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A NAC transcription factor MNAC3-centered regulatory network negatively modulates rice immunity against blast disease

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Journal of Integrative Plant Biology 2024年第9期66卷 2017-2041页

作者： Hui Wang Yan Bi Yuqing Yan Xi Yuan yizhou Gao Muhammad Noman Dayong Li Fengming Song National Key Laboratory for Rice Biology and Breeding Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of BiotechnologyZhejiang UniversityHangzhou 310058China College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004China

NAC transcription factors(TFs)are pivotal in plant immunity against diverse ***,we report the functional and regulatory network of MNAC3,a novel NAC TF,in rice ***3,a transcriptional activator,negatively modulates rice immunity against blast and bacterial leaf blight diseases and pathogen-associated molecular pattern(PAMP)-triggered immune ***3 binds to a CACG cis-element and activates the transcription of immune-negative target genes OsINO80,OsJAZ10,and *** negative function of MNAC3 in rice immunity depends on its transcription of downstream genes such as OsINO80 and ***3 interacts with immunity-related OsPP2C41(a protein phosphatase),ONAC066(a NAC TF),and OsDjA6(a DnaJ chaperone).ONAC066 and OsPP2C41 attenuate MNAC3 transcriptional activity,while OsDjA6 promotes *** of MNAC3 at S163 is critical for its negative functions in rice ***2C41,which plays positive roles in rice blast resistance and chitin-triggered immune responses,dephosphorylates MNAC3,suppressing its transcriptional activity on the target genes OsINO80,OsJAZ10,and OsJAZ11 and promoting the translocation of MNAC3 from nucleus to *** results establish a MNAC3-centered regulatory network in which OsPP2C41 dephosphorylates MNAC3,attenuating its transcriptional activity on downstream immune-negative target genes in ***,these findings deepen our understanding of molecular mechanisms in rice immunity and offer a novel strategy for genetic improvement of rice disease resistance.

关键词： NAC transcription factor MNAC3 OsINO80 OsJAZ10 OsJAZ11 protein phosphatase OsPP2C41 rice immunity

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Flat Zn deposition at battery anode via an ultrathin robust interlayer

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Nano Research 2024年第9期17卷 8104-8111页

作者： yizhou Wang Jianyu Chen Zibo Chen Qian He Zhengnan Tian Jin Zhao Yanwen Ma Husam N.Alshareef Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia State Key Laboratory of Organic Electronics and Information Displays(KLOEID)and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Suzhou Vocational Institute of Industrial Technology Suzhou 215104China

Rechargeable aqueous zinc(Zn)ion batteries(AZIBs)using low-cost and safe Zn metal anodes are considered promising candidates for future grid-scale energy storage systems,but the Zn dendrite problem severely hinders the further prospects of *** Zn depositing behaviors toward horizontal alignment is highly effective and thus has received huge ***,such a strategy is usually based on previous substrate engineering,which requires complex preparation or expensive ***,it is essential to develop a novel solution that can realize horizontally aligned Zn flake deposition via easy operation and low ***,we report an ultrathin and robust Kevlar membrane as the interlayer to mechanically suppress Zn dendrite *** to the randomly distributed flaky dendrites in the control group,the deposited Zn sheets would grow into parallel alignment with the existence of such *** the dendrites are effectively suppressed,Zn||Cu asymmetric,Zn||Zn symmetric,and Zn||MnO_(2)full batteries using Kevlar interlayer deliver significantly improved cycling ***,the Zn||MnO_(2)pouch cell using a Kevlar interlayer delivers stable cycling performance and shows stable operation during multi-angle *** believe this work provides a new possibility for regulating Zn deposition from a crystallographic perspective.

关键词： Zn metal anodes Zn dendrites aqueous Zn ion batteries dendrite suppression (002)crystal plane

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A multimodal integration pipeline for accurate diagnosis, pathogen identification, and prognosis prediction of pulmonary infections

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The Innovation 2024年第4期5卷 63-73,62页

作者： Jun Shao Jiechao Ma yizhou Yu Shu Zhang Wenyang Wang Weimin Li Chengdi Wang Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and MultimorbidityWest China HospitalWest China School of MedicineSichuan UniversityChengdu 610041China Targeted Tracer Research and Development Laboratory Institute of Respiratory HealthFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610213China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu 610213China AI Lab Deepwise HealthcareBeijing 100080China Department of Computer Science The University of Hong KongHong Kong SARChina

