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New developments in immunotherapy for lymphoma

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Cancer Biology & Medicine 2018年第3期15卷 189-209页

作者： Benjamin Heyman yiping yang Division of Hematologic Malignancies and Cellular Therapy Department of Medicine Department of Immunology Duke University

The development of immunotherapies for lymphoma has undergone a revolutionary evolution over the past decades. Since the advent of rituximab as the first successful immunotherapy for B-cell non-Hodgkin lymphoma over two decades ago, a plethora of new immunotherapeutic approaches to treat lymphoma has ensued. Four of the most exciting classes of immunotherapies include:chimeric antigen receptor T-cells, bispecific antibodies, immune checkpoint inhibitors, and vaccines. However, with addition of these novel therapies the appropriate timing of treatment, optimal patient population, duration of therapy, toxicity, and cost must be considered. In this review, we describe the most-promising immunotherapeutic approaches for the treatment of lymphoma in clinical development, specifically focusing on clinical trials performed to date and strategies for improvement.

关键词： CAR-T cells immune checkpoint blockade bispecific antibodies

TWO-STEP ESTIMATORS IN PARTIAL LINEAR MODELS WITH MISSING RESPONSE VARIABLES AND ERROR-PRONE COVARIATES

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Journal of Systems Science & Complexity 2011年第6期24卷 1165-1182页

作者： yiping yang Liugen XUE Weihu CHENG College of Mathematics and Statistics Chongqing Technology and Business University Chongqing 400067 China College of Applied Sciences Beijing University of Technology Beijing 100124 China

A partial linear model with missing response variables and error-prone covariates is considered. The imputation approach is developed to estimate the regression coefficients and the nonparametric function. The proposed parametric estimators are shown to be asymptotically normal, and the estimators for the nonparametric part are proved to converge at an optimal rate. To construct confidence regions for the regression coefficients and the nonparametric function, respectively, the authors also propose the empirical-likelihood-based statistics and investigate the limit distributions of the empirical likelihood ratios. The simulation study is conducted to compare the finite sample behavior for the proposed estimators. An application to an AIDS dataset is illustrated.

关键词： Empirical likelihood imputation approach measurement error partial linear model X2-distribution.

The occurrence of metallic copper and redistribution of copper in the shocked Suizhou L6 chondrite

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Acta Geochimica 2024年第5期43卷 827-837页

作者： Xiande Xie Xiangping Gu yiping yang Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Materials Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China

Copper possesses very strong chacophile properties,but under the conditions found in meteorites,its behavior is like that of siderophile *** Suizhou meteorite is a highly shocked L6 *** and taenite are considered the main primary carrier of copper in this meteorite,and the post-shock thermal episode is considered the main reason that elemental Cu migrates from its original host phase and forms metallic *** Suizhou meteorite contains a few very thin shock melt *** occurrence and behavior of metallic copper in this meteorite were studied by optical microscopic examination,electron microprobe analyses,and high-resolution X-ray elemental intensity *** results show that metallic copper is abundant in the Suizhou chondritic *** copper grains adjacent to small troilite grains inside FeNi metal are the most common occurrence,and those at the FeNi metal–troilite interface are the second most common *** metallic copper grains occurring at the interface of FeNi metal/troililte and silicate are rather *** copper grains are not observed within the Suizhou shock veins,Instead,Cu in elemental form is transferred through shock metamorphism into FeNi metal+troilite *** diff erent occurrence types of Cu in the FeNi metal+troilite intergrowths have been identifi ed:the concentrations of Cu in the FeNi+FeS intergrowths for four occurrence types are rather close,we estimate it might be lower than 1 wt%.

关键词： Suizhou chondrite Shock vein Metallic copper Metal-troilite intergrowth Elemental intensity mapping

Corrected empirical likelihood for a class of generalized linear measurement error models

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Science China Mathematics 2015年第7期58卷 1523-1536页

作者： yang yiping LI GaoRong TONG TieJun College of Mathematics and Statistics Chongqing Technology and Business University Beijing Center for Scientific and Engineering Computing Beijing University of Technology College of Applied Sciences Beijing University of Technology Department of Mathematics Hong Kong Baptist University

Generalized linear measurement error models, such as Gaussian regression, Poisson regression and logistic regression, are considered. To eliminate the effects of measurement error on parameter estimation, a corrected empirical likelihood method is proposed to make statistical inference for a class of generalized linear measurement error models based on the moment identities of the corrected score function. The asymptotic distribution of the empirical log-likelihood ratio for the regression parameter is proved to be a Chi-squared distribution under some regularity conditions. The corresponding maximum empirical likelihood estimator of the regression parameter π is derived, and the asymptotic normality is shown. Furthermore, we consider the construction of the confidence intervals for one component of the regression parameter by using the partial profile empirical likelihood. Simulation studies are conducted to assess the finite sample performance. A real data set from the ACTG 175 study is used for illustrating the proposed method.

