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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology research 2025年第1期33卷 199-212页

作者： Wen yang Bin Tang Dan Xu Wenxiu yang Department of Pathology Guizhou Medical University The Affiliated Hospital of Guizhou Medical University Guiyang 550004 China.

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma (DLBCL) has been reported previously. However, the detailed mechanisms of CCR7 in DLBCL, particularly regarding its interaction with lenalidomide treatment, are not fully understood.Methods:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control groups. Immunohistochemical data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of DLBCL. Furthermore, and experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide treatment.Results:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in DLBCL. Notably, 31.14% and 36.0% (44/122) of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively, establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression analysis. Additionally, our studies demonstrated that the external application of the protein CCL21 promoted proliferation, migration, invasion, and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 expression. This effect was mitigated by CCR7 silencing through siRNA, application of ERK inhibitors, or lenalidomide treatment. experiments reinforced the efficacy of lenalidomide, significantly reducing tumor growth rate, tumor mass, serum total LDH levels, and expression of CCR7 and p-ERK1/2 in a SU-DHL-2 xenograft model in nude mice ( < 0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCL21 CCR7 Diffuse large B-cell lymphoma (DLBCL) ERK1/2 Lenalidomide

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Simulation of Evapotranspiration Based on BEPS-TerrainLab V2.0 from 1990 to 2018 in the Dajiuhu Basin

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Chinese Geographical Science 2020年第6期30卷 1095-1110页

作者： WU Zongfan ZHANG Lihua LIU Dandan ZHANG Kang ZHU Zhiru FU yasheng MA Yongming Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information Engineerings China University of GeosciencesWuhan 430074China Guizhou Electric Power Design Research Institute Co. Ltd.Power Construction Corporation of ChinaGuiyang 550002China School of Earth Sciences China University of GeosciencesWuhan 430074China

Accurate estimations of evapotranspiration(ET)are essential for understanding land-atmosphere coupling and atmosphere-underlying surface energy and water vapor *** on input data processing,this paper simulates the temporal and spatial variation of ET in the Dajiuhu Basin from 1990 to 2018 using the BEPS-Terrain Lab V2.0 *** with the ET measured by an eddy covariance(EC)tower,the model explained 80.1%of the ET *** 1990 to 2018,the average annual ET in the Dajiuhu Basin was 1262.7 mm/yr indicating a downward trend(–27.12 mm/yr).In 2005,a sudden change point was observed based on the Mann-Kendall(MK)test and 3-year moving *** 2005,the downward trend in ET slowed and the proportional trend of ET to precipitation changed from upward trend to downward *** spatial distribution,the ET in the basin’s central part was smaller than that in the basin’s surrounding area,the ET of the southern slope was higher than that of the northern slope,and the decrease in the ET rate on the sunny side was lower than that on the shady *** decreased as the elevation increased,with the fastest decrease observed between 2184 and 2384 *** different landcover types,the average ET exhibited the following order:deciduous forest>mixed forest>wetland>grass>agriculture *** solar radiation is the main reason for the decreased ET in the Dajiuhu Basin,followed by increased wind speed and relative humidity,which together contribute 83.9%to the ET *** paper provides a theoretical basis for the study of ET changes and the mechanism of ET and provides a decision-making reference for water resource management in the Dajiuhu Basin and even the South-to-North Water Transfer Project.

关键词： evapotranspiration spatiotemporal pattern BEPS-TerrainLab V2.0 environmental factor Dajiuhu Basin

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WTO《促进发展的投资便利化协定》透明度条款及我国实施方案

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国际商务研究 2025年第1期46卷 59-72页

作者：杨欣中国石油大学(华东) 山东青岛266580

《促进发展的投资便利化协定》旨在提高国家投资政策透明度,简化外国投资审核程序,创造规范性、便利化和高透明度的投资环境。透明度措施是该协定最重要的措施之一,通过投资信息公布、单一窗口平台建设、投诉评论机制构建等措施着力提... 详细信息

《促进发展的投资便利化协定》旨在提高国家投资政策透明度,简化外国投资审核程序,创造规范性、便利化和高透明度的投资环境。透明度措施是该协定最重要的措施之一,通过投资信息公布、单一窗口平台建设、投诉评论机制构建等措施着力提高国际投资透明度。我国不仅是该协定谈判的坚定引领者,也是该协定履行的积极行动者,加入该协定以来,采取一系列措施优化便利投资环境,提高透明度水平。然而,当前我国在国际投资透明度立法体例、国际投资透明度具体要求以及国际投资单一窗口平台建设方面均与该协定透明度要求存在差距,应当从修改立法体例、完善具体要求以及完善国际投资单一窗口等3个方面探究我国投资透明度措施与该协定条款的良好衔接方案,构建高度透明、高效便利的国际投资环境。

