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Frontiers of Materials Science 2015年第3期9卷 282-292页

作者： Jin-Ning WANG Bin PI Peng WANG xue-Feng LI Hui-Lin yang xue-song ZHU Department of Orthopaedic Surgery The first Affiliated Hospital of Soochow University Suzhou 215006 China

The reinforcement of calcium phosphate materials with silk fibroin （SF） has been one of the strategies to overcome the brittleness. However, the lack of osteoinductivity may still restrict their further use. This study aimed to investigate the biocompatibility and osteogenesis capacity of a novel Semaphorin 3A-loaded chitosan microspheres/SF/a-tricalcium phosphate composite （Sema3A CMs/SF/a-TCP） in vitro. Sema3A was first incorporated into CMs, and the Sema3A CMs/SF/a-TCP composite was then prepared. The morphology of the CMs was observed using SEM. The in vitro release kinetics, cytotoxicity, and cell compatibility were evaluated, and the real-time quantitative polymerase chain reaction （RT-qPCR） and activity of alkaline phosphatase （ALP） were used to evaluate the osteogenesis capacity of the composite. The in vitro release of Sema3A from the Sema3A CMs/SF/a-TCP composite showed a temporally controlled manner. The extract of the Sema3A CMs/SF/a-TCP composite presented no obvious side effect on the MC3T3-E1 cell proliferation, nor promote cell proliferation. The MC3T3-E1 cells were well-spread and presented an elongated shape on the Sema3A CMs/SF/a-TCP composite surface; the ALP activity and the osteogenic-related gene expression were higher than those seeded on the surface of the CMs/SF/a-TCP and SF/a-TCP composites. In conclusion, Sema3A CMslSF/a-TCP has excellent biocompatibility and contributes to the osteoblastic differentiation of MC3T3-E1 cells.

关键词： α-tricalcium phosphate (o-TCP) silk fibroin (SF) Semaphorin 3A osteo-blastic differentiation MC3T3-EI cell

Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing,China

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Biomedical and Environmental Sciences 2012年第1期25卷 61-68页

作者： DAI Xiao Qiu LIU Min ZHANG Tuo Hong yang xue song LI song Lin LI Xiao Guang LI Yu Ling KADEERBAI Hai San WU Huang Department of Epidemiology and Bio-statistics School of Public Health Peking University Health Science Center Beijing 100191 China Department of Health Policy and Management School of Public Health Peking University Health Science Center Beijing 100191 China Third Hospital Peking University Beijing 100191 China Civil Aviation General Hospital Beijing 100025 China

Objective Symptomatic predictors of influenza could assess risks and improve decisions about isolation and outpatient treatment. To develop such predictors, we undertook a prospective analysis of pandemic （HIN1） 2009 and seasonal influenza （H3N2） in patients attending fever clinics. Methods From 1 May 2009 to 1 January 2010, all adult patients admitted to fever clinics for suspected influenza, confirmed by real time RT-PCR, were enrolled. Predictors of influenza virus infection were selected with logistic regression models. Measures of sensitivity, specificity, positive and negative likelihood ratios （LRs） were calculated to identify the best predictors. Results The clinical features and routine blood test results of influenza （H1N1） 2009 and seasonal influenza were similar. The positive and negative LRs of current US CDC influenza-like illness （ILl） criteria were modest in predicting influenza infection. Our modified clinic predictors improved the ability of the positive and negative LRs to recognize pandemic （HIN1） 2009 and seasonal influenza. The revised criteria are： fever ~ 38 ~C accompanied by at least one of the following--cough, arthralgia or relative iymphopenia. Conclusion Patients with symptoms and signs that meet the new criteria are likely to have influenza and timely antiviral therapy may be appropriate. In addition, physicians should ascertain if influenza is circulating within the community or if there is a contact history of influenza and combine this information with the newly developed criteria to clinically diagnose influenza.

关键词： Diagnosis Fever Influenza A, H1N1 H3N2 Signs, Symptoms

Preliminary study on phonetic characteristics of patients with pulmonary nodules

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Journal of Integrative Medicine 2020年第6期18卷 499-504页

作者： xue-yang song Si-jing Wang Zhao-xia Xu Yi-ming Hao Lu Feng Xiao-dong Ding Hui Gao Yi-qin Wang College of Basic Medicine Shanghai University of Traditional Chinese Medicine.Shanghai 201203China

