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Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.

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Chinese Journal of Natural Medicines 2021年第11期19卷 868-873页

作者： WU Jie-Wei TANG Chun-Ping YAO Sheng KE Chang-Qiang ye yang Mathematical Engineering Academy of Chinese Medicine Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Drug Research and Natural Products Chemistry DepartmentShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Life Science and Technology Shanghai Tech UniversityShanghai 201203China

Dicarabrols B and C(1 and 2),two new carabrane sesquiterpenoid dimers,along with one new carabrane sesquiterpenoid(3)were isolated from the whole plant of Carpesium abrotanoides *** full structures were established by extensive analysis of HR-ESI-MS and NMR spectroscopic data,and time-dependent density functional theory(TDDFT)electronic circular dichroism(ECD)*** B possesses a novel C30 skeleton featuring a methylene-tethered bridge between two sesquiterpene moieties,while dicarabrol C presents the unique linkage of a cyclopentane ring in the *** C exhibited potent inhibitory effects on HL−60 cells with an IC50 value of 3.7μmol·L^(−1).

关键词： Sesquiterpenoid dimer Carpesium abrotanoides L. Carabrane sesquiterpenoid Dicarabrol B Dicarabrol C 11R-hydroxycarabrol

3,4-seco-Isopimarane and 3,4-seco-pimarane diterpenoids from Callicarpa nudiflora

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Chinese Journal of Natural Medicines 2021年第8期19卷 632-640页

作者： HUANG Hang TANG Chun-Ping KE Chang-Qiang SHU Ren-Geng ye yang State Key Laboratory of Drug Research and Natural Products Chemistry Department Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchang 330004China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China

A phytochemical investigation was carried out on the extract of a medicinal plant Callicarpa nudiflora,resulting in the characterization of five new 3,4-seco-isopimarane(1-5)and one new 3,4-seco-pimarane diterpenoid(6),together with four known *** structures of the new compounds were fully elucidated by extensive analysis of MS,1 D and 2 D NMR spectroscopic data,and time-dependent density functional theory(TDDFT)calculation of electronic circular dichroism(ECD)spectra,and DFT calculations for NMR chemical shifts and optical rotations.

关键词： Callicarpa nudiflora 3,4-seco-Isopimarane 3,4-seco-Pimarane TDDFT-ECD DFT calculation

Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： ye yang Wu Wen Feng-Lin Chen Ying-Jie Zhang Xiao-Cong Liu Xiao-Yan yang Shan-Shan Hu ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

Effects of Acupuncture on Endometrium and Pregnancy Outcomes in Patients with Polycystic Ovarian Syndrome Undergoing in vitro Fertilization-Embryo Transfer:A Randomized Clinical Trial

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Chinese Journal of Integrative Medicine 2022年第8期28卷 736-742页

作者： WU Jia-man NING Yan ye yang-yang LIU Yu-lei TANG Meng HU Shan ZHUO Yuan-yuan Department of Traditional Chinese Medicine Affiliated Shenzhen Maternity&Child Healthcare HospitalSouthern Medical UniversityShenzhenGuangdong Province518028China First College of Clinical Medicine Guangzhou University of Traditional Chinese MedicineGuangzhou510405China Department of Acupuncture and Moxibustion Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong Province518033China

Objective:To observe the effect of acupuncture on endometrium and pregnancy outcomes in patients with polycystic ovary syndrome(PCOS)infertility undergoing in vitro fertilization-embryo transfer(IVF-ET).Methods:Eighty-three patients were randomly assigned to observation group(40 cases)and control group(43 cases)according to the random numbers generated by SPSS *** patients of the two groups received GnRH agonist long protocol as a routine *** the observation group,acupuncture was given at two acupoint groups for 30 min once every other *** 1 included Guanyuan(CV 4),Qihai(CV 6),Zhongji(CV 3),bilateral acupoints Zigong(EX-CA1).Group 2 included Mingmen(GV 4),Yaoyangguan(GV 3),bilateral Shenshu(BL 23)and Ciliao(BL 32).The two groups of acupoints were used *** whole needling process was performed at the time of ovulation induction until the transplantation day and consisted of3 courses,while the control group did not receive acupuncture *** Gn dosage and Gn stimulation time,endometrial thickness and type(A,B,and C),serum oestradiol(E2)and progesterone(P)levels on the day of injection of human chorionic gonadotropin(hCG),clinical pregnancy rate,as well as live birth rate were *** reactions were also be *** patients were followed up for the pregnant rate 14 days after IVF-ET and live birth rate after *** adverse reactions(AEs)of acupuncture were recorded during the ***:The Gn dosage and Gn stimulation time in the observation group were lower in the observation group than in the control group(P<0.01).The proportion of type A endometrium in the observation group were higher than that in the control group(P<0.05).The serum E2 and P levels on the day of hCG injection was lower and the clinical pregnancy rate was higher in the observation group compared to those in the control group(P<0.05).There was no serious AEs during this ***:Acupuncture can improve the proportion of t

关键词： acupuncture in vitro fertilization-embryo transfer polycystic ovarian syndrome endometrium

Cloning, Expression and Purification of Wheat Acetyl-CoA Carboxylases CT Domain in E. coil

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Chemical Research in Chinese Universities 2008年第6期24卷 752-755页

作者： WANG Rui-jian yang Xue-ying ZHENG Liang-yu yang ye GAO Gui CAO Shu-gui Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education Jilin University Changchun 130021 P. R. China College of Forestry Beihua University Jilin 132013 P. R. China

The entire gene of carboxyltransferase（CT） domain of acetyl-CoA carboxylase（ACCase） from Chinese Spring wheat（CSW） plastid was cloned firstly, and the 2.3 kb gene was inserted into PET28a^＋ vector and expressed in E. coil in a soluble state. The （His）6 fusion protein was identified by SDS-PAGE and Western blot. The recombinant protein was purified by affinity chromatography, and the calculated molecular mass（Mr） was 88000. The results of the sequence analysis indicate that the cloned gene（GeneBank accession No. EU124675） was a supplement and revision of the reported ACCase CT partial cDNA from Chinese Spring wheat plastid. The recombinant protein will be significant for us to investigate the recognizing mechanism between ACCase and herbicides, and further to screen new herbicides.

