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Generation mechanism and motion behavior of sliver defect in single crystal Ni-based superalloy

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Journal of Materials Science & Technology 2023年第6期137卷 232-246页

作者： Huxiang Xia yanhong yang Qiushui Feng Qingyan Xu Hongbiao Dong Baicheng Liu Key Laboratory for Advanced Materials Processing Technology(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Engineering University of LeicesterLeicesterLE17RHUnited Kingdom

Sliver is a common but easily neglected defect in single crystal Ni-based superalloy *** date,there is still no unified viewpoint on its formation mechanism and generation *** this work,the orientation discontinuity and motion behavior of sliver defects were studied through experiments and numerical *** ultrathin wedge-shaped specimen containing the grain boundary of the sliver and the matrix was prepared at the initial position of the sliver defect for the observation of equal thick-ness *** discontinuity of equal thickness fringes on both sides of the grain boundary was ob-served through a transmission electron microscope,which directly confirms the abrupt change in the orientation between the sliver and matrix from the *** crystal lattices at the smooth area and the bulging area of the grain boundary were found to have unusually different *** irregular lattice arrangement at the bulging area shows that the grain boundary has experienced high-stress *** results of sliver orientation deviation with a further composition analysis show the micro protuberance of the mold shell has a noticeable inductive effect on the sliver ***,a self-developed three-dimensional phase-field simulation model coupled with the spatial topology algorithm is established to simulate the orientation deflection behavior and orientation devia-tion threshold of fractured *** simulation results indicated that there is an upper limit of the cross-section solid fraction at the fracture position for the motion of the fractured *** the cross-section solid fraction at the fracture position is higher than this upper limit,it will be difficult to produce large deviation slivers due to the structural limitation of surrounding *** upper limit does not change with the solidification temperature gradient.

关键词： Single crystal Ni-based superalloys Directional solidification Sliver defect Phase-field simulation

Quantifying the Influences of Carbides and Porosities on the Fatigue Crack Evolution of a Ni-Based Single-Crystal Superalloy using X-ray Tomography

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Acta Metallurgica Sinica(English Letters) 2022年第1期35卷 133-145页

作者： Keli Liu Junsheng Wang Bing Wang Pengcheng Mao yanhong yang Yizhou Zhou School of Materials Science&Engineering Beijing Institute of TechnologyBeijing100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China Center for Micro and Nano Technologies Beijing Institute of TechnologyBeijing100081China Superalloys Division Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The detrimental effects of carbides and porosity on the fatigue crack initiation and propagation of nickel-based single-crystal superalloys have been reported by many previous ***,few studies have quantitatively compared the fatigue damaging effects of carbides and pores on the fatigue crack *** this study,a high-resolution X-ray computed tomography(XCT)characterization of a DD5 nickel-based single-crystal superalloy during fatigue test was *** evolution of carbides,pores and cracks at all stages was observed and *** order to quantify the 3D microstructures,a new damage factor that correlates the morphology of fracture surface with crack evolution behaviors was *** was found that porosity was more detrimental than carbides in crack initiation and propagation during fatigue ***,pore spacing has been found to be the most significant factor among all controlling pore characteristics in the crack initiation stage and sphericity is the most critical pore characteristic in the crack propagation ***,by statistically analyzing the evolution of carbides and pores during fatigue tests in this study,the underlying fatigue cracking mechanism of nickel-based superalloys is revealed.

关键词： X-ray tomography Ni-based superalloys Fatigue Porosity Carbide Crack initiation Crack propagation

Federated double DQN based multi-energy microgrid energy management strategy considering carbon emissions

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Global Energy Interconnection 2023年第6期6卷 689-699页

作者： yanhong yang Tengfei Ma Haitao Li Yiran Liu Chenghong Tang Wei Pei Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190P.R.China Faculty of Information Technology Beijing University of TechnologyBeijing 100124P.R.China State Grid Electric Power Research Institute Nanjing211100P.R.China

Multi-energy microgrids(MEMG)play an important role in promoting carbon neutrality and achieving sustainable *** study investigates an effective energy management strategy(EMS)for ***,an energy management system model that allows for intra-microgrid energy conversion is developed,and the corresponding Markov decision process(MDP)problem is ***,an improved double deep Q network(iDDQN)algorithm is proposed to enhance the exploration ability by modifying the calculation of the Q value,and a prioritized experience replay(PER)is introduced into the iDDQN to improve the training speed and ***,taking advantage of the federated learning(FL)and iDDQN algorithms,a federated iDDQN is proposed to design an MEMG energy management strategy to enable each microgrid to share its experiences in the form of local neural network(NN)parameters with the federation layer,thus ensuring the privacy and security of *** simulation results validate the superior performance of the proposed energy management strategy in minimizing the economic costs of the MEMG while reducing CO_2 emissions and protecting data privacy.

