检索结果-南通市图书馆

重症感染性休克外周血单个核细胞TLRs信号通路变化

在线全文

学校读者我要写书评

暂无评论

中华医院感染学杂志 2024年第13期34卷 1939-1943页

作者：吴若君范学朋高媛媛杨秀红胡述立熊蓉卢蓉武汉市第一医院重症医学科湖北武汉430022

目的探究重症感染性休克患者外周血单个核细胞(PBMCs)Toll样受体(TLRs)信号通路及细胞免疫炎症因子变化。方法选取2017年1月一2021年1月武汉市第一医院收治的101例重症感染性休克患者为研究组,根据患者人住重症监护病房(ICU)后28d内预... 详细信息

目的探究重症感染性休克患者外周血单个核细胞(PBMCs)Toll样受体(TLRs)信号通路及细胞免疫炎症因子变化。方法选取2017年1月一2021年1月武汉市第一医院收治的101例重症感染性休克患者为研究组,根据患者人住重症监护病房(ICU)后28d内预后情况分为病死组33例和生存组68例,另外选取同期体检的120名健康体检者为对照组,采集重症感染性休克患者感染部位分泌物及血液标本进行病原菌鉴定,比较研究组和对照组以及病死组和生存组PBMCs中TLRs信号通路相关因子TLR2mRNA、TLR4mRNA、核因子κB(NF-κB)表达、外周血T淋巴细胞亚群以及炎症因子水平差异。结果101例重症感染性休克患者共分离得到病原菌117株,其中革兰阴性菌占68.38%;研究组PBMCs中TLR2mRNA、TLR4mRNA、NF-κB表达及外周血CD_(4)^(+)、白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)水平高于对照组(P<0.05),CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、IL-10、干扰素-γ(IFN-γ)水平低于对照组(P<0.05);病死组PBMCs中TLR2mRNA、TLR4mRNA、NF-κB表达及外周血CD_(8)^(+)、IL-4、TNF-α水平高于生存组(P<0.05),CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、IL-10、IFN-γ水平低于生存组(P<0.05)。结论重症感染性休克感染的病原菌以革兰阴性菌为主,TLRs信号通路异常激活、免疫抑制以及炎症反应加重与重症感染性休克及其预后密切相关。

关键词：重症感染性休克 Toll样受体外周血单个核细胞:T淋巴细胞亚群炎症因子

同方期刊数据库

PAHs Sorption and Desorption on Soil Influenced by Pine Needle Litter-Derived Dissolved Organic Matter

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2014年第5期24卷 575-584页

作者： yang xiu-hong P.GARNIER WANG Shi-Zhong V.BERGHEAUD HUANG Xiong-Fei QIU Rong-Liang School of Environmental Science and Engineering Sun Yat-sen University Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology INRA UMR1091 EGCBP 01 F-78850 Thiverval-Grignon (France)

Study of the relationship between plant litter-derived dissolved organic matter(DOM) and organic pollutant transport in soil is important for understanding the role of forest litter carbon cycling in influencing pollutant behaviour and fate in forest *** the aim of providing insight into the capacity of plant litter-derived DOM to influence sorption and desorption of selected polycyclic aromatic hydrocarbons(PAHs) on soil, batch experiments were carried out with application of a sorption-desorption model incorporating DOM effects. Freshly fallen pine(Pinus elliottii) needles were used as the source of organic matter. Input of the pine needle litter-derived DOM was found to significantly decrease desorption hysteresis as well as soil adsorption capacity of phenanthrene(PHE) and fluoranthene(FLA). Addition of 1 728 mg L-1dissolved organic carbon(DOC) lowered the organic carbon-normalized sorption distribution coefficient of PHE from 7 776 to 2 541 L kg-1C and of FLA from 11 503 to 4 368 L kg-1C. Decreases of the apparent sorption-desorption distribution coefficients of PHE and FLA with increased DOC concentration indicated that DOM favored desorption of PAHs from soil. Increases in the fraction of apparently dissolved PAHs were attributable to the dissolved PAH-DOM complexes, accounting for the dissolved proportions of 39% to 69% for PHE and 26% to 72% for FLA in the sorption and desorption processes as the concentration of the added DOM solution rose from 0 to 1 728 mg L-1. Our results suggest that pine needle litterderived DOM can have a substantial effect of inhibiting PAHs sorption and promoting PAHs desorption, thus leading to enhanced leaching in soil, which should be taken into account in risk assessment of PAHs accumulated in forest soil.