关键词： generalized linear model empirical likelihood measurement error corrected score

Evolution of the Southern Yellow Sea Cold Water Mass during the last 7 kyr from benthic foraminiferal evidence

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Science China Earth Sciences 2018年第10期61卷 1406-1418页

作者： Fuchang ZHONG Rong XIANG yiping yang Meixun ZHAO Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301 China University of Chinese Academy of Sciences Beijing 100039 China Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of ChinaQingdao 266100 China

The Southern Yellow Sea Cold Water Mass(YSCWM) is closely related to the modern circulation system of the east China shelf seas, which has significantly influenced regional marine environmental changes. The study of the Holocene evolution of the YSCWM will greatly improve our understanding of the mechanisms of regional environmental change. Benthic foraminifera are sensitive to bottom water environmental changes and can serve as useful indicators in bottom water environmental reconstruction. In this study, benthic foraminifera were analyzed in core N02 from the northwestern margin of the southern Yellow Sea Mud to decipher the phase evolution of the YSCWM during the last 7 kyr. Benthic foraminifera census counts and Q-mode factor analysis indicate that the Holocene sedimentary environment can be divided into three stages: From6.9–5.0 ka, the fauna was dominated by Ammonia ketienziensis, indicating that the YSCWM was at its strongest during the last 7 kyr, while the Yellow Sea Coastal Current(YSCC) had a weak influence on the bottom water of the study area. From 5.0–2.9 ka,the relative abundance of Hanzawaia nipponica remarkably increased while the abundance of A. ketienziensis decreased significantly, reflecting that the strength of the YSCWM was relatively weak and the range of the YSCWM might have contracted. The influence of the YSCC on the bottom water might have slightly increased, although its influence was still weak during this time. A notable increase in low-temperature and low-salinity species, such as Protelphidium tuberculatum and Buccella spp. has occurred since 2.9 ka, indicating that the YSCC has had a strong influence on bottom water during this period,while the strength of the YSCWM has been at its weakest during the last 7 kyr. Generally, the influence of the YSCWM and the YSCC on the bottom water properties of the study area show an obvious seesaw pattern, with one's influence increasing while the other's influence decreases and vice versa. The fl

关键词： Benthic foraminifera Yellow Sea Cold Water Mass Holocene El Nifio Southern Oscillation East Asian Winter Monsoon

Relationship between groundwater cadmium and vicinity resident urine cadmium levels in the non-ferrous metal smelting area,China

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Frontiers of Environmental Science & Engineering 2023年第5期17卷 41-50页

作者： Yujie Pan Yalan Li Hongxia Peng yiping yang Min Zeng yang Xie Yao Lu Hong Yuan College of Environmental Sciences and Engineering Peking UniversityBeijing 100091China Clinical Research Center The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Geography School of Geography and Information EngineeringChina University of GeosciencesWuhan 430079China Wuhan Geological Survey Center of China Geological Survey Wuhan 430205China School of Economics and Management Beihang UniversityBeijing 100191China Laboratory for Low-carbon Intelligent Governance Beihang UniversityBeijing 100191China School of Life Course Sciences King’s College LondonLondonWC2R 2LSUK Department of Cardiology The Third Xiangya HospitalCentral South UniversityChangsha 410013China

Cadmium(Cd)has received widespread attention owing to its persistent toxicity and *** in the human body is mainly absorbed from the external environment and is usually assessed using urinary *** Province is the heartland of the Chinese non-ferrous mining area,where several serious Cd pollution events have occurred,including high levels of Cd in the urine of ***,the environmental factors influencing high urinary Cd levels(UCLs)in nearby residents remain ***,211 nearby residents’UCLs and the corresponding sociological characteristics from nine groundwater samples in this area were analyzed using statistical analysis *** Cd concentration ranged from 0.02 to 1.15μg/L,aligning with class III of the national standard;the range of UCL of nearby residents was 0.37–36.60μg/L,exceeding the national guideline of 0–2.5μg/*** Cd levels were positively correlated with the UCL(P<0.001,correlation coefficient 95%CI=9.68,R^(2)=0.06).In addition,sociological characteristics,such as smoking status and education level,also affect *** results indicate that local governments should strengthen the prevention and abatement of groundwater Cd *** study is the first to systematically evaluate the relationship between groundwater Cd and UCL using internal and external environmental exposure *** findings provide essential bases for relevant departments to reduce Cd exposure in regions where the heavy metal industry is globally prevalent.

