检索结果-南通市图书馆

Divergent Protein Engineering of Transaminase for the Synthesis of Chiral Rivastigmine and Apremilast Precursors

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第19期42卷 2335-2340页

作者： Langyu Tang xinjie yang Ningning Sun Guojiao Wu Yuzhou Wu Fangrui Zhong Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Hubei Key Laboratory of Bioinorganic Chemistry&Materia MedicaSchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology1037 Luoyu RoadWuhanHubei 430074China Longgang Institute of Zhejiang Sci-Tech University WenzhouZhejiang 325802China Shenzhen Huazhong University of Science and Technology Research Institute ShenzhenGuangdong 518000China

Comprehensive Summary The implementation of divergent protein engineering on the natural transaminase Vf-ω-TA led to the development of two effective mutants(M2 and M8),enabling the enzymatic synthesis of chiral amine precursors of Rivastigmine and Apremilast,*** evolution of the enzymes was guided by crystal structures and a focused mutagenesis strategy,allowing them to effectively address the challenging ketone substrates with significant steric *** the optimized reaction parameters,transamination proceeded smoothly in good conversions and with perfect stereochemical control(>99%ee).These processes utilize inexpensiveα-methylbenzylamine as an amine donor and avoid the continuous acetone removal and costly LDH/GDH/NADH systems.

关键词： Asymmetric catalysis Chiral amine Protein engineering Directed evolution Biocatalysis Transaminase Enantioselectivity Syntheticmethods Amination Enzymes

The Current Analysis of Protection Path of Farmers＇ Rights and Causes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Technology Management 2014年第11期 121-123页

作者： xinjie yang Luohe Medical College Luohe462000 China

The problem of Chinese peasant in society is a very important issue in the process of China＇ s legal system; the farmer is very worthy subject of rights concern. The author believes that China has the right to protect their farmers in three main ways： private relief, public relief and gray channels, which play a major role in the private relief for farmers. For these channels, they are a unique reason; the rule of law should be the vision and balance for them to choose their own presence in China.

关键词： Farmers' Rights Protection Relief

Increased Incidence of Severe Adverse Events in Non-Small Cell Lung Cancer Patients with Previous Tuberculosis Episode Treated with PD-1 Inhibitors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第7期37卷 785-789页

作者： Hui Zhang Jinfeng Yuan Yuanyuan Xu Mengjie yang Jialin Lyu xinjie yang Shuyan Sheng Zhe Qian Qunhui Wang Yu Pang Ying Hu Department of Medical Oncology Beijing Chest HospitalCapital Medical University&Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Bacteriology and Immunology Beijing Key Laboratory on Drug-Resistant Tuberculosis ResearchBeijing Chest HospitalCapital Medical University/Beijing Tuberculosis&Thoracic Tumor Research InstituteBeijing 101149China Chinese Center for Disease Control and Prevention Beijing 102206China

Lung cancer is the top cause of cancer deaths *** in immune checkpoint inhibitors(ICIs)have transformed cancer treatment,but their use in lung cancer has led to more side *** study examined if past pulmonary tuberculosis(TB)affects ICIs’effectiveness and safety in lung cancer *** reviewed lung cancer patients treated with ICIs at Beijing Chest Hospital from January 2019 to August 2022.

关键词： Lung lung Cancer

Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2018年第1期30卷 112-121页

作者： Jingxiao Wang xinjie yang Haibo Han Limin Wang Weiqian Bao Shanshan Wang Robert M.Hoffman Meng yang Hui Qi Chao An Kaiwen Hu Beijing University of Chinese Medicine Beijing 100029 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Biobank Peking University Cancer Hospital & Institute Beijing 100142 China Anti Cancer Inc. San DiegoCA 92111 USA Department of Surgery University of California San Diego CA 92103-8220 USA Anti Cancer Biotech Co Ltd. Beijing102200 China Department of Oneology Dongfang Hospital Beijing University of Chinese Medicine Beijing 100078 China

Objective： Triple-negative breast cancer（TNBC） is highly invasive and metastatic, which is in urgent need of transformative therapeutics. Tubeimu（TBM）, the rhizome of Bolbostemma paniculatum（Maxim.） Franquet, is one of the Chinese medicinal herbs used for breast diseases since the ancient times. The present study evaluated the efficacy, especially the anti-metastatic effects of the dichloromethane extract of Tubeimu（ETBM） on TNBC orthotopic mouse models and cell ***： We applied real-time imaging on florescent orthotopic TNBC mice model and tested cell migration and invasion abilities with MDA-MB-231 cell line. Digital gene expression sequencing was performed and Kyoto Encyclopedia of Genes and Genomes（KEGG） analysis applied to explore the pathways influenced by ***, quantitative real-time polymerase chain reactions（q RT-PCR） and Western blot were delivered to confirm the gene expression ***： ETBM exhibited noticeable control on tumor metastasis and growth of TNBC tumors with no obvious toxicity. In compliance with this, it also showed inhibition of cell migration and invasion in vitro. Its impact on the changed biological behavior in TNBC may be a result of decreased expression of integrin β1（ITGβ1）, integrin β8（ITGβ8） and Rho GTPase activating protein 5（ARHGAP5）, which disabled the focal adhesion pathway and caused change in cell ***： This study reveals that ETBM has anti-metastatic effects on MDA-MB-231-GFP tumor and may lead to a new therapeutic agent for the integrative treatment of highly invasive TNBC.