关键词： dissolved organic carbon distribution coefficient fluoranthene hysteresis phenanthrene

在线全文

学校读者我要写书评

暂无评论

基于张量扩散的小波域修复模型(英文)

自动化学报 2013年第7期39卷 1071-1079页

作者： yang xiu-hong GUO Bao-Long WU Xian-Xiang ICIE Institute School of Electromechanical EngineeringXidian University

Due to the lossy transmission in the JPEG2000 image compression standard,the loss of wavelet coefficients heavily af-fects the quality of the received *** this paper,we propose a novel wavelet inpainting model based on tensor diffusion(TDWI)to restore the missing or damaged wavelet coefficients.A hybrid model is built by combining structure-adaptive anisotropic regu-larization with wavelet *** associated Euler-Lagrange equation is also given for analyzing its regularity *** to the matrix representation of the structure tensor in the regularization term,the shape of diffusion kernel changes adaptivelyaccording to the image features,including sharp edges,corners and homogeneous *** with existing wavelet inpaint-ing models,the proposed one can control more adaptively and accurately the geometric regularity in the image and exhibits betterrobustness to *** addition,an effective and proper numerical scheme is adopted to improve the *** on a variety of loss scenarios are given to demonstrate the advantages of our proposed model.

关键词：小波系数扩散张量修复图像压缩标准 JPEG2000 应用拉格朗日方程自适应结构

Thioredoxin and impaired spatial learning and memory in the rats exposed to intermittent hypoxia

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第17期125卷 3074-3080页

作者： yang xiu-hong LIU Hui-guo LIU Xue CHEN Jun-nan Department of Respiratory and Critical Care Medicine Tongji HospitalTong3i Medical CollegeHuazhong University of Science and Technology Key Laboratory of Respiratory Disease of the Ministry of Health WuhanHubei 430030China

Background Obstructive sleep apnea （OSA） can cause cognitive dysfunction and may be a reversible cause of cognitive loss in patients with Alzheimer＇s disease （AD）. Chronic exposure to intermittent hypoxia （IH）, such as encountered in OSA, is marked by neurodegenerative changes in rat brain. We investigated the change of thioredoxin （Trx）, spatial learning and memory in rats exposed to chronic intermittent hypoxia （CIH）. Methods Forty healthy male Sprague-Dawley （SD） rats were randomly divided into four groups of ten each： a CIH＋normal saline （CIH＋NS group）, a N-acetylcystein-treated CIH （CIH＋NAC） group, a sham CIH group （sham CIH＋NS）, and a sham NAC-treated sham CIH （CIH＋NAC） group. Spatial learning and memory in each group was assessed with the Morris water maze. Real-time PCR and Western blotting were used to examine mRNA and protein expression of Trx in the hippocampus tissue. The terminal deoxynucleotidyl transferase-mediated dUTP-nick end-labeling （TUNEL） method was used to detect the apoptotic cells of the hippocampus CA1 region. Results CIH-rats showed impaired spatial learning and memory in the Morris water maze, including longer mean latencies for the target platform, reduced numbers of passes over the previous target platform and a smaller percentage of time spent in the target quadrant. Trx mRNA and protein levels were significantly decreased in the CIH-hippocampus, meanwhile, an elevated apoptotic index revealed apoptosis of hippocampal neurons of rats exposed to CIH. The rats, which acted better in the Morris water maze, showed higher levels of the Trx mRNA and protein in the hippocampus; apoptotic index of the neurons in the hippocampus of each group was negatively correlated with the Trx mRNA and protein levels. Conclusion The Trx deficit likely plays an important role in the impaired spatial learning and memory in the rats exposed to CIH and may work through the apoptosis of neurons in the hippocampus.