关键词： Groundwater Cd Urinary Cd level Relationship Non-ferrous metal smelting area China

Rare earth element enrichment in sedimentary phosphorites formed during the Precambrian-Cambrian transition,Southwest China

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Geoscience Frontiers 2024年第2期15卷 334-348页

作者： Jieqi Xing Yuhang Jiang Haiyang Xian Wubin yang yiping yang Hecai Niu Hongping He Jianxi Zhu CAS Key Laboratory of Mineralogy and Metallogeny Guangdong Provincial Key Laboratory of Mineral Physics and MaterialsGuangzhou Institute of GeochemistryChinese Academy of Sciences(CAS)Guangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China

Numerous sedimentary phosphorites in Southwest China were formed around the Precambrian–Cambrian transition(PC–C),including the upper Ediacaran Doushantuo Formation and lower Cambrian Gezhongwu *** Gezhongwu phosphorites in Zhijin exhibit marked rare earth element(REE)enrichment(>1000 ppm),and may represent new REE *** the main characteristics of the Gezhongwu phosphorites have been well constrained,the REE enrichment mechanisms remain *** undertook a comparative study of three typical sedimentary phosphorites with variable REE contents formed at the PC–C transition in central Guizhou Province,Southwest *** include sections A and B of the Doushantuo phosphorites(560±8 Ma)from the Weng’an area(i.e.,WA-A and WA-B),and the Gezhongwu phosphorites(527±24 Ma)from the Zhijin area(ZJ).The phosphorites were investigated with state-of-the-art macroscale to nanoscale analytical *** contrast to the extraordinary REE enrichment in the ZJ phosphorites(average RREE=1157 ppm),the phosphorites in WA-A(average RREE=234 ppm)and WA-B(average RREE=114 ppm)are *** mapping by laser ablation–inductively coupled plasma–mass spectrometry,along with transmission electron microscopy analyses,showed the REEs in the studied phosphorites are hosted in nanoscale *** 87Sr/86Sr and Y/Ho ratios of the francolite grains indicate that greater terrigenous input may have led to more REE enrichment in the WA-A than WA-B phosphorites,but this cannot explain the extraordinary REE enrichment in the ZJ *** F/P_(2)O_(5)values of the francolite grains in the ZJ phosphorites(~0.097)are higher than those in the WA-A(~0.084)and WA-B(~0.084)phosphorites,and the grain size of the francolite in the ZJ phosphorites(~89.9 nm)is larger than those in the WA-A(~56.6 nm)and WA-B(~57.4 nm)phosphorites,indicative of more intense reworking of the ZJ than WA phosphorites during early diagenesis.A plot of Nd concentration versus Ce/Ce^(*)r

关键词： REE enrichment Francolite,phosphorites Sedimentary reworking Rate of sedimentary

Orthogonality Based Empirical Likelihood Inferences for Linear Mixed Effects Models

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Journal of Mathematical Research with Applications 2020年第2期40卷 209-220页

作者： Changqing LIU Peixin ZHAO yiping yang College of Mathematics and Statistics Baise University College of Mathematics and Statistics Chongqing Technology and Business University Chongqing Key Laboratory of Social Economy and Applied Statistics

Based on empirical likelihood method and QR decomposition technique, an orthogonality empirical likelihood based estimation method for the fixed effects in linear mixed effects models is proposed. Under some regularity conditions, the proposed empirical log-likelihood ratio is proved to be asymptotically chi-squared, and then the confidence intervals for the fixed effects are constructed. The proposed estimation procedure is not affected by the random effects,and then the resulting estimator is more effective. Some simulations and a real data application are conducted for further illustrating the performances of the proposed method.

关键词： Linear mixed effects model orthogonality empirical likelihood QR decomposition random effects

Phase-selection and metastable phase formation in highly undercooled eutectic Ni78.6Si21.4alloys

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Progress in Natural Science:Materials International 2006年第3期16卷 287-291页

作者： LU yiping, yang Gencang, yang Changlin, WANG Haipeng and ZHOU Yaohe (State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China Department of Applied Physics, Northwestern Polytechnical University, Xi'an 710072, China) [a]State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi'an China [b]Department of Applied Physics Northwestern Polytechnical University Xi'an China

A large undercooling (250 K) was achieved in eutectic Ni78.6 Si21.4 melt by the combination of molten-glass denucleation and cyclic superheating. The metastable phase formation process in the bulk undercooled eutectic Ni78.6 Si21.4 melts was investigated. With the increase of undercooling, different metastable phases form in eutectic Ni78.6 Si21.4 melts and part of these metastable phases can be kept at room temperature through slow post-solidification. Under large undercooling, the metastable phases β2-Ni3Si, Ni31Si12 and Ni3Si2 were identified. Especially, the Ni3Si2 phase was obtained in eutectic Ni78.6 Si21.4 alloy for the first time. Based on the principle of free energy minimum and transient nucleation theory, the solidification behavior of melts was analyzed with regard to the metastable phase formation when the melts were in highly undercooled state.

关键词： undercooling molten-glass metastable phase rapid solidification.