关键词： Tubeimu triple negative breast cancer(TNBC) orthotopic mouse models Traditional Chinese Medicine(TCM) integrins Rho GTPase activating protein 5

The perineural invasion of the salivary adenoid cystic carcinoma

在线全文

学校读者我要写书评

暂无评论

The perineural invasion of the salivary adenoid cystic carci...

Direct C-H Alkenylation of Functionalized Indazoles under High-speed Ball-milling Conditions

第十四次中国口腔颌面外科学术会议

作者： xinjie yang The Fourth Military Medical University

Salivary adenoid cystic carcinoma(SACC)has a striking characteristic named perineural invasion,which is the research hotspot in the field of the head and neck *** spatial-temporal features and molecular mechanism of t...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Direct C-H Alkenylation of Functionalized Indazoles under Hi...

美国中学历史教科书的国家形象建构及作用机理

中国化学会·第十五届全国有机合成化学学术研讨会

作者： xinjie yang 俞静波 Weike Su Collaborative Innovation Center of yangtze River Delta Region Green Pharmaceuticals Zhejiang University of Technology 浙江工业大学

Transition metal-catalyzed alkenylation of heteroarene C-H bonds has regained considerable attention over recent years .These reactions can potentially provide concise routes for constructing various drugs and drug *** an important class of heteroarenes, indazole motifs are embedded in numerous pharmaceuticals with a broad range of biological activities , including axitinib, pazopanib, benzydamine, granisetron, and ***, the installation of alkenyl groups onto the indazole ring has had limited success, particularly for(1H) indazole which confront with formidable challenge due to lack of *** two examples of alkenylation of(1H) indazole have been reported so far .However, these methods are more or less suffered from harsh reaction conditions such as noble metal oxidant, environmentally unfriendly solvent, or high ***, both their yields and substrate scope remain to be substantially ***, we developed a highly efficient and mild catalytic system for the C-3 alkenylation of(1H) indazole through C-H activation under high-speed ball-milling(HSBM) conditions with wide substrate scope and good yields.

关键词： indazoles C-H activation alkenylation ball milling

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

比较教育研究 2024年第3期46卷 22-32页

作者：罗生全杨馨洁西南大学西南民族教育与心理研究中心重庆400700 西南大学教育学部重庆400700

教科书是国家形象建构的重要载体,对学生形成国家认同具有重要作用。鉴于美国在国家形象建构方面的典型性,关注其教科书中的国家形象建构尤为必要。为此选取美国霍顿·米夫林·哈考特版中学历史教科书《1877年以来的美国历史》,从国家... 详细信息

教科书是国家形象建构的重要载体,对学生形成国家认同具有重要作用。鉴于美国在国家形象建构方面的典型性,关注其教科书中的国家形象建构尤为必要。为此选取美国霍顿·米夫林·哈考特版中学历史教科书《1877年以来的美国历史》,从国家形象的概念解析中确立分析框架,从物质、制度、文化和国民四个维度考察其中的美国国家形象现实样态。研究发现,该版教科书中的国家形象呈现出整合集体记忆、善用“他者”对比、融入美国价值观、巧用微观史学的建构特征。其中暗含的多维国家形象的内在作用机理是:以国家精英的一致行动为基础,以制度性标准约束与规范其行动路向,以美国价值观作为逻辑主线,以多种叙事模式权威化教科书。

关键词：美国历史教育教科书国家形象

地方意识与国家认同:美国得克萨斯州中学历史教科书的叙事逻辑

在线全文

学校读者我要写书评

暂无评论

外国教育研究 2024年第10期51卷 49-61页

作者：罗生全杨馨洁西南大学西南民族教育与心理研究中心重庆400700 西南大学教师教育学院重庆400700

爱国与爱乡的一体性使地方历史教科书承担着传承地方文化与培育国家认同的双重使命。《得克萨斯州历史》作为美国地方历史教科书的代表,在地方意识与国家认同的关系叙事中有着典型经验。该教科书在事件的可续性中呈现出国家形象的主客... 详细信息

爱国与爱乡的一体性使地方历史教科书承担着传承地方文化与培育国家认同的双重使命。《得克萨斯州历史》作为美国地方历史教科书的代表,在地方意识与国家认同的关系叙事中有着典型经验。该教科书在事件的可续性中呈现出国家形象的主客镜像转变,在中央与地方的事权划分中建构联邦制国家形象,在地方文化的符号联想中具象化自由主义国家形象。其叙事遵循三重逻辑:一是以合法性叙事形成国家与地方权力运行认同向度的底层逻辑;二是以国家叙事与地方叙事的话语互嵌达成共识的话语逻辑;三是以价值叙事形塑地方认同与国家认同路径的价值逻辑,并呈现出以培养具有美国精神的公民为共同目标,以意识形态国家机器淡化争议性历史过往,以制度性标准倒逼教科书生产价值渗透的特征。

关键词：美国教科书地方意识国家形象国家认同叙事

在线全文

学校读者我要写书评

暂无评论

中国共产党执政初期反腐倡廉的思想与实践

中共中央党校学报 2010年第3期14卷 49-52页

作者：祝彦杨鑫洁中共中央党校中共党史教研部北京海淀100089 中共中央党校研究生院北京海淀100089

执政初期,我党坚持了一贯的自身建设,对反腐败问题十分重视,并在既往经验的基础上,进一步加大了惩治和预防的力度,取得了一定成绩。总结其经验和教训,对于今天的执政党建设具有重要意义。

关键词：执政初期中国共产党反腐倡廉