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Medium-Chain Triglyceride Activated Brown Adipose Tissue and Induced Reduction of Fat Mass in C57BL/6J Mice Fed High-fat Diet

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Biomedical and Environmental Sciences 2015年第2期28卷 97-104页

作者： ZHANG Yong XU Qing LIU Ying Hua ZHANG Xin Sheng WANG Jin YU Xiao Ming ZHANG Rong Xin xue Chao yang xue yan xue Chang Yong Department of Nutrition Chinese PLA General Hospital Peking University Health Science Center

Objective To investigate activation of brown adipose tissue （BAT） stimulated by medium-chain triglyceride （MCT）. Methods 30 Male C57BL/6J obese mice induced by fed high fat diet （HFD） were divided into 2 groups, and fed another HFD with 2% MCT or long-chain triglyceride （LCT） respectively for 12 weeks. Body weight, blood biochemical variables, interscapular brown fat tissue （IBAT） mass, expressions of mRNA and protein of beta 3-adrenergic receptors （β3-AR）, uncoupling protein-1 （UCP1）, hormone sensitive lipase （HSL）, protein kinase A （PKA）, and adipose triglyceride lipase （ATGL） in IBAT were measured. Results Significant decrease in body weight and body fat mass was observed in MCT group as compared with LCT group （P〈O.05） after 12 weeks. Greater increases in IBAT mass was observed in MCT group than in LCT group （P〈O.05）. Blood TG, TC, LDL-C in MCT group were decreased significantly, meanwhile blood HDL-C, ratio of HDL-C/LDL-C and norepinephrine were increased markedly. Expressions of mRNA and protein of β3-AR, UCP1, PKA, HSL, ATGL in BAT were greater in MCT group than in LCT group （P〈O.05）. Conclusion Our results suggest that MCT stimulated the activation of BAT, possible via norepinephrine pathway, which might partially contribute to reduction of the body fat mass in obese mice fed high fat diet.

关键词： Medium-chain triglyceride Brown adipose tissue Uncoupling protein-l Beta 3-adrenergicreceptor

Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities

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Chinese Journal of Natural Medicines 2017年第12期15卷 938-943页

作者： yang xue-yan ZHANG Yi-Fan LIU Li-Jia WANG Yi SHANG Ming-Ying XU Feng LIU Guang-xue CAI Shao-Qing Department of Natural Medicine School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100191China

A new lignan, tirpitzin A(17) together with 20 known compounds(1-16, and 18-21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7-21 were isolated from Linaceae family for the first time. The pharmacological activity of the crude extracts was tested using a mouse inflammation model induced by dimethyl benzene. The results demonstrated that the ethyl acetate soluble fraction had anti-inflammatory activity. Moreover, the cytotoxic and anti-inflammatory activities of some compounds were studied. The new compound 17 showed moderate cytotoxic effect against Bx PC-3 cell line(IC_50 = 19.51μmol·L^(-1)) and Compound 10 showed significant cytotoxicity against Hep G2, HL-60, U87 and Bx PC-3 cell lines with IC_50 values in the range 4.2-8.3μmol·L^(-1). Additionally, Compounds 2, 10, 11, and 13 exhibited potent inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages at the concentration of 50μmol·L^(-1).

关键词： Tirpitzia ovoidea Linaceae Lignans Diterpenes Cytotoxic activity Anti-inflammatory activity

Caprylic Acid Improves Lipid Metabolism, Suppresses the Inflammatory Response and Activates the ABCA1/p-JAK2/pSTAT3 Signaling Pathway in C57BL/6J Mice and RAW264.7 Cells

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Biomedical and Environmental Sciences 2022年第2期35卷 95-106页