Pulmonary infections pose formidable challenges in clinical settings with high mortality rates across all age groups *** diagnosis and early intervention are crucial to improve patient *** intelligence(AI)has the capability to mine imaging features specific to different pathogens and fuse multimodal features to reach a synergistic diagnosis,enabling more precise investigation and individualized clinical *** this study,we successfully developed a multimodal integration(MMI)pipeline to differentiate among bacterial,fungal,and viral pneumonia and pulmonary tuberculosis based on a real-world dataset of 24,107 *** area under the curve(AUC)of the MMI system comprising clinical text and computed tomography(CT)image scans yielded 0.910(95%confidence interval[CI]:0.904–0.916)and 0.887(95%CI:0.867–0.909)in the internal and external testing datasets respectively,which were comparable to those of experienced ***,the MMI system was utilized to rapidly differentiate between viral subtypes with a mean AUC of 0.822(95%CI:0.805–0.837)and bacterial subtypes with a mean AUC of 0.803(95%CI:0.775–0.830).Here,the MMI system harbors the potential to guide tailored medication recommendations,thus mitigating the risk of antibiotic ***,the integration of multimodal factors in the AI-driven system also provided an evident advantage in predicting risks of developing critical illness,contributing to more informed clinical *** revolutionize medical care,embracing multimodal AI tools in pulmonary infections will pave the way to further facilitate early intervention and precise management in the foreseeable future.

关键词： diagnosis modal integration

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Enhancing the electrochemical performance of Na metal anodes via local eutectic melting in porous Al-Cu alloy hosts

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Nano Research 2024年第7期17卷 6111-6118页

作者： Tao Hu Qiang Wu Cheng Wang Jialu Chen Fu Su Zibo Chen yizhou Wang Jianyu Chen Yanwen Ma Jin Zhao State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Suzhou Vocational Institute of Industrial Technology 1 Zhineng AvenueSuzhou International Education ParkSuzhou 215104China

Sodium(Na)metal batteries(SMBs)have emerged as promising alternatives to lithium metal batteries for large-scale energy storage applications,owing to their cost-effectiveness,abundance,and favorable redox ***,the practical implementation of SMBs faces several challenges associated with the Na metal anode,including the formation of dendrites,low Coulombic efficiency,and capacity ***,we propose a novel approach to enhance the electrochemical performance of Na metal anodes through a porous Al-Cu alloy host(PAC)fabricated by a local eutectic melting *** local eutectic melting facilitates the development of a conductive network,offering mechanical support,and the porous structure provides abundant channels for the diffusion of Na ions and accommodates volume fluctuations in the Na metal during charge–discharge ***,the PAC exhibits a high average Coulombic efficiency of 99.8%at 1 mA·cm^(−2)for 1 mAh·cm^(−2)and a low voltage polarization of 19 mV during 500 *** study provides valuable insight into the design and fabrication of highperformance Na metal anodes,which hold significant promise for the advancements of next-generation energy storage systems.

关键词： Na metal anode porous Al-Cu alloy porous current collector local eutectic melting

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Stability and variability of molecular subtypes:comparative analysis of primary and metastatic triple-negative breast cancer

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Cancer Biology & Medicine 2024年第9期21卷 784-798页

作者： Xiuzhi Zhu Xiaohan Ying Yin Liu Yunyi Wang Li Chen Zhiming Shao Xi Jin yizhou Jiang Zhonghua Wang Key Laboratory of Breast Cancer in Shanghai Shanghai Institute of Infectious Disease and BiosecurityDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200000China Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200000China

Objective:Triple-negative breast cancer(TNBC)is a heterogeneous and aggressive *** our previous study classified primary TNBC into four subtypes,comprehensive longitudinal investigations are ***:We assembled a large-scale,real-world cohort comprised of 880 TNBC patients[465 early-stage TNBC(eTNBC)and 415 metastatic TNBC(mTNBC)patients]who were treated at Fudan University Shanghai Cancer *** longitudinal dynamics of TNBC subtypes during disease progression were elucidated in this patient *** analysis was performed to compare primary and metastatic lesions within specific TNBC ***:The recurrence and metastasis rates within 3 years after initial diagnosis in the eTNBC cohort were 10.1%(47/465).The median overall survival(OS)in the mTNBC cohort was 27.2 months[95%confidence interval(CI),24.4–30.2 months],which indicated a poor *** prognostic significance of the original molecular subtypes in both eTNBC and mTNBC patients was *** molecular subtypes were maintained in 77.5%of the patients throughout disease progression with the mesenchymal-like(MES)subtype demonstrating a tendency for subtype transition and brain ***,a precision treatment strategy based on the metastatic MES subtype of target lesions resulted in improved progression-free survival in the FUTURE ***:Our longitudinal study comprehensively revealed the clinical characteristics and survival of patients with the original TNBC subtypes and validated the consistency of most molecular subtypes throughout disease ***,we emphasize the major importance of repeat pathologic confirmation of the MES subtype.

