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Global signatures of protein binding on structured RNAs in Saccharomyces cerevisiae

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Science China(Life Sciences) 2014年第1期57卷 22-35页

作者： yang yucheng UMETSU Jumpei LU Zhi John MOE Key Lab of Bioinformatics School of Life Sciences Tsinghua University Department of Biological Information Tokyo Institute of TechnologyTokyo 152-8850 Japan

Protein binding is essential to the transport,decay and regulation of almost all RNA ***,the structural preference of protein binding on RNAs and their cellular functions and dynamics upon changing environmental conditions are poorly ***,we integrated various high-throughput data and introduced a computational framework to describe the global interactions between RNA binding proteins(RBPs)and structured RNAs in yeast at single-nucleotide *** found that on average,in terms of percent total lengths,~15%of mRNA untranslated regions(UTRs),~37%of canonical non-coding RNAs(ncRNAs)and^11%of long ncRNAs(lncRNAs)are bound by *** RBP binding sites,in general,tend to occur at single-stranded loops,with evolutionarily conserved signatures,and often facilitate a specific RNA structure conformation in *** found that four nucleotide modifications of tRNA are significantly associated with RBP *** also identified various structural motifs bound by RBPs in the UTRs of mRNAs,associated with localization,degradation and stress ***,we identified>200 novel lncRNAs bound by RBPs,and about half of them contain conserved secondary *** present the first ensemble pattern of RBP binding sites in the structured non-coding regions of a eukaryotic genome,emphasizing their structural context and cellular functions.

关键词： RNA binding protein non-coding RNA UTR RNA structure Saccharomyces cerevisiae

Search for topological defect of axionlike model with cesium atomic comagnetometer

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Chinese Physics B 2021年第5期30卷 157-164页

作者： yucheng yang Teng Wu Jianwei Zhang Hong Guo State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronicsand Center for Quantum Information TechnologyPeking UniversityBeijing 100871China School of Physics Peking UniversityBeijing 100871China

Many terrestrial experiments have been designed to detect domain walls composed of axions or axionlike particles(ALPs), which are promising candidates of dark matter. When the domain wall crosses over the Earth, the pseudoscalar field of ALPs could couple to the atomic spins. Such exotic spin-dependent couplings can be searched for by monitoring the transient-in-time change of the atomic spin precession frequency in the presence of a magnetic field. We propose here a single-species cesium atomic comagnetometer, which measures the spin precession frequencies of atoms in different ground-state hyperfine levels, to eliminate the common-mode magnetic-field variations and search for the exotic nonmagnetic couplings solely between protons and ALPs. With the single-species atomic comagnetometer, we experimentally rule out the possibility that the decay constant of the linear pseudoscalar couplings of ALPs to protons is fp■ 3.71 ×107 Ge V. The advanced system has the potential to constrain the constant to be fp■ 10.7 × 109 Ge V, promising to improve astrophysical constraint level by at least one order of magnitude. Our system could provide a sensitive detection method for the global network of optical magnetometers to search for exotic physics.

关键词： atomic comagnetometer atomic magnetometer domain wall axions and axionlike particles

Improving thermal stability and creep resistance by Sc addition in near-αhigh-temperature titanium alloy

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Journal of Materials Science & Technology 2024年第16期183卷 1-11页

作者： Xiuyang Zhong Tongsheng Deng Wenlong Xiao Xiaochun Liu Zhi Liu yucheng yang Olanrewaju A.Ojo Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China School of Materials Science and Engineering Beihang UniversityBeijing 100191China Institute of Metals College of Materials Science and EngineeringChangsha University of Science&TechnologyChangsha 410004China Department of Mechanical Engineering University of ManitobaWinnipegMB R3T 5V6Canada

