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AZGP1P2/UBA1/RBM15 Cascade Mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPM1 m6A Modification

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Research 2024年第3期6卷 151-167页

作者： Hong Wang Jj Liu Xiaojun zhu Bin yang Zuping He Xudong Yao Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Urologic Cancer Institute School of MedicineTongji UniversityShanghaiChina. Department of Urology Surgery The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina. The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province School of MedicineHunan Normal UniversityThe Engineering Research Center of Reproduction and Translational Medicine of Hunan ProvinceChangshaChina Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghaiChina.

Prostate cancer(PCa)is a common malignant tumor with high morbidity and mortality *** prostate cancer stem cell(PCSC)model provides novel insights into the pathogenesis of PCa and its therapeutic ***,the roles and molecular mechanisms of specific genes in mediating fate decisions of PCSCs and carcinogenesis of PCa remain to be *** this study,we have explored the expression,function,and mechanism of AZGP1P2,a pseudogene of AZGP1,in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer(CRPC).We revealed that AZGP1P2 was downregulated in CRPC cell lines and PCSCs,while it was positively associated with progression-free *** of the AZGP1P2 enhanced the sensitivity of docetaxel treatment in CRPCs via inhibiting their *** pull-down associated with mass spectrometry analysis,co-immunoprecipitation assay,and RNA immunoprecipitation assay demonstrated that AZGP1P2 could bind to UBA1 and RBM15 as a“writer”of methyltransferase to form a ***1,an E1 ubiquitin-activating enzyme,contributed to RBM15 protein degradation via ubiquitination *** RNA immunoprecipitation assay displayed that RBM15 controlled the mRNA decay of TPM1 in m6A ***,a xenograft mouse model and patient-derived organoids showed that the therapeutic effect of docetaxel in CRPC was increased by AZGP1P2 in ***,these results imply that AZGP1P2 mediates the stemness and apoptosis of PCSCs and promotes docetaxel therapeutic effect by suppressing tumor growth and metastasis via UBA1/RBM15-mediated TPM1 mRNA decay in CRPC.

关键词： Prostate TPM1 m6A

A Novel Sensing Imaging Equipment Under Extremely Dim Light for Blast Furnace Burden Surface:Starlight High-Temperature Industrial Endoscope

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 893-906页

作者： Zhipeng Chen Xinyi Wang Weihua Gui Jilin zhu Chunhua yang Zhaohui Jiang The authors are with the school of Automation Central South UniversityChangsha 410083China

Blast furnace(BF)burden surface contains the most abundant,intuitive and credible smelting information and acquiring high-definition and high-brightness optical images of which is essential to realize precise material charging control,optimize gas flow distribution and improve ironmaking *** has been challengeable to obtain high-quality optical burden surface images under high-temperature,high-dust,and extremelydim(less than 0.001 Lux)*** on a novel endoscopic sensing detection idea,a reverse telephoto structure starlight imaging system with large field of view and large aperture is *** with a water-air dual cooling intelligent self-maintenance protection device and the imaging system,a starlight high-temperature industrial endoscope is developed to obtain clear optical burden surface images stably under the harsh *** on an endoscope imaging area model,a material flow trajectory model and a gas-dust coupling distribution model,an optimal installation position and posture configuration method for the endoscope is proposed,which maximizes the effective imaging area and ensures large-area,safe and stable imaging of the device in a confined *** experiments and applications indicate that the proposed method obtains clear and reliable large-area optical burden surface images and reveals new BF conditions,providing key data support for green iron smelting.

关键词： Blast furnace(BF) burden surface extremely dim light industrial endoscope sensing imaging starlight

Operando investigation of particle re-entrainment mechanism in electrostatic capture process on the lab-on-a-chip

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Journal of Environmental Sciences 2024年第2期136卷 337-347页

作者： Yong zhu Yikun Zhang Xiaoyong yang Shanlong Tao Mingxia Chen wenfeng Shangguan Research Center for Combustion and Environmental technology School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Inhalable particle is a harmful air pollutant that causes a significant threat to people's health and ecological environments,which should be removed to purify air,but there exists limited removal efficiency due to particle ***,Operando observation system based on microscopic visualization method is developed to make in situ test of particle migration,deposition and re-entrainment characteristics on a lab-on-a-chip to achieve the investigation in micro-level *** deposition evolution of charged particles is recorded in electric field region intuitively,which confirms the fracture of particle chain occurs during the growth process of deposited *** captures the instantaneous process that a larger particle with micron size due to the coagulation of submicron particles fractures from main body of the particle chain for the first *** analysis of migration behavior of a single submicron particle near electrode surface demonstrates the direct influence of drag force on the fracture of particle *** work is the first-time visualization of dynamic process and mechanism elucidation of particle re-entrainment at the micron level,and the findings will provide the theory support for the particle re-entrainment mechanism and bring inspires of enhancing capture efficiency of inhalable particle.