Objective: Pulmonary nodules(PNs) are one of the imaging manifestations of early lung cancer screening,which should receive more attention. Traditional Chinese medicine believes that voice changes occur in patients with pulmonary diseases. The purpose of this study is to explore the differences in phonetic characteristics between patients with PNs and able-bodied ***: This study explores the phonetic characteristics of patients with PNs in order to provide a simpler and cheaper method for PN screening. It is a case-control study to explore the differences in phonetic characteristics between individuals with and without PNs. This study performed non-parametric statistics on acoustic parameters of vocalizations, collected from January 2017 to March 2018 in Shanghai,China, from these two groups;it explores the differences in third and fourth acoustic parameters between patients with PNs and a normal control group. At the same time, computed tomography(CT) scans,course of disease, combined disease and other risk factors of the patients were collected in the form of questionnaire. According to the grouping of risk factors, the phonetic characteristics of the patients with PNs were ***: This study was comprised of 200 patients with PNs, as confirmed by CT, and 86 healthy people that served as a control group. Among patients with PNs, 43% had ground glass opacity, 32% had nodules with a diameter ≥ 8 mm, 19% had a history of smoking and 31% had hyperlipidemia. Compared with the normal group, there were statistically significant differences in pitch, intensity and shimmer in patients with PNs. Among patients with PNs, patients with diameters ≥ 8 mm had a significantly higher third formant. There was a significant difference in intensity, fourth formant and harmonics-to-noise ratio(HNR)between smoking and non-smoking patients. Compared with non-hyperlipidemia patients, the pitch, jitter and shimmer of patients with PNs and hyperlipidemia were higher a

关键词： Pulmonary nodules Risk factors Phonetic characteristics Traditional Chinese medicin

Extraction Phase Simulation of Cargo Airdrop System

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Chinese Journal of Aeronautics 2006年第4期19卷 315-321页

作者：柯鹏杨春信杨雪松 Faculty 505 Beijing University of Aeronautics and Astronautics Aerospace Life-support Industries LTD. China Aviation Industry Corporation I

To study the characteristics of cargo extraction, the initial phase of airdrop process, a high fidelity and extendibility simulation model with uniform motion equations for all states during extraction is developed on the basis of dynamics methods and contact models between cargo and aircraft. Simulation results agree well with tests data. Cargo exit parameters, which contribute to cargo pitch after extraction, are studied. Simplified computation model of dimensionless exit time is developed and used to evaluate the relation between extraction phase and landing accuracy. Safe interval model is introduced to evaluate the safety of extraction process. Also, relations between initial parameters, including pull coefficient, aircraft pitch and CG coefficient, etc, and result parameters, including exit time, cargo safety, pitch, etc, are developed to help design of airdrop system, especially the selection of extraction parachute and cargo deployment.

关键词： cargo airdrop system cargo extraction dimensionless exit time safety analysis

基于经验知识遗传算法优化的神经网络模型实现时间反演信道预测

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物理学报 2019年第17期68卷 66-73页

作者：院琳杨雪松王秉中电子科技大学物理学院

人工神经网络由于具有较强的非线性拟合能力,可用来建立终端位置与接收信号之间的映射关系,从而获得不同位置的信道特性.神经网络建模的精度一般由所使用的训练样本数量决定,训练样本数目越多,模型往往越精确.但大量的训练数据的获取,... 详细信息

人工神经网络由于具有较强的非线性拟合能力,可用来建立终端位置与接收信号之间的映射关系,从而获得不同位置的信道特性.神经网络建模的精度一般由所使用的训练样本数量决定,训练样本数目越多,模型往往越精确.但大量的训练数据的获取,耗时较多.本文将经验知识融入遗传算法,对人工神经网络模型进行优化,实现了时间反演电磁信道的快速建模.通过提取时间反演信号的传播参数,并将其作为经验知识用于遗传算法的适应度函数,来优化神经网络模型的权值和阈值.在保证训练样本数量不变的情况下,相比直接利用神经网络建模,提高了建模的精度.以一种简单的室内时间反演场景为例,验证了方法的有效性.

关键词：时间反演信道建模人工神经网络经验知识

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企业绩效管理系统在煤炭企业中的应用

煤炭技术 2013年第10期32卷 263-264页

作者：杨雪松开滦(集团)有限责任公司河北唐山063018

当前我国煤炭企业人力资源存在着人员文化素质偏低,整体素质欠佳;人员结构体系分配不合理;人力资源的管理机制尚未完善。煤炭企业绩效管理存在的问题主要有:对于绩效管理的认识上的误区;绩效指标的片面化与单一化;绩效管理实施者存在问... 详细信息

当前我国煤炭企业人力资源存在着人员文化素质偏低,整体素质欠佳;人员结构体系分配不合理;人力资源的管理机制尚未完善。煤炭企业绩效管理存在的问题主要有:对于绩效管理的认识上的误区;绩效指标的片面化与单一化;绩效管理实施者存在问题。对于绩效管理系统在煤炭企业中的应用,文章主要从绩效管理的过程控制与绩效管理实施前的准备工作进行相关的论述,以期对煤炭企业的发展起到积极的促进作用。

