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Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica

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Chinese Journal of Natural Medicines 2019年第10期17卷 785-791页

作者： Zhamilya Abilova YUAN Jie Janar Jenis TANG Chun-Ping ye yang University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Drug Research and Natural Products Chemistry DepartmentShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Research Center for Medicinal Plants Al-Farabi Kazakh National UniversityAI-Farabi ave.71050040 AlmatyRepublic of Kazakhstan School of Life Science and Technology Shanghailech UniversityShanghai 201210China

One new dimeric(1) and two monomeric sesquiterpene lactones(5 and 13), together with 10 known compounds(2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC50 values ranging from 2 to 25μmol·L^-1.

关键词： Artemisia heptapotamica Artemisiane E Artemdubolide I Ajaniaolide B Sesquiterpene lactone Anti-inflammation

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杨晔

世界建筑 2021年第5期 23-23,124页

作者：杨晔沈抚改革创新示范区管委会

1980年代的最后4年在西冶求学,有幸聆听过刘宝仲、张似赞、侯继尧、夏云、佟裕哲、张缙学、李觉、汤道烈、李树涛、刘永德、姜佐盛、赵秀兰、刘振亚、郑士奇等先生们的教诲,感受过周若祁、乔征、李京生、王竹、刘临安、刘晓波、冯晓红... 详细信息

1980年代的最后4年在西冶求学,有幸聆听过刘宝仲、张似赞、侯继尧、夏云、佟裕哲、张缙学、李觉、汤道烈、李树涛、刘永德、姜佐盛、赵秀兰、刘振亚、郑士奇等先生们的教诲,感受过周若祁、乔征、李京生、王竹、刘临安、刘晓波、冯晓红、邵晓光、刘克成、刘辉亮这些当年的年轻教师的才华与热情。

关键词：刘宝刘振亚年轻教师刘晓波赵秀兰李京生刘永德

A restoration method using dual generate adversarial networks for Chinese ancient characters

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Visual Informatics 2022年第1期6卷 26-34页

作者： Benpeng Su Xuxing Liu Weize Gao ye yang Shanxiong Chen College of Computer and Information Science Southwest UniversityChongqing 400715China Chongqing Key Lab of Automated Reasoning and Cognition Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China

Ancient books that record the history of different periods are precious for human *** the protection of them is facing serious problems such as *** is significant to repair the damaged characters in ancient books and restore their original *** requirement of the restoration of the damaged character is keeping the stroke shape correct and the font style *** order to solve these problems,this paper proposes a new restoration method based on generative adversarial *** use the shape restoration network to complete the stroke shape recovery and the font style *** texture repair network is responsible for reconstructing texture *** order to improve the accuracy of the generator in the shape restoration network,we use the adversarial feature loss(AFL),which can update the generator and discriminator synchronously to replace the traditional perceptual ***,the font style loss is proposed to maintain the stylistic consistency for the whole *** model is evaluated on the datasets Yi and Qing,and shows that it outperforms current state-of-the-art techniques quantitatively and *** particular,the Structural Similarity has increased by 8.0%and 6.7%respectively on the two datasets.

关键词： Stroke shape restoration Texture restoration Calligraphy style

Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning

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Neural Regeneration Research 2024年第12期19卷 2723-2734页

作者： Xiaolu Li ye yang Senming Xu Yuchang Gui Jianmin Chen Jianwen Xu Department of Rehabilitation Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Rehabilitation Medicine Guilin People’s HospitalGuilinGuangxi Zhuang Autonomous RegionChina Department of Rehabilitation Medicine The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina

Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal co rd *** can greatly affect nerve regeneration and functional ***,there is still limited understanding of the peripheral immune inflammato ry response in spinal cord inju *** this *** obtained microRNA expression profiles from the peripheral blood of patients with spinal co rd injury using high-throughput *** also obtained the mRNA expression profile of spinal cord injury patients from the Gene Expression Omnibus(GEO)database(GSE151371).We identified 54 differentially expressed microRNAs and 1656 diffe rentially expressed genes using bioinformatics *** enrichment analysis revealed that various common immune and inflammation-related signaling pathways,such as neutrophil extracellular trap formation pathway,T cell receptor signaling pathway,and nuclear factor-κB signal pathway,we re abnormally activated or inhibited in spinal cord inju ry patient *** applied an integrated strategy that combines weighted gene co-expression network analysis,LASSO logistic regression,and SVM-RFE algorithm and identified three biomarke rs associated with spinal cord injury:ANO10,BST1,and *** verified the expression levels and diagnostic perfo rmance of these three genes in the original training dataset and clinical samples through the receiver operating characteristic *** polymerase chain reaction results showed that ANO20 and BST1 mRNA levels were increased and ZFP36L2 mRNA was decreased in the peripheral blood of spinal cord injury *** also constructed a small RNA-mRNA interaction network using ***,we evaluated the proportion of 22 types of immune cells in the peripheral blood of spinal co rd injury patients using the CIBERSORT *** proportions of naive B cells,plasma cells,monocytes,and neutrophils were increased while the proportions of memory B cells,C

关键词： bioinformatics analysis biomarker CIBERSORT GEO dataset LASSO miRNA-mRNA network RNA sequencing spinal cord injury SVM-RFE weighted gene co-expression network analysis

Clinical prediction of insufficient vaults after implantable collamer lens implantation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1300-1306页

作者： Jun Zhu Dan Cheng Xue-Ying Zhu Fen-Fen Li ye yang Yu-Feng ye National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)***:The participants underwent ICL surger... 详细信息

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(yes)and 36 patients(63 eyes)were in the low and normal vault groups,*** implantation procedures were uneventful with no cataract formation in the early postoperative *** sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after *** 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in ***:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these *** the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.

关键词： insufficient vault implantable collamer lens ciliary body posterior chamber

Investment Promotion for Development Zones in China:Underlying Rationale and Policy Options

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China Economist 2023年第5期18卷 98-123页

作者： Chen Qiangyuan Zhao Haoyun ye yang National Academy of Development and Strategy Renmin University of ChinaBeijingChina Business School Central South UniversityChangshaChina

Development zones(DZs)have emerged as a significant policy initiative for promoting regional coordination and facilitating resources *** serve as an organizational framework for fostering industrial agglomeration and driving high-quality *** attract and accommodate resource factors,firms,and projects,thereby functioning as a central catalyst for economic *** study utilizes data collected at the“DZ,City and Countrycountry”levels through manual compilation,textual analysis,and innovation *** aims to empirically examine the theoretical rationale and practical preferences for promoting business and investment in China’s *** study considers several factors such as industry attribute,firm attribute,agglomeration theory,and industrial chain *** on our research findings,DZs exhibit distinct ***,industry attribute:DZs align with both national and regional strategic planning and adhere to the industrial endowments of the respective ***,firm attribute:DZs prioritize attracting firms that are productive and innovative,and have an international presence,rather than those that primarily contribute to taxes and job ***,DZs are guided by the agglomeration theory,which suggests that they prefer firms that generate strong agglomeration ***,DZs also consider the industrial chain layout,aiming to attract firms that not only align with their existing industrial strengths but also extend to the upstream and downstream supply chain *** conclusions are substantiated by the performance of robustness *** success of DZs in China can be attributed to the five key principles:Adherence to national and regional strategic planning,prioritizing the actual industrial foundation,incorporating the theory of agglomeration externalities,strengthening corporate competitiveness,and expanding industrial chains.

