that selectively inhibit CSC growth are rarely *** designed and synthesized several series of natural products and their *** biological assay revealed that some compounds can selectively eradicate cancer stem or progenitor *** them,one compound was able to reduce the proportion of cancer stem cells and colony-forming units,and maintained high activity against multiple drug resistant ***,it was submitted to SFDA as an investigational new drug.

关键词： targeting cancer stem cell natural product micheliolide rakicidin A

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

代际视角下工作价值观对建言行为的影响研究

软科学 2017年第7期31卷 71-75页

作者：栾贞增杨东涛詹小慧青岛大学商学院山东青岛266071 南京大学商学院南京210093

从代际视角出发,检验了工作价值观的代际差异,以及代对工作价值观和建言行为关系的调节作用。结果发现:80后比60后更重视能力与成长;能力与成长、地位与独立对建言行为有显著正向影响;安全与舒适只对促进性建言有显著负向影响;不同代际... 详细信息

从代际视角出发,检验了工作价值观的代际差异,以及代对工作价值观和建言行为关系的调节作用。结果发现:80后比60后更重视能力与成长;能力与成长、地位与独立对建言行为有显著正向影响;安全与舒适只对促进性建言有显著负向影响;不同代际群体间工作价值观对建言行为的影响没有显著差异。

关键词：工作价值观代际视角促进性建言抑制性建言

在线全文

学校读者我要写书评

暂无评论

多维地震作用下大跨空间结构的减震控制分析

地震工程学报 2018年第3期40卷 398-405页

作者：赵祥刘忠华王社良杨涛展猛西安建筑科技大学土木工程学院陕西西安710055

考虑到多维地震输入对网架结构的不利影响,基于形状记忆合金超弹性,研制出一种兼具自复位、高耗能及放大功能于一体的形状记忆合金复合黏滞阻尼器(Hybrid Shape Memory Alloy Viscous Dampers,简称HSMAVD),并通过试验研究该阻尼器在循... 详细信息

考虑到多维地震输入对网架结构的不利影响,基于形状记忆合金超弹性,研制出一种兼具自复位、高耗能及放大功能于一体的形状记忆合金复合黏滞阻尼器(Hybrid Shape Memory Alloy Viscous Dampers,简称HSMAVD),并通过试验研究该阻尼器在循环荷载作用下的力学性能;然后以平面四角锥网架模型为基础,将该阻尼器替换部分网架结构杆件,并分析该阻尼器减震控制效果。结果表明形状记忆合金与黏滞阻尼器复合后具有良好的协同工作能力,可有效发挥形状记忆合金的超弹性和黏滞阻尼器的速度相关特性,使其具有稳定的滞回性能和良好的耗能能力;采用阻尼杆件替换原杆件的方法既能对结构进行有效的减震控制,又不改变原有的结构形式,是一种优越的减震控制方法,并为HSMAVD被动控制系统在结构抗震中的实际应用提供新思路。

关键词：空间结构减震控制多维地震输入形状记忆合金黏滞阻尼器

在线全文

学校读者我要写书评

暂无评论

云南芒市地区常用饮用水质检测与分析

云南民族大学学报（自然科学版） 2010年第4期19卷 298-300页

作者：邓芳轶杨占涛云南民族大学化学与生物技术学院云南昆明650031 云南省德宏州卫生学校云南德宏671000

本实验对芒市地区常用饮用水余氯、细菌总数、大肠菌群等是否超标进行了调查、检测与分析,目的是防止水污染,为市民安全、卫生地使用饮用水提供科学的依据.

关键词：饮用水细菌总数测定

Self-Triggered Impulsive Control for Nonlinear Stochastic Systems

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2025年第1期 264-266页

作者： tao zhan Yi Ji Yabin Gao Hongyi Li Yuanqing Xia the School of Mathematics and Statistics Southwest University the School of Astronautics Harbin Institute of Technology IEEE the College of Electronic and Information Engineering Southwest University Zhongyuan University of Technology the School of Automation Beijing Institute of Technology

Dear Editor,This letter deals with the stabilization problem of nonlinear stochastic systems via self-triggered impulsive control(STIC), where the timing of impulsive control actions is not dependent on continuous state monitoring. In contrast to the existing self-triggered control method, novel self-triggered mechanism(STM) is proposed by incorporating a waiting time for stabilizing impulses. This allows for direct prediction of the next impulsive instant.

关键词：

Effects of Process Parameters on the Temperature Field in Ti-6Al-4V Alloy Blade Precision Forging Process

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2006年第4期22卷 473-477页

作者： Yuli LIU He yang tao GAO Mei zhan College of Materials Science and Engineering Northwestern Polytechnical University Xi＇an 710072 China

Blade precision forging is a high temperature and large plastic deformation process. Process parameters have a great effect on temperature distribution in billet, so in this paper, by taking a Ti-6Al-4V alloy blade with a tenon as an object, the influence of process parameters on the temperature distribution in precision forging process was investigated using 3D coupled thermo-mechanical FEM （finite element method） code developed by the authors. The results obtained illustrate that：（1） the gradient of temperature distribution increases with increasing the deformation degree; （2） with increasing the initial temperature of the billet, the zones of high temperature become larger, and the gradient of temperature distribution hardly has any increase; （3） friction factors have little effect on the distribution of temperature field; （4） with increasing upper die velocity, temperature of the billet increases while the temperature gradient in billet decreases. The results are helpful to the design and optimization of the process parameters in precision forging process of Ti-alloy blade.