关键词： Chinese Spring wheat Acetyl-CoA carboxylase Carboxyltransferase(CT) domain Cloning Expression Purification

In situ Synthesis of Rosin Derived Chiral Derivatizing Agents for 31p NMR Assays of Amine and Alcohol Enantiomers

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Chemical Research in Chinese Universities 2013年第5期29卷 894-899页

作者： WU Qiang YAO Gui-yang ZHANG ye WANG Heng-shan yang Lin ZHU Yong-tao PAN Ying-ming Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry & Pharmaceutical Sciences of Guangxi Normal University Guilin 541004 P R. China

Chiral alcohols（3, 5） were synthesized in optically pure forms from easily available rosin acid in short-steps. A comprehensive protocol for the enantiomeric excess assays of mono- or di-functional-grouped chiral secondary amine or alcohol has been established with them used as chiral auxiliary for chiral phosphorus derivatizing agents（CPDAs） in 3Jp NMR tests. Chemical shift difference（△δp） values ranging from 4.5 to 0.15 between two dias- tereoisomers of the CPDAs and the aryl substrates were obtained. Positive △δR-S was observed for all the tested alco- hol P（III） and P（V） derivatives, while negative △δR-S was observed for all the amines.

关键词： Chiral phosphorus derivatizing agent Rosin Enantiodiscrimination 31p NMR

Rearranged diterpenoids from the seeds of Caesalpinia sappan

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Chinese Chemical Letters 2016年第12期27卷 1751-1754页

作者： Fang Xiao Chun-Ping Tang Chang-Qiang Ke Sheng Yao yang ye State Key Laboratory of Drug Research & Natural Products Chemistry Department Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China University of Chinese Academy of Sciences Beijing 100049 China School of Life Science and Technology Shanghai Tech University Shanghai 201210 China

Two new rearranged diterpenoids, tomocinol C （1） and spirocaesalmin C （2） were isolated from the seeds of Caesalpinia sappan. Their structures were elucidated based on comprehensive analysis of spectroscopic data,... 详细信息

关键词： Diterpenoid Tomocinol C Spirocaesalmin C Caesalpinia sappan Absolute configuration X-ray crystallography

Detection of Thrips Defect on Green-Peel Citrus Using Hyperspectral Imaging Technology Combining PCA and B-Spline Lighting Correction Method

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Journal of Integrative Agriculture 2014年第10期13卷 2229-2235页

作者： DONG Chun-wang ye yang ZHANG Jian-qiang ZHU Hong-kai LIU Fei Tea Research Institute Chinese Academy of Agricultural Sciences School of Food and Biological Engineering Jiangsu University

In order to find an effective method of detecting thrips defect on green-peel citrus, a defect segmentation method was developed using a single threshold value based on combination of characteristic wavelengths principal component analysis （PCA） and B-spline lighting correction method in this study. At first, four characteristic wavelengths （523, 587, 700 and 768 nm） were obtained using PCA of Vis-NIR （visible and near-infrared） bands and analysis of weighting coefficients; secondarily, PCA was performed using characteristic wavelengths and the second principal component （PC2） was selected to classify images; then, B-spline lighting correction method was proposed to overcome the influence of lighting non-uniform on citrus when thrips defect was segmented; finally, thrips defect on citrus was extracted by global threshold segmentation and morphological image processing. The experimental results show that thrips defect in citrus can be detected with an accuracy of 96.5% by characteristic wavelengths PCA and B-spline lighting correction method. This study shows that thrips defect on green-peel citrus can be effectively identified using hyperspectral imaging technology.

关键词： hyperspectral images principal component analysis lighting correction green-peel citrus thrips defect

Altered proteomic expression in the prefrontal cortex of morphine-addicted rats

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Neural Regeneration Research 2011年第4期6卷 300-303页

作者： ye yang Chunyan Zhang Han Liu Bin Wang Haiying Lin Lisha Wu Department of Biochemistry Luzhou Medical College Luzhou 646000 Sichuan Province China Audio-bisual Educational Center Luzhou Medical College Luzhou 646000 Sichuan Province China Department of Cardiology the People's Hospitial of Luzhou Luzhou 646000 Sichuan Province China Department of Physiology Luzhou Medical College Luzhou 646000 Sichuan Province China

The prefrontal cortex is involved in the regulation and control of substance addiction-related cognitive, behavioral, and emotional changes. The present study identified prefrontal cortex protein profiles in morphine-addicted rats; these were subsequently compared with normal rats. Results showed 87 protein spots with differentially expressed levels in the morphine addiction group, with the majority located in meta acid zones at pH 4.2-6.8 and having a molecular weight of 30-110 kDa In addition, 2 protein spots were identified as being associated with neurotoxicity （Snap25 isoform β-Snap25 of synaptosomal-associated protein 25 and βactin）.

关键词： addiction morphine prefrontal cortex proteome 2-dimensional gel electrophoresis