关键词： Investment promotion by development zones basic rationale policy options agglomeration externalities spatial allocation of resources

Clinical application of individualized total arterial coronary artery bypass grafting in coronary artery surgery

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World Journal of Clinical Cases 2021年第19期9卷 5073-5081页

作者： Wei-Guang Chen Bai-Chun Wang Yong-Ri Jiang ye-yang Wang yang Lou Second Ward Department of Heart and Great Arteries SurgeryFourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Total arterial revascularization is associated with increased patency and long-term efficacy and decreased perioperative morbidity and mortality and incidence of cardiac-related events and sternal wound infection compared with conventional coronary artery bypass surgery(CABG),in which the left internal mammary artery(LIMA)is typically grafted to the left anterior descending artery with additional saphenous vein grafts often *** study determined whether these favorable clinical results could be realized at the authors’*** To summarize the early efficacy and clinical experience of individualized total arterial coronary artery bypass grafting *** CABG was performed on 35 patients with non-single-vessel coronary artery disease by adopting total arterial grafts at Fourth Affiliated Hospital of Harbin Medical University between April 2016 and December *** was used in 35 patients,radial artery(RA)was used in 35 patients,and right gastroepiploic artery(RGEA)was used in 9 *** complications were observed,short-term graft patency rate was followed-up,and quality of life was *** All patients underwent off-pump coronary artery bypass and the surgeries were *** of them were discharged without any complications or *** the follow-up,it was found that patients’angina symptoms were relieved and New York Heart Association classification for cardiac function was class I to class II.A total of 90 vessels were grafted with no occlusion for internal mammary artery,three occlusions for RA,and one occlusion for *** The individualized total arterial strategy based on the vessels targeting individual anatomic characteristics can achieve complete revascularization with satisfactory short-term grafting patency rate.

关键词： Total arterial revascularization Coronary artery bypass grafting Radial artery Right gastroepiploic artery

Electrocatalytic Synthesis of Non-Symmetric Biphenols Mediated by Tri(p-bromophenyl)amine:Selective Oxidative Cross-Coupling of Different Phenols and Naphthols

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Chinese Journal of Chemistry 2019年第4期37卷 352-358页

作者： Qing-Qing Wang yang-ye Jiang Cheng-Chu Zeng Bao-Guo Sun Beijing Advanced Innovation Center for Food Nutrition and Human Health School of Food and Chemical EngineeringBeijing Technology and Business UniversityBeijing 100048China Beijing Key Laboratory of Environmental and Viral Oncology College of Life Science & BioengineeringBeijing University of TechnologyBeijing 100124China

An efficient electrochemical access to the non-symmetric biphenols using tri(p-bromophenyl)amine(TBPA)as a redox mediator has been *** electrochemical protocol features highly selective cross-coupling products in up t... 详细信息

关键词： Non-Symmetric Biphenols Mediated Tri(p-bromophenyl)amine Phenols Naphthols

Human pescadillo induces large-scale chromatin unfolding

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Science China(Life Sciences) 2005年第3期48卷 270-276页

作者： ZHANG Hao FANG Yan HUANG Cuifen yang Xiao ye Qinong Beijing Institute of Biotechnology Beijing100850China Beijing Institute of Biotechnology Beijing100850China Beijing Institute of Biotechnology Beijing100850China Beijing Institute of Biotechnology Beijing100850China Beijing Institute of Biotechnology Beijing100850China

The human pescadillo gene encodes a protein with a BRCT domain. Pescadillo plays an important role in DNA synthesis, cell proliferation and transformation. Since BRCT do- mains have been shown to induce chromatin large-scale unfolding, we tested the role of Pesca- dillo in regulation of large-scale chromatin unfolding. To this end, we isolated the coding region of Pescadillo from human mammary MCF10A cells. Compared with the reported sequence, the isolated Pescadillo contains in-frame deletion from amino acid 580 to 582. Targeting the Pesca- dillo to an amplified, lac operator-containing chromosome region in the mammalian genome re- sults in large-scale chromatin decondensation. This unfolding activity maps to the BRCT domain of Pescadillo. These data provide a new clue to understanding the vital role of Pescadillo.

关键词： Pescadillo, large-scale chromatin unfolding, replication.