关键词： Ti-alloy blade Precision forging Process parameter Temperature field Finite element method (FEM)

Fouling process and anti-fouling mechanisms of dynamic membrane assisted by photocatalytic oxidation under sub-critical fluxes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2019年第8期27卷 1798-1806页

作者： tao yang Fen Liu Houfeng Xiong Qiyong yang Fushan Chen Changchao zhan School of Chemistry and Environment Engineering Jiujiang UniversityJiujiang 332005China Jiangxi Province Engineering Research Center of Ecological Chemical Industry Jiujiang UniversityJiujiang 332005China State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology Zhejiang University of TechnologyHangzhou 310014China

Membrane fouling is often considered as a hindrance for the application of microfiltration/ultrafiltration(MF/UF) for drinking water production. A novel process of photocatalytic membrane reactor/dynamic membrane(PMR/DM), operating in a continuous mode under sub-critical flux, was proposed for the mitigation of membrane fouling caused by humic acids(HAs) in water. The mechanism of membrane fouling alleviation with synergistic photocatalytic oxidation and dynamic layer isolating effect was comprehensively investigated from the characterization of foulant evolution responsible for the reversible and irreversible fouling. The results showed that the PMR/DM utilized photocatalytic oxidation to enhance the porosity and hydrophilicity of the fouling layer by converting the high molecular weight(MW) and hydrophobic HA molecules with carboxylic functional groups and aromatic structures into low-MW hydrophilic or transphilic fractions, including tryptophan-like or fulvic-like substances. The fouling layer formed in the PMR/DM by combination of photocatalytic oxidation and DM running at a sub-critical flux of 100 L·h^-1·m^-2, was more hydrophilic and more porous, resulting in the lowest trans-membrane pressure(TMP) growth rates, as compared to the processes of ceramic membrane(CM), DM and PMR/***, the dynamic layer prevented the foulants, particularly the high-MW hydrophobic fractions,from contacting the primary membrane, which enabled the membrane permeability to be restored easily.

关键词： Dynamic membrane Photocatalytic membrane reactor Humic acids Membrane fouling Sub-critical flux

Release Method of Microobjects Based on Piezoelectric Vibration

在线全文

学校读者我要写书评

暂无评论

Transactions of Nanjing University of Aeronautics and Astronautics 2017年第1期34卷 37-42页

作者： Chen tao Wang Yaqiong yang zhan Liu Huicong Sun Lining Jiangsu Provincial Key Laboratory of Advanced Robotics&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215123P.R.China

A release method of microobjects is presented based on the piezoelectric *** achieve an effective release,the piezoelectric vibration is added to overcome adhesion force happened in the *** technique employs inertia force to overcome adhesion force,thereby achieving 90%repeatability with a releasing accuracy of 4± 0.5μm,which was experimentally quantified through the manipulation of 20—80μm polystyrene spheres under an optical *** results confirmed that this adhesion control technique was independent of *** analyses were conducted to understand the releasing ***,the micromanipulation system proved to be effective for active releasing of micromanipulation.A novel gripper structure with triple finger is *** the design,three cantilevers are considered as the end effectors of the fingers,driven by piezoelectric ceramic transducer(PZT).Tungsten tipped probes are used to pick and place the micro objects.

关键词： microelectromechanical systems (MEMS) micromanipulation piezoelectric vibration

A facile method to synthesize water-soluble Pd8 nanoclusters unraveling the catalytic mechanism of p-nitrophenol to p-aminophenol

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第10期12卷 2589-2596页

作者： Pan An Rajini Anumula Chaonan Cui yang Liu Fei zhan Ye tao Zhixun Luo Beijing National Laboratory for Molecular Sciences(BNLMS)and State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Hydroge nation of p-n itrophe nol(PNP)towards the con versi on to p-ami nophe no I(PAP)by metal catalysis is known as a simple and I eco-frie ndly tech nique for the production of corresp on ding in dustrial and pharmaceutical in *** continu ous efforts are paid for§more sustainable and greener procedures by using transition metal catalysts,atomic-precise reaction mechanism for the PNP-to-PAP is still illusive to be fully un *** ng a dry-wet com bined strategy,here we have syn thesized water-soluble Pd8 nano clusters(NCs)with mercaptosuccinic acid(H2SMA)as the ligand,and the Pd8 NCs found high catalytic performance for the conversion of PNP-to-PAP,as identified by the electrospray ionization mass spectrometer(ESI-MS)*** gradual changes over time of ultraviolet-visible(UV-vis)spectra of PNP really display the catalytic reduction by NaBH4 in presence of Pd8 ***,in-depth charge transfer interactions between PNP and the Pd8 clusters at the proton-rich conditions are investigated by natural bond orbital(NBO)analysis and electron density differenee(EDD)*** exothermic and kinetic-favorable reaction pathways are addressed,based on successive PNP hydrogenation and H2O removal processes,clarifying the reaction mechanism of Pd *** is worth noting that this solid-state synthetic route for such Pd8 clusters enables gram-scale quantity of production in likely practical use.

关键词： catalytic clusters mechanism