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Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury

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Chinese Journal of Traumatology 2024年第2期27卷 97-106页

作者： Peng Qi Meng-Jie Huang Wei Wu Xue-Wen Ren Yong-Zhi Zhai Chen qiu Hai-yan Zhu Department of Emergency First Medical Center of Chinese PLA General HospitalBeijing100853China Department of Nephrology.First Medical Center of Chinese PLA General Hospital Beijing100853China Department of Anesthesiology.First Medical Center of Chinese PLA General Hospital Beijing100853China Department of Orthopedics Fourth Medical Center of Chinese PLA General HospitalBeijing100853China

Purpose:Acute kidney injury(AKI)is one of the most common functional injuries observed in trauma ***,certain trauma medications may exacerbate renal ***,the early detection of trauma-related AKI holds paramount importance in improving trauma ***:Qualified datasets were selected from public databases,and common differentially expressed genes related to trauma-induced AKI and hub genes were identified through enrichment analysis and the establishment of protein-protein interaction(PPI)***,the specificity of these hub genes was investigated using the sepsis dataset and conducted a comprehensive literature review to assess their *** raw data from both datasets were downloaded using R software(version 4.2.1)and processed with the"affy"package19 for correction and ***:Our analysis revealed 585 upregulated and 629 downregulated differentially expressed genes in the AKI dataset,along with 586 upregulated and 948 downregulated differentially expressed genes in the trauma ***,the establishment of the PPI network and subsequent topological analysis highlighted key hub genes,including CD44,CD163,TIMP metallopeptidase inhibitor 1,cytochrome b-245 beta chain,versican,membrane spanning 4-domains A4A,mitogen-activated protein kinase 14,and early growth response ***,their receiver operating characteristic curves displayed areas exceeding 75%,indicating good diagnostic ***,our findings postulated a unique molecular mechanism underlying trauma-related ***:This study presents an alternative strategy for the early diagnosis and treatment of trauma-related AKI,based on the identification of potential biomarkers and therapeutic ***,this study provides theoretical references for elucidating the mechanisms of trauma-related AKI.

关键词： Trauma Acutekidney injury Bioinformatic analysis Differentially expressed genes Biomarker

The Maximum and Minimum Value of Exponential RandićIndices of Quasi-Tree Graph

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1804-1818页

作者： Lei qiu Xijie Ruan yan Zhu School of Mathematics East China University of Science and Technology Shanghai China

The exponential Randić index has important applications in the fields of biology and chemistry. The exponential Randić index of a graph G is defined as the sum of the weights e 1 d( u )d( v ) of all edges uv of G, where d( u ) denotes the degree of a vertex u in G. The paper mainly provides the upper and lower bounds of the exponential Randić index in quasi-tree graphs, and characterizes the extremal graphs when the bounds are achieved.

关键词： Exponential Randić Index Quasi-Tree Graph Extremal Value Extremal Graphs

The importance of Righi-Leduc heat flux to the ablative Rayleigh-Taylor instability during a laser irradiating targets

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High Power Laser Science and Engineering 2024年第3期 14-24页

作者： Ye Cui Xiao-Hu yang yan-Yun Ma Guo-Bo Zhang Bi-Hao Xu Ze-Hao Chen Ze Li Fu-qiu Shao Jie Zhang Department of Nuclear Science and Technology National University of Defense Technology Collaborative Innovation Centre of IFSA Shanghai Jiao Tong University College of Advanced Interdisciplinary Studies National University of Defense Technology Department of Physics National University of Defense Technology Key Laboratory for Laser Plasmas (Ministry of Education) School of Physics and Astronomy Shanghai Jiao Tong University

The Righi±Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh±Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic simulations. The perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of teslas. The Righi±Leduc effect plays an essential impact both in the linear and nonlinear stages, and it deflects the total heat flux towards the spike base. Compared to the case without the self-generated magnetic field included, less heat flux is concentrated at the spike tip, finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike tip. It is shown that the linear growth rate is increased by about 10%and the amplitude during the nonlinear stage is increased by even more than 10%due to the feedback of the magnetic field,respectively. Our results reveal the importance of Righi±Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field, especially during the acceleration stage in inertial confinement fusion.

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Experiments and simulation on the overall DMG of long-haul cascade FM-EDFA systems

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Chinese Optics Letters 2024年第4期22卷 53-59页

作者：江歆睿武保剑严伟文峰邱昆 Key Laboratory of Optical Fiber Sensing and Communications Ministry of EducationUniversity of Electronic Science and Technology of ChinaChengdu 611731China

All-fiber few-mode erbium-doped fiber amplifiers(FM-EDFAs) with isolation and wavelength division multiplexers(IWDMs)have been developed to enable flexible pumping in different directions. The FM-EDFA can achieve >30 d B modal gain with<0.3 d B differential modal gain(DMG). We experimentally simulate the DMG performance of a cascade FM-EDFA system using the equivalent spectrum method. The overall DMG reaches 1.84 d B after 10-stage amplification. We also build a recirculating loop to simulate the system, and the developed FM-EDFA can support transmission up to 3270 km within a 2 d B overall DMG by optimizing the few-mode fiber length in the loop.

关键词： mode division multiplexing few-mode erbium-doped fiber amplifier gain equalization

安全保障义务补充责任辨析——以第三人侵犯人身权为限

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河南纺织高等专科学校学报 2007年第1期19卷 32-35页

作者：杨秋颜河南大学河南开封475001

对经营者因违反安全保障义务所担当的补充责任这一制度的设定的合理性提出质疑,以公平性原则为切入点,对此问题提出了自己的一些看法。

关键词：经营者安全保障义务侵权行为补充责任

靖-那高速泥灰岩地质路基高填深挖设计和施工分析

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西部交通科技 2018年第3期 41-43,47页

作者：杨燕球广西桂通工程咨询有限公司广西南宁530028

为保证高速公路全线平稳性,在建设时不可避免需对原有地形进行改造,出现一些需要填方和挖方路段,而保证该路段路基稳定性成为了决定公路质量的核心点之一。靖-那高速公路在建造时需穿过泥灰岩地层,构造复杂且地下水含量大,文章介绍了该... 详细信息

为保证高速公路全线平稳性,在建设时不可避免需对原有地形进行改造,出现一些需要填方和挖方路段,而保证该路段路基稳定性成为了决定公路质量的核心点之一。靖-那高速公路在建造时需穿过泥灰岩地层,构造复杂且地下水含量大,文章介绍了该路段填方、挖方及路基支挡和防护设计方案,并阐述了相应的施工工艺要点,为类似工程施工提供技术参考。

关键词：靖-那高速泥灰岩地质路基填方深挖设计施工

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西宁特钢750开坯生产线均热炉改造设计

包钢科技 2016年第1期42卷 1-4页

作者：杨秋彦中冶东方工程技术有限公司包头贝瑞工业炉分公司内蒙古包头014010

西宁特殊钢股份有限公司750开坯生产线均热炉改造,采用高速烧嘴结合脉冲燃烧控制技术,每座坑单独控制炉压。自投产以来,节能效果好,产量增加,经济效益明显。文章结合工程实例,对均热炉的设计进行了介绍,为类似工程设计提供参考。

关键词：开坯生产线均热炉高速烧嘴脉冲燃烧技术节能设计