关键词：《促进发展的投资便利化协定》投资便利化透明度

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基于LabVIEW的拖拉机电气故障诊断系统设计

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农机化研究 2025年第2期47卷 239-243,248页

作者：张扬山西职业技术学院太原030006

设计了一种基于LabVIEW的拖拉机电气故障诊断系统,其采用模块化设计,可以自动检测和诊断拖拉机的电气故障,并提供可视化的诊断结果。系统由数据采集模块、信号处理模块、故障诊断模块和用户界面模块组成。数据采集模块负责采集拖拉机各... 详细信息

设计了一种基于LabVIEW的拖拉机电气故障诊断系统,其采用模块化设计,可以自动检测和诊断拖拉机的电气故障,并提供可视化的诊断结果。系统由数据采集模块、信号处理模块、故障诊断模块和用户界面模块组成。数据采集模块负责采集拖拉机各个部件的电气参数数据,信号处理模块对采集到的数据进行处理和分析,故障诊断模块通过分析处理后的数据来判断拖拉机是否存在故障,并给出相应的诊断结果,用户界面模块提供友好的交互界面。试验结果表明:系统可以准确地诊断拖拉机的电气故障,具有良好的应用前景和推广价值。

关键词：拖拉机电气故障诊断 LabVIEW 数据采集模块化设计

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论黑格尔语言哲学的独特理论个性

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武汉大学学报（哲学社会科学版） 2025年第1期78卷 86-96页

作者：杨兴凤广西大学马克思主义学院广西南宁530004

从语言哲学角度去考察黑格尔哲学会动摇一种常见的哲学信念:黑格尔哲学是以语言分析为主阵地的英美哲学所要拒绝的对象。实质上,黑格尔哲学中有着丰富的语言哲学论述,对其特征的阐明能够揭示出其与英美语言哲学传统不同的语言分析进路... 详细信息

从语言哲学角度去考察黑格尔哲学会动摇一种常见的哲学信念:黑格尔哲学是以语言分析为主阵地的英美哲学所要拒绝的对象。实质上,黑格尔哲学中有着丰富的语言哲学论述,对其特征的阐明能够揭示出其与英美语言哲学传统不同的语言分析进路。让·依波利特甚至认为黑格尔把逻辑学建构为一种语言哲学,也有人主张黑格尔是真正实施罗蒂提出的“语言转向”的第一位哲学家。黑格尔引入的辩证法语言具有整体主义与历史主义特征、运动承诺及模糊性与意义转换特征,这使得其语言哲学思想与英美语言哲学进路有着根本的差异。

关键词：黑格尔语言哲学辩证法语言

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Quantitative Evaluation of the Sea-level Drop at the End-Permian: Based on Reefs

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Acta Geologica Sinica(English Edition) 2003年第1期77卷 95-102页

作者： WU yasheng and FAN Jiasong Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029 Chinese Acad Sci Inst Geol & Geophys Beijing 100029 Peoples R China

The amplitude of pre-Quaternary sea level drop, H, can be calculated by usingthe formula H = D + To, where To is the original thickness from the top of the tidal deposits onthe reef core to the bottom of the tidal deposits on the reef front, or to the bottom of the ancientmeteoric vadose zone, or to the edge of the mixed-water dolostone zone. The identity and similaritybetween the sea-level drop amplitudes calculated from different reefs far away from each otherindicates that such sea-level changes are eustatic rather than relative changes. Evidence of anend-Permian sea-level drop has been found on the Changxingian (i.e. the end of the Palaeofusulinazone) reefs at Ziyun in South China, including algal laminated deposits, sabkha-related dolostone,desiccation cracks, dissolution collapse breccia. According to calculation based on the meteoricdissolution zone of the reef-core sequence at Ziyun, Guizhou province, the amplitude of thesea-level drop at the end-Permian is about 89.3 m. Calculation via the dolomitized upper part of theChangxingian reef in Lichuan, Hubei Province, yields an 88.9 m amplitude of the sea-level drop atthe end-Permian. Comparison shows that the sea-level drop recorded in the two distantly locatedreefs may be of eustatic type. So the amplitude of the sea level drop of the Tethys Sea at theend-Permian might be at least 89.3 m.

