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Role of toll-like receptor 4/mutant myeloid differentiation primary response 88/nuclear factor kappa-B mediated inflammation in diabetes mellitus with Northwest dryness syndrome

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Journal of Traditional Chinese Medicine 2024年第5期44卷 963-973页

作者： DENG Deqiang XIAO yan MA Dan qiu Jinling HAO Congli WANG Di ZHANG Miao State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Medical University Department of Endocrinology Traditional Chinese Medicine Hospital of Urumqi

OBJECTIVE: To investigate the role of toll-like receptor 4(TLR4)/mutant myeloid differentiation primary response 88(MyD88)/nuclear factor kappa-B(NF-κB) signaling pathway-mediated inflammation in diabetes mellitus with Northwest dryness ***: Rats were randomly divided into the normal control, type 2 diabetes(T2DM) model, Northwest dryness syndrome + T2DM(Northwest dryness), and simple internal dampness + T2DM(internal dampness)groups. Enzyme-linked immunosorbent assay was used to detect biochemical indexes and inflammatory *** histopathological observation was *** real-time polymerase chain reaction and Western blot analysis were used to detect the mRNA and protein expression levels, ***: Compared with the T2DM group, the glycosylated hemoglobin A1c, insulin, glucose tolerance,the homeostasis model assessment of insulin resistance,tumor necrosis factor-α, interleukin 1β, interleukin 16,malondialdehyde, blood lipid, alanine aminotransferase,and aspartate aminotransferase were significantly elevated in the internal dampness group. Their levels were significantly elevated in the Northwest dryness group than in the T2DM and internal dampness *** superoxide dismutase, glutathione peroxidase, liver glycogen, and organ-to-weight ratio were significantly declined in the internal dampness group and the Northwest dryness group than in the T2DM ***, these levels were elevated in the Northwest dryness group than in the internal dampness ***, the mRNA expression levels of interferon regulatory factor 5 and NF-κB p65, and the protein expression levels of TLR4, MyD88, and NF-κB were significantly higher in the internal dampness and the Northwest dryness groups than the T2DM ***, the mRNA and protein levels were significantly higher in the Northwest dryness group than in the internal dampness ***: Northwest dryness syndrome-mediated TLR4/MyD88/NF-κB pathway and chronic i

关键词： NF-kappa B Northwest dryness syndrome diabetes mellitus inflammation myeloid differentiation factor 88 toll-like receptor 4

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Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease:Mechanism,clinical evidence,and prospect

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World Journal of Gastroenterology 2024年第8期30卷 833-842页

作者： Xiao-Xia qiu Sheng-Li Cheng yan-Hui Liu Yu Li Rui Zhang Nan-Nan Li Zheng Li Research and Education Department Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Anhui Provincial Hospital The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230000Anhui ProvinceChina Department of Clinical Pharmacy Anhui Provincial Children’s HospitalHefei 230000Anhui ProvinceChina Department of Pharmacy Taihe County People’s Hospital of Anhui ProvinceFuyang 236600Anhui ProvinceChina Department of Pharmacy The Second People’s Hospital of HefeiHefei Hospital Affiliated to Anhui Medical UniversityHefei 230000Anhui ProvinceChina University of Science and Technology of China The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells College of Health SciencesSchool of Life SciencesJiangsu Normal UniversityXuzhou 221000Jiangsu ProvinceChina

The population of non-alcoholic fatty liver disease(NAFLD)patients along with relevant advanced liver disease is projected to continue growing,because currently no medications are approved for *** microbiota transplantation(FMT)is believed a novel and promising therapeutic approach based on the concept of the gut-liver axis in liver *** has been an increase in the number of pre-clinical and clinical studies evaluating FMT in NAFLD treatment,however,existing findings diverge on its ***,we briefly summarized the mechanism of FMT for NAFLD treatment,reviewed randomized controlled trials for evaluating its efficacy in NAFLD,and proposed the prospect of future trials on FMT.