关键词： Multi-energy microgrid Federated learning Improved double DQN Energy conversion

Progenitor-age dependence of type Ia supernova luminosity and its cosmological implication

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 180-181页

作者： yanhong Yao yang Wang Haitao Miao School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Peng Cheng Laboratory Shenzhen 518000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

Empirically standardised peak luminosity of Type Ia supernovae(SNe Ia)as a standard candle has become one of the most powerful probes of the expansion history of the late *** the existence of such a consistent peak luminosity could be interpreted as a consequence of the fixed critical Chandrasekhar mass at which a carbon-oxygen white dwarf explodes,there is growing evidence for a more complex environmental dependence to the SN Ia luminosity beyond the current understanding of the SN Ia physics.

关键词： luminosity supernova consequence

kisspeptin调控Notch1/Akt/Foxo1通路参与复发性流产患者子宫内膜蜕膜化

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四川大学学报（医学版） 2024年第3期55卷 542-551页

作者：杨艳红张建亮李冬晓刘翠平郭融肖伊周玲佟玲霞张弘苏州大学附属第二医院妇产科苏州215004 苏州大学附属第一医院江苏省临床免疫研究所苏州215021

目的 kisspeptin是一种肿瘤抑制因子,由KISS1基因编码。Notch1/Akt/Foxo1是调节细胞增殖、分化的重要信号通路。本研究探讨kisspeptin通过Notch1/Akt/Foxo1信号通路调控子宫内膜蜕膜化在复发性流产(RSA)中的作用机制。方法纳入2020年6... 详细信息

目的 kisspeptin是一种肿瘤抑制因子,由KISS1基因编码。Notch1/Akt/Foxo1是调节细胞增殖、分化的重要信号通路。本研究探讨kisspeptin通过Notch1/Akt/Foxo1信号通路调控子宫内膜蜕膜化在复发性流产(RSA)中的作用机制。方法纳入2020年6月–2020年12月苏州大学附属第二医院生殖中心门诊收治的RSA患者45例及同期计划生育门诊择期人工流产女性50例,Western blot、RT-qPCR检测蜕膜组织中kisspeptin(及其基因KISS1)、蜕膜化标志物胰岛素样生长因子结合蛋白1(insulin-like growth factor binding protein 1, IGFBP1)、Notch1、Akt、Foxo1表达水平。使用siRNA干扰KISS1或添加kisspeptin10(kisspeptin的活性片段)处理永生化子宫内膜基质细胞(hESC)后,命名为siKP组或KP10组,并设转染空白siRNA的hESC为对照组,CCK8检测增殖情况。对3组hESC进行体外诱导蜕膜化,免疫荧光检测siKP组和KP10组细胞Notch1表达及蜕膜化形态差异,RT-qPCR和Western blot检测3组细胞IGFBP1、Notch1、Akt、Foxo1的表达。hESC添加Notch1、Akt、Foxo1对应抑制剂后诱导蜕膜化(以仅诱导蜕膜化、未添加抑制剂的hESC为正常对照组),检测4组细胞上述蛋白和基因的表达。建立正常妊娠(CBA/J×BALB/c)和复发性流产(CBA/J×DBA/2)小鼠模型,即NP模型和RSA模型,实验组分别给予kisspeptin10和kisspeptin234(阻滞剂)隔日1次腹腔注射(RSA-KP10组和NP-KP234组),对照组给予生理盐水隔日1次腹腔注射(RSA-NS组和NP-NS组),共4组,每组6只,取孕9.5 d的子宫组织,观察胚胎吸收的情况,检测上述蛋白和基因的表达。结果与正常妊娠(NP)女性相比,RSA患者kisspeptin、IGFBP1、Notch1、Akt、Foxo1的蛋白及其基因表均降低(P<0.01或P<0.05)。hESC添加kisspeptin10后蜕膜化能力增强,Notch1、Akt、Foxo1的蛋白及基因表达增加,干扰KISS1后表达降低;免疫荧光见增殖状态的hESC呈细长形,蜕膜化后细胞变圆、变大,Notch1表达增加,添加kisspeptin10后蜕膜化程度增高,干扰KISS1后减弱;分别用Notch1、Akt、Foxo1抑制剂处理hESC,发现三者按Notch1/Akt/Foxo1的顺序依次调控(P<0.05)。与注射生理盐水组相比,正常妊娠小鼠注射kisspeptin234后吸收胎增多(P<0.001),IGFBP1、Notch1、Akt、Foxo1的蛋白及基因表达下降(P<0.05);复发流产小鼠注射kisspeptin10后吸收胎减少(P<0.001),上述蛋白及基因表达升高(P<0.05)。结论 kisspeptin可能通过Notch1/Akt/Foxo1信号通路调控子宫内膜蜕膜化,其表达下调导致蜕膜化不良,可能是导致RSA发病的原因之一。

关键词： kisspeptin Notch1 子宫内膜蜕膜化复发性流产

Multi-objective Optimization of Integrated Energy Systems Considering Ladder-type Carbon Emission Trading and Refined Load Demand Response

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 828-839页

作者： yanhong Luo Haowei Hao Dongsheng yang Bowen Zhou the Department of Electric Engineering Northeastern UniversityShenyang 110004China