High-temperature titanium alloys’thermal stability and creep resistance are significant during service in high *** study systematically investigated the thermal stability and mechanical properties of Ti-6.5A1-2.5Sn-9Zr-0.5Mo-1Nb-1W-0.3Si-xSc(x,0-0.5 wt.%)at 650°*** lamellar secondaryαphase is refined and the formation of Sc_(2)O_(3)is increased with the increasing scandium(Sc)additions,which im-proves the strength of the alloy,while excessive Sc_(2)O_(3)becomes the crack source and deteriorates the *** oxygen content in the matrix is reduced by the interaction between Sc and oxygen,in-hibiting the growth of the Ti3 Al phase and improving the thermal stability of the ***,Sc accelerates the dissolution of the residualβphase and precipitation of fine,diffusely distributed ellip-soidal silicides,which strongly prevents dislocation *** enhancement of creep resistance for the Sc-containing alloy is attributed to the refined lamellar secondaryαphases,Sc_(2)O_(3)particles,Ti3 Al phase,and silicides,especially the precipitated ***,the 0.3 Sc alloy shows optimal ther-mal stability(the plasticity loss rate 17.3%)and creep resistance(steady-state creep rate 4.4×10^(-7) s^(-1)).The investigation results provide new insights into the mechanism and thermal stability improvement in high-temperature titanium alloys modified by rare earth(RE).

关键词： Titanium alloy Creep Microstructure Silicide Scandium

Stacking driven Raman spectra change of carbon based 2D semiconductor C_(3)N

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Chinese Chemical Letters 2022年第5期33卷 2600-2604页

作者： yucheng yang Wenya Wei Peng He Siwei yang Qinghong Yuan Guqiao Ding Zhi Liu Xiaoming Xie School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceKey Laboratory of Polar Materials and Devices(MOE)East China Normal UniversityShanghai 200241China

As a two-dimensional carbon based semiconductor,C_(3)N acts as a promising material in many application ***,the basic physical properties such as Raman spectrum properties of C_(3)N is still not *** this paper,we clarify the Raman spectrum properties of multilayer C_(3)***,the stacking driven Raman spectra change of multilayer C_(3)N is also discussed.

关键词： C_(3)N Raman spectrum Carbon based semiconductor 2D materials Stacking structure

A Grad-CAM and capsule network hybrid method for remote sensing image scene classification

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Frontiers of Earth Science 2024年第3期18卷 538-553页

作者： Zhan HE Chunju ZHANG Shu WANG Jianwei HUANG Xiaoyun ZHENG Weijie JIANG Jiachen BO yucheng yang Shenzhen Data Management Center of Planning and Natural Resources Key Laboratory of Urban Land Resources Monitoring and Simulation(Ministry of Natural Resources)Shenzhen 518000China Key Laboratory of Jianghuai Arable Land Resources Protection and Eco-restoration(Ministry of Natural Resources) Hefei 230088China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Civil Engineering Hefei University of TechnologyHefei 230009China

Remote sensing image scene classification and remote sensing technology applications are hot research *** CNN-based models have reached high average accuracy,some classes are still misclassified,such as“freeway,”“spare residential,”and“commercial_area.”These classes contain typical decisive features,spatial-relation features,and mixed decisive and spatial-relation features,which limit high-quality image scene *** address this issue,this paper proposes a Grad-CAM and capsule network hybrid method for image scene *** Grad-CAM and capsule network structures have the potential to recognize decisive features and spatial-relation features,*** using a pre-trained model,hybrid structure,and structure adjustment,the proposed model can recognize both decisive and spatial-relation features.A group of experiments is designed on three popular data sets with increasing classification *** the most advanced experiment,92.67%average accuracy is ***,83%,75%,and 86%accuracies are obtained in the classes of“church,”“palace,”and“commercial_area,”*** research demonstrates that the hybrid structure can effectively improve performance by considering both decisive and spatial-relation ***,Grad-CAM-CapsNet is a promising and powerful structure for image scene classification.

关键词： image scene classification CNN Grad-CAM CapsNet DenseNet

创造性地把马克思主义哲学思维转化为战略思维——《中国共产党人的战略思维》评介

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中国特色社会主义研究 2019年第1期 109-112页

作者：杨玉成中共中央党校(国家行政学院)哲学部

习近平指出:'战略问题是一个政党、一个国家的根本性问题。战略上判断得准确,战略上谋划得科学,战略上赢得主动,党和人民事业就大有希望。'重视并善于运用战略思维是中国共产党人治国理政的一大特色,也是中国共产党人领导中国革命、建... 详细信息