关键词： Non-alcoholic fatty liver disease Fecal microbiota transplantation Randomized controlled trial Mechanism Efficacy

Differential expression profile of circular RNAs in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527

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Genes & Diseases 2024年第3期11卷 59-62页

作者： Yingfeng Shi yan Hu Hui Chen Jinqing Li Min Tao Xun Zhou Qin Zhong Andong qiu Shougang Zhuang Na Liu Department of Nephrology Shanghai East HospitalTongji University School of MedicineShanghai 200120China School of Life Science and Technology Advanced Institute of Translational MedicineTongji UniversityShanghai 200092China Department of Medicine Rhode Island Hospital and Alpert Medical SchoolBrown UniversityProvidenceRI 02912USA

CircRNAs,a novel type of endogenous non-coding RNAs(ncRNAs),are typically produced by back-splicing from exons of protein-coding genes,which are characterized by a covalently closed structure with neither 5'to 3'polarity nor a poly(A)tail.'On the one hand,circRNAs are involved in the regulation of a variety of important biological processes,such as apoptosis,proliferation,migration,and inflammatory responses.'On the other hand,the relationship between circRNAs and several fibrotic diseases has been reported.2 However.

关键词： endogenous peritoneal diseases

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天然甲烷与全氘甲烷同位素的色谱分离

原子能科学技术 2005年第2期39卷 138-142页

作者：邢丕峰罗顺忠羊衍秋陈绍华中国工程物理研究院核物理与化学研究所四川绵阳621900

采用四极质谱仪在线测定了CD4和CH4同位素色谱总分离度(K1)与色谱条件、进样量之间的关系。结果表明,K1受色谱柱填料、长径比和样品量影响较大,载气流速影响不明显,柱温的影响与色谱柱的填料有关。

关键词：进样量载气流速色谱柱四极质谱柱填料柱温甲烷天然影响 CD4

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SF_6示踪剂远程泄漏监测系统设计及性能

原子能科学技术 2014年第9期48卷 1686-1692页

作者：田杰羊衍秋杨亮聂诗良杨通在王丽雄张海涛中国工程物理研究院核物理与化学研究所四川绵阳621900 西南科技大学信息工程学院四川绵阳621010

非放射性气体示踪技术是一种常用的泄漏检测技术,SF6是常用的气体示踪剂。对一些特殊检测场所,如贮存放射性和有毒有害气体的容器的泄漏监测,建立示踪剂在线采样和分析系统十分必要。本文阐述了SF6示踪剂多监测点在线监测系统的设计思... 详细信息

非放射性气体示踪技术是一种常用的泄漏检测技术,SF6是常用的气体示踪剂。对一些特殊检测场所,如贮存放射性和有毒有害气体的容器的泄漏监测,建立示踪剂在线采样和分析系统十分必要。本文阐述了SF6示踪剂多监测点在线监测系统的设计思路和主要功能模块流程。该系统的样品消耗量小,可通过压力控制减小样品消耗。实验证实,系统运行对色谱基线无影响,同一样品通过不同监测通道在不同时刻的分析结果的相对标准偏差小于1%,不同监测通道样品无交叉污染,采样点的温度、压力监测结果与就地仪表监测精度相当。

关键词：气体示踪剂 SF6 远程控制系统在线监测

Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs

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Chinese Chemical Letters 2024年第8期35卷 481-485页

作者： Jiaqi Huang Renjiang Kong yanmei Li Ni yan Yeyang Wu Ziwen qiu Zhenming Lu Xiaona Rao Shiying Li Hong Cheng School of Biomedical Engineering&Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou Medical UniversityGuangzhou 511436China

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense ***,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of *** a result,HCCS obviously increases the ROS production to elevate intracellular oxidative ***,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ***,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in *** study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.

关键词： Human serum albumin Drug delivery Reactive oxygen species Positive feedback uptake Oxidative damage

“箫剑”与“鹏蝶”——龚自珍对庄子美学的接受实践

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烟台大学学报（哲学社会科学版） 2020年第6期33卷 41-48页

作者：杨艳秋刘东影黑龙江大学中国语言文学博士后流动站黑龙江哈尔滨150080 黑龙江八一农垦大学人文社会科学学院黑龙江大庆163319

中国近代美学在生成之初亟需冲破理学传统和文化范式,以龚自珍为代表的启蒙思想家在向中国古典哲学溯源和求解的过程中,以主体性的自醒和个人志趣的自得为基础,从美学主张到诗文创作,全面吸收庄子思想。在诗文创作中,以丰富的自然意象... 详细信息