关键词： Triple-negative breast cancer molecular subtype metastasis primary tumor overall survival

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新时代新征程国家完全统一新路线图——新时代党解决台湾问题的总体方略之核心要义

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现代台湾研究 2023年第5期 1-12页

作者：杨毅周全国台联全国政协

党的十八大以来,习近平总书记就对台工作提出一系列重要理念、重大政策主张,形成新时代党解决中国台湾问题的总体方略,为新时代新征程推进国家完全统一提供了根本遵循和行动指南。新时代党解决中国台湾问题的总体方略统筹“两个大局”,... 详细信息

党的十八大以来,习近平总书记就对台工作提出一系列重要理念、重大政策主张,形成新时代党解决中国台湾问题的总体方略,为新时代新征程推进国家完全统一提供了根本遵循和行动指南。新时代党解决中国台湾问题的总体方略统筹“两个大局”,准确把握台海新形势,坚持以“和平统一、一国两制”为主轴,描绘了新时代新征程推进国家完全统一的新路线图:以“一国两制”中国台湾方案作为国家和平统一的新形式,以深化两岸各领域融合发展作为国家和平统一的新路径,以一个中国原则和“九二共识”夯实国家和平统一的政治基础,以开展“双反斗争”筑牢维护国家和平统一前景的战略屏障。新时代党解决中国台湾问题的总体方略体现了推进国家统一的基本原则:一定要坚持在祖国内地发展进步基础上解决中国台湾问题,一定要坚持携手团结中国台湾同胞共同促进国家统一,一定要坚持党中央对对台工作的集中统一领导。

关键词：新征程解决台湾问题总体方略国家统一路线图

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地籍数据库点线拓扑一致性并行检查方法

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国防科技大学学报 2015年第5期37卷 40-46页

作者：杨宜舟吴立新郭甲腾刘善军东北大学测绘遥感与数字矿山研究所辽宁沈阳110819 中国矿业大学物联网(感知矿山)研究中心江苏徐州221008

针对拓扑检查算法复杂、计算量大,串行计算已远不能满足海量地籍数据高效拓扑检查需求的问题,在分析了点线拓扑关系的并行特点基础上,将界址点的数据划分方法与界址线的Q&R空间索引方法相结合,实现了界址点与界址线的并行拓扑计算。用... 详细信息

针对拓扑检查算法复杂、计算量大,串行计算已远不能满足海量地籍数据高效拓扑检查需求的问题,在分析了点线拓扑关系的并行特点基础上,将界址点的数据划分方法与界址线的Q&R空间索引方法相结合,实现了界址点与界址线的并行拓扑计算。用某地区实际的界址点集与界址线集对点线拓扑并行检查进行实验。测试结果表明:并行检查算法的并行效率随着进程数的增加而有所衰减,但稳定在30%以上,加速比达到5以上,且相比于Arc GIS效率提升了30倍以上。并行检查方法以工具的方式集成应用于高性能地理计算平台中,应用效果良好。

关键词：地籍数据库拓扑关系数据质量并行计算高性能地理计算平台

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2019年3月柴达木盆地茫崖5.0级地震构造与油田井损关系分析

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地质学报 2020年第6期94卷 1911-1922页

作者：张长好杨屹洲郭召杰朱立林中国石油青海油田分公司勘探事业部甘肃敦煌736202 造山带与地壳演化教育部重点实验室北京100871 北京大学地球与空间科学学院北京100871 中国石油青海油田分公司采油三厂青海茫崖816400