习近平指出:'战略问题是一个政党、一个国家的根本性问题。战略上判断得准确,战略上谋划得科学,战略上赢得主动,党和人民事业就大有希望。'重视并善于运用战略思维是中国共产党人治国理政的一大特色,也是中国共产党人领导中国革命、建设和改革开放事业取得成功的重要保证。

关键词：共产党人战略思维习近平总书记马克思主义哲学思维

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两种新自由主义与国际金融危机

中共中央党校学报 2015年第3期19卷 92-96页

作者：杨玉成中共中央党校哲学教研部北京海淀100091

西方学术界出现的"新自由主义"思潮,有"改良论新自由主义"与"保守论新自由主义"之分。对于2008年爆发的国际金融危机,两种新自由主义都负有相应的思想指导责任。两个英文术语翻译为一个中文术语,混淆了两种不同的新自由主义概念。我国... 详细信息

西方学术界出现的"新自由主义"思潮,有"改良论新自由主义"与"保守论新自由主义"之分。对于2008年爆发的国际金融危机,两种新自由主义都负有相应的思想指导责任。两个英文术语翻译为一个中文术语,混淆了两种不同的新自由主义概念。我国一些学者把国际金融危机归咎保守论新自由主义,带来诸多理解困境,不利于真正把握新自由主义与国际金融危机之间的关系。

关键词：古典自由主义改良论新自由主义保守论新自由主义国际金融危机

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旋转泡沫填料反应器的研究进展

化工进展 2018年第6期37卷 2046-2052页

作者：杨宇成杨时颖 MOSES Arowo 华侨大学化工学院化工与制药系福建厦门361021 莫伊大学化学工程与工艺系埃尔多雷特肯尼亚390030100

旋转泡沫填料反应器是一种新型多相搅拌釜式反应器,其将传统的搅拌桨替换成圆环型泡沫填料,可有效强化反应器内多相间传质混合过程,且多孔填料可作为催化剂载体,能减小多相催化反应中固体催化剂的使用量,具有替换传统多相搅拌釜式反应... 详细信息

旋转泡沫填料反应器是一种新型多相搅拌釜式反应器,其将传统的搅拌桨替换成圆环型泡沫填料,可有效强化反应器内多相间传质混合过程,且多孔填料可作为催化剂载体,能减小多相催化反应中固体催化剂的使用量,具有替换传统多相搅拌釜式反应器和浆态反应器的潜力,将有较好的应用前景。本文详细阐述了旋转泡沫填料反应器的结构和反应器内多相流动形式,着重介绍了反应器内多相流动特性的研究进展及反应器内传质性能的研究现状,并与传统的多相反应器传质性能进行比较;从应用方面分析了反应器用于葡萄糖催化氧化、苯乙烯催化加氢等多相过程的强化方式及优势,通过对比得出旋转泡沫填料反应器能有效降低化工过程中物耗、提高物料的利用率;介绍了与旋转泡沫填料反应器类似的其他多孔式搅拌桨反应器的研究进展,分析了这类反应器的优势,并对其性能进行对比;最后,对旋转泡沫填料反应器研究的不足及未来的发展进行了阐述和展望。

关键词：旋转泡沫填料反应器多相反应器多相流传质催化

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论习近平的创新思维

理论视野 2022年第12期274卷 31-37页

作者：杨玉成哲学教研部

党的二十大报告进一步明确创新思维在推进党的理论创新中的重要作用。习近平的创新思维是在继承和发扬马克思主义创新思维基础上形成的,是在挖掘和传承中华民族创新智慧基础上升华的,也是在其长期创新实践基础上炼就的。其创新思维主要... 详细信息

党的二十大报告进一步明确创新思维在推进党的理论创新中的重要作用。习近平的创新思维是在继承和发扬马克思主义创新思维基础上形成的,是在挖掘和传承中华民族创新智慧基础上升华的,也是在其长期创新实践基础上炼就的。其创新思维主要包括四个方面:一是破除迷信、超越陈规;二是守正创新;三是在结合中创新;四是集成创新。习近平新时代中国特色社会主义思想中的许多重要理念、重要论断和重要命题都是创新思维的成果。学习和掌握习近平的创新思维方法,有助于我们更加深刻理解习近平新时代中国特色社会主义思想理论上的原创性。

关键词：习近平创新思维创新理论创新实践