关键词： Inhalable particle Re-entrainment mechanism Operando observation Lab-on-a-chip Capture efficiency

Membrane-less MoO_(3-x)@TiO_(2)-bromine battery with excellent rate capability and cyclic stability

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Journal of Energy Chemistry 2024年第6期93卷 316-321,I0008页

作者： wenjie Huang Hui Wang Bin Yuan Liuzhang Ouyang Lichun yang Min zhu school of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510640GuangdongChina

Bromine has attracted significant attention as a cathode material for aqueous batteries due to its high reduction potential of 1.05 V(Br_(3)^(-)+2e~-■3Br~-),impressive theoretical specific capacity of 223 mA h g^(-1),and rapid reaction kinetics in the ***,searching for compatible anode materials to match with bromine has posed a challenge due to its highly corrosive *** this study,we developed oxygen-deficient MoO_(3) with TiO_(2) coating(referred to as MoO_(3-x)@TiO_(2))as an anode material to pair with a bromine cathode in static full *** oxygen deficiency contributes to enhanced electronic and protonic diffusion within the MoO_(3-x)lattice,while the TiO_(2) coating mitigates structural dissolution and proton trapping during *** MoO_(3-x)@TiO_(2) demonstrates fast charge storage kinetics and excellent resistance to bromine *** impressive compatibility between MoO_(3-x)@TiO_(2) and bromine enables the construction of membrane-less full batteries with exceptional rate capability and cyclic *** MoO_(3-x)@TiO_(2)-bromine battery achieves an energy density of70.8 W h kg^(-1)at a power density of 328.1 W kg^(-1),showcasing an impressive long-term cyclic life of 20,000 *** study provides valuable insights for the development of high-performance aqueous secondary batteries.

关键词： Molybdenum trioxide Oxygen deficiency TiO_(2)coating Compatibility Bromine-based battery

Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in china

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World Journal of Psychiatry 2024年第4期14卷 523-532页

作者： Jing-wen Xu Xiao-Bo Guan Xue-Ying Wang yang Feng Qi Zhang Jun-Juan zhu Jian-Hua Chen Department of Medicine Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China The Fourth Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Psychotic DisordersShanghai 200030China The First Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China

BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is *** To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS *** This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric *** plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid *** patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were *** Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female *** and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 *** male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total *** Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.

关键词： Antipsychotics Risperidone 9-hydroxyrisperidone Plasma drug concentration monitoring Chronic schizophrenia

In-situ decorated cobalt phosphide cocatalyst on Hittorfs phosphorus triggering efficient photocatalytic hydrogen production

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Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation

结构化学 2024年第2期43卷 13-16页

作者： Abiduweili Sikandaier Yukun zhu Dongjiang yang school of Environmental Science and Engineering State Key Laboratory of Bio-fibers and Eco-textilesQingdao UniversityQingdao266071China

Hydrogen production through semiconductor-based photocatalytic water splitting is an appropriate strategy to convert solar energy into hydrogen fuels[1].In recent years,metal-free elemental red phosphorus(RP)materials,including amorphous,fibrous,and Hittorfs phosphorus(HP)possessing moderate bandgap and bandstructure have been explored as potential visible-light-driven hydrogen evolution reaction(HER)photocatalyst[2].However,the slow charge migration capacity and sluggish surface reaction kinetics of RP materials have limited their HER efficiency to unsatisfactory *** overcome these limitations and improve the photocatalytic HER efficiency,various strategies,including building heterostructures,morphology control,and surface modification have been investigated[3].For instance,[001]-oriented HP nanorods decorated on polymeric carbon nitride exhibited excellent photocatalytic HER activity,which was attributed to accelerated photo-generated electron-holes transfer along the[001]direction of HP[4].In addition to enhancing the charge transfer ability by morphology regu-lation to allow more electrons to migrate to the surface to participate in HER,loading cocatalysts on RP surface to enhance HER kinetics is another effective strategy for altering HER activity[5].