关键词： intermittent hypoxia thioredoxin spatial learning oxidative stress sleep apnea

Ability of Helicobacter pylori to internalize into Candida

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第16期30卷 2281-2284页

作者： Zheng-hong Chen Jian-Chao Sun Ting-xiu yang Gu-Zhen Cui Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Key Laboratory of Endemic and Ethnic Diseases of Ministry of Education Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Joint Laboratory of Helicobacter Pylori and Intestinal Microecology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Department of Quality Control Guizhou Provincial Center for Clinical LaboratoryGuiyang 550002Guizhou ProvinceChina Department of Hospital Infection and Management Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

The following are our views regarding the“letter to the editor”(Helicobacter is preserved in yeast vacuoles!Does Koch’s postulates confirm it?)by Alipour and Gaeini,and the response“letter to the editor”(Candida accommodates nonculturable Helicobacter pylori in its vacuole-Koch’s postulates aren’t applicable)by Siavoshi and *** and Gaeini rejected the methods,results,discussion,and conclusions summarized in a review article by Siavoshi and *** present article reviews and discusses evidence on the evolutionary adaptation of Helicobacter pylori(***)to thrive in Candida cell vacuoles and concludes that Candida could act as a Trojan horse,transporting potentially infectious *** into the stomach of humans.

关键词： Helicobacter pylori Candida yeast Intracellular presence Helicobacter pylori-specific gene Helicobacter pylori transmission

Oxidation behavior of 4774DD1 Ni-based single-crystal superalloy at 980℃ in air

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Foundry 2024年第2期21卷 116-124页

作者： Yu Fang Ya-zhou Li Qiang yang Qun-gong He xiu-fang Gong Qian Duan Hai-yang Song Fu Wang Qiong-yuan Zhang hong Zeng State Key Laboratory of Long-Life High Temperature Materials Dongfang Turbine Co.Ltd.Deyang 618000SichuanChina State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

The oxidation behavior of a novel Ni-based single-crystal 4774DD1 superalloy for industrial gas turbine applications was investigated by the isothermal oxidation at 980℃ and discontinuous oxidation weight gain *** phase constitution and morphology of surface oxides and the characteristics of the crosssection oxide film were analyzed by XRD,SEM and *** show that the oxidation kinetics of the 4774DD1 superalloy follows the cubic law,indicating its weak oxidation resistance at this *** the oxidation time increases,the composition of the oxide film evolves as following:One layer consisting of a bottom Al_(2)O_(3)sublayer and an upper(Al_(2)O_(3)+NiO)mixture sublayer after oxidized for 25 ***,two layers composed of an outermost small NiO discontinuous grain layer and an internal layer for 75 *** internal layer is consisted of the bottom Al_(2)O_(3)sublayer,an intermediate narrow CrTaO_(4)sublayer,and an upper(Al_(2)O_(3)+NiO)mixture *** two layers comprising an outermost relative continuous NiO layer with large grain size and an internal layer as the oxidation time increases to 125 *** internal layer is composed of the upper(Al_(2)O_(3)+NiO)mixture sublayer,an intermediate continuous(CrTaO_(4)+NiWO_(4))mixture sublayer,and a bottom Al_(2)O_(3)***,three layers consisting of an outermost(NiAl2O_(4)+NiCr2O_(4))mixture layer,an intermediate(CrTaO_(4)+NiWO_(4))mixture layer,and a bottom Al_(2)O_(3)layer for 200 h.