作者： ZHANG Xin Sheng ZHANG Peng LIU Ying Hua XU Qing ZHANG Yong LI Hui Zi LIU Lu LIU Yu Meng yang xue yan xue Chang Yong Department of Nutrition the First Medical Center of PLA General HospitalBeijing 100853China Guizhou Crops of Chinese Armed Police Force Guiyang 550001GuizhouChina Department of Nutrition PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Objective This study aimed to investigate the effects of caprylic acid(C8:0)on lipid metabolism and inflammation,and examine the mechanisms underlying these effects in mice and *** Fifty-six 6-week-old male C57BL/6J mice were randomly allocated to four groups fed a highfat diet(HFD)without or with 2%C8:0,palmitic acid(C16:0)or eicosapentaenoic acid(EPA).RAW246.7 cells were randomly divided into five groups:normal,lipopolysaccharide(LPS),LPS+C8:0,LPS+EPA and LPS+*** serum lipid profiles,inflammatory biomolecules,and ABCA1 and JAK2/STAT3 mRNA and protein expression were *** C8:0 decreased TC and LDL-C,and increased the HDL-C/LDL-C ratio after injection of *** LPS,it decreased TC in mice(P<0.05).Moreover,C8:0 decreased the inflammatory response after LPS treatment in both mice and cells(P<0.05).Mechanistic investigations in C57BL/6J mouse aortas after injection of LPS indicated that C8:0 resulted in higher ABCA1 and JAK2/STAT3 expression than that with HFD,C16:0 and EPA,and resulted in lower TNF-α,NF-κB mRNA expression than that with HFD(P<0.05).In RAW 264.7 cells,C8:0 resulted in lower expression of pNF-κBP65 than that in the LPS group,and higher protein expression of ABCA1,p-JAK2 and p-STAT3 than that in the LPS and LPS+cAMP groups(P<0.05).Conclusion Our studies demonstrated that C8:0 may play an important role in lipid metabolism and the inflammatory response,and the mechanism may be associated with ABCA1 and the p-JAK2/p-STAT3 signaling pathway.

关键词： Caprylic acid Inflammatory cytokine ATP binding cassette transporter A1 Janus kinase 2 Signal transducer and activator of transcription 3

Handgrip Strength as a Predictor of Nutritional Status in Chinese Elderly Inpatients at Hospital Admission

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Biomedical and Environmental Sciences 2017年第11期30卷 802-810页

作者： ZHANG Xin Sheng LIU Ying Hua ZHANG Yong XU Qing YU Xiao Ming yang xue yan LIU Zhao LI Hui Zi LI Feng xue Chang Yong Department of Nutrition Chinese PLA General Hospital Department of Nutrition Chinese PLA General Hospital of Rocket Forces

Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening（NRS 2002） and Subjective Global Assessment（SGA） were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic（ROC） curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves（AUCs） were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg（65-74 years） and 21.0 kg（75-90 years） for men and 17.0 kg（65-74 years） and 14.6 kg（75-90 years） for women. According to SGA, the optimal HGS cut-points were 24.9 kg（65-74 years） and 20.8 kg（75-90 years） for men and 15.2 kg（65-74 years） and 13.5 kg（75-90 years） for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China.

关键词： Handgrip strength Elderly inpatients Nutrition assessment Nutrition status Malnutrition

基于过程和结果的评价:社会性别公平性评价体系

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系统工程理论与实践 2008年第6期28卷 151-157页

作者：杨雪燕西安交通大学公共管理与政策学院人口与发展研究所西安710049

目的:将社会性别视角纳入中国县区级计划生育/生殖健康优质服务的评价框架中,建立县区级计划生育/生殖健康优质服务的社会性别公平性评价体系,为在更广泛的领域当中进行公共卫生的社会性别公平性评价提供思路和方法.方法:采用文献查阅... 详细信息

目的:将社会性别视角纳入中国县区级计划生育/生殖健康优质服务的评价框架中,建立县区级计划生育/生殖健康优质服务的社会性别公平性评价体系,为在更广泛的领域当中进行公共卫生的社会性别公平性评价提供思路和方法.方法:采用文献查阅、访谈、专家评议等方法进行评价体系的设计;并通过在中国东部的安徽省巢湖市居巢区进行大规模调查、进行数据分析的方法验证该评价体系的可行性和有效性.结果:形成了包括过程和结果在内的中国县区级计划生育优质服务系统的社会性别公平性评价体系,并分别从过程和结果两个方面对安徽巢湖市居巢区的计划生育/生殖健康优质服务的社会性别公平进行了评价.结论:该评价体系是可行的,但是在稳定性和适用范围方面还需要进一步改进.

关键词：社会性别公平性评价体系中国县区级计划生育优质服务系统分析

Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells

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Chinese Journal of Natural Medicines 2017年第3期15卷 225-233页

作者： WANG Qing-Hui GUO Shuai yang xue-yan ZHANG Yi-Fan SHANG Ming-Ying SHANG Ying-Hui XIAO Jun-Jun CAI Shao-Qing Department of Natural Medicine School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Department of Cell Biology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Four prenylated flavonoids compounds 1-4,named sinopodophyllines A-D,and a flavonoid glycoside(compound 13),sinopodophylliside A,together with 19 known compounds(compounds 5-12 and 14-24) were isolated from the fruits of Sinopodophyllum *** structures of new compounds were elucidated by extensive spectroscopic analysis,including HRESIMS,1D and 2D *** 1-6,9-11,and 14-17 were tested for their cytotoxicity against human breast-cancer T47 D,MCF-7 and MDA-MB-231 cells in vitro,and compounds 2,5,6,10 and 11 showed significant cytotoxicity(IC50 values < 10 μmol·L^(-1))against T47 D cells.