In this paper,a novel multi-objective optimization model of integrated energy systems(IESs)is proposed based on the ladder-type carbon emission trading mechanism and refined load demand response ***,the carbon emission trading mechanism is introduced into the optimal scheduling of IESs,and a ladder-type carbon emission cost calculation model based on rewards and penalties is established to strictly control the carbon emissions of the ***,according to different response characteristics of electric load and heating load,a refined load demand response model is built based on the price elasticity matrix and substitutability of energy supply *** these basis,a multi-objective optimization model of IESs is established,which aims to minimize the total operating cost and the renewable energy source(RES)***,based on typical case studies,the simulation results show that the proposed model can effectively improve the economic benefits of IESs and the utilization efficiency of RESs.

关键词： Integrated energy system carbon emission trading load demand response renewable energy source

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临床医学专业“预防医学”课程的教改研究

赤峰学院学报（自然科学版） 2024年第5期40卷 53-56页

作者：林建维杨艳红张秀慧赵苏赤峰学院基础医学院内蒙古赤峰024000 赤峰学院临床医学院内蒙古赤峰024000

预防疾病离不开临床医生的积极参与,基于提升临床医学生的岗位胜任力,本文提出了在临床医学专业开设预防医学课程的三种教改路径,分别是缺铁性贫血的流行病学诊断与预防,营养学分析、运动处方的制定和营养调查的设计和实施。这些教学方... 详细信息

预防疾病离不开临床医生的积极参与,基于提升临床医学生的岗位胜任力,本文提出了在临床医学专业开设预防医学课程的三种教改路径,分别是缺铁性贫血的流行病学诊断与预防,营养学分析、运动处方的制定和营养调查的设计和实施。这些教学方法不仅使学生掌握了基本知识,还培养了学生实践操作能力,同时和临床工作内容相联系,提升了岗位胜任力,学生学习兴趣浓厚,教学效果良好,为预防医学的教学改革提供初步思路。

关键词：预防医学缺铁性贫血运动处方营养调查

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小细胞外囊泡(sEVs)介导HBV感染及相关机制的研究进展

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中国免疫学杂志 2024年第2期40卷 428-432页

作者：刘佳敏张自力曾蓉徐旭杨艳红彭彬戢敏潘万龙川北医学院基础医学与法医学研究所南充637000 川北医学院电子显微镜结构研究单位南充637000 简阳市人民医院成都641400

小细胞外囊泡(sEVs)是由大多数细胞分泌的具有脂质双分子层的纳米级别的膜性囊泡,因其是物质交换和信号传递的重要媒介,而被研究者广泛关注。治愈乙型肝炎的基础在于充分掌握HBV复制调控分子机制,HBV主要通过与膜表面受体结合进行复制传... 详细信息

小细胞外囊泡(sEVs)是由大多数细胞分泌的具有脂质双分子层的纳米级别的膜性囊泡,因其是物质交换和信号传递的重要媒介,而被研究者广泛关注。治愈乙型肝炎的基础在于充分掌握HBV复制调控分子机制,HBV主要通过与膜表面受体结合进行复制传代,但其并不是唯一传染途径,除受体途径外,sEVs可将游离的HBV传播给未感染的肝细胞。但sEVs介导HBV感染的机制并不十分明确,因此,本文主要对HBV感染后肝细胞分泌的sEVs与HBV病毒传递的关系和感染机制进行探讨,为临床上治疗HBV感染疾病提供科学的理论指导。

关键词： HBV 小细胞外囊泡(sEVs) 感染机制

凯氏定氮法测定杏鲍菇中蛋白质的条件优化研究

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现代食品 2024年第11期30卷 81-85,91页

作者：阳焱红朱斐淇曾静莫寒杨期辉刘会敬衡阳师范学院南岳学院生命科学系湖南衡阳421000 衡阳师范学院生命科学学院湖南衡阳421000 南岳山区生物资源保护与利用湖南省重点实验室湖南衡阳421000

采用凯氏定氮法检测杏鲍菇中蛋白质含量,并通过单因素和响应面试验对消化时间、消化温度及催化剂用量等条件进行了优化。结果显示,凯氏定氮法检测杏鲍菇中蛋白质含量的最优条件参数为消化时间1.85 h,消化温度438℃,催化剂浓硫酸用量14.8... 详细信息

采用凯氏定氮法检测杏鲍菇中蛋白质含量,并通过单因素和响应面试验对消化时间、消化温度及催化剂用量等条件进行了优化。结果显示,凯氏定氮法检测杏鲍菇中蛋白质含量的最优条件参数为消化时间1.85 h,消化温度438℃,催化剂浓硫酸用量14.8 mL,该条件下测定的杏鲍菇中蛋白质含量最高,为20.71 g/100 g。与国标法比较,本研究中优化后的方法提高了蛋白质含量的检测效率,减少了催化剂浓硫酸的用量,缩短了消化时间。

关键词：蛋白质响应面分析法凯氏定氮法杏鲍菇