中国近代美学在生成之初亟需冲破理学传统和文化范式,以龚自珍为代表的启蒙思想家在向中国古典哲学溯源和求解的过程中,以主体性的自醒和个人志趣的自得为基础,从美学主张到诗文创作,全面吸收庄子思想。在诗文创作中,以丰富的自然意象、恣意的卮言手法传承并实践庄子美学,展现追求自由人生的内在境界。分析龚自珍诗文对庄子美学的传承与接受,是研究龚自珍启蒙思想的重要路径。

关键词：龚自珍庄子美学近代美学诗文创作

吲哒帕胺联合氯沙坦对老年高血压病人血尿酸及β_2-微球蛋白的影响

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中国老年学杂志 2005年第9期25卷 1023-1024页

作者：杨艳秋冷吉燕孙立娟吉林大学第一医院干部病房吉林长春130021 吉林大学中日联谊医院内分泌科

目的探讨氯沙坦联合吲哒帕胺对老年高血压患者的血压、血尿酸(UA)及血、尿β2-微球蛋白(β2-MG)的影响。方法50例老年高血压患者随机分成两组,对照组(吲哒帕胺组)24例,观察组(氯沙坦加吲哒帕胺组)26例,观察12 w,比较治疗前后患者血压、... 详细信息

目的探讨氯沙坦联合吲哒帕胺对老年高血压患者的血压、血尿酸(UA)及血、尿β2-微球蛋白(β2-MG)的影响。方法50例老年高血压患者随机分成两组,对照组(吲哒帕胺组)24例,观察组(氯沙坦加吲哒帕胺组)26例,观察12 w,比较治疗前后患者血压、血钾、血UA及血、尿β2-MG等指标的变化。结果治疗后两组收缩压及舒张压均较治疗前明显下降(P0.05);对照组治疗前后比较,血UA浓度明显升高(P<0.01),血、尿β2-MG浓度无明显变化,血钾明显降低(P<0.05),观察组治疗前后血UA及血、尿β2-MG均明显下降(P<0.01)。结论吲哒帕胺和氯沙坦联合治疗老年高血压病,较单独用药更有效地控制血压,降低血UA及减少低血钾的发生,保护靶器官,具有良好的安全性和耐受性。

关键词：老年高血压吲哒帕胺氯沙坦尿酸 β2-微球蛋白

南海神狐海域热解成因与天然气水合物稳定带底界

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中国矿业大学学报 2010年第6期39卷 870-875页

作者：龚建明杨艳秋闫桂京胡学平李刚马立杰国土资源部海洋油气资源与环境地质重点实验室青岛海洋地质研究所山东青岛266071 东方地球物理公司物探技术研究中心河北涿州072750 中国科学院海洋研究所山东青岛266071

为了探讨神狐海域热解成因天然气水合物存在的可能性及其稳定带底界,对神狐海域2口井(SH-2井,LW3-1-1井)的天然气组成和δ13C进行了对比;对研究区气体运移通道、热解成因水合物相平衡条件以及不同成因水合物稳定带底界深度进行了分析.... 详细信息

为了探讨神狐海域热解成因天然气水合物存在的可能性及其稳定带底界,对神狐海域2口井(SH-2井,LW3-1-1井)的天然气组成和δ13C进行了对比;对研究区气体运移通道、热解成因水合物相平衡条件以及不同成因水合物稳定带底界深度进行了分析.结果表明:该区充足的热解气源具有形成热解成因水合物的可能性.随着水深从SH-2井的1230m增加到LW3-1-1井的3200m,相同成因水合物(如:生物成因水合物)的稳定带底界埋深变大,从SH-2井的1526m增加到LW3-1-1井的3707m;不同成因水合物的稳定带厚度差变小,从SH-2井的89m减小到LW3-1-1井的37m.基于墨西哥湾热解成因水合物稳定带底界与强反射带顶界的对应关系,通过对该区高分辨率地震资料精细解释可以认为,部分生物成因水合物稳定带基底之下出现的空白带和断续的强反射带很可能是热解成因水合物的表现,其强反射带顶界很可能是热解成因水合物稳定带的底界,其稳定带厚度更大,稳定带底界更深.

关键词：稳定带底界强反射带热解成因水合物神狐海域