关键词：绩效管理煤炭企业问题应用

浅谈文学翻译教学中学生联想思维的培养——以《未选择的路》为例

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教育理论与实践 2016年第24期36卷 59-60页

作者：杨雪松四川大学外国语学院

文学翻译教学首先建立于学生对作品的审美感受,在这一阶段,教师必须展开联想思维活动,学生才能得到翻译实践的启发和顿悟。结合美国诗人费罗斯特的《未选择的路》一诗,在文学翻译教学中,教师应巧妙应用学生的联想思维,引导学生准确把握... 详细信息

文学翻译教学首先建立于学生对作品的审美感受,在这一阶段,教师必须展开联想思维活动,学生才能得到翻译实践的启发和顿悟。结合美国诗人费罗斯特的《未选择的路》一诗,在文学翻译教学中,教师应巧妙应用学生的联想思维,引导学生准确把握作品的意象、意境和主题。

关键词：文学翻译教学学生联想思维《未选择的路》诗歌审美感受

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我国煤炭企业人力资源管理现状及措施研究

煤炭技术 2014年第1期33卷 249-250页

作者：杨雪松开滦(集团)有限责任公司河北唐山063018

煤炭企业在人力资源管理中往往注重常规管理,即招聘、培训、绩效考核等,而对于从企业思想文化相融合的角度创新人力资源管理模式则较少重视。由此,人力资源管理若能与思想文化的时代品质相契合,则将提升管理工作的效果。在措施构建上可... 详细信息

煤炭企业在人力资源管理中往往注重常规管理,即招聘、培训、绩效考核等,而对于从企业思想文化相融合的角度创新人力资源管理模式则较少重视。由此,人力资源管理若能与思想文化的时代品质相契合,则将提升管理工作的效果。在措施构建上可围绕着重塑人力资源管理目的、创新人力资源管理手段、构建人力资源管理指标等方面来进行。

关键词：煤炭企业人力资源现状措施

改进HHT在线滤波算法在电液伺服系统控制中的应用

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控制理论与应用 2016年第8期33卷 1096-1104页

作者：黄静李长春延皓杨雪松北京交通大学机械与电子控制工程学院北京100044

希尔伯特一黄变换(Hilbert-Huang transform,HHT)是一种针对非线性非平稳信号时频分析的有效方法,在诸多领域有着广泛应用.目前HHT变换主要应用于离线分析,为了将HHT变换引入电液伺服控制系统,实现了一种HHT的在线滤波方法,通过改进的... 详细信息

希尔伯特一黄变换(Hilbert-Huang transform,HHT)是一种针对非线性非平稳信号时频分析的有效方法,在诸多领域有着广泛应用.目前HHT变换主要应用于离线分析,为了将HHT变换引入电液伺服控制系统,实现了一种HHT的在线滤波方法,通过改进的经验模式分解法(EMD),能对系统的输出信号进行实时滤波处理,并适用于电液伺服控制系统.首先设定一定长度的滤波窗口,利用文中改进后的EMD分解法对窗口内的数据进行经验模态分解,从中得到噪声分量和其他干扰信号分量.然后从原信号中去除噪声和干扰信号分量,达到滤波的效果.由于该滤波器的时延特性不随控制信号频率的改变而改变,只与滤波器的窗口长度有关,因此在控制器中可进行延时补偿,将基于HHT在线滤波器的控制方法应用于电液伺服控制系统中,系统输出在相位和控制效果方面都取得了良好的效果,验证了该方法的实用性.

关键词：在线分析 Hilbert-Huang变换(HHT) 电液伺服系统

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重型货物空投系统过程仿真及特性分析

航空学报 2006年第5期27卷 856-860页

作者：柯鹏杨春信杨雪松孙晓伟北京航空航天大学505教研室北京100083 中国航空工业第一集团航宇救生装备有限公司湖北襄樊441022

建立了货物空投系统仿真计算模型,包括货台在舱内和舱外全过程的运动特性、降落伞拉直和充气过程的轨迹特性计算等,提出了伞群模拟和多吊带系统分析的新方法。结合目前已有的降落伞性能计算模型和物伞系统运动模型,对重型货物空投全过... 详细信息

建立了货物空投系统仿真计算模型,包括货台在舱内和舱外全过程的运动特性、降落伞拉直和充气过程的轨迹特性计算等,提出了伞群模拟和多吊带系统分析的新方法。结合目前已有的降落伞性能计算模型和物伞系统运动模型,对重型货物空投全过程进行了完整计算,开发了空投过程三维动画仿真软件,通过与试验数据的对比,表明本模型能很好地满足应用的需要。分析了空投速度、伞包安装位置和牵引比等因素对空投过程的影响,指出了实际系统的改进方向。

关键词：重型货物空投计算机仿真运动特性出机过程伞群效率多吊带系统