地震引起的油气勘探开发过程中的钻井破坏日益引发关注,研究地震构造与钻井破坏之间的关系对油田安全生产非常重要。2019年3月28日青海省茫崖地区发生一系列地震,最大震级达5.0级,震中位于柴西狮子沟构造,并且在地震期间狮子沟地区钻井... 详细信息

地震引起的油气勘探开发过程中的钻井破坏日益引发关注,研究地震构造与钻井破坏之间的关系对油田安全生产非常重要。2019年3月28日青海省茫崖地区发生一系列地震,最大震级达5.0级,震中位于柴西狮子沟构造,并且在地震期间狮子沟地区钻井发生破坏。结合高精度地震勘探数据与钻井资料,本文刻画了狮子沟地区的地震构造与井损点分布特征,进一步探讨钻井破坏的原因。研究表明狮子沟构造是本次地震的发震构造,由盐上滑脱构造与盐下基底卷入的正花状构造组成,两者夹有厚度不均匀的盐岩体。在地震中被破坏的钻井集中分布于狮子沟背斜北东翼,靠近盐岩体厚度最大的区域。钻井井损点大致位于盐岩体顶面的连面且平行于地层层面。震源机制解指示存在倾向南南东、倾角较陡、以逆倾滑分量为主、兼有左行走滑分量与倾向北东、倾角较缓、兼有逆倾滑分量与右行走滑分量的两节面,分别对应盐下基底断裂的分支断裂与盐上逆冲滑脱断裂。考虑到震源位置的不确定性,盐下分支断裂或盐上逆冲滑脱断裂可能是本次地震的发震断裂,其中后者具有更大的可能性。钻井破坏的原因是同震断层活动造成的沿不稳定盐层顶面发生顺层剪切。因此,本文报道了盐构造环境下地震造成钻井破坏的实例。

关键词：柴达木盆地茫崖地震狮子沟构造盐层井损

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概率神经网络用于机匣振动故障诊断

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机械科学与技术 2016年第12期35卷 1805-1810页

作者：杨一舟蒋东翔清华大学热能工程系燃气轮机研究所北京100084

对机匣振动加速度信号进行采集与分析是航空发动机振动故障诊断的重要方法。对振动信号进行处理与特征提取后,可以利用神经网络非线性映射的能力,对振动故障实现分类。利用转子-轴承-机匣耦合振动实验台模拟了5种风扇机匣的振动故障,从... 详细信息

对机匣振动加速度信号进行采集与分析是航空发动机振动故障诊断的重要方法。对振动信号进行处理与特征提取后,可以利用神经网络非线性映射的能力,对振动故障实现分类。利用转子-轴承-机匣耦合振动实验台模拟了5种风扇机匣的振动故障,从频谱的初步分析中并未能够实现对故障的准确判断。对振动数据进行了处理,提取了振动波形的频域与幅域参数,采用概率神经网络的方法实现单一故障的分类,并对不同参数所训练的网络进行了比较,检验了该诊断方法对于机匣振动故障的可行性。

关键词：风扇机匣振动加速度概率神经网络故障诊断

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Ceria nanoparticles: biomedical applications and toxicity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 361-388页

作者： Xiaoxuan FU Peng LI Xi CHEN Yuanyuan MA Rong WANG Wenxuan JI Jiakuo GU Bowen SHENG yizhou WANG Zhuhong ZHANG School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China Department of Nephrology Yantai Yuhuangding HospitalQingdao UniversityYantai 264005China Institute of Crop Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China

Ceria nanoparticles(CeO_(2) NPs)have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation,cancer therapy,photocatalytic degradation of pollutants,sensors,*** methods,including gas phase,solid phase,liquid phase,and the newly proposed green synthesis method,have been reported for the synthesis of CeO_(2) *** to the wide application of CeO_(2) NPs,concerns about their adverse impacts on human health have been *** review covers recent studies on the biomedical applications of CeO_(2) NPs,including their use in the treatment of various diseases(e.g.,Alzheimer's disease,ischemic stroke,retinal damage,chronic inflammation,and cancer).CeO_(2) NP toxicity is discussed in terms of the different systems of the human body(e.g.,cytotoxicity,genotoxicity,respiratory toxicity,neurotoxicity,and hepatotoxicity).This comprehensive review covers both fundamental discoveries and exploratory progress in CeO_(2) NP research that may lead to practical developments in the future.

关键词： Ceria nanoparticle Synthetic method Biomedical application Oxidative stress Toxicity

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