关键词： Sinopodophylli Fructus Prenylated flavonoids Flavonoid glycosides Breast-cancer cell lines

The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women

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Biomedical and Environmental Sciences 2016年第1期29卷 1-11页

作者： Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing yang xue yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng xue Chang Yong Lu yan Ping Department of Nutrition Chinese PLA General HospitalBejjing 100853China Department of Gynaecology and Obstetrics Chinese PLA General HaspitalBeijing 100853China Sihai Huachen Technology Co LtdBeijing 102629China Department of Nutrition Beijing HospialBeijing 100730China Department of Nutrition Beijing Tongren HospialBeijing 100005China Haidian District Health Center for Women and Children Beijing 100080China Department of Nutrition Jishuitan HospitalBeijing 100035China Department of Nutrition Sixth People's HospitalShanghai 200233China Department of Nutrition Chinese Air Force General HospitalBejjing 100036China Department of Nurition People's Hospital of Sichuan ProvinceChengdu 610072SichuanChina Department of Nutrition Bethune International Peace HospitalShijiazhuang 130100HebeiChina Department of Nutrition No.304 Chinese PLA HospitalBeijing100037China

Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus （GDM）. Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks＇ gestation （WG）. Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDIVl morbidity. Results Age, pre-pregnant body weight （BW）, and body mass index （BMI） were associated with increased risk of GDM. Fat mass （FM）, fat mass percentage （FMP）, extracellular water （ECW）, BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass （FFM）, muscular mass （MM）, and intracellular water （ICW） were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity.

关键词： Gestational diabetes mellitus Body composition Dietary intake

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大气湍流对平流层星光导航中星光传输的影响

宇航学报 2017年第4期38卷 359-366页

作者：杨博朱雪妍北京航空航天大学宇航学院

以平流层飞行器用星光导航为背景,研究在平流层内星光传输过程受大气湍流的影响机理,揭示平流层中星光的衰减规律,为建立平流层星光导航星库以及电耦合器件(CCD)所摄取的星图补偿方法提供理论依据。研究提出将流场密度和流场密度脉动变... 详细信息

以平流层飞行器用星光导航为背景,研究在平流层内星光传输过程受大气湍流的影响机理,揭示平流层中星光的衰减规律,为建立平流层星光导航星库以及电耦合器件(CCD)所摄取的星图补偿方法提供理论依据。研究提出将流场密度和流场密度脉动变化大的区域划分为宽度为L的特性截面,并基于几何光学法及统计光学理论分别计算星光穿过各特性截面后产生的光线偏折及平均光强衰减,进而推导整个平流层内星光传输过程中的能量衰减变化曲线。采用基于k-ε双方程湍流模型的雷诺平均法计算不同极端情况下的大气湍流场密度及密度脉动分布。通过计算机数值仿真表明:星光穿过具有湍流的平流层时将发生明显偏折,其偏折程度与流场密度值有关;同时星光光强衰减,衰减程度与流场密度脉动值有关。

关键词：星光导航大气湍流大气光学效应星等

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宁夏回族民俗文化旅游资源开发探析

干旱区资源与环境 2009年第1期23卷 147-153页

作者：杨学燕宁夏大学人文学院银川750021

随着现代旅游的发展,民俗文化旅游已成为现代旅游的一大潮流。宁夏作为全国唯一的回族自治区具有浓郁的民俗特色资源,充分利用这一优势,发展宁夏回族民俗文化旅游。有利于宁夏旅游业在激烈的市场竞争中获得长远发展。本文通过分析宁夏... 详细信息

随着现代旅游的发展,民俗文化旅游已成为现代旅游的一大潮流。宁夏作为全国唯一的回族自治区具有浓郁的民俗特色资源,充分利用这一优势,发展宁夏回族民俗文化旅游。有利于宁夏旅游业在激烈的市场竞争中获得长远发展。本文通过分析宁夏回族民俗文化旅游资源及目前开发存在问题,对宁夏回族民俗文化旅游资源进行评价后提出开发宁夏回族民俗文化旅游资源的模式。

关键词：民俗文化旅游资源开发模式回族宁夏