关键词： EVOLUTION

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Rare Metals 2024年第10期43卷 5186-5201页

作者： wen-Jing Zhang Li-Guo Jin Shui-Lin Wu Chao-Feng Wang Yu-Feng Zheng Zhao-yang Li Zhen-Duo Cui Hui Jiang Sheng-Li zhu Xiang-Mei Liu school of Materials Science and Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin University Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer MaterialsMinistry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science&EngineeringHubei University school of Materials Science and Engineering Peking University school of Health Science and Biomedical Engineering Hebei University of Technology

Deep tissue infections caused by pathogenic bacteria seriously threat the lives of *** this study a smart heterostructured Au/Cu-BTA （BTA=1,2,4,5-benzenetetramine） with microwave （MW） response is synthesized via NaBH4reduction of HAuCl4on the ***/Cu-BTA exhibits excellent hyperthermy and dynamics under MW *** MW thermal mechanism of Au/Cu-BTA is attributed to the excellen dielectric loss and polarization of the heterogeneous ***,the surface energy levels of the Cu-BTA interface alleviate the difficulty of electron hopping through multistage ***,MW can excite Cu-BTA to produce free ***,Au nanoparticles rapidly increase electron transfer and inhibit electron-hole ***,the yields of reactive oxygen species can be enhanced for MW dynamic therapy Consequently,under 10 min of MW irradiation,Au/Cu-BTA killed 99.998%±0.001% of Gram-positive Staphylococcus aureus,99.966%±0.014% of methicillin-resistant Staphylococcus aureus,and 96.871%±0.831% of Gram-negative Pseudomonas *** effective MW bacteria-killing strategy designed in this study shows significant potential for application in the MW-responsive treatment of deep tissue infections without antibiotics.

关键词： Anti-infection Antibacterial Microwave therapy

A 14.11-approximation algorithm for sorting by short block-moves

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Science china(Information Sciences) 2011年第2期54卷 279-292页

作者： JIANG HaiTao & zhu DaMing school of computer Science and technology, Shandong university, Jinan 250101, china 1. school of computer Science and technology Shandong University Jinan 250101 China

Block-move is one of the popular operations for genome rearrangement. A short block-move is an operation on a permutation that moves an element at most two positions away from its original position. Heath and Vergara investigated the problem of finding a minimum-length sorting sequence of short block-moves for a given permutation and devised a 4/3-approximation algorithm. In this paper, we present a new 14.11-approximation algorithm for this problem. Firstly, we devise an exact polynomial time algorithm for sorting a special kind of sub permutations called umbrella; then we split the permutation into a series of related umbrellas and sort them greedily. We obtain a new lower bound of the short block-move distance by exploiting the properties of five kinds of sub-permutations. After some complicated analysis, we prove that the approximation ratio of the new algorithm is at most 14.11.

关键词： short block-move approximation algorithm

A midgut transcriptional regulatory loop favors an insect host to withstand a bacterial pathogen

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The Innovation 2024年第5期5卷 36-45,35页

作者： Zhaojiang Guo Liuhong zhu Zhouqiang Cheng Lina Dong Le Guo yang Bai Qingjun Wu Shaoli Wang Xin yang wen Xie Neil Crickmore Xuguo Zhou RenéLafont Youjun Zhang State Key Laboratory of Vegetable Biobreeding Department of Plant ProtectionInstitute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China school of Life Sciences University of SussexBrighton BN19QEUK Department of Entomology School of Integrative BiologyCollege of Liberal Arts&SciencesUniversity of Illinois Urbana-ChampaignUrbanaIL 61801-3795USA Sorbonne Université CNRS-IBPS(BIOSIPE)75005 ParisFrance

Mounting evidence suggests that insect hormones associated with growth and development also participate in pathogen *** have discovered a previously undescribed midgut transcriptional control pathway that modulates the availability of 20-hydroxyecdysone(20E)in a worldwide insect pest(Plutella xylostella),allowing it to defeat the major virulence factor of an insect pathogen Bacillus thuringiensis(Bt).A reduction of the transcriptional inhibitor(PxDfd)increases the expression of a midgut microRNA(miR-8545),which in turn represses the expression of a newly identified ecdysteroid-degrading glucose dehydrogenase(PxGLD).Downregulation of PxGLD reduces 20E degradation to increase 20E titer and concurrently triggers a transcriptional negative feedback loop to mitigate 20E *** moderately elevated 20E titer in the midgut activates a MAPK signaling pathway to increase Bt tolerance/*** findings deepen our understanding of the functions attributed to these classical insect hormones and help inform potential future strategies that can be employed to control insect pests.

关键词： elevated transcriptional loop