关键词： sea-level drop eustatic reef Permian Changxingian

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Dynamic changes in hair cell ribbon synapse induced by loss of spiral ganglion neurons in mice

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Chinese Medical Journal 2014年第10期127卷 1941-1946页

作者： Yuan yasheng Chi Fanglu Department of Otolaryngology Eye Ear Nose & Throat HospitalFudan University Shanghai 200031 China Department of Otolaryngology MEEI Harvard Medical SchoolBoston MA 02115 USA (Yuan YS)

Background Previous studies have suggested that primary degeneration of hair cells causes secondary degeneration of spiral ganglion neurons （SGNs）,but the effect of SGN degeneration on hair cells has not been *** the adult mouse inner ear ouabain can selectively and permanently induce the degeneration of type 1 SGNs while leaving type 2 SGNs,efferent fibers,and sensory hair cells relatively *** study aimed to investigate the dynamic changes in hair cell ribbon synapse induced by loss of SGNs using ouabain application to the round window niche of adult *** In the analysis,24 CBA/CAJ mice aged 8-10 weeks,were used,of which 6 normal mice were used as the control *** ouabain application in the round window niche 6 times in an hour,ABR threshold shifts at least 30 dB in the three experimental groups which had six mice for 1-week group,six for 1-month group,and six for 3-month *** 24 animals underwent function test at 1 week and then immunostaining at 1 week,1 month,and 3 *** The loss of neurons was followed by degeneration of postsynaptic specializations at the afferent synapse with hair *** week after ouabain treatment,the nerve endings of type 1 SGNs and postsynaptic densities,as measured by Na/K ATPase and PSD-95,were affected but not entirely missing,but their partial loss had consequences for synaptic ribbons that form the presynaptic specialization at the synapse between hair cells and primary afferent *** numbers in inner hair cells decreased （some of them broken and the ribbon number much decreased）,and the arrangement of the synaptic ribbons had undergone a dynamic reorganization：ribbons with or without associated postsynaptic densities moved from their normal location in the basal membrane of the cell to a more apical location and the neural endings alone were also found at more apical locations without associated *** 1 month,when the neural postsynaptic densities had completed their de

关键词： auditory neurons hair cells ribbon synapse degeneration

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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan yang Lingxi Qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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Effect of reduced energy density of close-up diets on dry matter intake,lactation performance and energy balance in multiparous Holstein cows

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Journal of Animal Science and Biotechnology 2015年第1期6卷 47-54页

作者： Wenming Huang Yujia Tian Yajing Wang Aminamu Simayi Amingguli yasheng Zhaohai Wu Shengli Li Zhijun Cao State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural University

Energy intake prepartum is critically important to health, milk performance, and profitability of dairy cows. The objective of this study was to determine the effect of reduced energy density of dose-up diets on dry matter intake （DMI）, lactation performance and energy balance （EB） in multiparous Holstein cows which were housed in a free-stall barn and fed for ad libitum intake. Thirty-nine dry cows were blocked and assigned randomly to three groups fed a high energy density diet [HD, n = 13; 6.8 MJ of net energy for lactation （NEL）/kg; 14.0% crude protein （CP） ], or a middle energy density diet （MD, n = 13; 6.2 MJ NEh/kg; 14.0% CP）, or a low energy density diet （LD, n = 13; 5.4 MJ NEh/kg; 14.0% CP） from d 21 before expected day of calving. After parturition, all cows were fed the same lactation diet to d 70 in milk （DIM）. The DMI and NEE intake prepartum were decreased by the reduced energy density diets （P 〈 0.05）. The LD group consumed 1.3 last 24 h before calving. The milk yield and the postpartum kg/d （DM） more diet compared with HD group in the DMI were increased by the reduced energy density diet prepartum （P 〈 0.05）. The changes in BCS and BW prepartum and postpartum were not affected by prepartum diets HD group had higher milk fat content and lower lactose content compared with LD group during the first 3 wk of lactation （P 〈 0.05）. The energy consumption for HD, MD and LD groups were 149.8%, 126.2% and 101.1 % of their calculated energy requirements prepartum （P 〈 0.05）, and 72.7%, 73.1% and 7.5.2% during the first 4 wk postpartum, respectively. In conclusion, the low energy density prepartum diet was effective in controlling NF_L intake prepartum, and was beneficial in increasing DMI and milk yield, and alleviating negative EB postpartum.

关键词： Dietary energy density Dry matter intake Energy balance Lactation performance Transition cow

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