关键词： nickel-base single crystal superalloy oxidation kinetics oxide film microstructure mechanism

In situ tracking of the lithiation and sodiation process of disodium terephthalate as anodes for rechargeable batteries by Raman spectroscopy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第1期17卷 245-252页

作者： xiu-Mei Lin Chong Han Xin-Tao yang Jia-Sheng Lin Wei-Qiang yang hong-Xu Guo Yao-Hui Wang Jin-Chao Dong Jian-Feng Li Department of Chemistry and Environment Science Fujian Province University Key Laboratory of Analytical ScienceMinnan Normal UniversityZhangzhou 363000China College of Energy College of Chemistry and Chemical EngineeringCollege of MaterialsState Key Laboratory of Physical Chemistry of Solid SurfacesiChEMXiamen UniversityXiamen 361005China Institute of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China

Organic compounds represent an appealing group of electrode materials for rechargeable batteries due to their merits of biomass,sustainability,environmental friendliness,and *** terephthalate(Na_(2)C_(8)H_(4)O_(4),Na_(2)TP),an organic salt with a theoretical capacity of 255 mAh·g^(-1),is electroactive towards both lithium and ***,its electrochemical energy storage(EES)process has not been directly observed via in situ characterization techniques and the underlying mechanisms are still under ***,in situ Raman spectroscopy was employed to track the de/lithiation and de/sodiation processes of *** appearance and then disappearance of the–COOLi Raman band at 1625 cm^(-1) during the de/lithiation,and the increase and then decrease of the–COONa Raman band at 1615 cm^(-1) during the de/sodiation processes of Na2TP elucidate the one-step with the 2Li+or 2Na+transfer *** also found that the inferior cycling stability of Na2TP as an anode for sodium-ion batteries(SIBs)than lithium-ion batteries(LIBs)could be due to the larger ion radium of Na+than Li+,which results in larger steric resistance and polarization during *** Na2TP,therefore,shows greater changes in spectra during de/sodiation than de/*** expect that our findings could provide a reference for the rational design of organic compounds for EES.

关键词： disodium terephthalate(Na_(2)C_(8)H_(4)O_(4) Na2TP) in situ Raman spectroscopy de/lithiation de/sodiation mechanisms

Morphology Study for GeV Emission of Nearby Supernova Remnant G332.5-5.6

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第4期24卷 134-140页

作者： Ming-hong Luo Qing-Wen Tang xiu-Rong Mo Department of Physics School of Physics and Materials ScienceNanchang UniversityNanchang 330031China

A spatial template is important to study nearby supernova remnants(SNRs).For SNR G332.5-5.6,we report a Gaussian disk with a radius of about 1°.06 to be a potential good spatial model in the γ-ray *** this new Gaussian disk,its GeV lightcurve shows a significant variability of about seven *** γ-ray observations of this SNR could be explained well either by a leptonic model or a hadronic model,in which a flat spectrum for the ejected electrons/protons is required.

关键词： ISM:supernova remnants gamma rays:ISM

Possibilities for the synthesis of superheavy element Z=121 in fusion reactions

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第6期35卷 90-100页

作者： Ming-Hao Zhang Yu-Hai Zhang Ying Zou xiu-xiu yang Gen Zhang Feng-Shou Zhang The Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China School of Physical Science and Technology Guangxi UniversityNanning 530004China National Laboratory of Heavy Ion Accelerator of Lanzhou Center of Theoretical Nuclear PhysicsLanzhou 730000China

Based on the dinuclear system model,the calculated evaporation residue cross sections matched well with the current experimental *** synthesis of superheavy elements Z=121 was systematically studied through combinations of stable projectiles with Z=21-30 and targets with half-lives exceeding 50 *** influence of mass asymmetry and isotopic dependence on the projectile and target nuclei was investigated in *** reactions^(254)Es(^(46)Ti,3n)^(297)121 and^(252)Es(^(46)Ti,3n)^(295)121 were found to be experimentally feasible for synthesizing superheavy element Z=121,with maximal evaporation residue cross sections of 6.619 and 4.123 fb at 219.9 and 223.9 MeV,respectively.

关键词： Superheavy nuclei Dinuclear system model Fusion reaction Evaporation residue cross section